Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

Hepatitis C virus (HCV) induces autophagosome formation in infected human hepatocytes. We have previously reported that HCV exploits autophagic machinery in favor of virus growth and survival in host cells (S. Shrivastava et al., Hepatology 53: 406–414, 2011); however, the mechanisms for autophag…