Cited by 214Cytomegalovirus and herpesvirus researchT-cell and B-cell ImmunologyImmune responses and vaccinations

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The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell Repertoire

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Pourgheysari, Batoul, Khan, Naeem, Best, Donna, Bruton, Rachel, Nayak, Laxman, Moss, Paul A. H.·2007·Journal of Virology

DOI 10.1128/jvi.01262-06PMC PMC1933343

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Abstract

Immune function in the elderly is associated with a number of phenotypic and functional abnormalities, and this phenomenon of immune senescence is associated with increased susceptibility to infection. The immune response to pathogens frequently declines with age, but the CD8 + T-cell response to cytomegalovirus (CMV) is unusual, as it demonstrates a significant expansion over time. Here we have documented the CD4 + T-cell immune response to CMV in healthy donors of different ages. The magnitude of the CMV-specific CD4 + T-cell immune response increases from a mean of 2.2% of the CD4 + T-cell pool in donors below 50 years of age to 4.7% in donors aged over 65 years. In addition, CMV-specific CD4 + T cells in elderly donors demonstrate decreased production of interleukin-2 and less dependence on costimulation. CMV seropositivity is associated with marked changes in the phenotype of the overall CD4 + T-cell repertoire in healthy aged donors, including an increase in CD57 + expression and a decrease in CD28 and CD27 expression, a phenotypic profile characteristic of immune senescence. This memory inflation of CMV-specific CD4 + T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals.

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Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“CCR7 expression is present on naı̈ve and central memory T cells but is absent on effector memory populations (23).”
Background
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · cited 1×
“Murine data have shown that a memory CD4 T-cell subset with predominant expression of IL-2 is preferentially located within lymphoid tissue, and examination of the frequency and cytokine production of CMV-specific CD4 T cells within secondary lymphoid tissue will be of interest (22).”
Background
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
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Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
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Karrer, U. W., Sierro, S. R., Wagner, M., Oxenius, A., Hengel, H., Koszinowski, U. H., Phillips, R. E., & Klenerman, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2022 · Cited by 444
Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
Wikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414
CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool
Hendriks, J., Xiao, Y., & Borst, J. G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030916 · Cited by 377
Emergence of a CD4+CD28− Granzyme B+, Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection
van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vossen, M. T. M., Rowshani, A. T., Dillen, P. M. E. W., van Lier, R. A. W., & ten Berge, I. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1834 · Cited by 369
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Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler‐Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck‐Loebenstein, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3675-3683.2005 · Cited by 356
Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection
Khan, N., Hislop, A. D., Gudgeon, N. H., Cobbold, M., Khanna, R., Nayak, L., Rickinson, A. B., & Moss, P. A. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7481 · Cited by 351
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Shi, X.-L., de Mare-Bredemeijer, E., Tapirdamaz, Ö., Hansen, B. E., van Gent, R., van Campenhout, M. J. H., Mancham, S., Litjens, N. H. R., Betjes, M. G. H., van der Eijk, A. A., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13288 · Cited by 30
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Bajwa, M. (2016)
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A.Yu., V., Kuchma, M. V., Yu, K. T., Tl, К., Yu, К. I., Еs, K., Смелянская, М. В., Перемот, С. Д., Кашпур, Н. В., & Мb, D. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5281/zenodo.167428
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Contreras, N. A. (2019) · UA Campus Repository (The University of Arizona)
Faculty Opinions recommendation of CMV status drives distinct trajectories of CD4+ T cell differentiation.
Maecker, H. T. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.740049948.793585672
Inflamm-Aging
Bucci, L., Ostan, R., Capri, M., Salvioli, S., Cevenini, E., Celani, L., Monti, D., & Franceschi, C. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_45

Authors: Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H.
Affiliations: University of Birmingham (GB)
University of Liverpool (GB)
Department of Applied Gerontology, Selly Oak, Birmingham, United Kingdom
Corresponding author: Moss, Paul A. H.
ORCID: Pourgheysari, Batoul
Khan, Naeem
Moss, Paul A. H.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2007-07-15
Volume: 81
Issue: 14
Pages: 7759-7765
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.01262-06
PMC: PMC1933343
OpenAlex: W2115516753
Cited by: 214
References: 29
Citations by year: 2025: 11 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 13
FWCI: 10.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: cytomegalovirus, CD4+ T cells, immunosenescence, aging, CMV-specific T-cell responses, interleukin-2, CD57, CD28, CD27, memory inflation, CMV seropositivity, elderly donors
MeSH terms: Aged, Aging, Cytomegalovirus, Humans, Interferon-gamma, Interleukin-2, CD4-Positive T-Lymphocytes

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The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell Repertoire

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