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Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
Open accessAbstract
Gut-associated lymphoid tissue (GALT) harbors the majority of T lymphocytes in the body and is an important target for human immunodeficiency virus type 1 (HIV-1). We analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4+T-cell depletion and the effect of HAART on the restoration of CD4+T cells in GALT. Severe depletion of intestinal CD4+T cells occurred during primary HIV-1 infection. Our results showed that the restoration of intestinal CD4+T cells following HAART in chronically HIV-1-infected patients was substantially delayed and incomplete. In contrast, initiation of HAART during early stages of infection resulted in near-complete restoration of intestinal CD4+T cells, despite the delay in comparison to peripheral blood CD4+T-cell recovery. DNA microarray analysis of gene expression profiles and flow-cytometric analysis of lymphocyte homing and cell proliferation markers demonstrated that cell trafficking to GALT and not local proliferation contributed to CD4+T-cell restoration. Evaluation of jejunal biopsy samples from long-term HIV-1-infected nonprogressors showed maintenance of normal CD4+T-cell levels in both GALT and peripheral blood. Our results demonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAART early in HIV-1 infection. Monitoring of the restoration and/or maintenance of CD4+T cells in GALT provides a more accurate assessment of the efficacy of antiviral host immune responses as well as HAART.
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“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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“It is known that especially integrin a 4 b 7 -expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART. 18,20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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Cites
Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia
Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404
Immune control of HIV-1 after early treatment of acute infection
Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002
Programmed Death of T Cells in HIV-1 Infection
Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898
Haase, A. T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.625 · Cited by 541
Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis
Ameisen, J. C., & Capron, A. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90092-8 · Cited by 527
Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 472
Lederman, M. M., Connick, E., LANDAY, A. L., Kuritzkes, D. R., Spritzler, J., Clair, M. S., Kotzin, B. L., Fox, L. L., Heath-Chiozzi, M. E., Leonard, J. M., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/515591 · Cited by 425
Overview of the Mucosal Immune System
Brandtzaeg, P. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74529-4_2 · Cited by 274
Cited by
Sorted by citations
Items 501–600 of 867
De, M. M., Blanco, M.-J., Márquez-Coello, M., Soto, M.-J., Fernández-Gutiérrez, C., Rodríguez-Ramos, C., & González, J. A. G. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02505.x · Cited by 16
RetractedGene Therapy - Developments and Future Perspectives
Kang, C. (2011) · InTech eBooks · doi:10.5772/748 · Cited by 16
Liu, J., Xiao, Q., Zhou, R., Wang, Y., Xian, Q., Ma, T., Zhuang, K., Zhou, L., Guo, D., Wang, X., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00371 · Cited by 17
Mwale, A., Hummel, A., Mvaya, L., Kamng’ona, R., Chimbayo, E. T., Phiri, J., Malamba, R., Kankwatira, A., Mwandumba, H. C., & Jambo, K. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.12869.2 · Cited by 16
Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques
Calenda, G., Frank, I., Arrode-Bruses, G., Pegu, A., Wang, K., Arthos, J. A., Cicala, C., Rogers, K. A., Shirreff, L., Grasperge, B. F., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007776 · Cited by 16
Cavarelli, M., & Grand, R. L. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1765622 · Cited by 18
Ding, J., Tasker, C., Valere, K., Sihvonen, T., Descalzi‐Montoya, D. B., Lu, W., & Chang, T. L.-Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076038 · Cited by 16
A transcriptome-based model of central memory CD4 T cell death in HIV infection
Olvera-García, G., Aguilar-García, T., Gutiérrez-Jasso, F., Imaz-Rosshandler, I., Rangel‐Escareño, C., Orozco, L., Aguilar-Delfín, I., Vázquez-Pérez, J. A., Zúñiga, J., Pérez-Patrigeón, S., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-3308-8 · Cited by 16
