Cited by 1,231Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Open access

Piddock, Laura J. V.·2006·Clinical Microbiology Reviews

DOI 10.1128/cmr.19.2.382-402.2006PMC PMC1471989

Open this paper in CoChat — free account

Abstract

SUMMARY: Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-resistant bacteria. Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug (antibiotic) resistance (MDR). However, the clinical relevance of efflux-mediated resistance is species, drug, and infection dependent. This review focuses on chromosomally encoded pumps in bacteria that cause infections in humans. Recent structural data provide valuable insights into the mechanisms of drug transport. MDR efflux pumps contribute to antibiotic resistance in bacteria in several ways: (i) inherent resistance to an entire class of agents, (ii) inherent resistance to specific agents, and (iii) resistance conferred by overexpression of an efflux pump. Enhanced efflux can be mediated by mutations in (i) the local repressor gene, (ii) a global regulatory gene, (iii) the promoter region of the transporter gene, or (iv) insertion elements upstream of the transporter gene. Some data suggest that resistance nodulation division systems are important in pathogenicity and/or survival in a particular ecological niche. Inhibitors of various efflux pump systems have been described; typically these are plant alkaloids, but as yet no product has been marketed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/cmr.19.2.382-402.2006

Cites

242 of 242 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999
Diekema, D. J., Pfaller, M. A., Schmitz, F., Smayevsky, J., Bell, J. M., Jones, R. N., Beach, M. L., & SENTRY Participants Group (2001) · Clinical Infectious Diseases · doi:10.1086/320184 · Cited by 1,363
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
Koronakis, V. E., Sharff, A., Koronakis, E., Luisi, B. F., & Hughes, C. (2000) · Nature · doi:10.1038/35016007 · Cited by 1,086
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Crystal structure of bacterial multidrug efflux transporter AcrB
Murakami, S., Nakashima, R., Yamashita, E., & Yamaguchi, A. (2002) · Nature · doi:10.1038/nature01050 · Cited by 1,018
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903
The importance of efflux pumps in bacterial antibiotic resistance
Webber, M. A. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg050 · Cited by 856
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 811

Flagged first, then by citations

Show all 242 references

Research works printed but not linked: 2

Alekshun, M. A., and S. B. Levy. 2004. The Escherichia coli mar locus—antibiotic resistance and more. ASM News70:451-456.
Olliver, A., M. Valle, E. Chaslus-Dancla, and A. Cloeckaert. 2004. Role of an acrR mutation in multidrug resistance of in vitro selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. FEMS Microbiol. Lett.238:267-272.

