The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Open accessAbstract
SUMMARY: Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-resistant bacteria. Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug (antibiotic) resistance (MDR). However, the clinical relevance of efflux-mediated resistance is species, drug, and infection dependent. This review focuses on chromosomally encoded pumps in bacteria that cause infections in humans. Recent structural data provide valuable insights into the mechanisms of drug transport. MDR efflux pumps contribute to antibiotic resistance in bacteria in several ways: (i) inherent resistance to an entire class of agents, (ii) inherent resistance to specific agents, and (iii) resistance conferred by overexpression of an efflux pump. Enhanced efflux can be mediated by mutations in (i) the local repressor gene, (ii) a global regulatory gene, (iii) the promoter region of the transporter gene, or (iv) insertion elements upstream of the transporter gene. Some data suggest that resistance nodulation division systems are important in pathogenicity and/or survival in a particular ecological niche. Inhibitors of various efflux pump systems have been described; typically these are plant alkaloids, but as yet no product has been marketed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are 5 major families of efflux pumps, including i) the major facilitator superfamily (MFS), ii) the small multidrug resistance family (SMR), iii) the resistance-nodulation-cell-division family (RND), iv) the ATP-binding cassette family (ABC), and v) the multidrug and toxic compound extrusion family (MATE).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Diekema, D. J., Pfaller, M. A., Schmitz, F., Smayevsky, J., Bell, J. M., Jones, R. N., Beach, M. L., & SENTRY Participants Group (2001) · Clinical Infectious Diseases · doi:10.1086/320184 · Cited by 1,363
Koronakis, V. E., Sharff, A., Koronakis, E., Luisi, B. F., & Hughes, C. (2000) · Nature · doi:10.1038/35016007 · Cited by 1,086
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Crystal structure of bacterial multidrug efflux transporter AcrB
Murakami, S., Nakashima, R., Yamashita, E., & Yamaguchi, A. (2002) · Nature · doi:10.1038/nature01050 · Cited by 1,018
Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903
The importance of efflux pumps in bacterial antibiotic resistance
Webber, M. A. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg050 · Cited by 856
Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 811
Research works printed but not linked: 2
- Alekshun, M. A., and S. B. Levy. 2004. The Escherichia coli mar locus—antibiotic resistance and more. ASM News70:451-456.
- Olliver, A., M. Valle, E. Chaslus-Dancla, and A. Cloeckaert. 2004. Role of an acrR mutation in multidrug resistance of in vitro selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. FEMS Microbiol. Lett.238:267-272.
Cited by
Sorted by citations
Items 101–200 of 1,000
Waltzing transporters and 'the dance macabre' between humans and bacteria
Lomovskaya, O., Zgurskaya, H. I., Totrov, M. M., & Watkins, W. J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2200 · Cited by 186
Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB
von Groll, A., Martin, A., Juréen, P., Hoffner, S., Vandamme, P. A. R., Portaels, F., Palomino, J. C., & da Silva, P. E. A. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00287-09 · Cited by 181
Bina, X. R., Provenzano, D., Nguyen, N., & Bina, J. E. (2008) · Infection and Immunity · doi:10.1128/iai.01620-07 · Cited by 178
The intrinsic resistome of bacterial pathogens
Olivares‐Pacheco, J., Bernardini, A., García‐León, G., Corona, F., Sánchez, M. B., & Martínez, J. L. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00103 · Cited by 175
Balganesh, M., Dinesh, N., Sharma, S., Kuruppath, S., Nair, A. V., & Sharma, U. K. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06003-11 · Cited by 176
Abouzeed, Y. M., Baucheron, S., & Cloeckaert, A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00084-08 · Cited by 173
Martı́nez-Suárez, J. V., Ortiz, S., & López-Alonso, V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00638 · Cited by 173
AcrB: a mean, keen, drug efflux machine
Kobylka, J., Kuth, M. S., Müller, R. T., Geertsma, E. R., & Pos, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14239 · Cited by 174
Antibiotics: Pharmacokinetics, toxicity, resistance and multidrug efflux pumps
Çolak, Ç. Y., & Özcengiz, G. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.10.005 · Cited by 171
Disinfectant resistance in bacteria: Mechanisms, spread, and resolution strategies
Tong, C., Hu, H., Chen, G., Li, Z., Li, A., & Zhang, J. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110897 · Cited by 172
Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor
Gupta, S., Tyagi, S. K., Almeida, D. V., Maiga, M. C., Ammerman, N. C., & Bishai, W. R. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0650oc · Cited by 168
Handzlik, J., Matys, A., & Kieć‐Kononowicz, K. (2013) · Antibiotics · doi:10.3390/antibiotics2010028 · Cited by 170
Zowalaty, M. E. E., Thani, A. A. A., Webster, T. J., Zowalaty, A. E. E., Schweizer, H. P., Nasrallah, G. K., Marei, H. E. S., & Ashour, H. M. (2015) · Future Microbiology · doi:10.2217/fmb.15.48 · Cited by 169
Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily
Kumar, S. H., Mukherjee, M. M., & Varela, M. F. (2013) · International Journal of Bacteriology · doi:10.1155/2013/204141 · Cited by 167
Andersen, J. L., He, G.-X., Kakarla, P., Ranjana, K. C., Kumar, S. H., Lakra, W. S., Mukherjee, M. M., Ranaweera, I., Shrestha, U., Tran, T., et al. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120201487 · Cited by 178
Antibiotic Adjuvants: A Versatile Approach to Combat Antibiotic Resistance
Dhanda, G., Acharya, Y., & Haldar, J. (2023) · ACS Omega · doi:10.1021/acsomega.3c00312 · Cited by 170
Antimicrobial Resistance and Its Drivers—A Review
Irfan, M., Almotiri, A., & AlZeyadi, Z. A. (2022) · Antibiotics · doi:10.3390/antibiotics11101362 · Cited by 190
The role of bacterial metabolism in antimicrobial resistance
Ahmad, M., Aduru, S. V., Smith, R. P., Zhao, Z., & Lopatkin, A. J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01155-0 · Cited by 186
Martins, M., Dastidar, S. G., Fanning, S., Kristiansen, J. E., Molnar, J. A., Pagès, J., Schelz, Z., Spengler, G., Viveiros, M., & Amaral, L. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.10.025 · Cited by 160
Challenges and future prospects of antibiotic therapy: from peptides to phages utilization
Mandal, S. M., Roy, A., Ghosh, A. K., Hazra, T. K., Basak, A., & Franco, O. L. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00105 · Cited by 162
Kourtesi, C., Ball, A. R., Huang, Y., Jachak, S. M., Vera, D. M. A., Khondkar, P., Gibbons, S., Hamblin, M. R., & Tegos, G. P. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010034 · Cited by 161
Keeney, D. R., Ruzin, A. V., McAleese, F., Murphy, E., & Bradford, P. A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm397 · Cited by 155
Microbial Efflux Pump Inhibition: Tactics and Strategies
Tegos, G. P., Haynes, M. K., Strouse, J. J., Khan, M. M. T., Bologa, C., Oprea, T. I., & Sklar, L. A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795703726 · Cited by 157
Mima, T., Joshi, S. M., Escalada, M. G., & Schweizer, H. P. (2007) · Journal of Bacteriology · doi:10.1128/jb.00850-07 · Cited by 153
Aparna, V., Kesavan, D. K., Mohanalakshmi, N., Velmurugan, D., & Hopper, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101840 · Cited by 152
Zhao, J., Chen, Z., Chen, S., Deng, Y., Liu, Y., Tian, W. X., Huang, X., Wu, C., Sun, Y., Sun, Y., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00139-10 · Cited by 152
Ecology and evolution of antibiotic resistance
Baquero, F., Alvarez‐Ortega, C., & Martínez, J. L. (2009) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2009.00053.x · Cited by 161
A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps
Martins, M., McCusker, M. P., Viveiros, M., Couto, I., Fanning, S., Pagès, J., & Amaral, L. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010072 · Cited by 148
Bhardwaj, A. K., & Mohanty, P. (2012) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489112799829710 · Cited by 148
Gupta, A. K., Katoch, V. M., Chauhan, D. S., Sharma, R., Singh, M., Venkatesan, K., & Sharma, V. D. (2009) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0054 · Cited by 147
Abbott, I. J., Cerqueira, G. M., Bhuiyan, S., & Peleg, A. Y. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.13.21 · Cited by 147
Resistance of Bacteria to Biocides
