Cited by 867HIV Research and TreatmentHIV/AIDS Research and InterventionsHIV-related health complications and treatments

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Open access

Guadalupe, Moraima, Reay, Elizabeth, Sankaran, Sumathi, Prindiville, Thomas, Flamm, Jason, McNeil, Andrew, Dandekar, Satya·2003·Journal of Virology

DOI 10.1128/jvi.77.21.11708-11717.2003PMC PMC229357

Open this paper in CoChat — free account

Abstract

Gut-associated lymphoid tissue (GALT) harbors the majority of T lymphocytes in the body and is an important target for human immunodeficiency virus type 1 (HIV-1). We analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4+T-cell depletion and the effect of HAART on the restoration of CD4+T cells in GALT. Severe depletion of intestinal CD4+T cells occurred during primary HIV-1 infection. Our results showed that the restoration of intestinal CD4+T cells following HAART in chronically HIV-1-infected patients was substantially delayed and incomplete. In contrast, initiation of HAART during early stages of infection resulted in near-complete restoration of intestinal CD4+T cells, despite the delay in comparison to peripheral blood CD4+T-cell recovery. DNA microarray analysis of gene expression profiles and flow-cytometric analysis of lymphocyte homing and cell proliferation markers demonstrated that cell trafficking to GALT and not local proliferation contributed to CD4+T-cell restoration. Evaluation of jejunal biopsy samples from long-term HIV-1-infected nonprogressors showed maintenance of normal CD4+T-cell levels in both GALT and peripheral blood. Our results demonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAART early in HIV-1 infection. Monitoring of the restoration and/or maintenance of CD4+T cells in GALT provides a more accurate assessment of the efficacy of antiviral host immune responses as well as HAART.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/jvi.77.21.11708-11717.2003

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia
Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832
Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection
Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404
Immune control of HIV-1 after early treatment of acute infection
Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002
Programmed Death of T Cells in HIV-1 Infection
Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898
POPULATION BIOLOGY OF HIV-1 INFECTION: Viral and CD4 + T Cell Demographics and Dynamics in Lymphatic Tissues
Haase, A. T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.625 · Cited by 541
Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis
Ameisen, J. C., & Capron, A. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90092-8 · Cited by 527
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints
Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 472
Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315
Lederman, M. M., Connick, E., LANDAY, A. L., Kuritzkes, D. R., Spritzler, J., Clair, M. S., Kotzin, B. L., Fox, L. L., Heath-Chiozzi, M. E., Leonard, J. M., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/515591 · Cited by 425
Overview of the Mucosal Immune System
Brandtzaeg, P. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74529-4_2 · Cited by 274

Show all 24 references

Sorted by citations

Items 201–300 of 867

Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals
Vujkovic-Cvijin, I., Rutishauser, R. L., Pao, M., Hunt, P. W., Lynch, S. V., McCune, J. M., & Somsouk, M. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1334034 · Cited by 74
Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution
Zeng, M., Paiardini, M., Engram, J. C., Beilman, G. J., Chipman, J. G., Schacker, T. W., Silvestri, G., & Haase, A. T. (2012) · Blood · doi:10.1182/blood-2012-03-418624 · Cited by 72
Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection
Dion, M.-L., Bordi, R., Zeidan, J., Asaad, R. J., Boulassel, M.-R., Routy, J., Lederman, M. M., Sékaly, R., & Cheynier, R. (2006) · Blood · doi:10.1182/blood-2006-09-047308 · Cited by 78
Comprehensive Assessment of HIV Target Cells in the Distal Human Gut Suggests Increasing HIV Susceptibility Toward the Anus
McElrath, M. J., Smythe, K. S., Randolph‐Habecker, J., Melton, K. R., Goodpaster, T. A., Hughes, S. M., Mack, M., Sato, A., Diaz, G., Steinbach, G., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182898392 · Cited by 72
Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection
Yates, A. J., Stark, J., Klein, N. J., Antia, R., & Callard, R. E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040177 · Cited by 72
Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy
Asmuth, D. M., Ma, Z.-M., Albanese, A. P., Utay, N. S., Devaraj, S., Knight, T. H., Flynn, N. M., Yotter, T., Garcia, J.-C., Tsuchida, E., et al. (2013) · AIDS · doi:10.1097/qad.0b013e328362e54c · Cited by 71
HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
Avettand-Fènoël, V., Prazuck, T., Hocqueloux, L., Mélard, A., Michau, C., Kerdraon, R., Agoute, E., & Rouzioux, C. (2008) · AIDS · doi:10.1097/qad.0b013e32830fbdbc · Cited by 71
Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection
Haas, A., Zimmermann, K., Graw, F., Slack, E. M. C., Rusert, P., Ledergerber, B., Bossart, W., Weber, R. K., Thurnheer, M. C., Battegay, M., et al. (2011) · Gut · doi:10.1136/gut.2010.224774 · Cited by 71
Relationship between Levels of Inflammatory Cytokines in the Genital Tract and CD4+Cell Counts in Women with Acute HIV‐1 Infection
Bebell, L. M., Passmore, J.-A. S., Williamson, C. E., Mlisana, K. P., Iriogbe, I., van Loggerenberg, F., Karim, Q. A., & Karim, S. S. A. (2008) · The Journal of Infectious Diseases · doi:10.1086/590503 · Cited by 71
Mucosal immunity in human and simian immunodeficiency lentivirus infections
Brenchley, J. M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.15 · Cited by 70
PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: Restricted expression of type I interferon receptor by CCR5-expressing leukocytes
Boasso, A., Hardy, A. W., LANDAY, A. L., Martinson, J., Anderson, S. A., Dolan, M. J., Clerici, M., & Shearer, G. M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.05.009 · Cited by 70
HIV-1 Infection of Human Intestinal Lamina Propria CD4+ T Cells In Vitro Is Enhanced by Exposure to Commensal Escherichia coli
Dillon, S. M., Manuzak, J. A., Leone, A. K., Lee, E. J., Rogers, L. M., McCarter, M. D., & Wilson, C. C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200681 · Cited by 71
The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
Covino, D. A., Sabbatucci, M., & Fantuzzi, L. (2015) · Current Drug Targets · doi:10.2174/138945011701151217110917 · Cited by 69
The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART
Belmonte, L., Olmos, M. A., Fanín, A., Parodi, C. M., Baré, P., Concetti, H., Pérez, H., de Bracco, M. M. E., & Cahn, P. E. (2007) · AIDS · doi:10.1097/qad.0b013e3282efb74b · Cited by 70
Plasmacytoid Dendritic Cells (pDCs) From HIV Controllers Produce Interferon-α and Differentiate Into Functional Killer pDCs Under HIV Activation
Barblu, L., Machmach, K., Gras, C., Delfraissy, J., Boufassa, F., Leal, M., Ruíz-Mateos, E., Lambotte, O., Herbeuval, J., & for the ANRS EP36 HIV Controllers Study Group (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis384 · Cited by 69
Role of immune activation in HIV pathogenesis
Hunt, P. W. (2007) · Current HIV/AIDS Reports · doi:10.1007/s11904-007-0007-8 · Cited by 68
Mechanisms of HIV persistence in HIV reservoirs
Mzingwane, M. L., & Tiemessen, C. T. (2017) · Reviews in Medical Virology · doi:10.1002/rmv.1924 · Cited by 68
Acutely dysregulated, chronically disabled by the enemy within: T‐cell responses to HIV‐1 infection
Munier, C. M. L., & Kelleher, A. D. (2006) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100015 · Cited by 73
Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
Balagopal, A., Ray, S. C., de Oca, R. M., Sutcliffe, C. G., Vivekanandan, P., Higgins, Y., Mehta, S. H., Moore, R. D., Sulkowski, M., Thomas, D. L., et al. (2009) · AIDS · doi:10.1097/qad.0b013e3283324344 · Cited by 67
The Humoral Response to HIV‐1: New Insights, Renewed Focus
Alter, G., & Moody, M. A. (2010) · The Journal of Infectious Diseases · doi:10.1086/655654 · Cited by 76
Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4 + T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells
Verhoeven, D. E., Sankaran, S., Silvey, M., & Dandekar, S. (2008) · Journal of Virology · doi:10.1128/jvi.02164-07 · Cited by 67
Self-citation
Cancer prevention in HIV-infected populations
Goncalves, P. H., Montezuma-Rusca, J. M., Yarchoan, R., & Uldrick, T. S. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.011 · Cited by 66
Soluble PD‐1 rescues the proliferative response of simian immunodeficiency virus‐specific CD4 and CD8 T cells during chronic infection
Onlamoon, N., Rogers, K. A., Mayne, A. E., Pattanapanyasat, K., Mori, K., Villinger, F. J., & Ansari, A. A. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02766.x · Cited by 65
Progressive Proximal-to-Distal Reduction in Expression of the Tight Junction Complex in Colonic Epithelium of Virally-Suppressed HIV+ Individuals
Chung, C. Y., Alden, S. L., Funderburg, N., Fu, P., & Levine, A. D. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004198 · Cited by 67
Immunodominant HIV-Specific CD8 + T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers
Ferre, A. L., Lemongello, D., Hunt, P. W., Morris, M. M., Garcia, J. C., Pollard, R. B., Yee, H. F., Martin, J. N., Deeks, S. G., & Shacklett, B. L. (2010) · Journal of Virology · doi:10.1128/jvi.00803-10 · Cited by 66
Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection
Glavan, T., Gaulke, C. A., Rocha, C. S., Sankaran‐Walters, S., Hirao, L. A., Raffatellu, M., Jiang, G., Bäumler, A. J., Goulart, L., & Dandekar, S. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.92 · Cited by 66
Self-citation
Effects of HIV-1 and Herpes Simplex Virus Type 2 Infection on Lymphocyte and Dendritic Cell Density in Adult Foreskins from Rakai, Uganda
Johnson, K. E., Redd, A. D., Quinn, T. C., Collinson-Streng, A. N., Cornish, T. C., Kong, X., Sharma, R. B., Tobian, A. A. R., Tsai, B., Sherman, M. E., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq091 · Cited by 64
Immunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm
Ford, E. S., Puronen, C. E., & Sereti, I. (2009) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328329c68c · Cited by 70
Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1–Infected Elite Controllers
Brandt, L., Benfield, T., Mens, H., Clausen, L. N., Katzenstein, T. L., Fomsgaard, A., & Karlsson, I. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318215a991 · Cited by 64
The lymph node in HIV pathogenesis
Lederman, M. M., & Margolis, L. B. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.06.001 · Cited by 67
Understanding the Failure of CD8+T-Cell Vaccination against Simian/Human Immunodeficiency Virus
de Boer, R. J. (2007) · Journal of Virology · doi:10.1128/jvi.01914-06 · Cited by 64
Opportunistic disorders of the gastrointestinal tract in the age of highly active antiretroviral therapy
Huppmann, A. R., & Orenstein, J. M. (2010) · Human Pathology · doi:10.1016/j.humpath.2010.06.007 · Cited by 63
Immune reconstitution in the sigmoid colon after long-term HIV therapy
Sheth, P. M., Chege, D., Shin, L. Y., Huibner, S., Yue, F.-Y., Loutfy, M. R., Halpenny, R., Persad, D., Kovacs, C. M., Chun, T.-W., et al. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.23 · Cited by 63
Altered distribution of mucosal NK cells during HIV infection
Sips, M., Sciaranghella, G., Diefenbach, T., Dugast, A., Berger, C. T., Liu, Q., Kwon, D. S., Ghebremichael, M. S., Estes, J. D., Carrington, M. N., et al. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.40 · Cited by 63
Impact of early cART in the gut during acute HIV infection
Deléage, C., Schuetz, A., Alvord, W. G., Johnston, L., Hao, X., Morcock, D. R., Rerknimitr, R., Fletcher, J. L. K., Puttamaswin, S., Phanuphak, N., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87065 · Cited by 71
Cannabinoids and inflammation
Costiniuk, C. T., & Jenabian, M.-A. (2019) · AIDS · doi:10.1097/qad.0000000000002345 · Cited by 62
The role of Th17 cells in viral infections
Aghbash, P. S., Hemmat, N., Nahand, J. S., Shamekh, A., Memar, M. Y., Babaei, A., & Baghi, H. B. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107331 · Cited by 66
Effects of a Th1- versus a Th2-biased immune response in protection against Helicobacter pylori challenge in mice
Taylor, J. M., Ziman, M. E., Canfield, D. R., Vajdy, M., & Solnick, J. V. (2007) · Microbial Pathogenesis · doi:10.1016/j.micpath.2007.06.006 · Cited by 62
The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection
Mehandru, S., Tenner‐Racz, K., Rácz, P., & Markowitz, M. H. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.040 · Cited by 61
Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics
Hummelen, R., Vos, A. P., Land, B. V., van Norren, K., & Reid, G. (2010) · International Reviews of Immunology · doi:10.3109/08830185.2010.505310 · Cited by 57
Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination
Manrique, M. L., Kozlowski, P. A., Wang, S.-W., Wilson, R., Micewicz, E. D., Montefiori, D. C., Mansfield, K., Carville, A., & Aldovini, A. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.103 · Cited by 60
Improving Defences at the Portal of HIV Entry: Mucosal and Innate Immunity
Shattock, R. J., Haynes, B. F., Pulendran, B., Flores, J., Esparza, J., & on behalf of a Working Group convened by the Global HIV Vaccine Enterprise (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050081 · Cited by 60
Longitudinal Analysis of Distribution and Function of Plasmacytoid Dendritic Cells in Peripheral Blood and Gut Mucosa of HIV Infected Patients
Lehmann, C., Jung, N., Forster, K., Koch, N., Leifeld, L., Fischer, J., Mauss, S., Drebber, U., Steffen, H., Romerio, F., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit612 · Cited by 59
Residual Viraemia in HIV‐1‐Infected Patients with Plasma Viral Load ≤20 copies/ml is Associated with Increased Blood Levels of Soluble Immune Activation Markers
Ostrowski, S. R., Katzenstein, T. L., Pedersen, B. K., Gerstoft, J., & Ullum, H. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02184.x · Cited by 59
Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection
Hofer, U., & Speck, R. F. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0158-3 · Cited by 59
HIV-Related Metabolic Comorbidities in the Current ART Era
Warriner, A. H., Burkholder, G., & Overton, E. T. (2014) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2014.05.003 · Cited by 62
New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression
Valverde-Villegas, J. M., Matte, M. C. C., de Medeiros, R. M., & Chies, J. A. B. (2015) · Journal of Immunology Research · doi:10.1155/2015/647916 · Cited by 63
Dendritic cells transmit HIV-1 through human small intestinal mucosa
Shen, R., Smythies, L. E., Clements, R. H., Novak, L., & Smith, P. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0909605 · Cited by 58
TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4 + T cells
Fontenot, D., He, H., Hanabuchi, S., Nehete, P. N., Zhang, M., Chang, M., Nehete, B. N., Wang, Y., Wang, Y.-H., Ma, Z.-M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907347106 · Cited by 58
Pulmonary Immune Dysregulation and Viral Persistence During HIV Infection
Alexandrova, Y., Costiniuk, C. T., & Jenabian, M.-A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.808722 · Cited by 58
Immune response to HIV
Perreau, M., Lévy, Y., & Pantaleo, G. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328361faf4 · Cited by 57
HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment
Rueda, C. M., Velilla, P. A., Chougnet, C. A., Montoya, C. J., & Rugeles, M. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030307 · Cited by 57
Microarray study reveals that HIV-1 induces rapid type-I interferon-dependent p53 mRNA up-regulation in human primary CD4+T cells
Imbeault, M., Ouellet, M., & Tremblay, M. J. (2009) · Retrovirology · doi:10.1186/1742-4690-6-5 · Cited by 58
Evidence for Translocation of Microbial Products in Patients with Idiopathic CD4 Lymphocytopenia
Lee, P. I., Ciccone, E. J., Read, S. W., Asher, A. I., Pitts, R., Douek, D. C., Brenchley, J. M., & Sereti, I. (2009) · The Journal of Infectious Diseases · doi:10.1086/598953 · Cited by 58
Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites
Mestecky, J. F. (2007) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2007.01.006 · Cited by 56
Exhausted CD8 T Cells Downregulate the IL-18 Receptor and Become Unresponsive to Inflammatory Cytokines and Bacterial Co-infections
Ingram, J. T., Yi, J. S., & Zajac, A. J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002273 · Cited by 55
The role of virus-induced regulatory T cells in immunopathology
Robertson, S. J., & Hasenkrug, K. J. (2006) · Springer Seminars in Immunopathology · doi:10.1007/s00281-006-0019-2 · Cited by 54
Gut Mucosal FOXP3 + Regulatory CD4 + T Cells and Nonregulatory CD4 + T Cells Are Differentially Affected by Simian Immunodeficiency Virus Infection in Rhesus Macaques
Allers, K., Loddenkemper, C., Hofmann, J., Unbehaun, A., Kunkel, D., Moos, V., Kaup, F., Stahl‐Hennig, C., Sauermann, U., Epple, H., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01715-09 · Cited by 57
Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer
Misumi, S., Masuyama, M., Takamune, N., Nakayama, D., Mitsumata, R., Matsumoto, H., Urata, N., Takahashi, Y., Muneoka, A., Sukamoto, T., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802928 · Cited by 53
Reduced Protection from Simian Immunodeficiency Virus SIV mac251 Infection Afforded by Memory CD8 + T Cells Induced by Vaccination during CD4 + T-Cell Deficiency
Vaccari, M., Mattapallil, J. J., Song, K., Tsai, W.-P., Hryniewicz, A., Venzon, D. J., Zanetti, M., Reimann, K. A., Roederer, M., & Franchini, G. (2008) · Journal of Virology · doi:10.1128/jvi.00893-08 · Cited by 53
Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors
Gaardbo, J. C., Hartling, H. J., Gerstoft, J., & Nielsen, S. D. (2012) · AIDS Research and Treatment · doi:10.1155/2012/161584 · Cited by 56
The role of polymorphonuclear neutrophils during HIV-1 infection
Yaseen, M. M., Abuharfeil, N. M., Yaseen, M. M., & Shabsoug, B. M. (2017) · Archives of Virology · doi:10.1007/s00705-017-3569-9 · Cited by 55
The Role of Integrin α4β7 in HIV Pathogenesis and Treatment
Arthos, J. A., Cicala, C., Nawaz, F., Byrareddy, S. N., Villinger, F. J., Santangelo, P. J., Ansari, A. A., & Fauci, A. S. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0382-3 · Cited by 51
Not just sheer luck! Immune correlates of protection against HIV-1 infection
Piacentini, L., Fenizia, C., Naddeo, V., & Clerici, M. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.11.062 · Cited by 52
Increases in Human Papillomavirus Detection During Early HIV Infection Among Women in Zimbabwe
Nowak, R. G., Gravitt, P. E., MORRISON, C. S., Gange, S. J., Kwok, C., Oliver, A., Howard, R., Pol, B. J. V. D., Salata, R. A., PADIAN, N. S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq172 · Cited by 52
Decreased NK Cell Frequency and Function Is Associated with Increased Risk of KIR3DL Allele Polymorphism in Simian Immunodeficiency Virus-Infected Rhesus Macaques with High Viral Loads
Boštík, P., Kobkitjaroen, J., Tang, W., Villinger, F. J., Pereira, L. E., Little, D. M., Stephenson, S. T., Bouzyk, M., & Ansari, A. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803580 · Cited by 50
Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival
Morre, M., & Beq, S. (2012) · Targeted Oncology · doi:10.1007/s11523-012-0210-4 · Cited by 51
Immunodeficiency lentiviral infections in natural and non-natural hosts
Brenchley, J. M., & Paiardini, M. (2011) · Blood · doi:10.1182/blood-2010-12-325936 · Cited by 54
HIV and hepatitis C coinfection
Page, E. E., Nelson, M. R., & Kelleher, P. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834bbc71 · Cited by 51
Early initiation of highly active antiretroviral therapy fails to reverse immunovirological abnormalities in gut-associated lymphoid tissue induced by acute HIV infection
Tincati, C., Biasin, M., Bandera, A., Violin, M., Marchetti, G. C., Piacentini, L., Vago, L., Balotta, C., Moroni, M., Franzetti, F., et al. (2008) · Antiviral Therapy · doi:10.1177/135965350901400310 · Cited by 51
Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
Holmes, D., Jiang, Q., Zhang, L., & Su, L. (2008) · Immunologic Research · doi:10.1007/s12026-008-8037-x · Cited by 51
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an “Emerging Syndemic”
Azevedo‐Pereira, J. M., Pires, D., Calado, M. S., Mandal, M., Santos‐Costa, Q., & Anes, E. (2023) · Microorganisms · doi:10.3390/microorganisms11040853 · Cited by 52
Plasmacytoid dendritic cells of the gut: Relevance to immunity and pathology
Lombardi, V. C., & Khaiboullina, S. F. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.04.007 · Cited by 54
Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway
Chen, Q., Swaminathan, S., Yang, D., Dai, L., Sui, H., Yang, J., Hornung, R. L., Wang, Y., Huang, D. W., Hu, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059194 · Cited by 50
Evolution of the HIV-1 env Gene in the Rag2 −/− γ C −/− Humanized Mouse Model
Ince, W. L., Zhang, L., Jiang, Q., Arrildt, K. T., Su, L., & Swanstrom, R. I. (2009) · Journal of Virology · doi:10.1128/jvi.02180-09 · Cited by 48
Generation of functionally active HIV-1 specific CD8+ CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization
Belyakov, I. M., Ahlers, J. D., Nabel, G. J., Moss, B., & Berzofsky, J. A. (2008) · Virology · doi:10.1016/j.virol.2008.08.019 · Cited by 50
Helicobacter pylori lipopolysaccharide promotes a Th1 type immune response in immunized mice
Taylor, J. M., Ziman, M. E., Huff, J. L., Moroski, N. M., Vajdy, M., & Solnick, J. V. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.03.043 · Cited by 50
Understanding the mechanisms and limitations of immune control of HIV
Davenport, M. P., Ribeiro, R. M., Zhang, L., Wilson, D. P., & Perelson, A. S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00485.x · Cited by 49
Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
Hardy, G. A. D., Sieg, S. F., Rodriguez, B. A., Jiang, W., Asaad, R. J., Lederman, M. M., & Harding, C. V. (2009) · Blood · doi:10.1182/blood-2008-11-190231 · Cited by 49
Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649–684, a mucosal subunit HIV/AIDS vaccine candidate
Matoba, N., Geyer, B. C., Kilbourne, J. A., Alfsen, A., Bomsel, M., & Mor, T. S. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.03.045 · Cited by 49
The Large Intestine as a Major Reservoir for Simian Immunodeficiency Virus in Macaques with Long‐Term, Nonprogressing Infection
Ling, B., Mohan, M., Lackner, A. A., Green, L. C., Marx, P. A., Doyle, L. A., & Veazey, R. S. (2010) · The Journal of Infectious Diseases · doi:10.1086/657413 · Cited by 47
Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages
Shen, R., Meng, G., Ochsenbauer, C., Clapham, P. R., Grams, J. M., Novak, L., Kappes, J. C., Smythies, L. E., & Smith, P. D. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002060 · Cited by 47
Systemic antibody responses to gut microbes in health and disease
Zimmermann, K., Haas, A., & Oxenius, A. (2012) · Gut Microbes · doi:10.4161/gmic.19344 · Cited by 47
The Immunomodulatory Nutritional Intervention NR100157 Reduced CD4+ T-Cell Decline and Immune Activation: A 1-Year Multicenter Randomized Controlled Double-Blind Trial in HIV-Infected Persons Not Receiving Antiretroviral Therapy (The BITE Study)
Cahn, P. E., Ruxrungtham, K., Gazzard, B., Diaz, R. S., Gori, A., Kotler, D. P., Vriesema, A. J. M., Georgiou, N., Garssen, J., Clerici, M., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit171 · Cited by 47
SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination
Klatt, N. R., Vinton, C. L., Lynch, R. M., Canary, L., Ho, J., Darrah, P. A., Estes, J. D., Seder, R. A., Moir, S. L., & Brenchley, J. M. (2011) · Blood · doi:10.1182/blood-2011-07-365874 · Cited by 47
HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition
Kis, O., Sankaran‐Walters, S., Hoque, M. T., Walmsley, S. L., Dandekar, S., & Bendayan, R. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02278-15 · Cited by 47
Self-citation
Intestinal Damage and Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV)–Exposed and HIV-Infected Zimbabwean Infants
Prendergast, A. J., Chasekwa, B., Rukobo, S., Govha, M., Mutasa, K., Ntozini, R., & Humphrey, J. H. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix367 · Cited by 47
Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection
Santangelo, P. J., Cicala, C., Byrareddy, S. N., Ortiz, K., Little, D. M., Lindsay, K. E., Gumber, S., Hong, J. J., Jelicic, K., Rogers, K. A., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.112 · Cited by 50
HIV-1 Reactivation Induced by the Periodontal Pathogens Fusobacterium nucleatum and Porphyromonas gingivalis Involves Toll-Like Receptor 4 and 9 Activation in Monocytes/Macrophages
González, O. A., Li, M., Ebersole, J. L., & Huang, C. B. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00009-10 · Cited by 47
Distinct Cytokine Patterns in Semen Influence Local HIV Shedding and HIV Target Cell Activation
Olivier, A. J., Masson, L., Ronacher, K., Walzl, G., Coetzee, D. J., Lewis, D. A., Williamson, A., Passmore, J.-A. S., & Burgers, W. A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit649 · Cited by 46
Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation
Crowell, T. A., Fletcher, J. L. K., Sereti, I., Pinyakorn, S., Dewar, R. L., Krebs, S. J., Chomchey, N., Rerknimitr, R., Schuetz, A., Michael, N. L., et al. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.21163 · Cited by 47
Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques
Mannioui, A., Bourry, O., Sellier, P., Delache, B., Brochard, P., Andrieu, T., Vaslin, B., Karlsson, I., Roques, P., & Grand, R. L. (2009) · Retrovirology · doi:10.1186/1742-4690-6-106 · Cited by 54
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K., & Palmer, C. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01311 · Cited by 47
HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities
Thompson, C. G., Gay, C. L., & Kashuba, A. D. M. (2017) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2016.0253 · Cited by 43
Characterization of Baseline Intestinal Mucosal Indices of Injury and Inflammation in Men for Use in Rectal Microbicide Trials (HIV Prevention Trials Network-056)
McGowan, I., Elliott, J. E., Cortina, G. R., Tanner, K., Siboliban, C., Adler, A. P., Cho, D., Boscardin, W. J., Soto-Torres, L. E., & Anton, P. A. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318156ef16 · Cited by 45
The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection
Hingrat, Q. L., Sereti, I., LANDAY, A. L., Pandrea, I., & Apetrei, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.695674 · Cited by 52
Depletion of CD4+ T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy
Politch, J. A., Mayer, K. H., & Anderson, D. J. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181989870 · Cited by 44
Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection
St-Pierre, C., Ouellet, M., Giguère, D., Ohtake, R., Roy, R., Sato, S., & Tremblay, M. J. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05595-11 · Cited by 44
Host and Viral Factors in HIV-Mediated Bystander Apoptosis
Garg, H., & Joshi, A. (2017) · Viruses · doi:10.3390/v9080237 · Cited by 48
Challenges in the management of HIV infection: update on the role of probiotic supplementation as a possible complementary therapeutic strategy for cART treated people living with HIV/AIDS
Ceccarelli, G., Statzu, M., Santinelli, L., Pinacchio, C., Bitossi, C., Cavallari, E. N., Vullo, V., Scagnolari, C., & d’Ettorre, G. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1638907 · Cited by 47

Authors: Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S.
Affiliations: University of California, Davis (US)
Departments of Medical Microbiology & Immunology
The Permanente Medical Group Inc.
ORCID: Flamm, Jason
Dandekar, Satya
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2003-11
Volume: 77
Issue: 21
Pages: 11708-11717
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.77.21.11708-11717.2003
PMC: PMC229357
OpenAlex: W2076120354
Cited by: 866
References: 24
Citations by year: 2026: 13 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 23 · 2021: 27 · 2020: 21 · 2019: 26 · 2018: 26 · 2017: 32 · 2016: 42 · 2015: 45 · 2014: 48 · 2013: 62 · 2012: 60
FWCI: 7.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 61297, R01DK061297)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords: HIV-1 infection, CD4+ T cell depletion, gut-associated lymphoid tissue, highly active antiretroviral therapy, CD4+ T cell recovery, jejunal biopsy, lymphocyte homing, nonprogressors, gene expression profiling, early treatment initiation
MeSH terms: Adult, Cell Movement, Chronic Disease, Female, Flow Cytometry, Humans, Immunohistochemistry, Jejunum, Lymphocyte Activation, Lymphoid Tissue, Male, Middle Aged, Time Factors, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, CD8-Positive T-Lymphocytes, CD4 Lymphocyte Count, Antiretroviral Therapy, Highly Active

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks