Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis
Open accessAbstract
A mutual symbiotic enhancement of growth of Porphyromonas gingivalis and Treponema denticola is described in this report. Brain heart infusion broth supplemented with vitamin K did not support the individual growth of P. gingivalis or T. denticola. However, when inoculated as a mixture, both bacterial species did grow significantly. The growth-stimulating factors produced by P. gingivalis and T. denticola were dialyzable and heat stable and were further identified as isobutyric acid and succinic acid, respectively. Since some forms of periodontal disease are associated with the presence, in affected sites, of high numbers of P. gingivalis and spirochetes, it is suggested that the bacterial interaction described in this report might be of utmost importance in the initiation and progression of the disease.
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“denticola in a dual species biofilm produces a significantly larger biomass compared to the total of the individual monospecies biofilms, and the organisms are synergistically pathogenic in murine models of periodontal disease [8, 10].”
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- Authors
- Grenier, D.
- Affiliations
- Université Laval (CA)
- Corresponding author
- Grenier, D
- ORCID
- Grenier, D
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1992-12
- Volume
- 60
- Issue
- 12
- Pages
- 5298-5301
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC258310
- OpenAlex
- W2172095976
- Cited by
- 166
- References
- 20
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 7 · 2022: 2 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 8 · 2014: 14 · 2013: 6 · 2012: 9
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Treponema denticola, Porphyromonas gingivalis, periodontal pathogens, bacterial symbiosis, periodontal disease, isobutyric acid, succinic acid, growth-stimulating factors, spirochetes, vitamin K
- MeSH terms
- Butyrates, Periodontal Diseases, Succinates, Symbiosis, Treponema, Porphyromonas gingivalis, Succinic Acid, Isobutyrates
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