Cited by 1,231Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Open access

Piddock, Laura J. V.·2006·Clinical Microbiology Reviews

DOI 10.1128/cmr.19.2.382-402.2006PMC PMC1471989

Open this paper in CoChat — free account

Abstract

SUMMARY: Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-resistant bacteria. Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug (antibiotic) resistance (MDR). However, the clinical relevance of efflux-mediated resistance is species, drug, and infection dependent. This review focuses on chromosomally encoded pumps in bacteria that cause infections in humans. Recent structural data provide valuable insights into the mechanisms of drug transport. MDR efflux pumps contribute to antibiotic resistance in bacteria in several ways: (i) inherent resistance to an entire class of agents, (ii) inherent resistance to specific agents, and (iii) resistance conferred by overexpression of an efflux pump. Enhanced efflux can be mediated by mutations in (i) the local repressor gene, (ii) a global regulatory gene, (iii) the promoter region of the transporter gene, or (iv) insertion elements upstream of the transporter gene. Some data suggest that resistance nodulation division systems are important in pathogenicity and/or survival in a particular ecological niche. Inhibitors of various efflux pump systems have been described; typically these are plant alkaloids, but as yet no product has been marketed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/cmr.19.2.382-402.2006

Cites

242 of 242 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999
Diekema, D. J., Pfaller, M. A., Schmitz, F., Smayevsky, J., Bell, J. M., Jones, R. N., Beach, M. L., & SENTRY Participants Group (2001) · Clinical Infectious Diseases · doi:10.1086/320184 · Cited by 1,363
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
Koronakis, V. E., Sharff, A., Koronakis, E., Luisi, B. F., & Hughes, C. (2000) · Nature · doi:10.1038/35016007 · Cited by 1,086
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Crystal structure of bacterial multidrug efflux transporter AcrB
Murakami, S., Nakashima, R., Yamashita, E., & Yamaguchi, A. (2002) · Nature · doi:10.1038/nature01050 · Cited by 1,018
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903
The importance of efflux pumps in bacterial antibiotic resistance
Webber, M. A. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg050 · Cited by 856
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 811

Flagged first, then by citations

Show all 242 references

Research works printed but not linked: 2

Alekshun, M. A., and S. B. Levy. 2004. The Escherichia coli mar locus—antibiotic resistance and more. ASM News70:451-456.
Olliver, A., M. Valle, E. Chaslus-Dancla, and A. Cloeckaert. 2004. Role of an acrR mutation in multidrug resistance of in vitro selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. FEMS Microbiol. Lett.238:267-272.

Sorted by citations

Items 201–300 of 1,000

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome
Guglierame, P., Pasca, M. R., Rossi, E. D., Buroni, S., Arrigo, P., Manina, G., & Riccardi, G. (2006) · BMC Microbiology · doi:10.1186/1471-2180-6-66 · Cited by 100
Inhibition of the TetK efflux-pump by the essential oil of Chenopodium ambrosioides L. and α-terpinene against Staphylococcus aureus IS-58
Limaverde, P. W., Campina, F. F., da Cunha, F. A. B., Crispim, F. D., Figueredo, F. G., de Lima, L. F., Oliveira–Tintino, C. D. D. M., de Matos, Y. M. L. S., Morais‐Braga, M. F. B., de Menezes, I. R. A., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.02.031 · Cited by 99
Development of a Recombinant Escherichia coli Strain for Overproduction of the Plant Pigment Anthocyanin
Lim, C. G., Wong, L., Bhan, N., Dvora, H., Xu, P., Venkiteswaran, S., & Koffas, M. A. G. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.01448-15 · Cited by 101
Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis
Rodrigues, L., Villellas, C., Bailo, R., Viveiros, M., & Aínsa, J. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01482-12 · Cited by 98
Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps
Olivares‐Pacheco, J., Alvarez‐Ortega, C., Alcalde‐Rico, M., & Martínez, J. L. (2017) · mBio · doi:10.1128/mbio.00500-17 · Cited by 98
Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria
Singh, S., Kalia, N. P., Joshi, P., Kumar, A., Sharma, P. R., Kumar, A., Bharate, S. B., & Khan, I. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01868 · Cited by 97
Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis
Machado, D., Girardini, M., Viveiros, M., & Pieroni, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01367 · Cited by 99
Prevalence of antibiotic resistance genes of wastewater and surface water in livestock farms of Jiangsu Province, China
Chen, B., Hao, L., Guo, X., Wang, N., & Ye, B. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4636-y · Cited by 97
Antibiotic resistance: it’s bad, but why isn’t it worse?
Waglechner, N., & Wright, G. D. (2017) · BMC Biology · doi:10.1186/s12915-017-0423-1 · Cited by 96
Dynamics of mobile genetic elements of Listeria monocytogenes persisting in ready-to-eat seafood processing plants in France
Palma, F., Brauge, T., Radomski, N., Mallet, L., Felten, A., Mistou, M., Brisabois, A., Guillier, L., & Midelet, G. (2020) · BMC Genomics · doi:10.1186/s12864-020-6544-x · Cited by 101
Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
Jadimurthy, R., Mayegowda, S. B., Nayak, S. C., Mohan, C. D., & Rangappa, K. S. (2022) · Biotechnology Reports · doi:10.1016/j.btre.2022.e00728 · Cited by 103
Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals
Suganya, T., Packiavathy, I. A. S. V., Aseervatham, G. S. B., Carmona, A., Rashmi, V., Mariappan, S., Devi, N. R., & Ananth, D. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.883839 · Cited by 104
Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs
Viveiros, M., Martins, M., Rodrigues, L., Machado, D., Couto, I., Aínsa, J. A., & Amaral, L. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.89 · Cited by 96
Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens
Chen, X., Liu, S.-R., Peng, B., Li, D., Cheng, Z.-X., Zhu, J.-X., Zhang, S., Peng, Y.-M., Li, H., Zhang, T.-T., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00207 · Cited by 92
The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy
Avakh, A., Grant, G. D., Cheesman, M. J., Kalkundri, T., & Hall, S. (2023) · Antibiotics · doi:10.3390/antibiotics12081304 · Cited by 96
Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli
Huseby, D., Pietsch, F., Brandis, G., Garoff, L., Tegehall, A., & Hughes, D. (2017) · Molecular biology and evolution · doi:10.1093/molbev/msx052 · Cited by 110
Modulation of drug resistance in staphylococcus aureus by a kaempferol glycoside from herissantia tiubae (malvaceae)
Falcão‐Silva, V. S., Silva, D. A., de Souza, M. D. F. V., & Siqueira-Júnior, J. P. (2009) · Phytotherapy Research · doi:10.1002/ptr.2695 · Cited by 92
Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
Coelho, T. S., Machado, D., Couto, I., Maschmann, R. D. A., Ramos, D. F., von Groll, A., Rossetti, M. L. R., Silva, P., & Viveiros, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00330 · Cited by 91
Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens
Kouidhi, B., Zmantar, T., Harzallah, H. J., Souiden, Y., Chaieb, K., Mahdouani, K., & Bakhrouf, A. (2011) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-10-29 · Cited by 91
Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)
Bohnert, J. A., Schuster, S., Fähnrich, E., Trittler, R., & Kern, W. V. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl426 · Cited by 91
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium
Xiong, X., Bromley, E. H. C., Oelschlaeger, P., Woolfson, D. N., & SPENCER, J. M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1296 · Cited by 92
Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter baumannii strains
Nemec, A., Maixnerová, M., van der Reijden, T. J. K., van den Broek, P. J., & Dijkshoorn, L. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm231 · Cited by 91
Fungicides enhanced the abundance of antibiotic resistance genes in greenhouse soil
Zhang, H., Chen, S., Zhang, Q., Long, Z., Yu, Y., & Fang, H. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2019.113877 · Cited by 90
Terpenes as bacterial efflux pump inhibitors: A systematic review
Dias, K. J. D. O., Miranda, G. M., Bessa, J. R., de Araújo, A. C. J., Freitas, P. R., de Almeida, R. S., Paulo, C. L. R., Neto, J. B. D. A., Coutinho, H. D. M., & Ribeiro‐Filho, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.953982 · Cited by 95
Evaluation of Efflux Activity of Bacteria by a Semi-automated Fluorometric System
Viveiros, M., Rodrigues, L., Martins, M., Couto, I., Spengler, G., Martins, A., & Amaral, L. (2010) · Methods in molecular biology · doi:10.1007/978-1-60327-279-7_12 · Cited by 89
Adaptation of Pseudomonas sp. Strain 7-6 to Quaternary Ammonium Compounds and Their Degradation via Dual Pathways
Takenaka, S., Tonoki, T., Taira, K., Murakami, S., & Aoki, K. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02426-06 · Cited by 89
Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care
Edgeworth, J. D. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq325 · Cited by 88
High-Level Antimicrobial Efficacy of Representative Mediterranean Natural Plant Extracts against Oral Microorganisms
Karygianni, L., Cecere, M., Skaltsounis, A., Argyropoulou, A., Hellwig, E., Aligiannis, N., Wittmer, A., & Al‐Ahmad, A. (2014) · BioMed Research International · doi:10.1155/2014/839019 · Cited by 88
Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex
Long, F., Su, C., Lei, H., Bolla, J. R., Do, S. V., & Yu, E. W. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0203 · Cited by 88
Identification of efflux pump-mediated multidrug-resistant bacteria by the ethidium bromide-agar cartwheel method.
Martins, M., Viveiros, M., Couto, I., Costa, S. S., Pacheco, T., Fanning, S., Pagès, J., & Amaral, L. (2011) · PubMed · Cited by 87
Amphiphilic Tobramycin–Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline
Lyu, Y., Yang, X., Goswami, S., Gorityala, B. K., Idowu, T., Domalaon, R., Zhanel, G. G., Shan, A., & Schweizer, F. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01742 · Cited by 86
Cross-resistance between biocides and antimicrobials: an emerging question
Davin‐Regli, A., & Pagès, J. (2012) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.31.1.2099 · Cited by 87
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress Conditions
Piedrafita, G., Keller, M. A., & Ralser, M. (2015) · Biomolecules · doi:10.3390/biom5032101 · Cited by 86
Understanding efflux in Gram-negative bacteria: opportunities for drug discovery
Schweizer, H. P. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.688949 · Cited by 84
Genomic Potential of Stenotrophomonas maltophilia in Bioremediation with an Assessment of Its Multifaceted Role in Our Environment
Mukherjee, P., & Roy, P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00967 · Cited by 83
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Lukačišinová, M., Fernando, B., & Bollenbach, T. (2020) · Nature Communications · doi:10.1038/s41467-020-16932-z · Cited by 80
Unraveling antimicrobial resistance using metabolomics
Kok, M., Maton, L., van der Peet, M., Hankemeier, T., & van Hasselt, J. G. C. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.03.015 · Cited by 83
Fluoroquinolone Resistance in Helicobacter pylori : Role of Mutations at Position 87 and 91 of GyrA on the Level of Resistance and Identification of a Resistance Conferring Mutation in GyrB
Rimbara, E., Noguchi, N., Kawai, T., & Sasatsu, M. (2012) · Helicobacter · doi:10.1111/j.1523-5378.2011.00912.x · Cited by 83
Acinetobacter baumannii : A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management
Singh, H. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/6337.3626 · Cited by 83
Assembly and transport mechanism of tripartite drug efflux systems
Misra, R., & Bavro, V. N. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.02.017 · Cited by 82
Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus
Mouwakeh, A., Kincses, A., Nové, M., Mosolygó, T., Mohácsi‐Farkas, C., Kiskó, G., & Spengler, G. (2019) · Phytotherapy Research · doi:10.1002/ptr.6294 · Cited by 83
Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum
Evans, K. C., Benomar, S., Camuy‐Vélez, L. A., Nasseri, E. B., Wang, X., Neuenswander, B., & Chandler, J. R. (2018) · The ISME Journal · doi:10.1038/s41396-018-0047-7 · Cited by 81
Bile-Inducible Efflux Transporter from Bifidobacterium longum NCC2705, Conferring Bile Resistance
Gueimonde, M., Garrigues, C., van Sinderen, D., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00172-09 · Cited by 81
Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations
Szumowski, J. D., Adams, K. N., Edelstein, P. H., & Ramakrishnan, L. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_300 · Cited by 86
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity
Debruycker, V., Hutchin, A., Masureel, M., Ficici, E., Martens, C., Legrand, P., Stein, R. A., Mchaourab, H. S., Faraldo-Gómez, J. D., Remaut, H., et al. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0464-y · Cited by 69
On the evolutionary ecology of multidrug resistance in bacteria
Lehtinen, S., Blanquart, F., Lipsitch, M., & Fraser, C. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007763 · Cited by 80
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
Bharatham, N., Bhowmik, P., Aoki, M., Okada, U., Sharma, S., Yamashita, E., Shanbhag, A. P., Rajagopal, S., Thomas, T., Sarma, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25679-0 · Cited by 86
Insights into the antibacterial mechanism of iron doped carbon dots
Huang, C., Duan, M., Shi, Y., Liu, H., Zhang, P., Zuo, Y., Yan, L., Xu, Y., & Niu, Y. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.149 · Cited by 80
Indole Based Weapons to Fight Antibiotic Resistance: A Structure–Activity Relationship Study
Lepri, S., Buonerba, F., Goracci, L., Velilla, I., Ruzziconi, R., Schindler, B. D., Seo, S. M., Kaatz, G. W., & Cruciani, G. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01219 · Cited by 79
Virulence-determinants and antibiotic-resistance genes of MDR-E. coli isolated from secondary infections following FMD-outbreak in cattle
Algammal, A. M., Hetta, ‏. F., Batiha, G. E., Hozzein, W. N., El-Kazzaz, W. M., Hashem, H. R., Tawfik, A. M., & El-Tarabili, R. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-75914-9 · Cited by 78
Nanomaterial-based strategies in antimicrobial applications: Progress and perspectives
Zhao, Y., Chen, L., Wang, Y., Song, X., Li, K., Yan, X., Yu, L., & He, Z. (2021) · Nano Research · doi:10.1007/s12274-021-3417-4 · Cited by 78
Virulence‐targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms
Ruer, S., Pinotsis, N., Steadman, D., Waksman, G., & Remaut, H. K. (2015) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12517 · Cited by 74
Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG
Ramón‐García, S., Mick, V., Dainese, E., Martı́n, C., Thompson, C. J., Rossi, E. D., Manganelli, R., & Aínsa, J. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05946-11 · Cited by 76
Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
Bolla, J. R., Su, C., Do, S. V., Radhakrishnan, A., Kumar, N., Long, F., Chou, T., Delmar, J. A., Lei, H., Rajashankar, K. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097903 · Cited by 76
Structure and mechanism of bacterial tripartite efflux pumps
Neuberger, A., Du, D., & Luisi, B. F. (2018) · Research in Microbiology · doi:10.1016/j.resmic.2018.05.003 · Cited by 74
Phytochemical Profiles, Antioxidant and Antibacterial Activities of Grape (Vitis vinifera L.) Seeds and Skin from Organic and Conventional Vineyards
Rădulescu, C., Buruleanu, C. L., Nicolescu, C. M., Olteanu, R. L., Bumbac, M., Holban, G. C., & Simal‐Gándara, J. (2020) · Plants · doi:10.3390/plants9111470 · Cited by 77
Genomic Evidence Reveals the Extreme Diversity and Wide Distribution of the Arsenic-Related Genes in Burkholderiales
Li, X., Zhang, L., & Wang, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092236 · Cited by 75
Temporal Interplay between Efflux Pumps and Target Mutations in Development of Antibiotic Resistance in Escherichia coli
Singh, R., Swick, M. C., Ledesma, K. R., Yang, Z., Hu, M., Zechiedrich, L., & Tam, V. H. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05693-11 · Cited by 75
Label-Free Quantitative Proteomics Analysis of Antibiotic Response in Staphylococcus aureus to Oxacillin
Liu, X., Hu, Y., Pai, P.-J., Chen, D., & Lam, H. (2013) · Journal of Proteome Research · doi:10.1021/pr400669d · Cited by 73
Biocides and health-care agents are more than just antibiotics: Inducing cross to co-resistance in microbes
Paul, D., Chakraborty, R., & Mandal, S. M. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.02.083 · Cited by 76
The pharmacogenomics of P‐glycoprotein and its role in veterinary medicine
Martinez, M. N., Modrić, S., Sharkey, M., Troutman, L., WALKER, L., & Mealey, K. L. (2008) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2008.00964.x · Cited by 74
Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification
Bailey, A. M., Constantinidou, C., Ivens, A. C., Garvey, M. I., Webber, M. A., Coldham, N. G., Hobman, J. L., Wain, J. R., Woodward, M. J., & Piddock, L. J. V. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp320 · Cited by 74
Self-citation
The Cus efflux system removes toxic ions via a methionine shuttle
Su, C., Long, F., & Yu, E. W. (2010) · Protein Science · doi:10.1002/pro.532 · Cited by 74
Effect of Efflux Pump Inhibitor Carbonyl Cyanide 3-Chlorophenylhydrazone on the Minimum Inhibitory Concentration of Ciprofloxacin in Acinetobacter baumannii Clinical Isolates
Ardebili, A., Talebi, M., Azimi, L., & Lari, A. R. (2014) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.8691 · Cited by 74
Genomics of antibiotic‐resistance prediction in Pseudomonas aeruginosa
Jeukens, J., Freschi, L., Kukavica‐Ibrulj, I., Emond-Rhéault, J.-G., Tucker, N. P., & Lévesque, R. C. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13358 · Cited by 78
Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters
Ramaswamy, V. K., Vargiu, A. V., Malloci, G., Dreier, J., & Ruggerone, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-08747-8 · Cited by 74
Ecology and Evolution of Chromosomal Gene Transfer between Environmental Microorganisms and Pathogens
Martínez, J. L. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.mtbp-0006-2016 · Cited by 79
Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections
Amaral, L., & Viveiros, M. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.01.012 · Cited by 73
In Vitro Selection of ramR and soxR Mutants Overexpressing Efflux Systems by Fluoroquinolones as Well as Cefoxitin in Klebsiella pneumoniae
Bialek-Davenet, S., Marcon, E., Leflon‐Guibout, V., Lavigne, J., Bert, F., Moreau, R., & Nicolas-Chanoine, M.-H. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00156-11 · Cited by 73
Rv1218c, an ABC Transporter of Mycobacterium tuberculosis with Implications in Drug Discovery
Balganesh, M., Kuruppath, S., Marcel, N., Sharma, S., Nair, A. V., & Sharma, U. K. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00610-10 · Cited by 73
The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance
Ebbensgaard, A. E., Løbner‐Olesen, A., & Frimodt-Møller, J. (2020) · Antibiotics · doi:10.3390/antibiotics9120855 · Cited by 70
Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
Kumar, S., Anwer, R., & Azzi, A. (2021) · Microorganisms · doi:10.3390/microorganisms9102104 · Cited by 72
Chlorhexidine Resistance or Cross-Resistance, That Is the Question
Abbood, H. M., Hijazi, K., & Gould, I. M. (2023) · Antibiotics · doi:10.3390/antibiotics12050798 · Cited by 72
Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria
Rajput, P., Nahar, K. S., & Rahman, K. M. (2024) · Antibiotics · doi:10.3390/antibiotics13121197 · Cited by 94
Correlation of Overexpression of Efflux Pump Genes with Antibiotic Resistance inEscherichia coliStrains Clinically Isolated from Urinary Tract Infection Patients
Yasufuku, T., Shigemura, K., Shirakawa, T., Matsumoto, M., Nakano, Y., Tanaka, K., Arakawa, S., Kinoshita, S., Kawabata, M., & Fujisawa, M. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00827-10 · Cited by 72
Enhancement of Antibiotic Activity against Multidrug-Resistant Bacteria by the Efflux Pump Inhibitor 3,4-Dibromopyrrole-2,5-dione Isolated from a Pseudoalteromonas sp.
Whalen, K. E., Poulson‐Ellestad, K. L., Deering, R. W., Rowley, D. C., & Mincer, T. J. (2015) · Journal of Natural Products · doi:10.1021/np500775e · Cited by 73
Increase in resistance rates of H. pylori isolates to metronidazole and tetracycline--comparison of three 3-year studies.
Siavoshi, F., Saniee, P., Latifi‐Navid, S., Massarrat, S., & Haj-Sheykholeslami, A. (2010) · PubMed · Cited by 70
PatA and PatB Form a Functional Heterodimeric ABC Multidrug Efflux Transporter Responsible for the Resistance of Streptococcus pneumoniae to Fluoroquinolones
Boncoeur, É., Durmort, C., Bernay, B., Ebel, C., Guilmi, A. M. D., Croizé, J., Vernet, T., & Jault, J. (2012) · Biochemistry · doi:10.1021/bi300762p · Cited by 70
Stress-Induced Mutagenesis, Gambler Cells, and Stealth Targeting Antibiotic-Induced Evolution
Pribis, J. P., Zhai, Y., Hastings, P. J., & Rosenberg, S. M. (2022) · mBio · doi:10.1128/mbio.01074-22 · Cited by 72
Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution
Kaščáková, S., Maigre, L., Chevalier, J., Réfrégiers, M., & Pagès, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038624 · Cited by 69
Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis
Jin, J., Zhang, J., Guo, N., Sheng, H., Li, L., Liang, J., Wang, X., Li, Y., Liu, M., Wu, X., et al. (2010) · Molecules · doi:10.3390/molecules15117750 · Cited by 69
Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps
German, N., Wei, P., Kaatz, G. W., & Kerns, R. J. (2008) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2008.01.042 · Cited by 68
Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance
Maia, G. L. D. A., Falcão-Silva, V. D. S., Aquino, P. G. V., de Araújo‐Júnior, J. X., Tavares, J. F., da Silva, M. S., Rodrigues, L. C., Siqueira-Júnior, J. P., & Barbosa‐Filho, J. M. (2011) · Molecules · doi:10.3390/molecules16064828 · Cited by 68
The Influence of Efflux Pump Inhibitors on the Activity of Non-Antibiotic NSAIDS against Gram-Negative Rods
Laudy, A. E., Mrówka, A., Krajewska, J., & Tyski, S. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147131 · Cited by 68
Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems
Imran, M., Jha, S. K., Hasan, N., Insaf, A., Shrestha, J., Shrestha, J., Devkota, H. P., Khan, S., Panth, N., Warkiani, M. E., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030586 · Cited by 71
Reduction of Cellular Stress by TolC-Dependent Efflux Pumps in Escherichia coli Indicated by BaeSR and CpxARP Activation of spy in Efflux Mutants
Rosner, J. L., & Martin, R. G. (2012) · Journal of Bacteriology · doi:10.1128/jb.01996-12 · Cited by 67
Mycoplasmas and Their Antibiotic Resistance: The Problems and Prospects in Controlling Infections
Chernova, O. A., Medvedeva, E. S., Mouzykantov, A. A., Baranova, N. B., & Chernov, V. M. (2016) · Acta Naturae · doi:10.32607/20758251-2016-8-2-24-34 · Cited by 66
Importance of Real-Time Assays To Distinguish Multidrug Efflux Pump-Inhibiting and Outer Membrane-Destabilizing Activities in Escherichia coli
Misra, R., Morrison, K. D., Cho, H. J., & Khuu, T. (2015) · Journal of Bacteriology · doi:10.1128/jb.02456-14 · Cited by 66
Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production
Shi, W., Li, K., Ji, Y., Jiang, Q., Wang, Y., Shi, M., & Zu-huang, M. (2013) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822013000200015 · Cited by 66
The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition
Bhattacharyya, T., Sharma, A., Akhter, J., & Pathania, R. (2017) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2017.03.005 · Cited by 66
Flavonoids as Inhibitors of Bacterial Efflux Pumps
Waditzer, M., & Bučar, F. (2021) · Molecules · doi:10.3390/molecules26226904 · Cited by 65
Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii
Boinett, C. J., Cain, A. K., Hawkey, J., Nhu, T. D. H., Nhu, N. T. K., Thanh, D. P., Dordel, J., Campbell, J. I., Lan, N. P. H., Mayho, M., et al. (2019) · Microbial Genomics · doi:10.1099/mgen.0.000246 · Cited by 65
Modulation of antimicrobial efflux pumps of the major facilitator superfamily in Staphylococcus aureus
Lekshmi, M., Parvathi, A., Adjei, J., Sanford, L. M., Shrestha, U., Kumar, S. H., & Varela, M. F. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.1.1 · Cited by 64
Efflux pumps in multidrug-resistant Acinetobacter baumannii: Current status and challenges in the discovery of efflux pumps inhibitors
Verma, P., Tiwari, M., & Tiwari, V. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104766 · Cited by 68
The Dynamics of the Antimicrobial Resistance Mobilome of Salmonella enterica and Related Enteric Bacteria
Algarni, S., Ricke, S. C., Foley, S. L., & Han, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.859854 · Cited by 69
Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7
Morita, Y., Tomida, J., & Kawamura, Y. (2012) · Microbiology · doi:10.1099/mic.0.054320-0 · Cited by 64
Natural Hot Spots for Gain of Multiple Resistances: Arsenic and Antibiotic Resistances in Heterotrophic, Aerobic Bacteria from Marine Hydrothermal Vent Fields
Farias, P., Santo, C. E., Branco, R., Francisco, R., Santos, S. S., Hansen, L. H., Sørensen, S. J., & Morais, P. V. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03240-14 · Cited by 64
In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumonia e
Zhou, X.-Y., Ye, X., He, L., Zhang, S.-R., Wang, R., Zhou, J. M., & He, Z.-S. (2016) · The Journal of Antibiotics · doi:10.1038/ja.2016.15 · Cited by 64
Inactivation or inhibition of AcrAB-TolC increases resistance of carbapenemase-producing Enterobacteriaceae to carbapenems
Saw, H. T. H., Webber, M. A., Mushtaq, S., Woodford, N., & Piddock, L. J. V. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw028 · Cited by 64
Self-citation
Transcriptional Profiling Suggests that Multiple Metabolic Adaptations are Required for Effective Proliferation of Pseudomonas aeruginosa in Jet Fuel
Gunasekera, T. S., Striebich, R. C., Mueller, S. S., Strobel, E. M., & Ruiz, O. N. (2013) · Environmental Science & Technology · doi:10.1021/es403163k · Cited by 64

Authors: Piddock, L. J. V.
Affiliations: University of Birmingham (GB)
Corresponding author: Piddock, Laura J. V.
ORCID: Piddock, Laura J. V.
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2006-04
Volume: 19
Issue: 2
Pages: 382-402
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.19.2.382-402.2006
PMC: PMC1471989
OpenAlex: W2112586763
Cited by: 1,231
References: 242
Citations by year: 2026: 37 · 2025: 45 · 2024: 66 · 2023: 65 · 2022: 69 · 2021: 99 · 2020: 75 · 2019: 69 · 2018: 53 · 2017: 79 · 2016: 72 · 2015: 69 · 2014: 72 · 2013: 57 · 2012: 63
FWCI: 2.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: multidrug resistance, efflux pumps, antibiotic resistance, pathogenic bacteria, efflux pump regulation, efflux pump inhibitors, plant alkaloids, drug transport mechanisms, insertion elements
MeSH terms: Alkaloids, Anti-Infective Agents, Bacteria, Bacterial Proteins, Biological Transport, Chromosomes, Bacterial, Disinfectants, DNA Transposable Elements, Genes, Regulator, Mutation, Promoter Regions, Genetic, Virulence, Drug Resistance, Multiple, Bacterial, Membrane Transport Proteins, ATP-Binding Cassette, Sub-Family C Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks