The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Practical Disk Diffusion Method for Detection of Inducible Clindamycin Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci
Open accessAbstract
Resistance to macrolides in staphylococci may be due to active efflux (encoded by msrA ) or ribosomal target modification (macrolide-lincosamide-streptogramin B [MLS B ] resistance; usually encoded by ermA or ermC ). MLS B resistance is either constitutive or inducible following exposure to a macrolide. Induction tests utilize closely approximated erythromycin and clindamycin disks; the flattening of the clindamycin zone adjacent to the erythromycin disk indicates inducible MLS B resistance. The present study reassessed the reliability of placing erythromycin and clindamycin disks in adjacent positions (26 to 28 mm apart) in a standard disk dispenser, compared to distances of 15 or 20 mm. A group of 130 clinical isolates of Staphylococcus aureus and 100 isolates of erythromycin-resistant coagulase-negative staphylococci (CNS) were examined by disk approximation; all CNS isolates and a subset of S. aureus isolates were examined by PCR for ermA , ermC , and msrA . Of 114 erythromycin-resistant S. aureus isolates, 39 demonstrated constitutive resistance to clindamycin, while 33 showed inducible resistance by disk approximation at all three distances. Only one isolate failed to clearly demonstrate induction at 26 mm. Of 82 erythromycin-resistant CNS isolates that contained ermA or ermC , 57 demonstrated constitutive clindamycin resistance, and 25 demonstrated inducible resistance, at 20 and 26 mm. None of the 42 S. aureus isolates or 18 CNS isolates containing only msrA and none of the erythromycin-susceptible isolates yielded positive disk approximation tests. Simple placement of erythromycin and clindamycin disks at a distance achieved with a standard disk dispenser allowed detection of 97% of S. aureus strains and 100% of CNS strains with inducible MLS B resistance in this study.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants
Roberts, M. C., Sutcliffe, J., Courvalin, P., Jensen, L. B., Rood, J., & Seppala, H. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2823 · Cited by 874
Lina, G., Quaglia, A., Reverdy, M.-E., Leclercq, R., Vandenesch, F., & Etienne, J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1062 · Cited by 548
Ross, J. I., Eady, E. A., Cove, J. H., Cunliffe, W. J., Baumberg, S., & Wootton, J. C. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00696.x · Cited by 358
Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children
FRANK, A. L., MARCINAK, J. F., MANGAT, P. D., TJHIO, J. T., KELKAR, S., SCHRECKENBERGER, P. C., & QUINN, J. P. (2002) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200206000-00010 · Cited by 271
Ligozzi, M., Bernini, C., Bonora, M. G., de Fatima, M., Zuliani, J., & Fontana, R. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.5.1681-1686.2002 · Cited by 265
Clindamycin treatment of Staphylococcus aureus expressing inducible clindamycin resistance
Drinkovic, D. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.2.315 · Cited by 189
Erythromycin-inducible Resistance in Staphylococcus aureus: Survey of Antibiotic Classes Involved
Weisblum, B., & Demohn, V. (1969) · Journal of Bacteriology · doi:10.1128/jb.98.2.447-452.1969 · Cited by 154
Clindamycin, Metronidazole, and Chloramphenicol
Kasten, M. J. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.8.825 · Cited by 139
Ross, J. I., Farrell, A. M., Eady, E. A., Cove, J. H., & Cunliffe, W. J. (1989) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/24.6.851 · Cited by 118
Clindamycin therapy of staphylococcus aureus endocarditis
Watanakunakorn, C. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90758-0 · Cited by 106
Cited by
Susceptibility Test Methods: Dilution and Disk Diffusion Methods
Jorgensen, J. H., & Turnidge, J. D. (2015) · Manual of Clinical Microbiology · doi:10.1128/9781555817381.ch71 · Cited by 585
Self-citationFrazee, B. W., Lynn, J., Charlebois, E. D., Lambert, L., Lowery, D., & Perdreau-Remington, F. (2005) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2004.10.011 · Cited by 494
Lewis, J. S., & Jorgensen, J. H. (2005) · Clinical Infectious Diseases · doi:10.1086/426894 · Cited by 313
Self-citationAl-Rawahi, G. N., Schreader, A. G., Porter, S. D., Roscoe, D. L., Gustafson, R., & Bryce, E. A. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01596-07 · Cited by 57
Nurjadi, D., Chanthalangsy, Q., Zizmann, E., Stuermer, V., Moll, M., Klein, S., Boutin, S., Heeg, K., & Zanger, P. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01510-21 · Cited by 10
Metadata
- Authors
- Fiebelkorn, K. R., Crawford, S. A., McElmeel, M. L., & Jorgensen, J. H.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2003-10
- Volume
- 41
- Issue
- 10
- Pages
- 4740-4744
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2115362037
- Cited by
- 454
- References
- 18
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Practical Disk Diffusion Method for Detection of Inducible Clindamycin Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci. https://app.cochat.ai/papers/10.1128/jcm.41.10.4740-4744.2003
- The paper
- Fiebelkorn, K. R., Crawford, S. A., McElmeel, M. L., & Jorgensen, J. H. (2003). Practical Disk Diffusion Method for Detection of Inducible Clindamycin Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.41.10.4740-4744.2003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