Ikumi, N. M., & Ondondo, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00202 · Cited by 16
Clay, C. C., Rodrigues, D. S., Harvey, D. J., Leutenegger, C. M., & Esser, U. (2005) · Journal of Virology · doi:10.1128/jvi.79.21.13759-13768.2005 · Cited by 16
Petravic, J., Ribeiro, R. M., Casimiro, D. R., Mattapallil, J. J., Roederer, M., Shiver, J. W., & Davenport, M. P. (2008) · Journal of Virology · doi:10.1128/jvi.01596-08 · Cited by 16
The Immunology of Human Immunodeficiency Virus Infection
Moir, S. L., Connors, M., & Fauci, A. S. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00123-5 · Cited by 16
Mestecky, J. F. (2006) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2006.05.006 · Cited by 16
Shakirzyanova, M., Ren, W., Zhuang, K., Tasca, S., & Cheng‐Mayer, C. (2010) · Journal of Virology · doi:10.1128/jvi.01478-10 · Cited by 15
Systemic immune activation in HIV and potential therapeutic options
Sinha, B., & Rubens, M. (2014) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2014.890217 · Cited by 15
Boukadida, C., Peralta-Prado, A., Chávez-Torres, M., Romero-Mora, K. A., Rincón-Rubio, A., Ávila‐Ríos, S., Garrido-Rodríguez, D., Reyes‐Terán, G., & Pinto-Cardoso, S. M. (2024) · Microbiome · doi:10.1186/s40168-024-01925-7 · Cited by 15
Loftin, L. M., Kienzle, M. F., Yi, Y., & Collman, R. G. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-s1-s3 · Cited by 15
Mucosal immunity in HIV infection
George, M. D., & Asmuth, D. M. (2014) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000059 · Cited by 18
Loiseau, C., Réquena, M., Nayrac, M., Mavigner, M., Cazabat, M., Iscache, A.-L., Carrère, N., Suc, B., Alric, L., Izopet, J., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz123 · Cited by 15
Pharmacology of HIV Cure: Site of Action
Devanathan, A. S., & Cottrell, M. L. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2187 · Cited by 15
Bere, A., Denny, L., Burgers, W. A., & Passmore, J.-A. S. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03172.x · Cited by 15
Christensen, A. B., Dige, A. K., Vad‐Nielsen, J., Brinkmann, C. R., Bendix, M., Østergaard, L. J., Tolstrup, M., Søgaard, O. S., Rasmussen, T. A., Nyengaard, J. R., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/120605 · Cited by 15
Treatment of acute HIV-1 infection: are we getting there?
Cellerai, C., Little, S. J., & Loes, S. K. (2008) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3282f31d4b · Cited by 15
Mkhize, N. N., Gumbi, P. P., Liebenberg, L. J. P., Ren, Y., Smith, P., Denny, L., & Passmore, J.-A. S. (2010) · Journal of Virology · doi:10.1128/jvi.00518-10 · Cited by 15
Human immunodeficiency virus (HIV) in developing countries
French, N., Kaleebu, P., Pisani, E., & Whitworth, J. A. G. (2006) · Annals of Tropical Medicine and Parasitology · doi:10.1179/136485906x97390 · Cited by 15
Smith, P. D., & Wahl, S. W. (2005) · Elsevier eBooks · doi:10.1016/b978-012491543-5/50071-1 · Cited by 15
Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders
Byrnes, S. J., Angelovich, T. A., Busman‐Sahay, K., Cochrane, C. R., Roche, M., Estes, J. D., & Churchill, M. J. (2022) · Viruses · doi:10.3390/v14091997 · Cited by 13
HIV-associated mucosal gene expression
Voigt, R. M., Keshavarzian, A., Losurdo, J., Swanson, G. R., Siewe, B. T., Forsyth, C. B., French, A. L., Demarais, P., Engen, P. A., Raeisi, S., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000569 · Cited by 14
Zhang, L., Tian, R., Zheng, H., Pan, G., Tuo, X., Xia, H., Xia, X., Pang, W., & Zheng, Y. (2016) · Immunology · doi:10.1111/imm.12574 · Cited by 14
Multimodal analysis of drug transporter expression in gastrointestinal tissue
Thompson, C. G., Fallon, J. K., Mathews, M. M., Charlins, P., Remling‐Mulder, L., Kovářová, M., Adamson, L., Srinivas, N., Schauer, A. P., Sykes, C., et al. (2017) · AIDS · doi:10.1097/qad.0000000000001554 · Cited by 14
Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART
Rochat, M.-A., Schlaepfer, E., Kuster, S. P., Li, D., Audigé, A., Ivic, S., Fahrny, A., & Speck, R. F. (2018) · Virology Journal · doi:10.1186/s12985-018-1101-9 · Cited by 16
Macrophage Tropism in Pathogenic HIV-1 and SIV Infections
Moeser, M., Nielsen, J. R., & Joseph, S. (2020) · Viruses · doi:10.3390/v12101077 · Cited by 14
Rousseau, R. K., Walmsley, S. L., Lee, T., Rosenes, R., Reinhard, R. J., Malazogu, F., Benko, E., Huibner, S., Kovacs, C. M., Singer, J., et al. (2021) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002840 · Cited by 14
"Immune activation, aging and gender" and progression of liver disease.
Nasta, P. (2011) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 14
Kubo, M., Nishimura, Y., Shingai, M., Lee, W., Brenchley, J. M., Lafont, B. A. P., Buckler-White, A. J., Igarashi, T., & Martin, M. A. (2009) · Journal of Virology · doi:10.1128/jvi.02522-08 · Cited by 14
Investigation of Small Bowel Abnormalities in HIV-Infected Patients Using Capsule Endoscopy
Sakai, E., Higurashi, T., Ohkubo, H., Hosono, K., Ueda, A., Matsuhashi, N., & Nakajima, A. (2017) · Gastroenterology Research and Practice · doi:10.1155/2017/1932647 · Cited by 14
McCarty, B., Mwamzuka, M., Marshed, F., Generoso, M., Alvarez, P., Ilmet, T., Kravietz, A., Ahmed, A. A., Borkowsky, W., Unutmaz, D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01901 · Cited by 14
Gene Expression: the Key to Understanding HIV-1 Infection?
Judge, M. A., Parker, E., Naniche, D., & Souëf, P. N. L. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00080-19 · Cited by 14
Blood and Guts and HIV: Preferential HIV Persistence in GI Mucosa
Yukl, S. A., & Wong, J. K. (2008) · The Journal of Infectious Diseases · doi:10.1086/527325 · Cited by 14
Endogenous retroelement expression in the gut microenvironment of people living with HIV-1
Dopkins, N., Fei, T., Michael, S., Liotta, N., Guo, K., Mickens, K. L., Barrett, B. S., Bendall, M. L., Dillon, S. M., Wilson, C. C., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105133 · Cited by 13
Schultheiss, T., Schulte, R., Sauermann, U., Ibing, W., & Stahl‐Hennig, C. (2011) · Retrovirology · doi:10.1186/1742-4690-8-24 · Cited by 13
Lui, J. B., McGinn, L., & Chen, Z. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1117737 · Cited by 14
George, J., Wagner, W., Lewis, M. G., & Mattapallil, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/673815 · Cited by 13
Kaltsidis, H., Cheeseman, H. M., Kopycinski, J. T., Ashraf, A., Cashin‐Cox, M., Clark, L., Anjarwalla, I., Dally, L., Bergin, P. J., Spentzou, A., et al. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.05.007 · Cited by 13
General issues on microbial translocation in HIV-infected patients.