Maillard, J. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.arba-0006-2017 · Cited by 147
Srinivasan, V. B., Rajamohan, G., & Gebreyes, W. A. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00748-09 · Cited by 145
Valle, D. L., Andrade, J. I., Puzon, J. J. M., Cabrera, E. C., & Rivera, W. L. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2015.04.005 · Cited by 146
Perry, E. K., Meirelles, L. A., & Newman, D. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00620-w · Cited by 149
Kovačević, J. J., Ziegler, J., Wałecka-Zacharska, E., Reimer, A. R., Kitts, D. D., & Gilmour, M. W. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03741-15 · Cited by 141
Chen, B., Han, J., Dai, H., & Jia, P. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117074 · Cited by 140
RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms
Ruggerone, P., Murakami, S., Pos, K. M., & Vargiu, A. V. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660220 · Cited by 138
Miladi, H., Zmantar, T., Kouidhi, B., Qurashi, Y. M. A. A., Bakhrouf, A., Chaabouni, Y., Mahdouani, K., & Chaieb, K. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.09.057 · Cited by 137
Bialek-Davenet, S., Lavigne, J., Guyot, K., Mayer, N., Tournebize, R., Brisse, S., Leflon‐Guibout, V., & Nicolas-Chanoine, M.-H. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku340 · Cited by 136
Quinolone Resistance: Much More than Predicted
Hernández, A., Sánchez, M. B., & Martínez, J. L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00022 · Cited by 141
Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria
Garvey, M. I., Rahman, M. M., Gibbons, S., & Piddock, L. J. V. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.10.027 · Cited by 135
Self-citationWebber, M. A., Bailey, A. M., Blair, J. M. A., Morgan, E., Stevens, M. P., Hinton, J. C. D., Ivens, A. C., Wain, J. R., & Piddock, L. J. V. (2009) · Journal of Bacteriology · doi:10.1128/jb.00363-09 · Cited by 134
Self-citationSharma, P., Haycocks, J. R. J., Middlemiss, A. D., Kettles, R. A., Sellars, L. E., Ricci, V., Piddock, L. J. V., & Grainger, D. C. (2017) · Nature Communications · doi:10.1038/s41467-017-01405-7 · Cited by 134
Self-citationRamón‐García, S., Martı́n, C., Thompson, C. J., & Aínsa, J. A. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00550-09 · Cited by 132
Bacterial multidrug transport through the lens of the major facilitator superfamily
Fluman, N., & Bibi, E. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.11.020 · Cited by 131
Bohnert, J. A., Schuster, S., Seeger, M. A., Fähnrich, E., Pos, K. M., & Kern, W. V. (2008) · Journal of Bacteriology · doi:10.1128/jb.00912-08 · Cited by 131
Schmid‐Hempel, P. (2021) · doi:10.1093/oso/9780198832140.001.0001 · Cited by 137
Efflux Pump Induction by Quaternary Ammonium Compounds and Fluoroquinolone Resistance in Bacteria
Buffet‐Bataillon, S., Tattevin, P., Maillard, J., Bonnaure‐Mallet, M., & Jolivet‐Gougeon, A. (2015) · Future Microbiology · doi:10.2217/fmb.15.131 · Cited by 127
Role of Novel Multidrug Efflux Pump Involved in Drug Resistance in Klebsiella pneumoniae
Srinivasan, V. B., Singh, B. B., Priyadarshi, N., Chauhan, N. K., & Rajamohan, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096288 · Cited by 128
Amaral, L., Martins, M., & Viveiros, M. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl500 · Cited by 128
Acinetobacter baumannii:an emerging multidrug-resistant threat
Gootz, T. D., & Marra, A. (2008) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.6.3.309 · Cited by 134
Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa
Askoura, M., Mattawa, W., Abujamel, T. S., & Taher, I. (2011) · Libyan Journal of Medicine · doi:10.3402/ljm.v6i0.5870 · Cited by 127
Strategies to Potentiate Antimicrobial Photoinactivation by Overcoming Resistant Phenotypes †
Vera, D. M. A., Haynes, M. H., Ball, A. R., Dai, T., Astrakas, C., Kelso, M. J., Hamblin, M. R., & Tegos, G. P. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01087.x · Cited by 125
DAVIES, J. E. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401022 · Cited by 128
Tolerance of Listeria monocytogenes to biocides used in food processing environments
Duze, S. T., Marimani, M. D., & Patel, M. (2021) · Food Microbiology · doi:10.1016/j.fm.2021.103758 · Cited by 124
