The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Acid-Susceptible Mutants of Mycobacterium tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment
Open accessAbstract
Mycobacterium tuberculosis can persist in macrophage phagosomes that acidify to a pH of ∼4.5 after activation of the macrophage with gamma interferon. How the bacterium resists the low pH of the acidified phagosome is incompletely understood. A screen of 10,100 M. tuberculosis transposon mutants for mutants hypersensitive to pH 4.5 led to the discovery of 21 genes whose disruption attenuated survival of M. tuberculosis at a low pH (41). Here, we show that acid-sensitive M. tuberculosis mutants with transposon insertions in Rv2136c, Rv2224c,ponA2, and lysX were hypersensitive to antibiotics, sodium dodecyl sulfate, heat shock, and reactive oxygen and nitrogen intermediates, indicating that acid resistance can be associated with protection against other forms of stress. The Rv2136c mutant was impaired in intrabacterial pH homeostasis and unable to maintain a neutral intrabacterial pH in activated macrophages. The Rv2136c, Rv2224c, and ponA2 mutants were attenuated in mice, with the Rv2136c mutant displaying the most severe level of attenuation. Pathways utilized by M. tuberculosis for acid resistance and intrabacterial pH maintenance are potential targets for chemotherapy.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis
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Gengenbacher, M., & Kaufmann, S. H. E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00331.x · Cited by 696
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Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 622
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Self-citationHow sisters grow apart: mycobacterial growth and division
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Metadata
- Authors
- Vandal, O. H., Roberts, J. A., Odaira, T., Schnappinger, D., Nathan, C. F., & Ehrt, S.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2009-01-15
- Volume
- 191
- Issue
- 2
- Pages
- 625-631
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2022725992
- Cited by
- 163
- References
- 6
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Acid-Susceptible Mutants of Mycobacterium tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment. https://app.cochat.ai/papers/10.1128/jb.00932-08
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- Vandal, O. H., Roberts, J. A., Odaira, T., Schnappinger, D., Nathan, C. F., & Ehrt, S. (2009). Acid-Susceptible Mutants of Mycobacterium tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment. Journal of Bacteriology. https://doi.org/10.1128/jb.00932-08
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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