Sorted by citations

Items 501–600 of 1,000

AcrAB–TolC Inhibition by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in Vitro and in Vivo
Sturge, C. R., Felder-Scott, C. F., Pifer, R., Pybus, C. A., Jain, R., Geller, B. L., & Greenberg, D. E. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00123 · Cited by 30
A Major Facilitator Superfamily (MFS) Efflux Pump, SCO4121, from Streptomyces coelicolor with Roles in Multidrug Resistance and Oxidative Stress Tolerance and Its Regulation by a MarR Regulator
Nag, A., & Mehra, S. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.02238-20 · Cited by 30
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples
Fergestad, M. E., Touzain, F., Vliegher, S. D., Visscher, A. D., Thiry, D., Tchamba, C. N., Mainil, J. G., L'Abée-Lund, T. M., Blanchard, Y., & Wasteson, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.715851 · Cited by 33
Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus
Abdel-Karim, S. A.-A. M., El-Ganiny, A. M., El-Sayed, M. A., & Abbas, H. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272417 · Cited by 32
Elevated N a + and pH influence the production and transport of saxitoxin in the cyanobacteria A nabaena circinalis AWQC131C and C ylindrospermopsis raciborskii T 3
Ongley, S. E., Pengelly, J. J. L., & Neilan, B. A. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13048 · Cited by 30
Targeted antibiotic discovery through biosynthesis-associated resistance determinants: target directed genome mining
O’Neill, E. C., Schorn, M., Larson, C. B., & Millán‐Aguiñaga, N. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1590307 · Cited by 30
Evaluation of efflux pump inhibitors of MexAB- or MexXY-OprM in Pseudomonas aeruginosa using nucleic acid dyes
Fujiwara, M., Yamasaki, S., Morita, Y., & Nishino, K. (2022) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2022.01.003 · Cited by 29
Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
Zalucki, Y. M., Dhulipala, V., & Shafer, W. M. (2012) · mBio · doi:10.1128/mbio.00446-12 · Cited by 29
Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant Gram-negative bacteria
Brunel, J. M., Lieutaud, A., Lôme, V., Pagès, J., & Bolla, J. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.12.030 · Cited by 29
The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump
Müller, R. T., & Pos, K. M. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0150 · Cited by 29
Antimicrobial Activity of Omadacycline Tested against Clinical Bacterial Isolates from Hospitals in Mainland China, Hong Kong, and Taiwan: Results from the SENTRY Antimicrobial Surveillance Program (2013 to 2016)
Carvalhaes, C. G., Huband, M. D., Reinhart, H. H., Flamm, R. K., & Sader, H. S. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02262-18 · Cited by 29
Genome-wide analysis of MATE transporters and response to metal stress in Cajanus cajan
Dong, B., Niu, L., Meng, D., Song, Z., Wang, L., Jian, Y., Fan, X.-H., Dong, M., Yang, Q., & Fu, Y. (2019) · Journal of Plant Interactions · doi:10.1080/17429145.2019.1620884 · Cited by 30
The social network: Impact of host and microbial interactions on bacterial antibiotic tolerance and persistence
Rocha-Granados, M. C., Zenick, B., Englander, H. E., & Mok, W. W. K. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109750 · Cited by 33
The Integration of Proteomics and Metabolomics Data Paving the Way for a Better Understanding of the Mechanisms Underlying Microbial Acquired Drug Resistance
Fortuin, S., & Soares, N. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.849838 · Cited by 29
The Antibiotic Resistome: Challenge And Opportunity For Therapeutic Intervention
Martínez, J. L. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.2 · Cited by 29
In vitro selection of fluoroquinolone resistance in Brucella melitensis
Ravanel, N., Gestin, B., & Maurin, M. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.01.002 · Cited by 29
Tobramycin-Linked Efflux Pump Inhibitor Conjugates Synergize Fluoroquinolones, Rifampicin and Fosfomycin against Multidrug-Resistant Pseudomonas aeruginosa
Yang, X., Domalaon, R., Lyu, Y., Zhanel, G. G., & Schweizer, F. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7070158 · Cited by 29
Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A
