The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
Open accessAbstract
Gut-associated lymphoid tissue (GALT) harbors the majority of T lymphocytes in the body and is an important target for human immunodeficiency virus type 1 (HIV-1). We analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4+T-cell depletion and the effect of HAART on the restoration of CD4+T cells in GALT. Severe depletion of intestinal CD4+T cells occurred during primary HIV-1 infection. Our results showed that the restoration of intestinal CD4+T cells following HAART in chronically HIV-1-infected patients was substantially delayed and incomplete. In contrast, initiation of HAART during early stages of infection resulted in near-complete restoration of intestinal CD4+T cells, despite the delay in comparison to peripheral blood CD4+T-cell recovery. DNA microarray analysis of gene expression profiles and flow-cytometric analysis of lymphocyte homing and cell proliferation markers demonstrated that cell trafficking to GALT and not local proliferation contributed to CD4+T-cell restoration. Evaluation of jejunal biopsy samples from long-term HIV-1-infected nonprogressors showed maintenance of normal CD4+T-cell levels in both GALT and peripheral blood. Our results demonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAART early in HIV-1 infection. Monitoring of the restoration and/or maintenance of CD4+T cells in GALT provides a more accurate assessment of the efficacy of antiviral host immune responses as well as HAART.
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“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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“It is known that especially integrin a 4 b 7 -expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART. 18,20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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Citations
Cites
Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia
Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404
Immune control of HIV-1 after early treatment of acute infection
Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002
Programmed Death of T Cells in HIV-1 Infection
Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898
Haase, A. T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.625 · Cited by 541
Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis
Ameisen, J. C., & Capron, A. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90092-8 · Cited by 527
Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 472
Lederman, M. M., Connick, E., LANDAY, A. L., Kuritzkes, D. R., Spritzler, J., Clair, M. S., Kotzin, B. L., Fox, L. L., Heath-Chiozzi, M. E., Leonard, J. M., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/515591 · Cited by 425
Overview of the Mucosal Immune System
Brandtzaeg, P. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74529-4_2 · Cited by 274
Cited by
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Li, H., Huang, X., Guo, C., Wang, W., Li, Z., Zhang, T., Peng, Q., Chen, X., & Wu, H. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.004 · Cited by 2
Baum, L. L., Mathieson, B. J., & Connick, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.14021-4 · Cited by 2
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Peters, P. J., Marston, B. J., Weidle, P. J., & Brooks, J. T. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-4390-4.00027-8 · Cited by 1
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Martinez-Martinez, Y. B., Huante, M. B., Naqvi, K. F., Shah, M. N., Lisinicchia, J. G., Files, M. A., Perez, J., Gelman, B. B., Endsley, M. A., & Endsley, J. J. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013897 · Cited by 1
CXCR4-tropic HIV-1 infection in an immunocompetent monkey model
Meyerson, N. R., Bauer, V. L., Fattor, W. T., Warren, C. J., Barbachano-Guerrero, A., Weiss, M. J., Dirasantha, O., Burris, B. L., Adesina, A. S., Timpona, J. L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70209-5 · Cited by 1
Yanamadala, Y., Gokulan, K., Karn, K., Sutherland, V. L., CUNNY, H. C., Santos, J. H., Davis, K., & Khare, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1668334 · Cited by 1
Salwe, S., & Shete, A. (2026) · Current HIV/AIDS Reports · doi:10.1007/s11904-026-00778-z · Cited by 1
Abad-Fernández, M., Gutiérrez, C., Madrid, N., Hernández‐Novoa, B., Díaz, L., Muñoz‐Fernández, M. Á., Moreno, S., & Vallejo, A. (2014) · HIV Medicine · doi:10.1111/hiv.12167 · Cited by 1
Li, C., & Hu, Q. (2009) · Virologica Sinica · doi:10.1007/s12250-009-3063-y · Cited by 1
Ostra/wczesna choroba retrowirusowa
Lemańska, M., & Jankowska, M. (2013) · HIV & AIDS Review · doi:10.1016/s1730-1270(13)70005-5 · Cited by 1
Immunopathogenesis of HIV/Hepatitis C Virus Coinfection
MacParland, S. A., Vali, B., & Ostrowski, M. (2011) · Future Virology · doi:10.2217/fvl.11.80 · Cited by 1
Pinnetti, C., Bandera, A., Mangioni, D., & Gori, A. (2012) · Future Virology · doi:10.2217/fvl.12.80 · Cited by 1
Schultheiss, T., & Stahl‐Hennig, C. (2010) · AIDS · doi:10.1097/qad.0b013e3283430034 · Cited by 1
Liaño, J. P. (2008) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(08)76610-2 · Cited by 1
Antonieta, A. M., Sardiñas, C., Hector, F., Ana, C., González, R., Yetsenia, D. G., Estefanie, G., & Garibaldi, L. (2018) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2018.95041 · Cited by 1
Gastrointestinal disorders in HIV including diarrhea
Vachon, M. C., & Dieterich, D. T. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0695-2.00018-3 · Cited by 1
González, O. A., Li, M., Ebersole, J. L., & Huang, C. B. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00424-10 · Cited by 1
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Sato, H., Ota, Y., Kido, Y., Matsumoto, T., Matsubara, Y., Matano, T., Hirata, Y., Kawana‐Tachikawa, A., Yamaoka, Y., Yotsuyanagi, H., et al. (2020) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2020.0086 · Cited by 1
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Hujoel, I. A., & Murray, J. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-90142-4_8 · Cited by 1
The Immunology of Human Immunodeficiency Virus Infection
MOIR, S., Connors, M., & Fauci, A. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00120-x · Cited by 1
Paneth Cells: The Gatekeepers of the Gut
Luvhengo, T. E., & Nalisa, M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104402 · Cited by 1
Anatomical and physiological aspects of the HIV infection pathogenesis in animal models
Михайлович, Н. А., Tyumentseva, M. A., Tyumentsev, A. I., & Акимкин, В. Г. (2022) · Journal of microbiology epidemiology immunobiology · doi:10.36233/0372-9311-307 · Cited by 1
Longitudinal analysis of microbiome composition in Ghanaians living with HIV-1
Runtuwene, L. R., Parbie, P. K., Mizutani, T., Ishizaka, A., Matsuoka, S., Abana, C. Z.-Y., Kushitor, D., Bonney, E. Y., Ofori, S. B., Kiyono, H., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1359402 · Cited by 1
Subtle Mimicry of HLA by HIV-1 GP120 – A Role for Anti HLA Antibodies?
Smith, P. L., & Dalgleish, A. G. (2010) · The Open Autoimmunity Journal · Cited by 1
The Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV infected patient – case report
Mikuła, T., Mian, M., Stańczak, W., & Cianciara, J. (2007) · HIV & AIDS Review · doi:10.1016/s1730-1270(10)60076-8 · Cited by 1
Kelleher, A. D., & Cooper, D. A. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-2882-6.50010-1 · Cited by 1
Рашатовна, Х. Г., Ганиевич, М. И., & Алексеевич, А. В. (2012) · Epidemiology and Infectious Diseases · doi:10.17816/eid40663 · Cited by 1
GALT CD4+PD-1hi T follicular helper (Tfh) cells repopulate after anti-retroviral therapy
Onabajo, O. O., Lewis, M. G., & Mattapallil, J. J. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104396 · Cited by 1
Viral Diseases: Cellular Understanding of Diseases
Kaushal, A., Kaushal, D., Shegokar, R., & Pathak, Y. V. (2023) · Springer eBooks · doi:10.1007/978-3-031-20537-8_3 · Cited by 1
Makhubele, T. G. (2015) · UpSpace Institutional Repository (University of Pretoria) · Cited by 1
HIV and the Mucosa: No Safe Haven
Dandekar, S., Sankaran, S., & Glavan, T. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8412-6_17 · Cited by 1
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Vrisekoop, N. (2007) · Utrecht University Repository (Utrecht University) · Cited by 1
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Courtney, A. N. (2010) · Digital Commons-TMC (Texas Medical Center) · Cited by 1
Perrin, D. (2008) · Dublin City University Open Access Institutional Repository (Dublin City University) · Cited by 1
Characterization of HIV-1 in the central nervous system during suppressive therapy
Dahl, V. (2013) · Figshare · Cited by 1
Ríos, C. M. R., & Hernández, P. (2009) · IATREIA · doi:10.17533/udea.iatreia.4545 · Cited by 1
Costa, P., Bozzano, F. M., Fenoglio, D., Beltrame, A., Cenderello, G., Biagio, A. D., Ferrea, G., Pagano, G., & Maria, A. D. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03988.x · Cited by 1
Of molecules, macaques and global AIDS
Katzenstein, D. A. (2006) · AIDS · doi:10.1097/01.aids.0000222081.98669.82 · Cited by 1
HIV-1 immune responses induced by natural infection or immunisation
Gudmundsdotter, L. (2009) · Figshare · Cited by 1
The characteristics and functional nature of T cells upon HIV-1 infection and exposure
Nyoka, N. S. (2008) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg) · Cited by 1
Acute HIV Infection: Implications for HIV Spread, Disease Progression, and Vaccine Development
Cohen, M. S., Anderson, J. A., & Swanstrom, R. I. (2005) · Cited by 1
Daharsh, L., Ramer‐Tait, A. E., & Li, Q. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.16.993956 · Cited by 1
Teeman, C. S. (2021) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fidc010264 · Cited by 1
Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J., Chomont, N., Finzi, A., & Ancuța, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.15.580166 · Cited by 1
Cloyd, M. W., Ji, J., Smith, M. M., & Braciale, V. L. (2007) · Springer eBooks · doi:10.1007/0-387-34132-3_17
Nonhuman Primate Models for AIDS
Haigwood, N. L., O’Neill, R., & Hirsch, V. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-285-4_58
Pérez, C. L. (2011) · Figshare
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Parrish, N. F. (2013) · ScholarlyCommons (University of Pennsylvania)
Koenen, P. (2007) · Utrecht University Repository (Utrecht University)
Quigley, M. F. (2006) · Figshare
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Luther, V. P., & Pegram, P. S. (2010) · doi:10.1002/9781444328417.ch55
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Fontenot, D. (2010) · Digital Commons-TMC (Texas Medical Center)
Recent Advances in the Understanding of HIV and Inflammatory Bowel Diseases
McGowan, I., & Cranston, R. (2010) · doi:10.1002/9781444318418.ch45
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Mild, M. (2007) · Lund University Publications (Lund University)
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Borggren, M. (2012) · Lund University Publications (Lund University)
Epple, H. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-6315
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Thắng, P. H. (2011) · Figshare
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Kabue, J. P. (2009) · SUNScholar (Stellenbosch University)
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Metadata
- Authors
- Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S.
- Affiliations
- University of California, Davis (US)
- Departments of Medical Microbiology & Immunology
- The Permanente Medical Group Inc.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-11
- Volume
- 77
- Issue
- 21
- Pages
- 11708-11717
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC229357
- OpenAlex
- W2076120354
- Cited by
- 866
- References
- 24
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 23 · 2021: 27 · 2020: 21 · 2019: 26 · 2018: 26 · 2017: 32 · 2016: 42 · 2015: 45 · 2014: 48 · 2013: 62 · 2012: 60
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 61297, R01DK061297)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- HIV-1 infection, CD4+ T cell depletion, gut-associated lymphoid tissue, highly active antiretroviral therapy, CD4+ T cell recovery, jejunal biopsy, lymphocyte homing, nonprogressors, gene expression profiling, early treatment initiation
- MeSH terms
- Adult, Cell Movement, Chronic Disease, Female, Flow Cytometry, Humans, Immunohistochemistry, Jejunum, Lymphocyte Activation, Lymphoid Tissue, Male, Middle Aged, Time Factors, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, CD8-Positive T-Lymphocytes, CD4 Lymphocyte Count, Antiretroviral Therapy, Highly Active
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