The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini
Open accessAbstract
The hepatitis C virus (HCV) H strain polyprotein is cleaved to produce at least nine distinct products: NH2-C-E1-E2-NS2-NS3-NS4A-NS4B-NS5A-NS5B-CO OH. In this report, a series of C-terminal truncations and fusion with a human c-myc epitope tag allowed identification of a tenth HCV-encoded cleavage product, p7, which is located between the E2 and NS2 proteins. As determined by N-terminal sequence analysis, p7 begins with position 747 of the HCV H strain polyprotein. p7 is preceded by a hydrophobic sequence at the C terminus of E2 which may direct its translocation into the endoplasmic reticulum, allowing cleavage at the E2/p7 site by host signal peptidase. This hypothesis is supported by the observation that cleavage at the E2/p7 and p7/NS2 sites in cell-free translation studies was dependent upon the addition of microsomal membranes. However, unlike typical cotranslational signal peptidase cleavages, pulse-chase experiments indicate that cleavage at the E2/p7 site is incomplete, leading to the production of two E2-specific species, E2 and E2-p7. Possible roles of p7 and E2-p7 in the HCV life cycle are discussed.
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Cites
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Metadata
- Authors
- Lin, C., Lindenbach, B. D., Prágai, B. M., McCourt, D. W., & Rice, C. M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-08
- Volume
- 68
- Issue
- 8
- Pages
- 5063-5073
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2152793674
- Cited by
- 355
- References
- 39
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, C., Lindenbach, B. D., Prágai, B. M., McCourt, D. W., & Rice, C. M. (1994). Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. Journal of Virology. https://doi.org/10.1128/jvi.68.8.5063-5073.1994
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