Baucheron, S., Monchaux, I., Hello, S. L., Weill, F., & Cloeckaert, A. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00012 · Cited by 28
The drug binding sites and transport mechanism of the RND pumps from Mycobacterium tuberculosis: Insights from molecular dynamics simulations
Sandhu, P., & Akhter, Y. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.01.007 · Cited by 28
Antimicrobial resistance in mollicutes: known and newly emerging mechanisms
Chernov, V. M., Chernova, O. A., Mouzykantov, A. A., Medvedeva, E. S., Baranova, N. B., Юрьевна, М. Т., Aminov, R. I., & Trushin, M. V. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny185 · Cited by 29
Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus
Rath, S. K., Singh, S., Kumar, S., Wani, N. A., Rai, R., Koul, S., Khan, I. A., & Sangwan, P. L. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.12.008 · Cited by 28
A Cross-Sectional Study of Dairy Cattle Metagenomes Reveals Increased Antimicrobial Resistance in Animals Farmed in a Heavy Metal Contaminated Environment
Gaeta, N. C., Bean, E., Miles, A. M., de Carvalho, D. U. O. G., Alemán, M. A. R., Carvalho, J. S., Gregory, L., & Ganda, E. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.590325 · Cited by 32
Molecular characterization of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from King Abdulaziz Specialist Hospital at Taif City, Saudi Arabia
Lagha, R., Abdallah, F. B., ALKhammash, A. A. H., Amor, N. M. S., Hassan, M. M., Mabrouk, I., Alhomrani, M., & Gaber, A. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2020.12.001 · Cited by 30
Macromolecular Nanotherapeutics and Antibiotic Adjuvants to Tackle Bacterial and Fungal Infections
Dey, R. K., Mukherjee, S., Barman, S., & Haldar, J. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100182 · Cited by 28
Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii
Meyer, C., Lucaβen, K., Gerson, S., Xanthopoulou, K., Wille, T., Seifert, H., & Higgins, P. G. (2022) · Antibiotics · doi:10.3390/antibiotics11111635 · Cited by 28
Triclosan-resistant bacteria isolated from feedlot and residential soils
Welsch, T. T., & Gillock, E. T. (2011) · Journal of Environmental Science and Health Part A · doi:10.1080/10934529.2011.549407 · Cited by 28
Biofunctionalized zinc peroxide (ZnO 2 ) nanoparticles as active oxygen sources and antibacterial agents
Bergs, C., Brück, L., Rosencrantz, R. R., Conrads, G., Elling, L., & Pich, A. (2017) · RSC Advances · doi:10.1039/c7ra06332f · Cited by 29
Effect of efflux pump inhibitors on the susceptibility of Mycobacterium tuberculosis to isoniazid
Jaiswal, I., Jain, A., Verma, S., Singh, P., Kant, S., & Singh, M. (2017) · Lung India · doi:10.4103/0970-2113.217567 · Cited by 27
Differential Selection of Single-Step AmpC or Efflux Mutants of Pseudomonas aeruginosa by Using Cefepime, Ceftazidime, or Ceftobiprole
Queenan, A. M., Shang, W., Bush, K., & Flamm, R. K. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00060-10 · Cited by 28
Efflux pump-mediated antibiotics resistance: Insights from computational structural biology
Fischer, N., Raunest, M., Schmidt, T. H., Koch, D. C., & Kandt, C. (2014) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-014-0191-3 · Cited by 27
Identification and characterization of carbapenem binding sites within the RND-transporter AcrB
Atzori, A., Malviya, V. N., Malloci, G., Dreier, J., Pos, K. M., Vargiu, A. V., & Ruggerone, P. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.10.012 · Cited by 27
Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance
Maiden, M. M., & Waters, C. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008529 · Cited by 27
Microbial diversity and activity in the Nematostella vectensis holobiont: insights from 16S rRNA gene sequencing, isolate genomes, and a pilot-scale survey of gene expression
Har, J. Y., Helbig, T., Lim, J. H., Fernando, S. C., Reitzel, A. M., Penn, K., & Thompson, J. R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00818 · Cited by 29
Gene Cloning and Characterization of EfmA, a Multidrug Efflux Pump, from Enterococcus faecium
Nishioka, T., Ogawa, W., Kuroda, T., Katsu, T., & Tsuchiya, T. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.483 · Cited by 27
Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds
de Oliveira, C. S., Falcão-Silva, V. D. S., Siqueira-Júnior, J. P., Harding, D. P., Lira, B. F., Lorenzo, J. G. F., Barbosa‐Filho, J. M., & de Athayde-Filho, P. F. (2011) · Molecules · doi:10.3390/molecules16032023 · Cited by 27
Antibiogram of clinical isolates from a hospital in Nigeria
Chikere, C. B., & Chikere, B. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i24.59590 · Cited by 27
Quantifying the Evolutionary Conservation of Genes Encoding Multidrug Efflux Pumps in the ESKAPE Pathogens To Identify Antimicrobial Drug Targets
Brooks, L., Ul-Hasan, S., Chan, B. K., & Sistrom, M. (2018) · mSystems · doi:10.1128/msystems.00024-18 · Cited by 27
Activated Carbon as a Cathode for Water Disinfection through the Electro-Fenton Process
Chen, L., Pinto, A. J., & Alshawabkeh, A. N. (2019) · Catalysts · doi:10.3390/catal9070601 · Cited by 27
Selected mechanisms of molecular resistance of Candida albicans to azole drugs
Gołąbek, K., Strzelczyk, J. K., Owczarek, A., Cuber, P., Ślemp-Migiel, A., & Wiczkowski, A. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2014_940 · Cited by 26
Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria
Herman, A., & Herman, A. P. (2022) · Planta Medica · doi:10.1055/a-1890-5559 · Cited by 26
NorA, Tet(K), MepA, and MsrA Efflux Pumps in Staphylococcus aureus, their Inhibitors and 1,8-Naphthyridine Sulfonamides
Coutinho, H. D. M., Oliveira–Tintino, C. D. D. M., Muniz, D. F., Barbosa, C. R. D. S., Pereira, R. L. S., Begnini, I. M., Rebelo, R. A., da Silva, L. E., Mireski, S. L., Nasato, M. C., et al. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221212101501 · Cited by 27
Metal nanoparticles and consequences on multi-drug resistant bacteria: reviving their role
Hasani, A., Madhi, M., Gholizadeh, P., Mojarrad, J. S., Rezaee, M. A., Zarrini, G., & Kafil, H. S. (2019) · SN Applied Sciences · doi:10.1007/s42452-019-0344-4 · Cited by 27
Molecular Interactions of Cephalosporins with the Deep Binding Pocket of the RND Transporter AcrB
Atzori, A., Malloci, G., Prajapati, J. D., Basciu, A., Bosin, A., Kleinekathöfer, U., Dreier, J., Vargiu, A. V., & Ruggerone, P. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b01351 · Cited by 26
A plethora of carbapenem resistance inAcinetobacter baumannii: no end to a long insidious genetic journey
Vahhabi, A., Hasani, A., Rezaee, M. A., Baradaran, B., Hasani, A., Kafil, H. S., Abbaszadeh, F., & Dehghani, L. (2020) · Journal of Chemotherapy · doi:10.1080/1120009x.2020.1847421 · Cited by 30
Antifungal Azoles as Tetracycline Resistance Modifiers in Staphylococcus aureus
Mahey, N., Tambat, R., Verma, D. K., Chandal, N., Thakur, K. G., & Nandanwar, H. S. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.00155-21 · Cited by 24
Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains
Oliveira–Tintino, C. D. D. M., Santana, J. E. G., Alencar, G. G., Siqueira, G. M., Gonçalves, S. A., Tintino, S. R., de Menezes, I. R. A., Rodrigues, J. P. V., Gonçalves, V. B. P., Nicolete, R., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102400 · Cited by 26
Pesticides and antimicrobial resistance: from environmental compartments to animal and human infections
Curuțiu, C., Lazăr, V., & Chifiriuc, M. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804299-1.00011-4 · Cited by 26
Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods
Laudy, A. E. (2018) · Polish Journal of Microbiology · doi:10.21307/pjm-2018-017 · Cited by 26
Determination of anti-staphylococcal activity of thymoquinone in combinations with antibiotics by checkerboard method using EVA capmat™ as a vapor barrier
Rondevaldová, J., Nový, P., Urban, J., & Kokoška, L. (2015) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2015.04.021 · Cited by 26
MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium
Song, S., Lee, B., Yeom, J., Hwang, S., Kang, I., Cho, J., Ha, N., Bae, J., Lee, K., & Kim, Y. (2015) · Infection and Immunity · doi:10.1128/iai.00653-15 · Cited by 25
Genome sequence and comparative analysis of a putative entomopathogenic Serratia isolated from Caenorhabditis briggsae
Abebe-Akele, F., Tisa, L. S., Cooper, V. S., Hatcher, P. J., Abebe, E., & Thomas, W. K. (2015) · BMC Genomics · doi:10.1186/s12864-015-1697-8 · Cited by 25
Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps inAcinetobacter baumannii
Li, L., Hassan, K. A., Brown, M. H., & Paulsen, I. T. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv460 · Cited by 25
Diversity of Aerobic Bacteria Isolated from Oral and Cloacal Cavities from Free-Living Snakes Species in Costa Rica Rainforest
Artavia‐León, A., Romero-Guerrero, A., Sancho-Blanco, C., Rojas, N., & Umaña-Castro, R. (2017) · International Scholarly Research Notices · doi:10.1155/2017/8934285 · Cited by 25
CsrA maximizes expression of the AcrAB multidrug resistance transporter
Ricci, V., Attah, V., Overton, T. W., Grainger, D. C., & Piddock, L. J. V. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx929 · Cited by 25
Self-citation
Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity
Straniero, V., Suigo, L., Casiraghi, A., Sebastián-Pérez, V., Hrast, M., Zanotto, C., Zdovc, I., Morghen, C. D. G., Radaelli, A., & Valoti, E. (2020) · Antibiotics · doi:10.3390/antibiotics9040160 · Cited by 25
In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis
Shen, S., Tang, C., Yang, W., Ding, L., Han, R., Shi, Q., Guo, Y. P., Yin, D., & Hu, F. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2356146 · Cited by 24
Antimicrobial resistance: Molecular drivers and underlying mechanisms
Solanki, S., & Das, H. K. (2024) · Journal of Medicine Surgery and Public Health · doi:10.1016/j.glmedi.2024.100122 · Cited by 28
Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA
Krügel, H., Licht, A., Biedermann, G., Petzold, A., Lassak, J., Hupfer, Y., Schlott, B., Hertweck, C., Platzer, M., Brantl, S., et al. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02143.x · Cited by 29
A Review on Efflux Pump Inhibitors of Gram-Positive and Gram-Negative Bacteria from Plant Sources
Kumar, R., & Patial, S. J. P. (2016) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2016.506.092 · Cited by 24
MexXY Multidrug Efflux System Is More Frequently Overexpressed in Ciprofloxacin Resistant French Clinical Isolates Compared to Hospital Environment Ones
Serra, C., Bouharkat, B., Touil-Meddah, A. T., Guénin, S., & Mullié, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00366 · Cited by 24
Phenotypic and Genotypic Characterization of Acinetobacter spp. Panel Strains: A Cornerstone to Facilitate Antimicrobial Development
D’Souza, R., Pinto, N. A., Phuong, N. L., Higgins, P. G., Vu, T. N., Byun, J., Cho, Y. L., Choi, J. R., & Yong, D. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00559 · Cited by 24
Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1,8-naphthyridines sulfonamides
Oliveira–Tintino, C. D. D. M., Tintino, S. R., Muniz, D. F., Barbosa, C. R. D. S., Pereira, R. L. S., Begnini, I. M., Rebelo, R. A., da Silva, L. E., Mireski, S. L., Nasato, M. C., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105753 · Cited by 23
Methods for prevention and constraint of antimicrobial resistance: a review
Valsamatzi-Panagiotou, A., Popova, K. B., & Prof. Robert Penchovsky, D. R. N. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01206-x · Cited by 23
Inhibition of the MepA efflux pump by limonene demonstrated by in vitro and in silico methods
Freitas, P. R., de Araújo, A. C. J., Barbosa, C. R. D. S., Muniz, D. F., de Almeida, R. S., de Menezes, I. R. A., da Costa, J. G. M., Rodrigues, F. F. G., Rocha, J. E., Junior, F. N. P., et al. (2021) · Folia Microbiologica · doi:10.1007/s12223-021-00909-6 · Cited by 23
A NiCoT family metal transporter of Mycobacterium tuberculosis (Rv2856/NicT) behaves as a drug efflux pump that facilitates cross-resistance to antibiotics
Adhikary, A., Biswal, S., Chatterjee, D., & Ghosh, A. S. (2022) · Microbiology · doi:10.1099/mic.0.001260 · Cited by 23
Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives
Bologna, E., Licari, L. C., Manfredi, C., Ditonno, F., Cirillo, L., Fusco, G. M., Abate, M., Passaro, F., Mauro, E. D., Crocetto, F., et al. (2024) · Medicina · doi:10.3390/medicina60020214 · Cited by 27
Resistant plasmid profile analysis of multidrug resistant Escherichia coli isolated from urinary tract infections in Abeokuta, Nigeria
Akingbade, O. A., Balogun, S. A., Ojo, D. A., Akinduti, P. A., Okerentugba, P. O., Nwanze, J. C., & Okonko, I. O. (2015) · African Health Sciences · doi:10.4314/ahs.v14i4.8 · Cited by 23
In Vitro Activity of Rifampicin and Verapamil Combination in Multidrug-Resistant Mycobacterium tuberculosis
Demitto, M. D. O., do Amaral, R. C. R., Maltempe, F. G., Siqueira, V. L. D., Scodro, R. B. D. L., Lopes, M. A., Caleffi-Ferracioli, K. R., Canezin, P. H., & Cardoso, R. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116545 · Cited by 23
Pantoea Natural Product 3 is encoded by an eight-gene biosynthetic gene cluster and exhibits antimicrobial activity against multi-drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa
Williams, A. N., & Stavrinides, J. (2020) · Microbiological Research · doi:10.1016/j.micres.2020.126412 · Cited by 23
The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors
Oliveira–Tintino, C. D. D. M., Muniz, D. F., Barbosa, C. R. D. S., Pereira, R. L. S., Begnini, I. M., Rebelo, R. A., da Silva, L. E., Mireski, S. L., Nasato, M. C., Krautler, M. I. L., et al. (2020) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2020.11.027 · Cited by 23
Antimicrobial resistance: use of phage therapy in the management of resistant infections
Ikpe, F., Williams, T., Orok, E. N., & Ikpe, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09870-2 · Cited by 23
Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus.
Bazzaz, B. S. F., Iranshahi, M., Naderinasab, M., Hajian, S., Sabeti, Z., & Masumi, E. (2010) · PubMed Central · Cited by 22
TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli
Ou, J., Elizalde, P., Guo, H., Qin, H., Tobe, B. T. D., & Choy, J. S. (2022) · mBio · doi:10.1128/mbio.02191-22 · Cited by 29
Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles
Trampari, E., Prischi, F., Vargiu, A. V., Assaf, J. A., Bavro, V. N., & Webber, M. A. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00001-8 · Cited by 22
Role of H- and D- MATE-Type Transporters from Multidrug Resistant Clinical Isolates of Vibrio fluvialis in Conferring Fluoroquinolone Resistance
Mohanty, P., Patel, A. B., & Bhardwaj, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035752 · Cited by 22
Evaluation of the contribution of gyrA mutation and efflux pumps to fluoroquinolone and multidrug resistance in pathogenic Escherichia coli isolates from dogs and cats
Shaheen, B. W., Boothe, D. M., Oyarzábal, O. A., Wang, C., & Johnson, C. M. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.1.25 · Cited by 22
Total Alkaloids of Sophorea alopecuroides‐induced Down‐regulation of AcrAB‐ToLC Efflux Pump Reverses Susceptibility to Ciprofloxacin in Clinical Multidrug Resistant Escherichia coli isolates
Zhou, X., Jia, F., Liu, X., & Wang, Y. (2012) · Phytotherapy Research · doi:10.1002/ptr.4623 · Cited by 22
EVALUATION OF PHYTOCHEMICALS AND SYNERGISTIC INTERACTION BETWEEN PLANT EXTRACTS AND ANTIBIOTICS FOR EFFLUX PUMP INHIBITORY ACTIVITY AGAINST SALMONELLA ENTERICA SEROVAR TYPHIMURIUM STRAINS
Mehta, J., Jandaik, S., & ., U. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2016v8i10.14062 · Cited by 22
Coordinated Expression of acrAB-tolC and Eight Other Functional Efflux Pumps Through Activating ramA and marA in Salmonella enterica serovar Typhimurium
Zhang, C.-Z., Chen, P.-X., Yang, L., Li, W., Chang, M.-X., & Jiang, H. (2017) · Microbial Drug Resistance · doi:10.1089/mdr.2017.0086 · Cited by 22
Synthesis and evaluation of the antibiotic and adjuvant antibiotic potential of organotin(IV) derivatives
Barbosa, A. S. L., Guedes, J. D. S., da Silva, D. R., Meneghetti, S. M. P., Meneghetti, S. M. P., da Silva, A. E., de Araújo, M. V., Alexandre‐Moreira, M. S., de Aquino, T. M., Siqueira-Júnior, J. P., et al. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.12.004 · Cited by 22
In silico epitope identification of unique multidrug resistance proteins from Salmonella Typhi for vaccine development
Jebastin, T., & Narayanan, S. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.11.020 · Cited by 22
The 2019 Garrod Lecture: MDR efflux in Gram-negative bacteria—how understanding resistance led to a new tool for drug discovery
Piddock, L. J. V. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz370 · Cited by 22
Self-citation
Computational approaches in efflux pump inhibitors: current status and prospects
Rathi, E., Kumar, A., & Kini, S. G. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.07.011 · Cited by 22
Characterization of heavy metal and antibiotic-resistant bacteria isolated from polluted localities in Egypt
Moghannem, S. A. M., Refaat, B. M., El-Sherbiny, G. M., El-Sayed, M. H., Elsehemy, I. A., & Kalaba, M. H. (2015) · Egyptian Pharmaceutical Journal · doi:10.4103/1687-4315.172856 · Cited by 21
Molecular Mechanisms of Antibiotic Resistance in Bacteria
Opal, S. M., & Pop-Vicas, A. E. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00018-7 · Cited by 26
Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus
Al-sallami, D., Alsultan, A. S., Abbas, K. H., & Clarke, S. R. (2023) · Open Veterinary Journal · doi:10.5455/ovj.2023.v13.i1.5 · Cited by 24
BC4707 Is a Major Facilitator Superfamily Multidrug Resistance Transport Protein from Bacillus cereus Implicated in Fluoroquinolone Tolerance
Simm, R., Vörös, A., Ekman, J. V., Sødring, M. S., Nes, I., Kroeger, J. K., Saidijam, M., Bettaney, K. E., Henderson, P. J. F., Salkinoja-Salonen, M. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036720 · Cited by 21
Phytochemical study of Pilosocereus pachycladus and antibiotic-resistance modifying activity of syringaldehyde
Filho, S. G. D. B., Maciel, J. K. D. S., Teles, Y. C. F., Fernandes, M. M. M. D. S., Chaves, O. S., Ferreira, M. D. L., Fernandes, P. D., Félix, L. P., Cirino, I. C. D. S., Siqueira-Júnior, J. P., et al. (2017) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2017.06.001 · Cited by 21
Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry
Li, N., Liu, C., Zhang, Z., Li, H., Song, T., Liang, T. B., Li, B., Li, L., Feng, S., Su, Q., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244896 · Cited by 21
Vanilla modulates the activity of antibiotics and inhibits efflux pumps in drug-resistant Pseudomonas aeruginosa
Arya, S. S., Sharma, M. M., Rookes, J. E., Cahill, D. M., & Lenka, S. K. (2020) · Biologia · doi:10.2478/s11756-020-00617-5 · Cited by 23
Room temperature and surfactant free synthesis of zinc peroxide (ZnO2) nanoparticles in methanol with highly efficient antimicrobials
Hussein, H. M., Ghafoor, D. D., & Omer, K. M. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103090 · Cited by 19
Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations
Santana, J. E. G., Oliveira–Tintino, C. D. D. M., Alencar, G. G., Siqueira, G. M., Alves, D. S., Moura, T. F., Tintino, S. R., de Menezes, I. R. A., Rodrigues, J. P. V., Goncalves, V., et al. (2023) · Molecules · doi:10.3390/molecules28227649 · Cited by 21
Decoding antimicrobial resistance: unraveling molecular mechanisms and targeted strategies
Singh, G., Rana, A., & Smriti (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03998-2 · Cited by 24
Antibiotic resistance and multidrug‐resistant efflux pumps expression in lactic acid bacteria isolated from pozol, a nonalcoholic Mayan maize fermented beverage
Wacher, C., Trejo‐Muñúzuri, T. P., Montiel‐Aguirre, J. F., Drago-Serrano, M. E., Gutiérrez‐Lucas, R. L., Castañeda‐Sánchez, J. I., & Sáinz‐Espuñes, T. (2015) · Food Science & Nutrition · doi:10.1002/fsn3.304 · Cited by 21
Molecular cloning and functional characterization of two novel membrane fusion proteins in conferring antimicrobial resistance in Acinetobacter baumannii
Srinivasan, V. B., Rajamohan, G., Pancholi, P., Marcon, M. J., & Gebreyes, W. A. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq469 · Cited by 21
Antibiotic cross-resistance in the lab and resistance co-occurrence in the clinic: Discrepancies and implications in E. coli
Obolski, U., Dellus-Gur, E., Stein, G. Y., & Hadany, L. (2016) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2016.02.017 · Cited by 21
Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
Gomez, A., Andreu, N., Ferrer‐Navarro, M., Yero, D., & Gibert, I. (2016) · Scientific Reports · doi:10.1038/srep26221 · Cited by 21
Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis
Kumar, M., Singh, K., Naran, K., Hamzabegovic, F., Hoft, D. F., Warner, D. F., Ruminski, P., Abate, G., & Chibale, K. (2016) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.6b00111 · Cited by 21
Trinity revealed: Stoichiometric complex assembly of a bacterial multidrug efflux pump
Pos, K. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902837106 · Cited by 21
Spirocyclic compounds: potential drug leads in the fight against Mycobacterium tuberculosis
Kumar, P., Singampalli, A., Bandela, R., Srimounika, B., Rajyalakshmi, S. I., Devi, A., Nanduri, S., & Yaddanapudi, V. M. (2025) · Future Medicinal Chemistry · doi:10.1080/17568919.2025.2479413 · Cited by 20

