The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses
Open accessAbstract
We describe a sensitive, internally controlled method for comparing the genetic adaptability and relative fitness of virus populations in constant or changing host environments. Certain monoclonal antibody-resistant mutants of vesicular stomatitis virus can compete equally during serial passages in mixtures with the parental wild-type clone from which they were derived. These genetically marked "surrogate wild-type" neutral mutants, when mixed with wild-type virus, allow reliable measurement of changes in virus fitness and of virus adaptation to different host environments. Quantitative fitness vector plots demonstrate graphically that even clones of an RNA virus are composed of complex variant populations (quasispecies). Variants of greater fitness (competitive replication ability) were selected within very few passages of virus clones in new host cells or animals. Even clones which were well adapted to BHK21 cells gained further fitness during repeated passages in BHK21 cells.
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Cites
Rapid Evolution of RNA Genomes
Holland, J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S., & VandePol, S. (1982) · Science · doi:10.1126/science.7041255 · Cited by 1,477
Self-citationThe accuracy of reverse transcriptase from HIV-1
Roberts, J. D., Bebenek, K., & Kunkel, T. A. (1988) · Science · doi:10.1126/science.2460925 · Cited by 997
Fidelity of HIV-1 reverse transcriptase
Preston, B. D., Poiesz, B. J., & Loeb, L. A. (1988) · Science · doi:10.1126/science.2460924 · Cited by 931
Rapid Evolution of RNA Viruses
Steinhauer, D. A., & Holland, J. J. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.002205 · Cited by 597
Self-citationNucleotide sequence heterogeneity of an RNA phage population
Domingo, E., Sabo, D., Taniguchi, T., & Weissmann, C. (1978) · Cell · doi:10.1016/0092-8674(78)90223-4 · Cited by 565
Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS
Hahn, B. H., Shaw, G. M., Taylor, M. E., Redfield, R. R., Markham, P. D., Salahuddin, S. Z., Wong-Staal, F., Gallo, R. C., Parks, E. S., & Parks, W. P. (1986) · Science · doi:10.1126/science.3012778 · Cited by 564
Domingo, E., Martínez-Salas, E., Sobrino, F., de la Torre, J. C., Portela, A., Ortín, J., López-Galindez, C., Pérez-Breña, P., Villanueva, N., Nájera, R., et al. (1985) · Gene · doi:10.1016/0378-1119(85)90017-4 · Cited by 503
Self-citationTHE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION
Theiler, M., & Smith, H. H. (1937) · Journal of Experimental Medicine · doi:10.1084/jem.65.6.787 · Cited by 445
Cattaneo, R., Schmid, A., Eschle, D., Baczko, K., ter Meulen, V., & Billeter, M. A. (1988) · Cell · doi:10.1016/0092-8674(88)90048-7 · Cited by 434
Stebbins, G. L., & Wright, S. (1977) · Systematic Botany · doi:10.2307/2418471 · Cited by 432
Cited by
RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
Self-citationEvolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Martell, M., Esteban, J. I., Quer, J., Genescà, J., Weiner, A., Esteban, R., Guardia, J., & Gómez, J. (1992) · Journal of Virology · doi:10.1128/jvi.66.5.3225-3229.1992 · Cited by 930
RNA Virus Populations as Quasispecies
Holland, J. J., De La Torre, J. C., & Steinhauer, D. A. (1992) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-77011-1_1 · Cited by 512
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Metadata
- Authors
- Holland, J. J., de la Torre, J. C., Clarke, D. K., & Duarte, E.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1991-06
- Volume
- 65
- Issue
- 6
- Pages
- 2960-2967
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1508451045
- Cited by
- 274
- References
- 56
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Holland, J. J., de la Torre, J. C., Clarke, D. K., & Duarte, E. (1991). Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses. Journal of Virology. https://doi.org/10.1128/jvi.65.6.2960-2967.1991
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
