Portrait of Candida albicans Adherence Regulators
Open accessAbstract
Cell-substrate adherence is a fundamental property of microorganisms that enables them to exist in biofilms. Our study focuses on adherence of the fungal pathogen Candida albicans to one substrate, silicone, that is relevant to device-associated infection. We conducted a mutant screen with a quantitative flow-cell assay to identify thirty transcription factors that are required for adherence. We then combined nanoString gene expression profiling with functional analysis to elucidate relationships among these transcription factors, with two major goals: to extend our understanding of transcription factors previously known to govern adherence or biofilm formation, and to gain insight into the many transcription factors we identified that were relatively uncharacterized, particularly in the context of adherence or cell surface biogenesis. With regard to the first goal, we have discovered a role for biofilm regulator Bcr1 in adherence, and found that biofilm regulator Ace2 is a major functional target of chromatin remodeling factor Snf5. In addition, Bcr1 and Ace2 share several target genes, pointing to a new connection between them. With regard to the second goal, our findings reveal existence of a large regulatory network that connects eleven adherence regulators, the zinc-response regulator Zap1, and approximately one quarter of the predicted cell surface protein genes in this organism. This limited yet sensitive glimpse of mutant gene expression changes had thus defined one of the broadest cell surface regulatory networks in C. albicans.
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Of these 30 transcriptional regulators, 4 (Bcr1, Ace2, Snf5, and Arg81) were also required for biofilm formation under common conditions (shaking in microtiter plates) for in vitro biofilm formation.
“Of these 30, 4 (Bcr1, Ace2, Snf5, and Arg81) were also required for biofilm formation under common conditions (shaking in microtiter plates) for in vitro biofilm formation.”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [57]
30 transcriptional regulators were identified as important for adherence to a silicone substrate under in vitro flow cell conditions.
“Here, 30 transcriptional regulators were identified as important for adherence to a silicone substrate under these conditions.”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [57]
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Self-citation
- Authors
- Finkel, J. S., Xu, W., Huang, D., Hill, E. M., Desai, J. V., Woolford, C. A., Nett, J. E., Taff, H., Norice, C. T., Andes, D. R., Lanni, F., & Mitchell, A. P.
- Affiliations
- Carnegie Mellon University (US)
- University of Wisconsin–Madison (US)
- Columbia University (US)
- Corresponding author
- Mitchell, Aaron P.
- ORCID
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-02-16
- Volume
- 8
- Issue
- 2
- Pages
- e1002525
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3280983
- OpenAlex
- W1980587680
- Cited by
- 228
- References
- 48
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 16 · 2023: 8 · 2022: 15 · 2021: 21 · 2020: 20 · 2019: 8 · 2018: 15 · 2017: 16 · 2016: 21 · 2015: 15 · 2014: 19 · 2013: 27 · 2012: 13
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository (cc-by)
- Funders
- Howard Hughes Medical Institute (GM007367, 52006917)
- Andrew W. Mellon Foundation
- Richard King Mellon Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007899)
- National Institute of General Medical Sciences (T32GM007367, T32GM008692)
- National Institute of Allergy and Infectious Diseases (R01AI067703, F32AI085521, R01AI073289)
- Division of Undergraduate Education
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, biofilm formation, transcription factors, BCR1, ACE2, SMARCB1, Zap1, device-related infection, silicone substrate, gene regulatory networks, mutant screen
- MeSH terms
- Candida albicans, Cell Adhesion, Fungal Proteins, Genes, Fungal, Biofilms, Gene Expression Profiling
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