The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell Repertoire
Open accessAbstract
Immune function in the elderly is associated with a number of phenotypic and functional abnormalities, and this phenomenon of immune senescence is associated with increased susceptibility to infection. The immune response to pathogens frequently declines with age, but the CD8 + T-cell response to cytomegalovirus (CMV) is unusual, as it demonstrates a significant expansion over time. Here we have documented the CD4 + T-cell immune response to CMV in healthy donors of different ages. The magnitude of the CMV-specific CD4 + T-cell immune response increases from a mean of 2.2% of the CD4 + T-cell pool in donors below 50 years of age to 4.7% in donors aged over 65 years. In addition, CMV-specific CD4 + T cells in elderly donors demonstrate decreased production of interleukin-2 and less dependence on costimulation. CMV seropositivity is associated with marked changes in the phenotype of the overall CD4 + T-cell repertoire in healthy aged donors, including an increase in CD57 + expression and a decrease in CD28 and CD27 expression, a phenotypic profile characteristic of immune senescence. This memory inflation of CMV-specific CD4 + T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals.
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“frequencies of CMV-specific and to a lesser extent EBV-specific CD8+ T cells tend to increase, successfully protecting aging individuals from CMV- and EBV-associated morbidities”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Pourgheysari et al., 2007
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“CCR7 expression is present on naı̈ve and central memory T cells but is absent on effector memory populations (23).”
BackgroundVisualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · cited 1×
“Murine data have shown that a memory CD4 T-cell subset with predominant expression of IL-2 is preferentially located within lymphoid tissue, and examination of the frequency and cytokine production of CMV-specific CD4 T cells within secondary lymphoid tissue will be of interest (22).”
BackgroundKhan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Self-citationOlsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Memory Inflation: Continuous Accumulation of Antiviral CD8+ T Cells Over Time
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Hendriks, J., Xiao, Y., & Borst, J. G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030916 · Cited by 377
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Khan, N., Hislop, A. D., Gudgeon, N. H., Cobbold, M., Khanna, R., Nayak, L., Rickinson, A. B., & Moss, P. A. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7481 · Cited by 351
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CMV Colitis Mimicking Crohn’s Disease in a Patient with CLL: A Case Report
Fares, E., Hoteit, M., Wehbe, S. R., & Bahr, A. (2022) · International Journal of Clinical Research · doi:10.38179/ijcr.v3i1.38
Niu, M., Bai, Z., Dong, L., Zheng, W., Wang, X., Dong, N., Si, T., & Zeng, K. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4182094
Caruso, B. P., & Moran, A. E. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.04.007
Carvalho, E., Pina, B. D. C., Neto, R., Lima, W., Bandeira, V., & Carvalho, L. (2023) · Advances in Infectious Diseases · doi:10.4236/aid.2023.132028
Hanafi, I., Hanafi, I., Alsalkini, M., Almouhammad, A., Salhab, G., Khoder, Q., Azzam, T., Hanafi, B., Sallam, S., Khamis, M. A., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4724609/v1
Niu, M., Bai, Z., Dong, L., Zheng, W., Wang, X., Dong, N., Si, T., & Zeng, K. (2024) · Clinical Medicine & Research · doi:10.3121/cmr.2024.1869
Li, W., Du, Z., Li, X., Hua, R., Zhang, F., Peng, C., Huang, L., Chen, Z., & Sun, H. (2025) · Research Square · doi:10.21203/rs.3.rs-7183389/v1
Alba-Cano, T., Alonso, R., Balastegui-Martín, H., Bravo‐Gallego, L. Y., Sánchez‐Mateos, P., Martín-López, M., & Gil-Herrera, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1659259
Markers of immunosenescence and oxidative stress in healthy adults
Turner, J. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham)
Kandil, S. K., Tharwat, A. I., Mohsen, S. M., Eldeeb, M., Abdallah, W., Hilal, A., Sweed, H., Mortada, M., Arif, E., Ahmed, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26567102
The immune response to cytomegalovirus and Epstein-Barr virus in systemic lupus erythematosus
Perks, E. L. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Synergistic effects of physical and psychological distress on immunesenescence
Duggal, N. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H.
- Affiliations
- University of Birmingham (GB)
- University of Liverpool (GB)
- Department of Applied Gerontology, Selly Oak, Birmingham, United Kingdom
- Corresponding author
- Moss, Paul A. H.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-07-15
- Volume
- 81
- Issue
- 14
- Pages
- 7759-7765
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC1933343
- OpenAlex
- W2115516753
- Cited by
- 214
- References
- 29
- Citations by year
- 2025: 11 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 13
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- cytomegalovirus, CD4+ T cells, immunosenescence, aging, CMV-specific T-cell responses, interleukin-2, CD57, CD28, CD27, memory inflation, CMV seropositivity, elderly donors
- MeSH terms
- Aged, Aging, Cytomegalovirus, Humans, Interferon-gamma, Interleukin-2, CD4-Positive T-Lymphocytes
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