Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia

Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832

Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease

Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786

Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection

Veazey, R. S., DeMaria, M. A., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998) · Science · doi:10.1126/science.280.5362.427 · Cited by 1,404

Immune control of HIV-1 after early treatment of acute infection

Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002

Programmed Death of T Cells in HIV-1 Infection

Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898

POPULATION BIOLOGY OF HIV-1 INFECTION: Viral and CD4 + T Cell Demographics and Dynamics in Lymphatic Tissues

Haase, A. T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.625 · Cited by 541

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

Ameisen, J. C., & Capron, A. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90092-8 · Cited by 527

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 472

Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315

Lederman, M. M., Connick, E., LANDAY, A. L., Kuritzkes, D. R., Spritzler, J., Clair, M. S., Kotzin, B. L., Fox, L. L., Heath-Chiozzi, M. E., Leonard, J. M., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/515591 · Cited by 425

Overview of the Mucosal Immune System

Brandtzaeg, P. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74529-4_2 · Cited by 274

Mucosal and Peripheral Lin − HLA-DR + CD11c/123 − CD13 + CD14 − Mononuclear Cells Are Preferentially Infected during Acute Simian Immunodeficiency Virus Infection

Moore, A. C., Bixler, S. L., Lewis, M. G., Verthelyi, D. I., & Mattapallil, J. J. (2011) · Journal of Virology · doi:10.1128/jvi.06372-11 · Cited by 27

Potential Implication of Residual Viremia in Patients on Effective Antiretroviral Therapy

Sahu, G. K. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0194 · Cited by 28

Isolating Mucosal Lymphocytes from Biopsy Tissue for Cellular Immunology Assays

Shacklett, B. L., Critchfield, J. W., & Lemongello, D. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-170-3_23 · Cited by 28

Impact of intensified antiretroviral therapy during early HIV infection on gut immunology and inflammatory blood biomarkers

Kim, C. J., Rousseau, R. K., Huibner, S., Kovacs, C. M., Benko, E., Shahabi, K., Kandel, G. P., Ostrowski, M., & Kaul, R. (2017) · AIDS · doi:10.1097/qad.0000000000001515 · Cited by 28

Probing the sequence space available for HIV-1 evolution

ter Brake, O., von Eije, K. J., & Berkhout, B. (2008) · AIDS · doi:10.1097/qad.0b013e328309efe3 · Cited by 28

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection

Ussher, J. E., Phalora, P. K., Cosgrove, C., Hannaway, R. F., Rauch, A., Günthard, H. F., Goulder, P., Phillips, R. E., Willberg, C. B., & Klenerman, P. (2015) · Medicine · doi:10.1097/md.0000000000001134 · Cited by 28

Blocking Type I Interferon Production: A New Therapeutic Option to Reduce the HIV-1-Induced Immune Activation

Ries, M., Pritschet, K., & Schmidt, B. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/534929 · Cited by 29

Anti‐retroviral therapy fails to restore the severe Th‐17: Tc‐17 imbalance observed in peripheral blood during simian immunodeficiency virus infection

Kader, M., Bixler, S. L., Piatak, M., Lifson, J. D., & Mattapallil, J. J. (2009) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2009.00373.x · Cited by 27

Use of predictive markers of HIV disease progression in vaccine trials

Gurunathan, S., Habib, R. E., Baglyos, L., Méric, C., Plotkin, S. A., Dodet, B., Corey, L., & TARTAGLIA, J. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.039 · Cited by 28

Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection

Kelleher, A. D., & Zaunders, J. J. (2006) · Current HIV/AIDS Reports · doi:10.1007/s11904-006-0002-5 · Cited by 27

Microbial Translocation and Metabolic and Body Composition Measures in Treated and Untreated HIV Infection

Timmons, T., Shen, C., Aldrovandi, G. M., Rollie, A., Gupta, S. K., Stein, J. H., & Dubé, M. P. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0162 · Cited by 27

Vaginal Protection and Immunity after Oral Immunization of Mice with a Novel Vaccine Strain ofListeria monocytogenesExpressing Human Immunodeficiency Virus Type 1gag

Zhao, X., Zhang, M., Li, Z., & Frankel, F. R. (2006) · Journal of Virology · doi:10.1128/jvi.00894-06 · Cited by 27

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection

Singh, V. B., Singh, M. V., Piekna‐Przybylska, D., Gorantla, S., Poluektova, L. Y., & Maggirwar, S. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-10241-0 · Cited by 27

Exosome release following activation of the dendritic cell immunoreceptor: A potential role in HIV-1 pathogenesis

Mfunyi, C. M., Vaillancourt, M., Vitry, J., Batomene, T.-R. N., Posvandzic, A., Lambert, A. A., & Gilbert, C. (2015) · Virology · doi:10.1016/j.virol.2015.05.013 · Cited by 28

Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals

Mela, C. M., Steel, A., Lindsay, J. O., Gazzard, B., Gotch, F. M., & Goodier, M. R. (2007) · AIDS · doi:10.1097/qad.0b013e3282f08b72 · Cited by 27

Behavioural, Mucosal and Systemic Immune Parameters in HIV-infected and Uninfected Injection Drug Users

Mehandru, S., & Deren, S. (2015) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000257 · Cited by 26

Preliminary in vivo efficacy studies of a recombinant rhesus anti-α4β7 monoclonal antibody

Pereira, L. E., Onlamoon, N., Wang, X., Wang, R., Li, J., Reimann, K. A., Villinger, F. J., Pattanapanyasat, K., Mori, K., & Ansari, A. A. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.06.012 · Cited by 26

Immune Activation Is Associated With Increased Gut Microbial Translocation in Treatment-Naive, HIV-Infected Children in a Resource-Limited Setting

Pilakka‐Kanthikeel, S., Kris, A., Selvaraj, A., Swaminathan, S., & Pahwa, S. G. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000096 · Cited by 26

Distinct roles of CD4+T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model

Nair, S., Bayer, W., Ploquin, M. J.-Y., Kassiotis, G., Hasenkrug, K. J., & Dittmer, U. (2011) · Retrovirology · doi:10.1186/1742-4690-8-76 · Cited by 27

Gene expression profiling of gut mucosa and mesenteric lymph nodes in simian immunodeficiency virus‐infected macaques with divergent disease course

George, M. D., Verhoeven, D. E., McBride, Z., & Dandekar, S. (2006) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2006.00180.x · Cited by 26

Long-Term Programming of Antigen-Specific Immunity from Gene Expression Signatures in the PBMC of Rhesus Macaques Immunized with an SIV DNA Vaccine

Belisle, S. E., Yin, J., Shedlock, D. J., Dai, A., Yan, J., Hirao, L. A., Kutzler, M. A., Lewis, M. G., Andersen, H., Lank, S. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019681 · Cited by 26

Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient

Cunha, M. D. P., Vilela, A. P. P., Molina, C. V., Acuña, S. M., Muxel, S. M., Barroso, V. D. M., Baroni, S., de Oliveira, L. G., Angelo, Y. D. S., Peron, J. P. S., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.760170 · Cited by 24

Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?

Mwimanzi, P., Markle, T. J., Ueno, T., & Brockman, M. A. (2012) · Viruses · doi:10.3390/v4091711 · Cited by 25

Antiretroviral Therapy Down-Regulates Innate Antiviral Response Genes in Patients With AIDS in Sub-Saharan Africa

Boulware, D. R., Meya, D. B., Bergemann, T. L., Williams, D. A., Louis, I. V.-S., Rhein, J., Staddon, J. H., Kambugu, A., Janoff, E. N., & Bohjanen, P. R. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181ef4963 · Cited by 25

A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract

Ruane, D., Do, Y., Brane, L., Garg, A., Bozzacco, L., Kraus, T., Caskey, M. F., Salazar, A. Μ., Trumpheller, C., & Mehandru, S. (2016) · Mucosal Immunology · doi:10.1038/mi.2015.133 · Cited by 25

Impact of antiretroviral therapy on viral tropism in HIV-infected patients followed longitudinally for over 5 years

Briz, V., Poveda, E., González, M. D. M., Martín‐Carbonero, L., González, R., & Soriano, V. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm469 · Cited by 25

Incomplete Normalization of Regulatory T-Cell Frequency in the Gut Mucosa of Colombian HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment

Rueda, C. M., Velilla, P. A., Chougnet, C. A., & Rugeles, M. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071062 · Cited by 24

Effects of viremia and CD4 recovery on gut “microbiome-immunity” axis in treatment-naïve HIV-1-infected patients undergoing antiretroviral therapy

Russo, E., Nannini, G., Sterrantino, G., Kiros, S. T., Pilato, V. D., Coppi, M., Baldi, S., Niccolai, E., Ricci, F., Ramazzotti, M., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i6.635 · Cited by 26

