The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Prospective Evaluation of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System in a Hospital Clinical Microbiology Laboratory for Identification of Bacteria and Yeasts: a Bench-by-Bench Study for Assessing the Impact on Time to Identification and Cost-Effectiveness
Open accessAbstract
Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has been found to be an accurate, rapid, and inexpensive method for the identification of bacteria and yeasts. Previous evaluations have compared the accuracy, time to identification, and costs of the MALDI-TOF MS method against standard identification systems or commercial panels. In this prospective study, we compared a protocol incorporating MALDI-TOF MS (MALDI protocol) with the current standard identification protocols (standard protocol) to determine the performance in actual practice using a specimen-based, bench-by-bench approach. The potential impact on time to identification (TTI) and costs had MALDI-TOF MS been the first-line identification method was quantitated. The MALDI protocol includes supplementary tests, notably for Streptococcus pneumoniae and Shigella , and indications for repeat MALDI-TOF MS attempts, often not measured in previous studies. A total of 952 isolates (824 bacterial isolates and 128 yeast isolates) recovered from 2,214 specimens were assessed using the MALDI protocol. Compared with standard protocols, the MALDI protocol provided identifications 1.45 days earlier on average ( P < 0.001). In our laboratory, we anticipate that the incorporation of the MALDI protocol can reduce reagent and labor costs of identification by $102,424 or 56.9% within 12 months. The model included the fixed annual costs of the MALDI-TOF MS, such as the cost of protein standards and instrument maintenance, and the annual prevalence of organisms encountered in our laboratory. This comprehensive cost analysis model can be generalized to other moderate- to high-volume laboratories.
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Seng, P., Drancourt, M., Gouriet, F., La Scola, B., Fournier, P., Rolain, J. M., & Raoult, D. (2009) · Clinical Infectious Diseases · doi:10.1086/600885 · Cited by 1,983 · cited 1×
“Matrix-assisted laser desorption ionization–time of flight mass spectroscopy (MALDI-TOF MS) is increasingly utilized by clinical microbiology laboratories for the identification of bacteria and yeasts (7, 18, 19, 21, 22).”
MethodBizzini, A., Durussel, C., Bille, J., Greub, G., & Prod'hom, G. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01794-09 · Cited by 615
Cherkaoui, A., Hibbs, J., Emonet, S., Tangomo, M., Girard, M., Francois, P., & Schrenzel, J. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01881-09 · Cited by 527
Wieser, A., Schneider, L., Jung, J., & Schubert, S. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3783-4 · Cited by 453
MALDI-TOF mass spectrometry tools for bacterial identification in clinical microbiology laboratory
Carbonnelle, E., Mesquita, C., Bille, E., Day, N., Dauphin, B., Beretti, J.-L., Ferroni, A., Gutmann, L., & Nassif, X. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.06.017 · Cited by 420
Dhiman, N., Hall, L., Wohlfiel, S. L., Buckwalter, S. P., & Wengenack, N. L. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02381-10 · Cited by 294
Alatoom, A. A., Cunningham, S. A., Ihde, S. M., Mandrekar, J., & Patel, R. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00506-11 · Cited by 256
Bizzini, A., Jaton, K., Romo, D., Bille, J., Prod'hom, G., & Greub, G. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01463-10 · Cited by 245
Martiny, D., Busson, L., Wybo, I., El Haj, R. A., Dediste, A., & Vandenberg, O. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.05971-11 · Cited by 238
Stevenson, L. G., Drake, S. K., Shea, Y. R., Zelazny, A. M., & Murray, P. R. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00687-09 · Cited by 236
Cited by
Simner, P. J., Miller, S., & Carroll, K. C. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix881 · Cited by 821
Self-citationLagier, J.-C., Hugon, P., Khelaifia, S., Fournier, P.-E., La Scola, B., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-14 · Cited by 831
Emerging Technologies for the Clinical Microbiology Laboratory
Buchan, B. W., & Ledeboer, N. A. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00003-14 · Cited by 297
McCarty, T. P., & Pappas, P. G. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.013 · Cited by 285
Candidemia and Invasive Candidiasis
McCarty, T. P., White, C. M., & Pappas, P. G. (2021) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2021.03.007 · Cited by 260
Metadata
- Authors
- Tan, K. E., Ellis, B. C., Lee, R., Stamper, P. D., Zhang, S. X., & Carroll, K. C.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2012-10
- Volume
- 50
- Issue
- 10
- Pages
- 3301-3308
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2167477904
- Cited by
- 326
- References
- 22
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Tan, K. E., Ellis, B. C., Lee, R., Stamper, P. D., Zhang, S. X., & Carroll, K. C. (2012). Prospective Evaluation of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System in a Hospital Clinical Microbiology Laboratory for Identification of Bacteria and Yeasts: a Bench-by-Bench Study for Assessing the Impact on Time to Identification and Cost-Effectiveness. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.01405-12
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