Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Molecular Basis of Bacterial Outer Membrane Permeability Revisited

Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316

The interaction between bacteria and bile

Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776

Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999

Diekema, D. J., Pfaller, M. A., Schmitz, F., Smayevsky, J., Bell, J. M., Jones, R. N., Beach, M. L., & SENTRY Participants Group (2001) · Clinical Infectious Diseases · doi:10.1086/320184 · Cited by 1,363

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

Koronakis, V. E., Sharff, A., Koronakis, E., Luisi, B. F., & Hughes, C. (2000) · Nature · doi:10.1038/35016007 · Cited by 1,086

Efflux-mediated antimicrobial resistance

Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082

Crystal structure of bacterial multidrug efflux transporter AcrB

Murakami, S., Nakashima, R., Yamashita, E., & Yamaguchi, A. (2002) · Nature · doi:10.1038/nature01050 · Cited by 1,018

Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy

Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903

The importance of efflux pumps in bacterial antibiotic resistance

Webber, M. A. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg050 · Cited by 856

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818

Molecular Properties of Bacterial Multidrug Transporters

Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 811

Regulation of the AcrAB efflux system by the quorum-sensing regulator AnoR in Acinetobacter nosocomialis

Subhadra, B., Surendran, S., Lim, B. R., Yim, J. S., Kim, D. H., Woo, K., Kim, H., Oh, M. H., & Choi, C. H. (2020) · The Journal of Microbiology · doi:10.1007/s12275-020-0185-2 · Cited by 20

A review on the origin of multidrug-resistant Salmonella and perspective of tailored phoP gene towards avirulence

Gangathraprabhu, B., Kannan, S., Santhanam, G., Suryadevara, N., & Murugan, M. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104352 · Cited by 20

Bacterial drug resistance towards natural products

Seukep, A. J., Nembo, E. N., Mbuntcha, H. G., & Kuete, V. (2022) · Advances in botanical research · doi:10.1016/bs.abr.2022.08.002 · Cited by 22

Carbapenem-Resistant Klebsiella pneumoniae: Diversity, Virulence, and Antimicrobial Resistance

Elmanakhly, A. R., Bendary, M. M., Safwat, N. A., Awad, E. A.-E., Alhomrani, M., Alamri, A. S., Khafagy, E., Alotaibi, H. F., & Abou-Elazm, F. I. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s387742 · Cited by 20

Effect of the inhibitors phenylalanine arginyl ß-naphthylamide (PAßN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis

Barrero, M. A. O., Pietralonga, P. A. G., Schwarz, D. G. G., Junior, A. S., de Paula, S. O., & Moreira, M. A. S. (2014) · Research in Veterinary Science · doi:10.1016/j.rvsc.2014.05.013 · Cited by 20

Molecular mechanisms of membrane impermeability in clinical isolates of Enterobacteriaceae exposed to imipenem selective pressure

Pávez, M., Vieira, C. A., de Araujo, M. R., Cerda, Á., de Almeida, L. M., Lincopán, N., & Mamizuka, E. M. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.04.016 · Cited by 20

Plasmid borne Carbapenem-Hydrolyzing Class D β-Lactamases (CHDLs) and AdeABC efflux pump conferring carbapenem-tigecycline resistance among Acinetobacter baumannii isolates harboring TnAbaRs

Savari, M., Ekrami, A., Shoja, S., & Bahador, A. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.01.045 · Cited by 20

Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters

Sandhu, P., & Akhter, Y. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1434-6 · Cited by 20

Susceptibility of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Various Clonal Lineages from Germany to Eight Biocides

Kernberger-Fischer, I., Krischek, C., Strommenger, B., Fiegen, U., Beyerbach, M., Kreienbrock, L., Klein, G., & Kehrenberg, C. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.00799-18 · Cited by 20

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Alzrigat, L. P., Huseby, D. L., Brandis, G., & Hughes, D. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa417 · Cited by 20

Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update

Barabote, R. D., Thekkiniath, J., Strauss, R. E., Vediyappan, G., Fralick, J. A., & Francisco, M. J. S. (2011) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470920541.ch6 · Cited by 22

Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of Escherichia coli

Atzori, A., Malloci, G., Cardamone, F., Bosin, A., Vargiu, A. V., & Ruggerone, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030860 · Cited by 19

Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors

Choquet, M., Lohou, E., Pair, E., Sonnet, P., & Mullié, C. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00710-21 · Cited by 19

The Two-Component System RstA/RstB Regulates Expression of Multiple Efflux Pumps and Influences Anaerobic Nitrate Respiration in Pseudomonas fluorescens

Li, D.-Y., Han, J.-T., Zhang, M.-Y., Yan, X., Zhang, N., Ge, H., Wang, Z., & He, Y.-X. (2021) · mSystems · doi:10.1128/msystems.00911-21 · Cited by 19

Disinfection Strategies for Carbapenem-Resistant Klebsiella pneumoniae in a Healthcare Facility

Ni, L., Zhang, Z., Shen, R. D., Liu, X., Li, X., Chen, B., Wu, X., Li, H., Xie, X., & Huang, S. (2022) · Antibiotics · doi:10.3390/antibiotics11060736 · Cited by 19

A mechanism of salt bridge–mediated resistance to FtsZ inhibitor PC190723 revealed by a cell-based screen

Sharma, A. K., Poddar, S. M., Chakraborty, J., Nayak, B. S., Kalathil, S., Mitra, N., Gayathri, P., & Srinivasan, R. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-12-0538 · Cited by 19

Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains

Saleh, N. M., Ezzat, H., El-Sayyad, G. S., & Hafez-Zedan, H. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03194-8 · Cited by 19

Emerging fluoroquinolone resistance in Streptococcus agalactiae in South Korea

Ki, M., Srinivasan, U., Oh, K.-Y., Kim, M. Y., Shin, J. H., Chong, Y., Dang, T. N.-D., Britt, Z., & Foxman, B. (2012) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-012-1685-8 · Cited by 19

The Analysis of the Antibiotic Resistome Offers New Opportunities for Therapeutic Intervention

Corona, F., Blanco, P., Alcalde‐Rico, M., Hernando‐Amado, S., Lira, F., Bernardini, A., Sánchez, M. B., & Martínez, J. L. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0027 · Cited by 20

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

Kalule, J. B., Fortuin, S., Calder, B., Robberts, F. J. L., Keddy, K. H., Nel, A. J. M., Garnett, S., Nicol, M. P., Warner, D. F., Soares, N. C., et al. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.09.003 · Cited by 19

The Transcriptomic Signature of Tigecycline in Acinetobacter baumannii

Li, L., Hassan, K. A., Tetu, S. G., Naidu, V., Pokhrel, A., Cain, A. K., & Paulsen, I. T. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.565438 · Cited by 19

Identification of a multidrug efflux pump inFlavobacterium johnsoniae

Clark, S. E., Jude, B. A., Danner, G. R., & Fekete, F. A. (2009) · Veterinary Research · doi:10.1051/vetres/2009038 · Cited by 19

Characterization of a Unique Outer Membrane Protein Required for Oxidative Stress Resistance and Virulence of Francisella tularensis

Alqahtani, M., Ma, Z., Ketkar, H., Suresh, R. V., Malik, M., & Bakshi, C. S. (2018) · Journal of Bacteriology · doi:10.1128/jb.00693-17 · Cited by 19

The Helicobacter hepaticus hefA Gene is Involved in Resistance to Amoxicillin

Belzer, C., Stoof, J., Breijer, S., Kusters, J. G., Kuipers, E. J., & van Vliet, A. H. M. (2009) · Helicobacter · doi:10.1111/j.1523-5378.2009.00661.x · Cited by 19

Ecological immunology

Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0005 · Cited by 19

Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications.

Halling, S. M., & Jensen, A. E. (2006) · BMC Microbiology · doi:10.1186/1471-2180-6-84 · Cited by 19

Efflux Pumps as an Important Mechanism for Quinolone Resistance

Vilà, J., Fàbrega, A., Roca, I., Hernández, A., & Martínez, J. L. (2011) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470920541.ch5 · Cited by 19

Small regulatory RNAs as key modulators of antibiotic resistance in pathogenic bacteria

Yang, Y., Hyeon, H., Joo, M., Lee, K., & Shin, E. (2025) · The Journal of Microbiology · doi:10.71150/jm.2501027 · Cited by 20

The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli

Chen, H., Sapula, S. A., Turnidge, J. D., & Venter, H. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00144-w · Cited by 18

Understanding the Structural Mechanisms of Antibiotic Resistance Sets the Platform for New Discovery

Reeve, S. M., Lombardo, M. N., & Anderson, A. C. (2015) · Future Microbiology · doi:10.2217/fmb.15.78 · Cited by 18

Mechanisms Involved in the Active Secretion of CTX-M-15 β-Lactamase by Pathogenic Escherichia coli ST131

Rangama, S., Lidbury, I. D. E. A., Holden, J. M., Borsetto, C., Murphy, A. R. J., Hawkey, P. M., & Wellington, E. M. H. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00663-21 · Cited by 18

1,3,4-oxadiazole conjugates of capsaicin as potent NorA efflux pump inhibitors of Staphylococcus aureus

Naaz, F., Khan, A. A., Kumari, A., Ali, I., Ahmad, F., Lone, B. A., Ahmad, N., Khan, I. A., Rajput, V. S., Grover, A., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105031 · Cited by 18

Genome-wide analysis of genes involved in efflux function and regulation within Escherichia coli and Salmonella enterica serovar Typhimurium

Holden, E. R., Yasir, M., Turner, A. K., Wain, J. R., Charles, I. G., & Webber, M. A. (2023) · Microbiology · doi:10.1099/mic.0.001296 · Cited by 18

Efflux-mediated Multidrug Resistance in Critical Gram-negative Bacteria and Natural Efflux Pump Inhibitors

Nanjan, P., & Bose, V. (2024) · Current Drug Research Reviews · doi:10.2174/0125899775271214240112071830 · Cited by 18

Structural analysis of resistance-nodulation cell division transporters

Klenotic, P. A., & Yu, E. W. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00198-23 · Cited by 16

Rosemary Compounds as Nutraceutical Health Products

Moreno, S., Ojeda-Sana, A. M., Gaya, M., Vernica, M., Olga, A., & van, C. (2012) · InTech eBooks · doi:10.5772/30883 · Cited by 18

Klebsiella oxytoca with reduced sensitivity to chlorhexidine isolated from a diabetic foot ulcer

Vali, L., Dashti, A. A., El‐Shazly, S., & Jadaon, M. M. (2015) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2015.03.021 · Cited by 18

Assessment of antibiotics susceptibility profiles of some selected clinical isolates from laboratories in Nigeria

Nkang, O., Okonko, I. O., Mejeha, O. K., Adewale, O. G., Udeze, A. O., Fowotade, A., Fajobi, E. A., Adedeji, A. O., & Babalola, E. T. (2009) · Journal of Microbiology and Antimicrobials · doi:10.5897/jma.9000012 · Cited by 18

Efflux Pumps in Chromobacterium Species Increase Antibiotic Resistance and Promote Survival in a Coculture Competition Model

Benomar, S., Evans, K. C., Unckless, R. L., & Chandler, J. R. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00908-19 · Cited by 18

Palmatine Is a Plasmid-Mediated Quinolone Resistance (PMQR) Inhibitor That Restores the Activity of Ciprofloxacin Against QnrS and AAC(6ʹ)-Ib-cr-Producing Escherichia coli

Wang, P., Hu, L., & Hao, Z. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s242304 · Cited by 18

Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB

Jesin, J. A., Stone, T. A., Mitchell, C. J., Reading, E., & Deber, C. M. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00417 · Cited by 18

Antimicrobial activity of PVP from an Antarctic bacterium, Janthinobacterium sp. Ant5-2, on multi-drug and methicillin resistant Staphylococcus aureus

Huang, J. P., Mojib, N., Goli, R. R., Watkins, S., Waites, K. B., Ravindra, R., Andersen, D. T., & Bej, A. K. (2012) · Natural Products and Bioprospecting · doi:10.1007/s13659-012-0021-4 · Cited by 18

Oligomeric behavior of the RND transporters CusA and AcrB in micellar solution of detergent

Stroebel, D., Sendra, V., Cannella, D., Helbig, K., Nies, D. H., & Covès, J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.03.008 · Cited by 18

Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae

Nasralddin, N. A., Haeili, M., Karimzadeh, S., & Alsahlani, F. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315847 · Cited by 17

Harnessing biological insights to accelerate drug discovery against ESKAPE pathogens

Palmo, T., Jamwal, V., Kumari, D., & Singh, K. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00358j · Cited by 17

Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli

Salcedo-Sora, J. E., Robison, A. T. R., Zaengle-Barone, J. M., Franz, K. J., & Kell, D. B. (2021) · Molecules · doi:10.3390/molecules26195826 · Cited by 17

Environmental complexity is more important than mutation in driving the evolution of latent novel traits in E. coli

Karve, S. M., & Wagner, A. (2022) · Nature Communications · doi:10.1038/s41467-022-33634-w · Cited by 17

In vitro-obtained meropenem-vaborbactam resistance mechanisms among clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates

Findlay, J., Poirel, L., & Nordmann, P. (2023) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2022.12.009 · Cited by 17

ABC superfamily transporter Rv1273c of Mycobacterium tuberculosis acts as a multidrug efflux pump

Adhikary, A., Chatterjee, D., & Ghosh, A. S. (2023) · FEMS Microbiology Letters · doi:10.1093/femsle/fnad114 · Cited by 17

Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli

Soparkar, K., Kinana, A. D., Weeks, J. W., Morrison, K. D., Nikaido, H., & Misra, R. (2015) · Journal of Bacteriology · doi:10.1128/jb.00547-15 · Cited by 17

Efflux Pumps in Mycobacteria: Antimicrobial Resistance, Physiological Functions, and Role in Pathogenicity

da Silva, P. E. A., Machado, D., Ramos, D. F., Couto, I., von Groll, A., & Viveiros, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-39658-3_21 · Cited by 17

Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae

Pantel, L., Juarez, P., Serri, M., Boucinha, L., Lessoud, E., Lanois, A., Givaudan, A., Racine, E., & Gualtiéri, M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00139-21 · Cited by 17

Risk Factors for Amoxicillin-Clavulanate Resistance in Community-Onset Urinary Tract Infections Caused by Escherichia coli or Klebsiella pneumoniae: The Role of Prior Exposure to Fluoroquinolones

Martínez-Casanova, J., Gómez-Zorrilla, S., Prim, N., Molin, A. D., Echeverría-Esnal, D., Gracia, M. P., Sendra, E., Güerri‐Fernández, R., Durán, X., Padilla, E., et al. (2021) · Antibiotics · doi:10.3390/antibiotics10050582 · Cited by 17

Changes in antimicrobial susceptibility in a population of Salmonella enterica serovar Dublin isolated from cattle in Japan from 1976 to 2005.

Akiba, M., Nakaoka, Y., Kida, M., Ishioka, Y., Sameshima, T., Yoshii, N., Nakazawa, M., Uchida, I., & Terakado, N. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm402 · Cited by 16

YnfA, a SMR family efflux pump is abundant in Escherichia coli isolates from urinary infection

Sarkar, S., Bhattacharyya, A., & Mandal, S. M. (2015) · Indian Journal of Medical Microbiology · doi:10.4103/0255-0857.148415 · Cited by 17

Genetic variations in the active efflux pump genes acrA/B and tolC in different drug-induced strains of Escherichia coli CVCC 1547

Liu, J. H., Pan, Y. S., Yuan, L., Wu, H., Hu, G., & Chen, Y. X. (2013) · Genetics and Molecular Research · doi:10.4238/2013.august.8.3 · Cited by 17

Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment

Nguyen, H. M., Nguyen, T. Y. N., Le, N. T. H., Le, T. N. T., Chau, N. T. N., Le, T. M. H., & Nguyen, B. Q. H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39229 · Cited by 16

Sophorae tonkinensis radix et rhizoma: A comprehensive review of the ethnopharmacology, phytochemistry, pharmacology, pharmacokinetics, toxicology and detoxification strategy

Zeng, F.-F., Chen, Z., Luo, F.-H., Liu, C., Yang, X., Zhang, F., & Shi, W. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118784 · Cited by 16

The Synergy of Machine Learning and Epidemiology in Addressing Carbapenem Resistance: A Comprehensive Review

Sakagianni, A., Koufopoulou, C., Koufopoulos, P., Feretzakis, G., Kalles, D., Paxinou, E., Myrianthefs, P. M., & Verykios, V. S. (2024) · Antibiotics · doi:10.3390/antibiotics13100996 · Cited by 19

High levels of multiresistance in quinolone resistant urinary tract isolates of Escherichia coli from Norway; a non clonal phenomen?

Strand, L., Jenkins, A., Henriksen, I. H., Allum, A. G., Grude, N., & Kristiansen, B. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-376 · Cited by 17

Culture-independent analysis of liver abscess using nanopore sequencing

Gong, L., Huang, Y., Wong, C., Chao, W., Wu, Z., Wei, C., & Liu, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190853 · Cited by 16

Crystal Structure of the Regulatory Domain of MexT, a Transcriptional Activator of the MexEFOprN Efflux Pump in Pseudomonas aeruginosa.

Kim, S., Kim, S. H., Ahn, J., Jo, I., Lee, Z., Choi, S. H., & Ha, N. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0168 · Cited by 16

Quantitative real-time PCR study of the expression and regulation of the tetracycline resistance gene inRiemerella anatipestifer

Zhong, C.-Y., Cheng, A., Wang, M., Zhu, D., Luo, Q., Chen, S., Zhang, S., & Chen, X. (2013) · Poultry Science · doi:10.3382/ps.2012-02672 · Cited by 16

A Single Acidic Residue Can Guide Binding Site Selection but Does Not Govern QacR Cationic-Drug Affinity

Peters, K. M., Brooks, B. E., Schumacher, M. A., Skurray, R. A., Brennan, R. G., & Brown, M. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015974 · Cited by 16

Development of an accumulation assay and evaluation of the effects of efflux pump inhibitors on the retention of chlorhexidine digluconate in Pseudomonas aeruginosa and Staphylococcus aureus

Mombeshora, M., & Mukanganyama, S. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2637-2 · Cited by 16

The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli

Donner, J., Reck, M., Bunk, B., Jarek, M., App, C. B., Meier‐Kolthoff, J. P., Overmann, J., Müller, R., Kirschning, A., & Wagner‐Döbler, I. (2017) · mSphere · doi:10.1128/mspheredirect.00375-17 · Cited by 16

Whole genome sequencing and antibiotic diffusion assays, provide new insight on drug resistance in the genus Pedobacter

Ullmann, I. F., Nygaard, A. B., Tunsjø, H. S., & Charnock, C. (2020) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiaa088 · Cited by 15

Isolation and characterization of a novel temperate bacteriophage infecting Aeromonas hydrophila isolated from a Macrobrachium rosenbergii larvae pond

Lyu, S., Xiong, F., Qi, T., Shen, W., Guo, Q., Han, M., Liu, L., Bu, W., Yuan, J., & Lou, B. (2023) · Virus Research · doi:10.1016/j.virusres.2023.199279 · Cited by 15

Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB

Wilhelm, J., & Pos, K. M. (2024) · Microbiology · doi:10.1099/mic.0.001438 · Cited by 14

Triterpenes and phenolic compounds isolated from the aerial parts ofHerissantia tiubaeand evaluation of 5,4′,-dihydroxy-3,6,7,8,3′-pentamethoxyflavone as a modulator of bacterial drug resistance

Silva, D. A. E., Falcão‐Silva, V. S., Gomes, A. Y. S., da Costa, D. A., Lemos, V. S., Agra, M. D. F., Braz‐Filho, R., Siqueira-Júnior, J. P., & de Souza, M. D. F. V. (2009) · Pharmaceutical Biology · doi:10.1080/13880200802436570 · Cited by 15

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

Allam, A., Maigre, L., de Sousa, R. A., Dumont, E., Vergalli, J., Pagès, J., & Artaud, I. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.10.054 · Cited by 15

Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review

Islamieh, D. I., Afshar, D., Yousefi, M., & Esmaeili, D. (2018) · International Journal of Medical Reviews · doi:10.29252/ijmr-050303 · Cited by 15

Antibiotic-in-Cyclodextrin-in-Liposomes: Formulation Development and Interactions with Model Bacterial Membranes

Vandera, K. A., Picconi, P., Valero, M., González‐Gaitano, G., Woods, A., Zain, N. M. M., Bruce, K. D., Clifton, L. A., Skoda, M. W. A., Rahman, K. M., et al. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00096 · Cited by 15

Simulated microgravity affects ciprofloxacin susceptibility and expression of acrAB-tolC genes in E. coli ATCC25922.

Xu, B., Li, C., Zheng, Y., Si, S., Shi, Y., Huang, Y., Zhang, J., Cui, Y., & Cui, Y. (2015) · PubMed Central · Cited by 15

Aeromonas spp.: fatores de virulência e perfis de resistência a antimicrobianos e metais pesados

Peixoto, L., de Sá, M. C. A., Gordiano, L. A., & da Costa, M. M. (2012) · Arquivos do Instituto Biológico · doi:10.1590/s1808-16572012000300020 · Cited by 15

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Wand, M. E. (2017) · Advances in environmental microbiology · doi:10.1007/978-3-319-60616-3_2 · Cited by 15

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Paul, D., Mondal, S. K., & Mandal, S. M. (2021) · Biologia Futura · doi:10.1007/s42977-021-00069-1 · Cited by 15

Assessment of the possible effect of the four antimicrobial treatment substances on the emergence of antimicrobial resistance - Scientific Opinion of the Panel on Biological Hazards

(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.659 · Cited by 15

Mechanisms of Action and of Resistance to Quinolones

Martínez, J. L. (2019) · doi:10.1002/9781119282549.ch2 · Cited by 15

Antibiotic Resistance

Périchon, B., & Courvalin, P. M. (2009) · Elsevier eBooks · doi:10.1016/b978-012373944-5.00218-2 · Cited by 15

Evaluating disinfectant efficacy on mixed biofilms comprising Shiga toxigenic Escherichia coli, lactic acid bacteria, and spoilage microorganisms

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Singh, S. K., Mishra, M., Sahoo, M., Patole, S., & Mohapatra, H. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.11.024 · Cited by 14

RND efflux pump systems in Acinetobacter , with special emphasis on their role in quorum sensing

Subhadra, B., Oh, M. H., & Choi, C. H. (2019) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2019.49.1.1 · Cited by 14

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Measuring the Activity of Active Efflux in Gram-Negative Bacteria

Webber, M. A., & Coldham, N. G. (2010) · Methods in molecular biology · doi:10.1007/978-1-60327-279-7_13 · Cited by 14

Implicancias Estructurales y Fisiológicas de la Célula Bacteriana en los Mecanismos de Resistencia Antibiótica

Troncoso, C., Pávez, M., Santos, A., Salazar, R., & Barrientos, L. (2017) · International Journal of Morphology · doi:10.4067/s0717-95022017000401214 · Cited by 14

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Synergism of Gentamicin and Norfloxacin with the Volatile Compounds of Lippia microphylla Cham. (Verbenaceae)

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Quinolones

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Fluoroquinolone Resistance: Mechanisms, Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds

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