Cited by 146Immune Response and InflammationImmunotherapy and Immune ResponsesImmune responses and vaccinations

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal β-Glucans and Toll-Like Receptor Agonists

Open access

Huang, Haibin, Ostroff, Gary R., Lee, Chrono K., Wang, Jennifer P., Specht, Charles A., Levitz, Stuart M.·2009·Infection and Immunity

DOI 10.1128/iai.00086-09PMC PMC2681737

Open this paper in CoChat — free account

Abstract

beta-Glucans derived from fungal cell walls have potential uses as immunomodulating agents and vaccine adjuvants. Yeast glucan particles (YGPs) are highly purified Saccharomyces cerevisiae cell walls composed of beta1,6-branched beta1,3-d-glucan and free of mannans. YGPs stimulated secretion of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) in wild-type murine bone marrow-derived myeloid dendritic cells (BMDCs) but did not stimulate interleukin-12p70 (IL-12p70) production. A purified soluble beta1,6-branched beta1,3-d-glucan, scleroglucan, also stimulated TNF-alpha in BMDCs. These two beta-glucans failed to stimulate TNF-alpha in Dectin-1 (beta-glucan receptor) knockout BMDCs. Costimulation of wild-type BMDCs with beta-glucans and specific Toll-like receptor (TLR) ligands resulted in greatly enhanced TNF-alpha production but decreased IL-12p70 production compared with TLR agonists alone. The upregulation of TNF-alpha and downregulation of IL-12p70 required Dectin-1, but not IL-10. Gamma interferon (IFN-gamma) priming did not overcome IL-12p70 reduction by beta-glucans. Similar patterns of cytokine regulation were observed in human monocyte-derived dendritic cells (DCs) costimulated with YGPs and the TLR4 ligand lipopolysaccharide. Finally, costimulation of BMDCs with YGPs and either the TLR9 ligand, CpG, or the TLR2/1 ligand, Pam(3)CSK(4), resulted in upregulated secretion of IL-1alpha and IL-10 and downregulated secretion of IL-1beta, IL-6, and IFN-gamma-inducible protein 10 but had no significant effects on IL-12p40, keratinocyte-derived chemokine, monocyte chemotactic protein 1, or macrophage inflammatory protein alpha, compared with the TLR ligand alone. Thus, beta-glucans have distinct effects on cytokine responses following DC stimulation with different TLR agonists. These patterns of response might contribute to the skewing of immune responses during mycotic infections and have implications for the design of immunomodulators and vaccines containing beta-glucans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/iai.00086-09

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 4,007
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
Lutz, M. B., Kukutsch, N. A., Ogilvie, A. L. J., Rößner, S., Koch, F., Romani, N., & Schuler, G. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00204-x · Cited by 2,972
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,682
A new receptor for β-glucans
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579
The structure and synthesis of the fungal cell wall
Bowman, S. M., & Free, S. J. (2006) · BioEssays · doi:10.1002/bies.20441 · Cited by 1,320
Dectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C. H., Botto, M., Gordon, S., et al. (2006) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,185
Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2
Hirschfeld, M. J., Ma, Y., Weis, J. H., Vogel, S. N., & Weis, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.618 · Cited by 1,155

