Cited by 97Viral Infections and Immunology ResearchVirology and Viral DiseasesEvolution and Genetic Dynamics

Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine‐associated polio cases

Lipskaya, Galina Y., Muzychenko, A. R., Kutitova, Olga K., Maslova, Svetlana V., Equestre, M., Drozdov, S. G., Bercoff, R. Perez, Agol, V. I.·1991·Journal of Medical Virology

Abstract

Five representatives from a collection of 21 Sabin type 2‐like poliovirus strains isolated from paralytic poliomyelitis cases in two regions of the USSR have been subjected t o limited nucleotide sequencing. All proved to be intertypic recombinants having the genes encoding capsid proteins of Sabin 2 origin and a 3'‐end portion of the genome derived from either type 1 (3 isolates) or type 3 (2 isolates) Sabin strains. The crossover points in all the 5 genomes have been mapped to different loci of the P3 region. At least 6 additional isolates from the same collection (and 2 isolates from healthy contacts), appeared to have a type 2/type 1 recombinant genome, as judged by oligonucleotide mapping. The biological significance of frequent occurrence of recombinants among field isolates of vaccine‐related strains is discussed.

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Crossref · 10.1002/jmv.1890350415

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31 of 31 references verified0 citation errors · 0 not checkable

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  • The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages, especially for closely related isolates.

    “The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages (84, 107), especially for closely related isolates (27).”

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Authors
Lipskaya, G. Y., Muzychenko, A. R., Kutitova, O. K., Maslova, S. V., Equestre, M., Drozdov, S. G., Bercoff, R. P., & Agol, V. I.
Affiliations
  • Lomonosov Moscow State University (RU)
  • Chumakov Institute of Poliomyelitis and Viral Encephalitides (RU)
  • Istituto Superiore di Sanità (IT)
Corresponding author
Agol, V. I.
Venue
Journal of Medical Virology
Publisher
Wiley
Published
1991-12
Volume
35
Issue
4
Pages
290-296
ISSN
  • 0146-6615 (ISSN-L)
  • 1096-9071
OpenAlex
W2113109377
Cited by
97
References
31
Citations by year
2024: 1 · 2023: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 8 · 2013: 2 · 2012: 4
FWCI
2.56
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medical Virology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
poliovirus, intertypic recombination, vaccine-associated poliomyelitis, paralytic poliomyelitis, coat protein gene, crossover point, oligonucleotide mapping, nucleotide sequencing
MeSH terms
Base Sequence, Child, Preschool, Chromosome Mapping, Feces, Humans, Infant, Molecular Sequence Data, Nucleotide Mapping, Poliomyelitis, Poliovirus Vaccine, Oral, Recombination, Genetic, RNA, Viral, Serotyping, USSR, Mutagenesis, Genome, Viral, Poliovirus

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