Novati, S., Sacchi, P., Cima, S., Zuccaro, V., Columpsi, P., Pagani, L., Filice, G., & Bruno, R. (2015) · PubMed · Cited by 13
Moodley, M., Moodley, J., & Naicker, T. (2020) · Pregnancy Hypertension · doi:10.1016/j.preghy.2020.03.007 · Cited by 13
Depincé-Berger, A.-E., Vergnon-Miszczycha, D., Girard, A., Fresard, A., Botelho-Nevers, É., Lambert, C., Tedesco, É. D., Genin, C., Pozzetto, B., Lucht, F., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0278-5 · Cited by 13
Dendritic cell type-specific HIV-1 activation in effector T cells
van der Sluis, R. M., van Capel, T. M. M., Speijer, D., Sanders, R. W., Berkhout, B., de Jong, E. C., Jeeninga, R. E., & van Montfort, T. (2015) · AIDS · doi:10.1097/qad.0000000000000637 · Cited by 12
Verhoeven, D. E., George, M. D., Hu, W. K., Dang, A. T., Smit‐McBride, Z., Reay, E., Macal, M., Fenton, A. N., Sankaran‐Walters, S., & Dandekar, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302415 · Cited by 12
Self-citationTargeting HIV-1 innate immune responses therapeutically
Ellegård, R., Shankar, E. M., & Larsson, M. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834970d8 · Cited by 12
Enterosgel: A Novel Organosilicon Enterosorbent with a Wide Range of Medical Applications
Nikolaev, V. G. (2010) · NATO science for peace and security series. A, Chemistry and biology · doi:10.1007/978-94-007-0217-2_21 · Cited by 12
Sakai, K., Gatanaga, H., Takata, H., Oka, S., & Takiguchi, M. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.01.013 · Cited by 12
van Marle, G., Sharkey, K. A., Gill, M. J., & Church, D. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075967 · Cited by 12
Centlivre, M., Sommer, P., Michel, M., Fang, R. H. T., Gofflo, S., Valladeau‐Guilemond, J., Schmitt, N., Wain–Hobson, S., & Sala, M. (2006) · AIDS · doi:10.1097/01.aids.0000216365.38572.2f · Cited by 12
Cui, J., Huang, D., & Zheng, Y. Z. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1210140 · Cited by 12
Nayrac, M., Réquena, M., Loiseau, C., Cazabat, M., Suc, B., Carrère, N., Barange, K., Alric, L., Martin‐Blondel, G., Izopet, J., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0286-6 · Cited by 17
Current advances and challenges in HIV-1 vaccines
Rodriguez-Chavez, I. R., Allen, M., Hill, E. L., Sheets, R., Pensiero, M. N., Bradac, J. A., & D’Souza, M. P. (2006) · Current HIV/AIDS Reports · doi:10.1007/s11904-006-0007-0 · Cited by 12
Gastrointestinal infections in the immunocompromised host
Mehta, S. J., & Fantry, L. E. (2005) · Current Opinion in Internal Medicine · doi:10.1097/00132980-200504000-00009 · Cited by 12
Kiene, M., Réthi, B., Jansson, M., Dillon, S. M., Lee, E., Lantto, R., Wilson, C. C., Pöhlmann, S., & Chiodi, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088195 · Cited by 12
Human thymic dendritic cells: Regulators of T cell development in health and HIV-1 infection
Evans, V. A., Cameron, P. U., & Lewin, S. R. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.016 · Cited by 12
Model refinement through high-performance computing: an agent-based HIV example
Perrin, D., Ruskin, H. J., & Crane, M. (2010) · Immunome Research · doi:10.1186/1745-7580-6-s1-s3 · Cited by 12
Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J., Chomont, N., Finzi, A., & Ancuța, P. (2024) · iScience · doi:10.1016/j.isci.2024.110670 · Cited by 15
Glavan, T., Gaulke, C. A., Hirao, L. A., Sankaran‐Walters, S., & Dandekar, S. (2015) · Journal of Medical Primatology · doi:10.1111/jmp.12187 · Cited by 11
Self-citationBranton, W. G., Fernandes, J. P., Mohammadzadeh, N., Doan, M. A. L., Laman, J. D., Gelman, B. B., Fagrouch, Z. C., Kondova, I. I., Mooij, P., Koopman, G., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.09.019 · Cited by 12
Moreno, E., Ron, R., & Villar, S. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1072655 · Cited by 11
HIV-1 and Its gp120 Inhibits the Influenza A(H1N1)pdm09 Life Cycle in an IFITM3-Dependent Fashion
Mesquita, M., Rodrigues, N. F., Sacramento, C. Q., Abrantes, J. L., Costa, E. D. A., Temerozo, J. R., Siqueira, M. M., Bou‐Habib, D. C., & Souza, T. M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101056 · Cited by 11
Chronically HIV-1 Infected Patients Exhibit Low Frequencies of CD25+ Regulatory T Cells
Ríos, C. M. R. (2012) · The Open Virology Journal · doi:10.2174/1874357901206010049 · Cited by 11
Acute HIV infection: the impact of anti-retroviral treatment on cellular immune responses
Hicks, C. B., Gay, C. L., & Ferrari, G. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03437.x · Cited by 11
Preferential and persistent impact of acute HIV-1 infection on CD4 + iNKT cells in colonic mucosa
Paquin‐Proulx, D., Lal, K. G., Phuang‐Ngern, Y., Creegan, M., Tokarev, A., Suhkumvittaya, S., Alrubayyi, A., Kroon, E. D. M. B., Pinyakorn, S., Slike, B. M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104721118 · Cited by 10
Imbalances of Gut-Homing CD4+ T-Cell Subsets in HIV-1–Infected Chinese Patients
Peng, Q., Wang, H., Wang, H., Li, X., Lu, X., Liu, L., Zhou, B., & Chen, Z. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318293a114 · Cited by 10
Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells
Yin, J., Dai, A., Kutzler, M. A., Shen, A., LeCureux, J., Lewis, M. G., Waldmann, T. A., Weiner, D. B., & Boyer, J. (2008) · AIDS · doi:10.1097/qad.0b013e32830efdae · Cited by 10
Shacklett, B. L., Ferre, A. L., & Kiniry, B. E. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000530 · Cited by 10
Breed, M. W., Jordan, A. P. O., Aye, P. P., Sugimoto, C., Alvarez, X. A., Kuroda, M. J., Pahar, B., Keele, B. F., Hoxie, J. A., & Lackner, A. A. (2013) · Journal of Virology · doi:10.1128/jvi.02126-13 · Cited by 10
Fukazawa, Y., Miyake, A., Ibuki, K., Inaba, K., Saito, N., Motohara, M., Horiuchi, R., Himeno, A., Matsuda, K., Matsuyama, M., et al. (2008) · Journal of Virology · doi:10.1128/jvi.02753-07 · Cited by 10
Choudhary, S. K., Walker, R. M., Powell, D. M., Planelles, V., Walsh, C. M., & Camerini, D. (2006) · Virology · doi:10.1016/j.virol.2006.04.037 · Cited by 10
The impact of viral and host elements on HIV fitness and disease progression
Henry, K. R., Weber, J., Quiñones‐Mateu, M. E., & Arts, E. J. (2007) · Current HIV/AIDS Reports · doi:10.1007/s11904-007-0006-9 · Cited by 10
Lundgren, J. D., Baxter, J., Deeks, S. G., & Lane, H. C. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833f2ed6 · Cited by 10
Recent trends in clinical trials of vaccines to prevent HIV/AIDS
Fast, P. (2006) · Current Opinion in HIV and AIDS · doi:10.1097/01.coh.0000232340.77790.7a · Cited by 10
Phelan, J. A., Abrams, W. R., Norman, R. G., Li, Y., Laverty, M., Corby, P. M. A., Jason, N., Neri, D., Barber, C. A., Aberg, J. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112901 · Cited by 9
The sooner the better: innate immunity as a path toward the HIV cure
Tomalka, J. A., Ghneim, K., Bhattacharyya, S., Aïd, M., Barouch, D. H., Sékaly, R., & Ribeiro, S. P. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.07.003 · Cited by 9
Residual Immune Activation and Latency
Bruzzesi, E., & Sereti, I. (2018) · Current topics in microbiology and immunology · doi:10.1007/82_2018_118 · Cited by 9
Wang, N., Chen, H., & Lin, T. (2022) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2022.11.010 · Cited by 9
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Metadata
- Authors
- Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S.
- Affiliations
- University of California, Davis (US)
- Departments of Medical Microbiology & Immunology
- The Permanente Medical Group Inc.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-11
- Volume
- 77
- Issue
- 21
- Pages
- 11708-11717
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC229357
- OpenAlex
- W2076120354
- Cited by
- 866
- References
- 24
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 23 · 2021: 27 · 2020: 21 · 2019: 26 · 2018: 26 · 2017: 32 · 2016: 42 · 2015: 45 · 2014: 48 · 2013: 62 · 2012: 60
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 61297, R01DK061297)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- HIV-1 infection, CD4+ T cell depletion, gut-associated lymphoid tissue, highly active antiretroviral therapy, CD4+ T cell recovery, jejunal biopsy, lymphocyte homing, nonprogressors, gene expression profiling, early treatment initiation
- MeSH terms
- Adult, Cell Movement, Chronic Disease, Female, Flow Cytometry, Humans, Immunohistochemistry, Jejunum, Lymphocyte Activation, Lymphoid Tissue, Male, Middle Aged, Time Factors, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, CD8-Positive T-Lymphocytes, CD4 Lymphocyte Count, Antiretroviral Therapy, Highly Active
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