Enteroaggregative Escherichia coli : An Emerging Enteric Food Borne Pathogen
Kaur, P., Chakraborti, A., & Asea, A. A. A. (2010) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2010/254159 · Cited by 124
Bombaywala, S., Mandpe, A., Paliya, S., & Kumar, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13143-x · Cited by 121
Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma
Shi, B., Abrams, M. T., & Sepp‐Lorenzino, L. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413503662 · Cited by 119
Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump
Ohene‐Agyei, T., Mowla, R., Rahman, T., & Venter, H. (2014) · MicrobiologyOpen · doi:10.1002/mbo3.212 · Cited by 119
The role played by drug efflux pumps in bacterial multidrug resistance
Chitsaz, M., & Brown, M. H. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160064 · Cited by 119
Jang, S. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0070 · Cited by 131
Jung, J., Popp, C., Sparbier, K., Lange, C., Kostrzewa, M., & Schubert, S. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02691-13 · Cited by 120
Zhang, S., Yang, G., Hou, S., Zhang, T., Li, Z., & Liang, F. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.031 · Cited by 118
Mechanisms of Antimicrobial Resistance (AMR) and Alternative Approaches to Overcome AMR
Moo, C.-L., Yang, S.-K., Yusoff, K., Ajat, M., Thomas, W., Abushelaibi, A. A., Lim, S. E., & Lai, K. (2019) · Current Drug Discovery Technologies · doi:10.2174/1570163816666190304122219 · Cited by 129
Masi, M., & Pagès, J. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010022 · Cited by 115
Multidrug efflux pumps in Staphylococcus aureus and their clinical implications
Jang, S. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5159-z · Cited by 117
Wieczorek, P., Sacha, P., Hauschild, T., Żórawski, M., Krawczyk, M., & Tryniszewska, E. A. (2008) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-008-0056-x · Cited by 120
Chantratita, N., Rholl, D. A., Sim, B., Wuthiekanun, V., Limmathurotsakul, D., Amornchai, P., Thanwisai, A., Chua, H. H., Ooi, W. F., Holden, M. T. G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111020108 · Cited by 117
Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli
Rinaldi, M. A., Ferraz, C. A., & Scrutton, N. S. (2021) · Natural Product Reports · doi:10.1039/d1np00025j · Cited by 117
Copper nanoparticles as an efflux pump inhibitor to tackle drug resistant bacteria
Christena, L. R., Mangalagowri, V., Pradheeba, P., Ahmed, K. B. A., Shalini, B. I. S., Vidyalakshmi, M., Veerappan, A., & Nagarajan, S. (2015) · RSC Advances · doi:10.1039/c4ra15382k · Cited by 115
Zhao, R., Feng, J., Huang, J., Li, X., & Li, B. J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142632 · Cited by 116
Dashtbani-Roozbehani, A., & Brown, M. H. (2021) · Antibiotics · doi:10.3390/antibiotics10121502 · Cited by 118
The Three Bacterial Lines of Defense against Antimicrobial Agents
Zhou, G., Shi, Q., Huang, X.-M., & Xie, X. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921711 · Cited by 125
Ortiz, S., López-Alonso, V., Rodríguez, P., & Martı́nez-Suárez, J. V. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02824-15 · Cited by 112
Pasqua, M., Grossi, M., Zennaro, A., Fanelli, G., Micheli, G., Barras, F., Colonna, B., & Prosseda, G. (2019) · Microorganisms · doi:10.3390/microorganisms7090285 · Cited by 111
Allen, K. J., Wałecka-Zacharska, E., Chen, J. C., Kosek-Paszkowska, K., Devlieghere, F., Meervenne, E. V., Osek, J., Wieczorek, K., & Bania, J. (2014) · Food Microbiology · doi:10.1016/j.fm.2014.08.006 · Cited by 110
Piddock, L. J. V., Garvey, M. I., Rahman, M. M., & Gibbons, S. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq079 · Cited by 111
Self-citationRajamohan, G., Srinivasan, V. B., & Gebreyes, W. A. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp427 · Cited by 111
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria
Compagne, N., Cruz, A. V. D., Müller, R. T., Hartkoorn, R. C., Flipo, M., & Pos, K. M. (2023) · Antibiotics · doi:10.3390/antibiotics12010180 · Cited by 110
Zack, K. M., Sorenson, T., & Joshi, S. G. (2024) · Pathogens · doi:10.3390/pathogens13030197 · Cited by 114
Novel approaches to the treatment ofPseudomonas aeruginosainfections in cystic fibrosis
Hurley, M. N., Cámara, M., & Smyth, A. R. (2012) · European Respiratory Journal · doi:10.1183/09031936.00042012 · Cited by 112