Authors: Piddock, L. J. V.
Affiliations: University of Birmingham (GB)
Corresponding author: Piddock, Laura J. V.
ORCID: Piddock, Laura J. V.
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2006-04
Volume: 19
Issue: 2
Pages: 382-402
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.19.2.382-402.2006
PMC: PMC1471989
OpenAlex: W2112586763
Cited by: 1,231
References: 242
Citations by year: 2026: 37 · 2025: 45 · 2024: 66 · 2023: 65 · 2022: 69 · 2021: 99 · 2020: 75 · 2019: 69 · 2018: 53 · 2017: 79 · 2016: 72 · 2015: 69 · 2014: 72 · 2013: 57 · 2012: 63
FWCI: 2.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: multidrug resistance, efflux pumps, antibiotic resistance, pathogenic bacteria, efflux pump regulation, efflux pump inhibitors, plant alkaloids, drug transport mechanisms, insertion elements
MeSH terms: Alkaloids, Anti-Infective Agents, Bacteria, Bacterial Proteins, Biological Transport, Chromosomes, Bacterial, Disinfectants, DNA Transposable Elements, Genes, Regulator, Mutation, Promoter Regions, Genetic, Virulence, Drug Resistance, Multiple, Bacterial, Membrane Transport Proteins, ATP-Binding Cassette, Sub-Family C Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks