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Cited by 418

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PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A

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Moskowitz, Samuel M., Ernst, Robert K., Miller, Samuel I.·2004·Journal of Bacteriology
DOI 10.1128/jb.186.2.575-579.2004
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Abstract

Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The mutations responsible for this phenotype were mapped to a two-component signal transduction system similar to PmrAB of Salmonella enterica serovar Typhimurium. Lipid A of these mutants contained aminoarabinose, an inducible modification that is associated with polymyxin resistance. Thus, P. aeruginosa possesses a mechanism that induces resistance to cationic antimicrobial peptides in response to environmental conditions.

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Metadata

Authors
Moskowitz, S. M., Ernst, R. K., & Miller, S. I.
Venue
Journal of Bacteriology
Publisher
American Society for Microbiology
Published
2004-01-15
Volume
186
Issue
2
Pages
575-579
ISSN
  • 0021-9193 (ISSN-L)
  • 1098-5530
DOI
10.1128/jb.186.2.575-579.2004
OpenAlex
W2091513339
Cited by
418
References
0
FWCI
3.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A. https://app.cochat.ai/papers/10.1128/jb.186.2.575-579.2004
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Moskowitz, S. M., Ernst, R. K., & Miller, S. I. (2004). PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A. Journal of Bacteriology. https://doi.org/10.1128/jb.186.2.575-579.2004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.