The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Genomic Features of Intertypic Recombinant Sabin Poliovirus Strains Excreted by Primary Vaccinees
Open accessAbstract
The trivalent oral poliomyelitis vaccine (OPV) contains three different poliovirus serotypes. It use therefore creates particularly favorable conditions for mixed infection of gut cells, and indeed intertypic vaccine-derived recombinants (VdRec) have been frequently found in patients with vaccine-associated paralytic poliomyelitis. Nevertheless, there have not been extensive searches for VdRec in healthy vaccinees following immunization with OPV. To determine the incidence of VdRec and their excretion kinetics in primary vaccinees, and to establish the general genomic features of the corresponding recombinant genomes, we characterized poliovirus isolates excreted by vaccinees following primary immunization with OPV. Isolates were collected from 67 children 2 to 60 days following vaccination. Recombinant strains were identified by multiple restriction fragment length polymorphism assays. The localization of junction sites in recombinant genomes was also determined. VdRec excreted by vaccinees were first detected 2 to 4 days after vaccination. The highest rate of recombinants was on day 14. The frequency of VdRec depends strongly on the serotype of the analyzed isolates (2, 53, and 79% of recombinant strains in the last-excreted type 1, 2, and 3 isolates, respectively). Particular associations of genomic segments were preferred in the recombinant genomes, and recombination junctions were found in the genomic region encoding the nonstructural proteins. Recombination junctions generally clustered in particular subgenomic regions that were dependent on the serotype of the isolate and/or on the associations of genomic segments in recombinants. Thus, VdRec are frequently excreted by vaccinees, and the poliovirus replication machinery requirements or selection factors appear to act in vivo to shape the features of the recombinant genomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many isolates from VAPP cases, AFP cases with incidental isolation of vaccine-related virus (much more frequent thanVAPPcases),andhealthyOPVrecipients are vaccine/vaccine recombinants (18, 33, 59, 91, 106).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617
RNA recombination in animal and plant viruses
Lai, M. M. C. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.61-79.1992 · Cited by 665
Evolutionary aspects of recombination in RNA viruses
Worobey, M., & Holmes, E. C. (1999) · Journal of General Virology · doi:10.1099/0022-1317-80-10-2535 · Cited by 556
Wimmer, E., Hellen, C. U. T., & Cao, X. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.002033 · Cited by 554
The mechanism of RNA recombination in poliovirus
Kirkegaard, K., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90600-8 · Cited by 499
Complete nucleotide sequences of all three poliovirus serotype genomes
Toyoda, H., Kohara, M., Kataoka, Y., Suganuma, T., Omata, T., Imura, N., & Nomoto, A. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90084-6 · Cited by 415
New Insights into the Mechanisms of RNA Recombination
Nagy, P. D., & Simon, A. E. (1997) · Virology · doi:10.1006/viro.1997.8681 · Cited by 389
Geographic distribution of wild poliovirus type 1 genotypes
Rico-Hesse, R., Pallansch, M. A., Nottay, B. K., & Kew, O. M. (1987) · Virology · doi:10.1016/0042-6822(87)90001-8 · Cited by 327
History of Sabin attenuated poliovirus oral live vaccine strains
Sabin, A. B., & Boulger, L. R. (1973) · Journal of Biological Standardization · doi:10.1016/0092-1157(73)90048-6 · Cited by 316
Genetic recombination with newcastle disease virus, polioviruses, and influenza
Hirst, G. K. (1962) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1962.027.001.028 · Cited by 269
Research works printed but not linked: 1
- Kew O. M. Nottay B. K. Evolution of the oral poliovaccine strains in humans occur by both mutation and intramolecular recombination.Modern approaches to vaccines. Chanock R. Lerner R. 1984 357 367 Cold Spring Harbor Press N.Y
Cited by
Sorted by citations
Items 101–136 of 136
Bolanaki, E., Kottaridi, C., Markoulatos, P., Margaritis, L. H., & Katsorchis, T. (2006) · Virus Genes · doi:10.1007/s11262-005-6909-x · Cited by 10
Vaccine derived bi- and multi-recombinant Sabin strains
Paximadi, E., Karakasiliοtis, I., Bolanaki, E., Krikelis, A., & Markoulatos, P. (2007) · Virus Genes · doi:10.1007/s11262-007-0146-4 · Cited by 10
Kyriakopoulou, Z., Pliaka, V., Tsakogiannis, D., Ruether, I. G. A., Komiotis, D., Gartzonika, C., Levidiotou-Stefanou, S., & Markoulatos, P. (2011) · Virus Genes · doi:10.1007/s11262-011-0688-3 · Cited by 9
Growth kinetic analysis of bi-recombinant poliovirus vaccine strains
Pliaka, V., Dedepsidis, E., Kyriakopoulou, Z., Papadi, G., Tsakogiannis, D., Pratti, A., Levidiotou-Stefanou, S., & Markoulatos, P. (2010) · Virus Genes · doi:10.1007/s11262-010-0448-9 · Cited by 9
Kew, O. M. (2014) · Springer eBooks · doi:10.1007/978-1-4899-7448-8_13 · Cited by 8
KITAMURA, K., & Shimizu, H. (2022) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2022.312 · Cited by 7
Correlation of mutations and recombination with growth kinetics of poliovirus vaccine strains
Pliaka, V., Kyriakopoulou, Z., Tsakogiannis, D., Ruether, I. G. A., Gartzonika, C., Levidiotou-Stefanou, S., Krikelis, A., & Markoulatos, P. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1033-9 · Cited by 7
Upadhyay, R. K. (2014) · Journal of Viruses · doi:10.1155/2014/516904 · Cited by 5
Poliovirus et entérovirus C, même espèce, même « tribu » virale
Andrianarivelo, M. R., Jégouic, S., Bessaud, M., & Delpeyroux, F. (2008) · médecine/sciences · doi:10.1051/medsci/2008245452 · Cited by 5
Self-citationRecombination in the Evolution of Picornaviruses
Peter Simmonds, K. (2014) · ASM Press eBooks · doi:10.1128/9781555816698.ch14 · Cited by 5
Cassemiro, K. M. S. D. M., Burlandy, F. M., & da Silva, E. E. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000484 · Cited by 5
Liu, J., Zhang, H., Zhao, Y., Xia, L., Guo, C., Yang, H. F., Luo, N., He, Z., & Ma, S. (2016) · Virology Journal · doi:10.1186/s12985-016-0615-2 · Cited by 5
Isolation and Identification of Inter-Species Enterovirus Recombinant Genomes
Bentley, K., Tee, H. K., Pearson, A., Lowry, K., Waugh, S., Jones, S., Chan, Y. F., & Evans, D. J. (2021) · Viruses · doi:10.3390/v13122390 · Cited by 5
New Human Parechoviruses: Six and Counting
Benschop, K., Stanway, G., & Wolthers, K. C. (2014) · ASM Press eBooks · doi:10.1128/9781555815592.ch4 · Cited by 5
Shakaryan, A. K., Mikhailova, Y. M., Chirova, A. V., Cherepanova, E. A., Baikova, O. Y., Yakovchuk, E. V., Karpova, E. V., Ap, I., Skryabina, S. V., Snitkovskaya, T. E., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70704 · Cited by 3
Dimitriou, T. G., Pliaka, V., Kyriakopoulou, Z., Ruether, I. G. A., Tsakogiannis, D., Fountoucidou, P., Gartzonika, C., Levidiotou-Stefanou, S., & Markoulatos, P. (2013) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2013.10.004 · Cited by 3
Chi, C., Tseng, F., Liu, D., Chang, Y.-W., Wu, H., Huang, Y.-F., Hwang, K., Hsu, Y.-W., Wang, S., Liu, H., et al. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.03.013 · Cited by 3
Romanenkova, N. I., Rozaeva, N. R., Александровна, Б. М., Kanaeva, O. I., & Chkhyndzheriya, I. G. (2019) · Journal Infectology · doi:10.22625/2072-6732-2019-11-3-102-109 · Cited by 2
Self-citationGuerrero-Tamayo, A., Sanz, B., Olivares, I., Moragues, M. D., Casado, C., & Pastor-López, I. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309391 · Cited by 1
Boot, H. J., Lukashov, V. V., van Remmerden, Y., & Kimman, T. G. (2006) · Virus Genes · doi:10.1007/s11262-006-0012-9 · Cited by 1
Facilitating viral recombination
Griffiths, P. D. (2002) · Reviews in Medical Virology · doi:10.1002/rmv.374 · Cited by 1
Polioviruses and the Endgame Strategy for Global Polio Eradication
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005)
Razafindratsimandresy, R., Rakoto Andrianarivelo, M., & Rousset, D. (2003) · PubMed
Dimitriou, T. G., Kyriakopoulou, Z., Tsakogiannis, D., Fikatas, A., Gartzonika, C., Levidiotou-Stefanou, S., & Markoulatos, P. (2016) · Virus Genes · doi:10.1007/s11262-016-1333-y
Molecular Analysis of Enteroviruses
Zhou, F. (2016) · Journal of Human Virology & Retrovirology · doi:10.15406/jhvrv.2016.03.00083
Stochastische Modellierung von Exitstrategien der Poliomyelitis
Krampol, M. (2007)
Romanenkova, N. I., Nguyen, T. T. T., Rozaeva, N. R., Kanaeva, O. I., Evseeva, V. A., & Александровна, Б. М. (2023) · Russian Journal of Infection and Immunity · doi:10.15789/2220-7619-soa-3403
Self-citationDiversity and molecular characterisation of enteroviruses detected in Hungary
Bujáki, E. (2023) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2022.150
Sauthier, J. T., Dias, J. B., Ferreira, C. D. S., Gomes, B. D. O. N., Fraga, K. A., Gonçalves, I. M. D. S., de Souza, A. A. A., dos Santos, A. A. C., Müller, B. D. L. A., Lima, L. F., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5180131
Lin, J., Zhou, L., Zhu, C., Li, J., Zhang, W., Zhu, S., Wang, D., Li, X., Zhu, H., Yang, Q., et al. (2025) · Virology Journal · doi:10.1186/s12985-025-03014-z
Insights on vaccine-derived poliovirus type 2 outbreaks and novel oral polio vaccine candidates
Aboshanab, K. M., Alshahrani, M. Y., Enshasy, H. A. E., Shabana, M. R., & Majeed, A. B. A. (2025) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2025.117221 · Cited by 1
Gretteau, P.-A. (2018) · theses.fr (ABES) · doi:10.70675/f4be6f18z80a8z47fcza5bfz0d10a6f6473c
Metadata
- Authors
- Cuervo, N. S., Guillot, S., Romanenkova, N., Combiescu, M., Aubert-Combiescu, A., Seghier, M., Caro, V., Crainic, R., & Delpeyroux, F.
- Affiliations
- Institut Pasteur (FR)
- Saint Petersburg Pasteur Institute (RU)
- Institutul Cantacuzino (RO)
- Institut Pasteur d'Algérie (DZ)
- <!--label omitted: 1-->Epidémiologie Moléculaire des Entérovirus, Institut Pasteur, Paris, France1;
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2001-07
- Volume
- 75
- Issue
- 13
- Pages
- 5740-5751
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC114290
- OpenAlex
- W1990942102
- Cited by
- 136
- References
- 52
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- European Commission
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- trivalent oral polio vaccine, excretion kinetics, recombination junctions, non-structural proteins, poliovirus serotypes, co-infection, vaccine-associated paralytic poliomyelitis
- MeSH terms
- Animals, Chlorocebus aethiops, Child, Humans, Poliovirus Vaccine, Oral, Recombination, Genetic, Polymorphism, Restriction Fragment Length, RNA, Viral, Vero Cells, Genome, Viral, Poliovirus, Reverse Transcriptase Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