Bellio, P., Luzi, C., Mancini, A., Cracchiolo, S., Passacantando, M., Pietro, L. D., Perilli, M., Amicosante, G., Santucci, S., & Celenza, G. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.07.002 · Cited by 108
Role of bacterial efflux pump proteins in antibiotic resistance across microbial species
Kumawat, M., Nabi, B., Daswani, M., Viquar, I., Pal, N., Sharma, P., Tiwari, S., Sarma, D. K., Shubham, S., & Kumar, M. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106182 · Cited by 110
Pontel, L. B., Audero, M. E. P., Espariz, M., Checa, S. K., & Soncini, F. C. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05963.x · Cited by 108
Antimicrobial Resistance and Respiratory Infections
Guitor, A. K., & Wright, G. D. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.06.019 · Cited by 109
Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus
Costa, S. S., Sobkowiak, B., Parreira, R., Edgeworth, J. D., Viveiros, M., Clark, T. G., & Couto, I. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00710 · Cited by 110
Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances
Jiang, H., & Wang, X. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108151 · Cited by 106
Arya, S. S., Sharma, M. M., Das, R. K., Rookes, J. E., Cahill, D. M., & Lenka, S. K. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02021 · Cited by 108
Garvey, M. I., & Piddock, L. J. V. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01644-07 · Cited by 104
Self-citationFadli, M., Chevalier, J., Saad, A., Mezrioui, N.-E., Hassani, L., & Pagès, J. (2011) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2011.05.005 · Cited by 104
Rovira, P., McAllister, T. A., Lakin, S. M., Cook, S. R., Doster, E., Noyes, N. R., Weinroth, M. D., Yang, X., Parker, J. K., Boucher, C. A., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01980 · Cited by 103
Schumacher, A., Trittler, R., Bohnert, J. A., Kümmerer, K., Pagès, J., & Kern, W. V. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl380 · Cited by 103
Blair, J. M. A., Smith, H. E., Ricci, V., Lawler, A. J., Thompson, L. J., & Piddock, L. J. V. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku380 · Cited by 102
Self-citationBacterial Resistance to Quaternary Ammonium Compounds (QAC) Disinfectants
Bragg, R. R., Jansen, A. C., Coetzee, M., van der Westhuizen, W., & Boucher, C. E. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-81-322-1774-9_1 · Cited by 101
Antibacterial terpenes from the oleo‐resin of Commiphora molmol (Engl.)
Rahman, M. M., Garvey, M. I., Piddock, L. J. V., & Gibbons, S. (2008) · Phytotherapy Research · doi:10.1002/ptr.2501 · Cited by 101
Self-citationSrinivasan, V. B., Vaidyanathan, V., Mondal, A., & Rajamohan, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033777 · Cited by 101
O’Regan, E., Quinn, T., Pagès, J., McCusker, M. P., Piddock, L. J. V., & Fanning, S. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01005-08 · Cited by 101
Self-citationPuzari, M., & Chetia, P. (2017) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-016-2190-5 · Cited by 100
Metadata
- Authors
- Piddock, L. J. V.
- Affiliations
- University of Birmingham (GB)
- Corresponding author
- Piddock, Laura J. V.
- ORCID
- Piddock, Laura J. V.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2006-04
- Volume
- 19
- Issue
- 2
- Pages
- 382-402
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC1471989
- OpenAlex
- W2112586763
- Cited by
- 1,231
- References
- 242
- Citations by year
- 2026: 37 · 2025: 45 · 2024: 66 · 2023: 65 · 2022: 69 · 2021: 99 · 2020: 75 · 2019: 69 · 2018: 53 · 2017: 79 · 2016: 72 · 2015: 69 · 2014: 72 · 2013: 57 · 2012: 63
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- multidrug resistance, efflux pumps, antibiotic resistance, pathogenic bacteria, efflux pump regulation, efflux pump inhibitors, plant alkaloids, drug transport mechanisms, insertion elements
- MeSH terms
- Alkaloids, Anti-Infective Agents, Bacteria, Bacterial Proteins, Biological Transport, Chromosomes, Bacterial, Disinfectants, DNA Transposable Elements, Genes, Regulator, Mutation, Promoter Regions, Genetic, Virulence, Drug Resistance, Multiple, Bacterial, Membrane Transport Proteins, ATP-Binding Cassette, Sub-Family C Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review