Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine‐associated polio cases
Abstract
Five representatives from a collection of 21 Sabin type 2‐like poliovirus strains isolated from paralytic poliomyelitis cases in two regions of the USSR have been subjected t o limited nucleotide sequencing. All proved to be intertypic recombinants having the genes encoding capsid proteins of Sabin 2 origin and a 3'‐end portion of the genome derived from either type 1 (3 isolates) or type 3 (2 isolates) Sabin strains. The crossover points in all the 5 genomes have been mapped to different loci of the P3 region. At least 6 additional isolates from the same collection (and 2 isolates from healthy contacts), appeared to have a type 2/type 1 recombinant genome, as judged by oligonucleotide mapping. The biological significance of frequent occurrence of recombinants among field isolates of vaccine‐related strains is discussed.
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The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages, especially for closely related isolates.
“The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages (84, 107), especially for closely related isolates (27).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [107]
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- Authors
- Lipskaya, G. Y., Muzychenko, A. R., Kutitova, O. K., Maslova, S. V., Equestre, M., Drozdov, S. G., Bercoff, R. P., & Agol, V. I.
- Affiliations
- Lomonosov Moscow State University (RU)
- Chumakov Institute of Poliomyelitis and Viral Encephalitides (RU)
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Agol, V. I.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 35
- Issue
- 4
- Pages
- 290-296
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W2113109377
- Cited by
- 97
- References
- 31
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 8 · 2013: 2 · 2012: 4
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- poliovirus, intertypic recombination, vaccine-associated poliomyelitis, paralytic poliomyelitis, coat protein gene, crossover point, oligonucleotide mapping, nucleotide sequencing
- MeSH terms
- Base Sequence, Child, Preschool, Chromosome Mapping, Feces, Humans, Infant, Molecular Sequence Data, Nucleotide Mapping, Poliomyelitis, Poliovirus Vaccine, Oral, Recombination, Genetic, RNA, Viral, Serotyping, USSR, Mutagenesis, Genome, Viral, Poliovirus
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