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Cited by 271

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells

Open access
Cardillo, F, Voltarelli, J C, Reed, S G, Silva, J S·1996·Infection and Immunity
DOI 10.1128/iai.64.1.128-134.1996
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Abstract

Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi infections, presumably by controlling the early replication of parasites in host macrophages. In this work, we show that NK cells represent an important cell type responsible for the production of most of the IFN-gamma in the early stage of T. cruzi infection and that the in vivo treatment of mice with anti-NK1.1 monoclonal antibody made resistant animals susceptible to the infection. Through in vitro experiments, we demonstrate that normal splenocytes from euthymic or athymic nude mice cultivated for 48 h with live T. cruzi trypomastigotes produced elevated levels of IFN-gamma. In addition, NK-depleted splenocytes show a drastic reduction of IFN-gamma production in response to live T. cruzi trypomastigotes. We also demonstrated that IFN-gamma production is dependent on a factor secreted by adherent cells. Supernatants of spleen cells from athymic nude mice are able to induce IFN-gamma production by normal splenocytes when cultured with trypomastigotes. The addition of anti-interleukin-10 to these cultures resulted in a marked increase in IFN-gamma production. On the other hand, the absence of NK cells led to an increased secretion of interleukin-10 upon in vitro stimulation with T. cruzi. Taken together, these results suggest that NK cells are the major source of IFN-gamma that could be involved in limiting the replication of T. cruzi in host macrophages during the early acute phase of the infection.

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Metadata

Authors
Cardillo, F., Voltarelli, J. C., Reed, S. G., & Silva, J. S.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1996-01
Volume
64
Issue
1
Pages
128-134
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.64.1.128-134.1996
OpenAlex
W1950868076
Cited by
271
References
38
FWCI
13.00
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. https://app.cochat.ai/papers/10.1128/iai.64.1.128-134.1996
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Cardillo, F., Voltarelli, J. C., Reed, S. G., & Silva, J. S. (1996). Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infection and Immunity. https://doi.org/10.1128/iai.64.1.128-134.1996

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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