The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
Open accessAbstract
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response to enteric flora or a normal immunological response to a specific pathogen. No study to date has combined both factors. The present studies were carried out with an immunologically manipulated mouse model of IBD. Mice homozygous for the severe combined immunodeficiency (scid) mutation develop IBD with adoptive transfer of CD4+ T cells expressing high levels of CD45RB (CD45RB(high) CD4+ T cells). These mice do not develop IBD in germfree conditions, implicating undefined intestinal flora in the pathogenesis of lesions. In controlled duplicate studies, the influence of a single murine pathogen, Helicobacter hepaticus, in combination with the abnormal immunological response on the development of IBD was assessed. The combination of H. hepaticus infection and CD45RB(high) CD4+ T-cell reconstitution resulted in severe disease expression similar to that observed in human IBD. This study demonstrates that IBD develops in mice as a consequence of an abnormal immune response in the presence of a single murine pathogen, H. hepaticus. The interaction of host immunity and a single pathogen in this murine system provides a novel model of human IBD, an immunity-mediated condition triggered by bacterial infection.
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Cites
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“These findings agree with human clinical observations that suggest a role for bacterial flora in IBD; antibiotic therapy with metronidazole or bypassing the fecal stream are effective in maintaining disease remission after surgery ( 19 , 27).”
BackgroundResultSpontaneous development of inflammatory bowel disease in T cell receptor mutant mice
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Cited by
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
The gut microbiota shapes intestinal immune responses during health and disease
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A microbial symbiosis factor prevents intestinal inflammatory disease
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Gut microbiota and IBD: causation or correlation?
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Metadata
- Authors
- Cahill, R. J., Foltz, C. J., Fox, J. G., Dangler, C. A., Powrie, F., & Schauer, D. B.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1997-08
- Volume
- 65
- Issue
- 8
- Pages
- 3126-3131
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2148455779
- Cited by
- 317
- References
- 23
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. https://app.cochat.ai/papers/10.1128/iai.65.8.3126-3131.1997
- The paper
- Cahill, R. J., Foltz, C. J., Fox, J. G., Dangler, C. A., Powrie, F., & Schauer, D. B. (1997). Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infection and Immunity. https://doi.org/10.1128/iai.65.8.3126-3131.1997
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