Show all 54 references

Sorted by citations

Immunity to fungal infections
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.002 · Cited by 665
C-type lectin receptors orchestrate antifungal immunity
Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460
Vascular endothelial cell Toll-like receptor pathways in sepsis
Khakpour, S., Wilhelmsen, K., & Hellman, J. (2015) · Innate Immunity · doi:10.1177/1753425915606525 · Cited by 239
Exit from dormancy in microbial organisms
Dworkin, J. E., & Shah, I. M. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2453 · Cited by 198
Innate Recognition of Fungal Cell Walls
Levitz, S. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000758 · Cited by 187
Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines
Demento, S. L., Siefert, A. L., Bandyopadhyay, A., Sharp, F. A., & Fahmy, T. M. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.02.004 · Cited by 177
Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded β-Glucan Particles
Huang, H., Ostroff, G. R., Lee, C. K., Specht, C. A., & Levitz, S. M. (2010) · mBio · doi:10.1128/mbio.00164-10 · Cited by 168
Carbohydrate-based immune adjuvants
Petrovsky, N., & Cooper, P. D. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.30 · Cited by 157
Delivery strategies to enhance oral vaccination against enteric infections
Davitt, C. J. H., & Lavelle, E. C. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.007 · Cited by 160
β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination
Smet, R. D., Demoor, T., Verschuere, S., Dullaers, M., Ostroff, G. R., Leclercq, G., Allais, L., Pilette, C., Dierendonck, M., Geest, B. G. D., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.007 · Cited by 158
Polysaccharides in Lentinus edodes : Isolation, Structure, Immunomodulating Activity and Future Prospective
Xu, X., Yan, H., Tang, J., Chen, J., & Zhang, X. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.587616 · Cited by 152
The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
Goyal, S., Castrillón-Betancur, J. C., Klaile, E., & Slevogt, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01261 · Cited by 148
Glucan Particles for Macrophage Targeted Delivery of Nanoparticles
Soto, E. R., Caras, A. C., Kut, L. C., Castle, M. K., & Ostroff, G. R. (2011) · Journal of Drug Delivery · doi:10.1155/2012/143524 · Cited by 142
Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles
Zhang, M., Kim, J. A., & Huang, A. Y.-C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00341 · Cited by 130
A Nonredundant Role for Plasmacytoid Dendritic Cells in Host Defense against the Human Fungal Pathogen Aspergillus fumigatus
Ramirez-Ortiz, Z. G., Lee, C. K., Wang, J. P., Boon, L., Specht, C. A., & Levitz, S. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.007 · Cited by 121
Inulin and Its Application in Drug Delivery
Afinjuomo, F., Abdella, S., Youssef, S. H., Song, Y., & Garg, S. (2021) · Pharmaceuticals · doi:10.3390/ph14090855 · Cited by 120
Innate Recognition of Cell Wall β-Glucans Drives Invariant Natural Killer T Cell Responses against Fungi
Cohen, N. R., Tatituri, R. V. V., Rivera, A., Watts, G. F. M., Kim, E. Y., Chiba, A., Fuchs, B. B., Mylonakis, E., Besra, G. S., Levitz, S. M., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.011 · Cited by 115
Relative Contributions of Dectin-1 and Complement to Immune Responses to Particulate β-Glucans
Huang, H., Ostroff, G. R., Lee, C. K., Agarwal, S., Ram, S., Rice, P. A., Specht, C. A., & Levitz, S. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200603 · Cited by 115
Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome
Wager, C. M. L., Hole, C. R., Wozniak, K. L., & Wormley, F. L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00105 · Cited by 109
Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses
Chai, L. Y. A., Vonk, A. G., Kullberg, B. J., Verweij, P. E., Verschueren, I., van der Meer, J. W. M., Joosten, L. A. B., Latgé, J., & Netea, M. G. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.10.005 · Cited by 101
Oral administration of soluble β‐glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor‐bearing mice
Masuda, Y., Inoue, H., Ohta, H., Miyake, A., Konishi, M., & Nanba, H. (2012) · International Journal of Cancer · doi:10.1002/ijc.27999 · Cited by 99
Mitogen activated protein kinases SakA HOG1 and MpkC collaborate for Aspergillus fumigatus virulence
Nascimento, A. C. M. D. O. B., dos Reis, T. F., de Castro, P. A., Hori, J. I., Bom, V. L. P., de Assis, L. J., Ramalho, L. N. Z., Rocha, M. C., Malavazi, I., Brown, N. A., et al. (2016) · Molecular Microbiology · doi:10.1111/mmi.13354 · Cited by 96
Aspergillus fumigatus MADS-Box Transcription Factor rlmA Is Required for Regulation of the Cell Wall Integrity and Virulence
Rocha, M. C., Fabri, J. H. T. M., de Godoy, K. F., de Castro, P. A., Hori, J. I., da Cunha, A. F., Arentshorst, M., Ram, A. F. J., van den Hondel, C. A. M. J. J., Goldman, G. H., et al. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.031112 · Cited by 96
Recognition of yeast nucleic acids triggers a host‐protective type I interferon response
Biondo, C., Signorino, G., Costa, A., Midiri, A., Gerace, E., Galbo, R., Bellantoni, A., Malara, A., Beninati, C., Teti, G., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141490 · Cited by 94
Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species
Specht, C. A., Lee, C. K., Huang, H., Hester, M. M., Liu, J., Luckie, B. A., Torres Santana, M. A., Mirza, Z., Khoshkenar, P., Abraham, A., et al. (2017) · mBio · doi:10.1128/mbio.01872-17 · Cited by 91
Immunosenescence and vaccine failure in the elderly: strategies for improving response
Boraschi, D., & Italiani, P. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.006 · Cited by 86
Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles ContainingCryptococcusAlkaline Extracts
Specht, C. A., Lee, C. K., Huang, H., Tipper, D. J., Shen, Z. T., Lodge, J. K., Leszyk, J., Ostroff, G. R., & Levitz, S. M. (2015) · mBio · doi:10.1128/mbio.01905-15 · Cited by 88
Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery
Li, Y., Yang, Y., Chen, H., Mei, L., & Zeng, X. (2021) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.07.002 · Cited by 86
Potential of the β-glucans to enhance innate resistance to biological agents
Thompson, I. J., Oyston, P. C. F., & Williamson, D. E. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.10 · Cited by 81
Strain Dependent Variation of Immune Responses to A. fumigatus: Definition of Pathogenic Species
Rizzetto, L., Giovannini, G., Bromley, M., Bowyer, P., Romani, L. R., & Cavalieri, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056651 · Cited by 76
β‐glucan as a new tool in vaccine development
Větvička, V., Vannucci, L. E., & Šíma, P. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12833 · Cited by 78
Potential of glucans as vaccine adjuvants: A review of the α-glucans case
Moreno-Mendieta, S. A., Guillén, D., Hernández‐Pando, R., Sánchez, S., & Rodrı́guez-Sanoja, R. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.02.030 · Cited by 77
Recent advances in oral vaccine development
Smet, R. D., Allais, L., & Cuvelier, C. A. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.28166 · Cited by 82
Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting
Bourgeois, C., Majer, O., Frohner, I. E., Tierney, L., & Kuchler, K. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.004 · Cited by 77
Carbohydrate Conjugates in Vaccine Developments
Lang, S., & Huang, X. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00284 · Cited by 70
Exploiting fungal cell wall components in vaccines
Levitz, S. M., Huang, H., Ostroff, G. R., & Specht, C. A. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0460-6 · Cited by 71
Dietary Mannan Oligosaccharides: Counteracting the Side Effects of Soybean Meal Oil Inclusion on European Sea Bass (Dicentrarchus labrax) Gut Health and Skin Mucosa Mucus Production?
Torrecillas, S., Montero, D., Caballero, M. J., Pittman, K., Custódio, M., Campo, A., Sweetman, J. W., & Izquierdo, M. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00397 · Cited by 69
Identification of novel mechanisms involved in generating localized vulvodynia pain
Falsetta, M. L., Foster, D. C., Woeller, C. F., Pollock, S. J., Bonham, A. D., Haidaris, C. G., Stodgell, C. J., & Phipps, R. P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.002 · Cited by 69
Developing a vaccine against aspergillosis
Stevens, D. A., Clemons, K. V., & Liu, M. (2010) · Medical Mycology · doi:10.3109/13693786.2010.497775 · Cited by 65
A Population of Langerin-Positive Dendritic Cells in Murine Peyer's Patches Involved in Sampling β-Glucan Microparticles
Jesus, M. D., Ostroff, G. R., Levitz, S. M., Bartling, T. R., & Mantis, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091002 · Cited by 67
Beta-Glucan Particles as Vaccine Adjuvant Carriers
Mirza, Z., Soto, E. R., Dikengil, F., Levitz, S. M., & Ostroff, G. R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7104-6_11 · Cited by 60
Soluble β-glucan fromGrifola frondosainduces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway
Masuda, Y., Togo, T., Mizuno, S., Konishi, M., & Nanba, H. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0711386 · Cited by 60
Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of Citrus unshiu
Shin, M., Park, S. B., & Shin, K. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.02.006 · Cited by 58
Glucan and Mannan—Two Peas in a Pod
Короленко, Т. А., Bgatova, N. P., & Větvička, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133189 · Cited by 57
Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages
Soto, E. R., O'Connell, O., Dikengil, F., Peters, P., Clapham, P., & Ostroff, G. (2016) · Journal of Drug Delivery · doi:10.1155/2016/8520629 · Cited by 44
Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan
Gagliardi, M. C., Teloni, R., Mariotti, S., Bromuro, C., Chiani, P., Romagnoli, G., Giannoni, F., Torosantucci, A., & Nisini, R. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310139 · Cited by 51
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies
Rockenstein, E. M., Ostroff, G. R., Dikengil, F., Rus, F., Mante, M., Florio, J. B., Adame, A., Trinh, I., Kim, C., Overk, C., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1170-17.2017 · Cited by 53
Oral hepatitis B vaccine: chitosan or glucan based delivery systems for efficient HBsAg immunization following subcutaneous priming
Soares, E. F. P., Jesus, S., & Borges, O. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.009 · Cited by 49
Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses
Liu, H., Jia, Z., Yang, C., Song, M. L., Jing, Z., Zhao, Y., Wu, Z., Zhao, L., Wei, D., Yin, Z., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.014 · Cited by 45
The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence
Bom, V. L. P., de Castro, P. A., Winkelströter, L. K., Mariné, M., Hori, J. I., Ramalho, L. N. Z., dos Reis, T. F., Goldman, M. H. S., Brown, N. A., Rajendran, R., et al. (2015) · Eukaryotic Cell · doi:10.1128/ec.00008-15 · Cited by 45
Current and New Approaches for Mucosal Vaccine Delivery
Rhee, J. H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811924-2.00019-5 · Cited by 46
Efficient delivery of antigen to DCs using yeast-derived microparticles
Pan, Y., Li, X., Kang, T., Meng, H., Chen, Z., Yang, L., Wu, Y., Wei, Y., & Gou, M. (2015) · Scientific Reports · doi:10.1038/srep10687 · Cited by 46
Whole glucan particles as a vaccine against murine aspergillosis
Clemons, K. V., Danielson, M. E., Michel, K. S., Liu, M., Ottoson, N. R., Leonardo, S. M., Martinez, M., Chen, V., Antonysamy, M. A., & Stevens, D. A. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.079681-0 · Cited by 43
Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling
Li, W., Yan, J., & Yu, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909870116 · Cited by 41
Triggering Dectin-1-Pathway Alone Is Not Sufficient to Induce Cytokine Production by Murine Macrophages
Walachowski, S., Tabouret, G., & Foucras, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148464 · Cited by 41
Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans
Agarwal, S., Specht, C. A., Huang, H., Ostroff, G. R., Ram, S., Rice, P. A., & Levitz, S. M. (2011) · mBio · doi:10.1128/mbio.00178-11 · Cited by 40
Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells
Álvarez, Y., Rodríguez, M. R., Municio, C., Hugo, E., Alonso, S., Ibarrola, N., Fernández, N., & Crespo, M. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391839 · Cited by 37
Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice
Deepe, G. S., Buesing, W. R., Ostroff, G. R., Abraham, A., Specht, C. A., Huang, H., & Levitz, S. M. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.04.047 · Cited by 37
Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system
Cordeiro, A. S., Crecente‐Campo, J., Bouzo, B. L., González, S., de la Fuente, M., & Alonso, M. J. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2018.1561886 · Cited by 35
Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant
Engel, A. L., Sun, G.-C., Gad, E. A., Rastetter, L., Strobe, K. L., Yang, Y., Dang, Y., Disis, M. L., & Lu, H. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.05.001 · Cited by 35
Co-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatus
Amarsaikhan, N., & Templeton, S. P. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00344 · Cited by 36
Adjuvants and delivery systems for antifungal vaccines: Current state and future developments
Portuondo, D. L., Ferreira, L. S., Urbaczek, A. C., Batista-Duharte, A., & Carlos, I. Z. (2014) · Medical Mycology · doi:10.1093/mmy/myu045 · Cited by 33
Signaling pathway and structural features of macrophage-activating pectic polysaccharide from Korean citrus, Cheongkyool peels
Park, H., Lee, S. J., Im, S.-B., Shin, M., Choi, H., Park, H., & Shin, K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.012 · Cited by 34
Characterization of immunostimulatory pectic polysaccharide isolated from leaves of Diospyros kaki Thumb . (Persimmon)
Shin, M.-S., Lee, H., Hong, H., & Shin, K. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.025 · Cited by 33
Chitosan:β-glucan particles as a new adjuvant for the hepatitis B antigen
Soares, E. F. P., Jesus, S., & Borges, O. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.07.018 · Cited by 33
Specifically targeted delivery of protein to phagocytic macrophages
Hong, Z., Yu, M., Chen, Z., Guo, W., Wang, J., Feng, Y., & Kong, X. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s75950 · Cited by 33
A novel antigen delivery system induces strong humoral and CTL immune responses
Yang, Z., Xu, M., Jia, Z., Zhang, Y., Wang, L., Zhang, H., Wang, J., Song, M. L., Zhao, Y., Wu, Z., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.035 · Cited by 31
Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity
Masuda, Y., Nawa, D., Nakayama, Y., Konishi, M., & Nanba, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0814-415rr · Cited by 32
Microparticulate β-glucan vaccine conjugates phagocytized by dendritic cells activate both naïve CD4 and CD8 T cells in vitro
Berner, V. K., duPre', S. A., Redelman, D. D., & Hunter, K. W. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.10.007 · Cited by 31
Vaccine strategies to enhance immune responses in the aged
Lefebvre, J. S., & Haynes, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.014 · Cited by 32
Candida Immunity
Naglik, J. R. (2014) · New Journal of Science · doi:10.1155/2014/390241 · Cited by 29
COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity
Jeong, S., Heo, Y., Jeong, J.-H., Ham, S.-J., Yum, J. S., Ahn, B.-C., Song, C., & Chun, E. (2021) · Vaccines · doi:10.3390/vaccines9090957 · Cited by 29
Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease
Dedloff, M. R., Effler, C. S., Holban, A. M., & Gestal, M. C. (2019) · Materials · doi:10.3390/ma12152445 · Cited by 28
Friend or foe: using systems biology to elucidate interactions between fungi and their hosts
Rizzetto, L., & Cavalieri, D. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.07.007 · Cited by 27
A novel vaccine platform using glucan particles for induction of protective responses againstFrancisella tularensisand other pathogens
Abraham, A., Ostroff, G. R., Levitz, S. M., & Oyston, P. C. F. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13356 · Cited by 25
Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles
Whelan, A. O., Flick-Smith, H. C., Homan, E. J., Shen, Z. T., Carpenter, Z. K., Khoshkenar, P., Abraham, A., Walker, N. J., Levitz, S. M., Ostroff, G. R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200213 · Cited by 26
Surface-modified yeast cells: A novel eukaryotic carrier for oral application
Kenngott, E. E., Kiefer, R., Schneider‐Daum, N., Hamann, A., Schneider, M., Schmitt, M., & Breinig, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.054 · Cited by 25
Combination of TLR1/2 and TLR3 ligands enhances CD4+ T cell longevity and antibody responses by modulating type I IFN production
Lee, B. R., Jeong, S. K., Ahn, B. C., Lee, B.-J., Shin, S. J., Yum, J. S., & Ha, S. (2016) · Scientific Reports · doi:10.1038/srep32526 · Cited by 27
Structural basis of immunomodulation by edible fungal polysaccharides: From molecular characteristics to action mechanisms
Gao, Z., Liu, X., Yu, J., Li, Z., Shi, H., Zhang, G., & Ling, J. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109591 · Cited by 24
Targeting the tumor immune microenvironment with “nutraceuticals”: From bench to clinical trials
Masuelli, L., Benvenuto, M., Focaccetti, C., Ciuffa, S., Fazi, S., Bei, A., Miele, M. T., Piredda, L., Manzari, V., Modesti, A., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107700 · Cited by 23
Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends
Jesus, S., Bernardi, N. S., Silva, J. D., Colaço, M., Costa, J. P., Fonte, P., & Borges, O. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00208 · Cited by 24
Effects of dietary yeast extract on turkey stress response and heterophil oxidative burst activity
Huff, G. R., Dutta, V., HUFF, W. E., & Rath, N. C. (2011) · British Poultry Science · doi:10.1080/00071668.2011.600753 · Cited by 23
Antifungal Activity of Plasmacytoid Dendritic Cells and the Impact of Chronic HIV Infection
Maldonado, S., & Fitzgerald-Bocarsly, P. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01705 · Cited by 24
Corynebacterium pyruviciproducens , as an immune modulator, can promote the activity of macrophages and up-regulate antibody response to particulate antigen
Tong, J., Han, Q., Wang, S., Su, Z., Zheng, D., Shen, P., Xia, S., Huang, X., Shao, Q., & Xu, H. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012181 · Cited by 22
Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats
Nasr, S., Varshosaz, J., & Hajhashemi, V. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00099-x · Cited by 21
Notch- and Transducin-like Enhancer of Split (TLE)-dependent Histone Deacetylation Explain Interleukin 12 (IL-12) p70 Inhibition by Zymosan
Álvarez, Y., Municio, C., Hugo, E., Zhu, J., Alonso, S., Hu, X., Fernández, N., & Crespo, M. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222158 · Cited by 21
The Unfolded Protein Response and the Phosphorylations of Activating Transcription Factor 2 in the trans-Activation of il23a Promoter Produced by β-Glucans*
Rodríguez, M., Domingo, E., Alonso, S., Frade, J. G., Eiros, J., Crespo, M. S., & Fernández, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522656 · Cited by 20
Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in A spergillus fumigatus
Chung, D., Thammahong, A., Shepardson, K. M., Blosser, S. J., & Cramer, R. A. (2014) · Molecular Microbiology · doi:10.1111/mmi.12626 · Cited by 21
Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells
Rodríguez, M. R., Márquez, S., Montero, O., Alonso, S., Frade, J. G., Crespo, M. S., & Fernández, N. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.12.001 · Cited by 19
In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells
Ahn, J. W., Kim, J. H., & Park, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010177 · Cited by 18
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability
Soto, E. R., Specht, C. A., Rus, F., Lee, C. K., Abraham, A., Levitz, S. M., & Ostroff, G. R. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.027 · Cited by 18
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent
Figueiredo, S., Cutrìn, J. C., Rizzitelli, S., Luca, E. D., Moreira, J. N., Geraldes, C. F. G. C., Aime, S., & Terreno, E. (2012) · Molecular Imaging and Biology · doi:10.1007/s11307-012-0603-x · Cited by 18
Baker's yeast expressing the Japanese encephalitis virus envelope protein on its cell surface: induction of an antigen‐specific but non‐neutralizing antibody response
Upadhyaya, B., & Manjunath, R. (2009) · Yeast · doi:10.1002/yea.1676 · Cited by 18
Glucan Particles as Carriers of Nanoparticles for Macrophage-Targeted Delivery
Soto, E. R., & Ostroff, G. R. (2012) · ACS symposium series · doi:10.1021/bk-2012-1119.ch003 · Cited by 18
Bioinspired β-glucan microcapsules deliver FK506 to lymph nodes for treatment of cardiac allograft acute rejection
Wu, Y., Jin, Q., Chen, Y., Li, H., Deng, C., Sun, Z., Li, Y., Wang, B., Li, H., Wu, C., et al. (2020) · Biomaterials Science · doi:10.1039/d0bm01028f · Cited by 17
The Modular Nature of Dendritic Cell Responses to Commensal and Pathogenic Fungi
Rizzetto, L., Buschow, S. I., Beltrame, L., Figdor, C. G., Schierer, S., Schuler, G., & Cavalieri, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042430 · Cited by 17
β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery
Dowdall, N., & Hoare, T. R. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501006 · Cited by 16
The Sulfated Polysaccharides of Brown Algae and Products of Their Enzymatic Transformation as Potential Vaccine Adjuvants
Kuznetsova, T. A., Persiyanova, E. V., Ermakova, S. P., Khotimchenko, M., & Besednova, N. N. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300837 · Cited by 15

Authors: Huang, H., Ostroff, G. R., Lee, C. K., Wang, J. P., Specht, C. A., & Levitz, S. M.
Affiliations: Department of Medicine
University of Massachusetts Chan Medical School (US)
Corresponding author: Levitz, Stuart M.
ORCID: Huang, Haibin
Ostroff, Gary R.
Wang, Jennifer P.
Specht, Charles A.
Levitz, Stuart M.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2009-05
Volume: 77
Issue: 5
Pages: 1774-1781
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00086-09
PMC: PMC2681737
OpenAlex: W2147497666
Cited by: 146
References: 54
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 9 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 17 · 2014: 12 · 2013: 6 · 2012: 10
FWCI: 5.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI025780, R01AI066087)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: β-glucan, scleroglucan, dendritic cells, cytokine production, TLR agonists, Dectin-1, TNF-α, IL-12p70, costimulation, lipopolysaccharide, CpG, Pam3CSK4, monocyte-derived dendritic cells, vaccine adjuvants
MeSH terms: Dectin-1, Animals, Cells, Cultured, Dendritic Cells, Humans, Membrane Proteins, Nerve Tissue Proteins, Saccharomyces cerevisiae, Down-Regulation, Up-Regulation, Cytokines, Mice, Knockout, Lectins, C-Type, beta-Glucans, Toll-Like Receptors, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal β-Glucans and Toll-Like Receptor Agonists

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks