Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review

Weltevrede, Marlies; Eilers, Renske; de Melker, Hester E.; van Baarle, Debbie

doi:10.1016/j.exger.2016.02.005

Cited by 129Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersT-cell and B-cell Immunology

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review

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Weltevrede, Marlies, Eilers, Renske, de Melker, Hester E., van Baarle, Debbie·2016·Experimental Gerontology

DOI 10.1016/j.exger.2016.02.005

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Abstract

Introduction Immunosenescence is the age-related deterioration of immunocompetence which is reflected in a poorer response to new antigens. This process is characterized by decreases in naïve T cells and increases in memory T cells. The highly prevalent β-herpesvirus cytomegalovirus (CMV) is thought to enhance T-cell immunosenescence. The aim of this study was to perform a systematic review on the current evidence regarding the relation between CMV-infection and immunosenescence in Western people aged fifty years and older.Methods Studies that investigated the relation between CMV infection and immune parameters in Western people aged 50 years and older were eligible for inclusion. No restrictions were placed on study type. This article focuses on the relation between CMV infections as measured by serology and T cell subsets. A narrative approach to data synthesis was applied.Results In the majority of included studies higher levels of Effector Memory (EM) and TEMRA (Effector Memory T cells re-expressing CD45RA) cells were found in the CD4+ and the CD8+ T cell pools in CMV-seropositive elderly compared to CMV-seronegative elderly. No clear evidence was found for lower levels of naïve T cells in CMV-seropositive elderly compared to CMV-seronegative elderly. The total CD8+ T cell pool appeared to be larger in CMV-seropositive elderly in three out of four studies, while the total CD4+ T cell pool appeared to be smaller in CMV-seropositive elderly in two out of four studies.Discussion CMV seems to enhance immunosenescence based on the high levels of the highly differentiated EM and TEMRA cells in the CD8+ and CD4+ T cell pools. The relation of the shifts within the T cell compartments in CMV-seropositive elderly in relation to susceptibility to infectious diseases remains to be investigated.

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Authors: Weltevrede, M., Eilers, R., de Melker, H. E., & van Baarle, D.
Affiliations: National Institute for Public Health and the Environment (NL)
University Medical Center Groningen (NL)
ORCID: Eilers, Renske
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2016-05
Volume: 77
Pages: 87-95
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2016.02.005
OpenAlex: W2283669950
Cited by: 128
References: 69
Citations by year: 2026: 9 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 17 · 2020: 13 · 2019: 18 · 2018: 12 · 2017: 16 · 2016: 5
FWCI: 2.30
Type: journal article
Language: en
Open access: green
research.rug.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: cytomegalovirus infection, T cell senescence, older adults, effector memory T cells, TEMRA cells, naive T cells, CD4+ T cells, CD8+ T cells, T cell subsets, CMV serostatus, age-related immunosenescence, betaherpesviruses
MeSH terms: Immunosenescence, Aged, Cytomegalovirus Infections, Cytomegalovirus, Humans, Immunologic Memory, Middle Aged, T-Lymphocytes

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Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review

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