Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections
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Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.
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Lowered percentages, but not absolute counts of naïve cells may also be observed due to expansions of TTDE population in persistent herpesviral infections, such as cytomegalovirus infection, but this does not impair immune protection against infections.
“Namely, lowered percentages, but not absolute counts of naïve cells may also be observed due to expansions of TTDE population in persistent herpesviral infections, such as cytomegalovirus infection [348], but this does not impair immune protection against infections [358].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [358]
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- Authors
- Marandu, T. F., Oduro, J. D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J. L., Drabig, A., Kröger, A., Nikolich-Zugich, J., & Cicin-Sain, L.
- Affiliations
- University of Dar es Salaam (TZ)
- Helmholtz Centre for Infection Research (DE)
- University of Arizona (US)
- Oregon Health and Science University (OHSU), Portland, Oregon, USA
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2015-11-15
- Volume
- 89
- Issue
- 22
- Pages
- 11715-11717
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC4645637
- OpenAlex
- W1751391168
- Cited by
- 37
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 9 · 2018: 2 · 2017: 4 · 2016: 3
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- aging, immunosenescence, murine cytomegalovirus, herpes simplex virus type 1, murine gammaherpesvirus 68, influenza virus, West Nile virus, vesicular stomatitis virus, CD8+ T cell responses, immune homeostasis
- MeSH terms
- Aging, Animals, Disease Models, Animal, Herpesviridae Infections, Mice, Inbred BALB C, Mice, Inbred C57BL, Orthomyxoviridae, Vesicular stomatitis Indiana virus, West Nile virus, Virus Latency, Rhadinovirus, Muromegalovirus, Herpesvirus 1, Human, CD8-Positive T-Lymphocytes, Mice
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