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E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c- myc
Abstract
Human papillomavirus type 16 (HPV-16) E6 activates telomerase specifically in epithelial cells. The oncogene c- myc has also been shown to activate telomerase in several cell types. Here we show that while both HPV-16 E6 and c- myc require intact E boxes to transactivate the hTERT promoter, E6 does not induce hTERT transcription simply by inducing expression of c- myc . Moreover, hTERT transactivation by HPV-16 E6 correlates with its ability to bind the cellular E6-associated protein (E6AP), suggesting that E6 and E6AP may target a regulator of hTERT expression.
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In the citing paper
“In reporter assays, E6 seems to require an intact proximal E box in the hTERT promoter for activity (Gewin and Galloway 2001; Veldman et al. 2003).”
From Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex (2004) · cites this paper as Gewin and Galloway 2001
In the citing paper
“Although c-Myc is able to bind the E boxes in the hTERT promoter and can induce hTERT expression in many cell types (Wang et al. 1998; Greenberg et al. 1999; Wu et al. 1999), we and others have found no correlation between c-Myc expression and the ability of E6 to induce hTERT (Gewin and Galloway 2001; Oh et al. 2001; Veldman et al. 2001).”
From Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex (2004) · cites this paper as Gewin and Galloway 2001
In the citing paper
“Although cMyc levels do not appear to change dramatically on E6 expression (Gewin and Galloway 2001; Veldman et al. 2001), two groups have recently found by chromatin immunoprecipitation that c-Myc is bound to the hTERT promoter in E6-expressing cells (Baege et al. 2002; Veldman et al. 2003).”
From Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex (2004) · cites this paper as Gewin and Galloway 2001
In the citing paper
“We have, however, determined that the promoter region including the proximal E box is important for E6-mediated hTERT induction (Gewin and Galloway 2001; Veldman et al. 2001).”
From Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex (2004) · cites this paper as Gewin and Galloway 2001
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Citations
Cites
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017 · cited 1×
“Presumably, E7 induces c-myc by binding retinoblastoma protein, thereby releasing E2F to activate cmyc in a manner similar to that demonstrated for simian virus 40 large T antigen (1, 6 ). Given the comparable c-Myc expression levels in lanes 5 and 6 of Fig. 1A, it is perplexing that HPV-16 E7 does not induce hTERT.”
BackgroundCreation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206
Self-citationVaziri, H., & Benchimol, S. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70109-5 · Cited by 1,003 · cited 1×
“Ectopic expression of hTERT in a number of different telomerase-negative cell types has been shown to confer immortality (2, 4, 18, 30 ).”
BackgroundDirect activation of TERT transcription by c-MYC
Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893
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Cited by
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898
Gewin, L., Myers, H., Kiyono, T., & Galloway, D. A. (2004) · Genes & Development · doi:10.1101/gad.1214704 · Cited by 277
Self-citationHorikawa, I., & Barrett, J. C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg085 · Cited by 211
Sanduja, S., Kaza, V., & Dixon, D. A. (2009) · Aging · doi:10.18632/aging.100086 · Cited by 65
Metadata
- Authors
- Gewin, L., & Galloway, D. A.
- Affiliations
- <!--label omitted: 1-->Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109,1, and
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2001-08
- Volume
- 75
- Issue
- 15
- Pages
- 7198-7201
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 156
- References
- 7
- Language
- en
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