SARS-CoV-2 immunity and vaccine strategies in people with HIV

Mullender, C., da Costa, K., Alrubayyi, A., Pett, S. L., & Peppa, D. (2022) · Oxford Open Immunology · doi:10.1093/oxfimm/iqac005 · Cited by 23

In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model

Chono, H., Saito, N., Tsuda, H., Shibata, H., Ageyama, N., Terao, K., Yasutomi, Y., Mineno, J., & Kato, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023585 · Cited by 24

Heterogeneous Memory T Cells in Antiviral Immunity and Immunopathology

Verhoeven, D. E., Teijaro, J. R., & Färber, D. L. (2008) · Viral Immunology · doi:10.1089/vim.2007.0002 · Cited by 29

CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide

Cassol, E., Rossouw, T. M., Malfeld, S., Mahasha, P. W., Slavík, T., Seebregts, C. J., Bond, R. P., du Plessis, J., Janssen, C., Roskams, T., et al. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1176-5 · Cited by 24

Primary and Chronic HIV Infection Differently Modulates Mucosal Vδ1 and Vδ2 T-Cells Differentiation Profile and Effector Functions

Cimini, E., Agrati, C., D’Offizi, G., Vlassi, C., Casetti, R., Sacchi, A., Lionetti, R., Bordoni, V., Tumino, N., Scognamiglio, P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129771 · Cited by 24

Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure

Khan, S., Telwatte, S., Trapečar, M., Yukl, S. A., & Sanjabi, S. (2017) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2017.0153 · Cited by 27

Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection

Hudson, L. L., Markert, M. L., Devlin, B. H., Haynes, B. F., & Sempowski, G. D. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.002 · Cited by 24

The aftermath of the Merck's HIV vaccine trial

Iaccino, E., Schiavone, M., Fiume, G., Quinto, I., & Scala, G. (2008) · Retrovirology · doi:10.1186/1742-4690-5-56 · Cited by 24

Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection

Asowata, O. E., Singh, A., Ngoepe, A., Herbert, N. G., Fardoos, R., Reddy, K., Zungu, Y., Nene, F., Mthabela, N., Ramjit, D., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.146162 · Cited by 22

Comparative Transcriptional Analysis Identified Characteristic Genes and Patterns in HIV-Infected Immunological Non-Responders

Liu, X., Lin, L., Lu, L., Li, X., Han, Y., Qiu, Z., Li, X., Li, Y., Song, X., Cao, W., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.807890 · Cited by 23

TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4+ memory T cell loss in SIVmac251-challenged rhesus macaques

Sui, Y., Gagnon, S. J., Dzutsev, A. H., Zhu, Q., Yu, H., Hogg, A. E., Wang, Y., Xia, Z., Belyakov, I. M., Venzon, D. J., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.10.043 · Cited by 23

Endotoxin in the gut and chylomicrons: translocation or transportation?

Grünfeld, C., & Feingold, K. R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.e800018-jlr200 · Cited by 23

Low Levels of Microbial Translocation Marker LBP Are Associated with Sustained Viral Response after Anti-HCV Treatment in HIV-1/HCV Co-Infected Patients

Nyström, J., Stenkvist, J., Häggblom, A., Weiland, O., & Nowak, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118643 · Cited by 24

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

Breed, M. W., Elser, S. E., Torben, W., Jordan, A. P. O., Aye, P. P., Midkiff, C. C., Schiro, F. R., Sugimoto, C., Alvarez-Hernandez, X., Blair, R. V., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01134-15 · Cited by 23

Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection

van Marle, G., Church, D. L., Nunweiler, K. D., Cannon, K., Wainberg, M. A., & Gill, M. J. (2010) · Retrovirology · doi:10.1186/1742-4690-7-74 · Cited by 23

Preferential loss of gut-homing α4β7 CD4+ T cells and their circulating functional subsets in acute HIV-1 infection

Lu, X., Li, Z., Li, Q., Jiao, Y., Ji, Y., Zhang, H., Liu, Z., Li, W., & Wu, H. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.60 · Cited by 22

Antiretroviral Treatment Start-Time during Primary SIVmac Infection in Macaques Exerts a Different Impact on Early Viral Replication and Dissemination

Sellier, P., Mannioui, A., Bourry, O., Dereuddre‐Bosquet, N., Delache, B., Brochard, P., Calvo, J., Prevot, S., & Roques, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010570 · Cited by 22

Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women

Hirbod, T., Kimani, J., Tjernlund, A., Cheruiyot, J., Petrova, A., Ball, T. B., Mugo, N., Jaoko, W. G., Plummer, F. A., Kaul, R., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301220 · Cited by 22

Antiretroviral Therapy Restores Diversity in the T-Cell Receptor Vβ Repertoire of CD4 T-Cell Subpopulations among Human Immunodeficiency Virus Type 1-Infected Children and Adolescents

Yin, L., Kou, Z. C., Rodriguez, C. A., Hou, W., Goodenow, M. M., & Sleasman, J. W. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00074-09 · Cited by 22

Impaired CD4+ T-Cell Restoration in the Small Versus Large Intestine of HIV-1–Positive South Africans Receiving Combination Antiretroviral Therapy

Cassol, E., Malfeld, S., Mahasha, P. W., Bond, R. P., Slavík, T., Seebregts, C. J., Poli, G., Cassol, S. A., der Merwe, V., & Rossouw, T. M. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit249 · Cited by 22

Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells

Cao, S., Jiang, Y., Zhang, H., Kondza, N., & Woodrow, K. A. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.06.005 · Cited by 22

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

Deléage, C., Türkbey, B., & Estes, J. D. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.07.002 · Cited by 21

Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection

Naidoo, K. K., Ndumnego, O. C., Ismail, N., Dong, K. L., & Ndung’u, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738743 · Cited by 21

Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function

Littlefield, K. M., Schneider, J. M., Neff, C. P., Soesanto, V., Siebert, J., Nusbacher, N. M., Moreno-Huizar, N., Cartwright, I. M., Armstrong, A. J. S., Colgen, S. P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1072720 · Cited by 22

Predictors of Poor CD4 and Weight Recovery in HIV-Infected Children Initiating ART in South Africa

Zanoni, B. C., Phungula, T., Zanoni, H. M., France, H., Cook, E. F., & Feeney, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033611 · Cited by 21

HIV’s Nef Interacts with β-Catenin of the Wnt Signaling Pathway in HEK293 Cells

Weiser, K., Barton, M., Gershoony, D., DasGupta, R., & Cardozo, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077865 · Cited by 21

Synthetic Consensus HIV-1 DNA Induces Potent Cellular Immune Responses and Synthesis of Granzyme B, Perforin in HIV Infected Individuals

Morrow, M. P., Tebas, P., Yan, J., Ramirez, L., Slager, A. M., Kraynyak, K. A., Diehl, M. C., Shah, D., Khan, A. S., Lee, J., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.245 · Cited by 21

Shift in Monocyte Apoptosis with Increasing Viral Load and Change in Apoptosis-Related ISG/Bcl2 Family Gene Expression in Chronically HIV-1-Infected Subjects

Patro, S. C., Pal, S., Bi, Y., Lynn, K., Mounzer, K., Kostman, J. R., Davuluri, R. V., & Montaner, L. J. (2014) · Journal of Virology · doi:10.1128/jvi.02382-14 · Cited by 20

Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA

Shanmugasundaram, U., Kovářová, M., Ho, P. T., Schramm, N. J., Wahl, A. R., Parniak, M. A., & García, J. V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159517 · Cited by 21

Chronic HIV Infection Enhances the Responsiveness of Antigen Presenting Cells to Commensal Lactobacillus

Nagy, L. H., Grishina, I., Macal, M., Hirao, L. A., Hu, W. K., Sankaran‐Walters, S., Gaulke, C. A., Pollard, R. B., Brown, J., Suni, M. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072789 · Cited by 21

Early Treatment and HIV-1 Reservoirs: A Stitch in Time?

Henrich, T. J., & Gandhi, R. T. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit307 · Cited by 21

Clinical studies with chemokine receptor-5 (CCR5)-inhibitors

Boesecke, C., & Pett, S. L. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328356e933 · Cited by 20

Immunogenicity of a Vaccine Regimen Composed of Simian Immunodeficiency Virus DNA, rMVA, and Viral Particles Administered to Female Rhesus Macaques via Four Different Mucosal Routes

Manrique, M. L., Kozlowski, P. A., Cobo-Molinos, A., Wang, S.-W., Wilson, R. L., Montefiori, D. C., Carville, A., & Aldovini, A. (2013) · Journal of Virology · doi:10.1128/jvi.03531-12 · Cited by 20

Resistance to Infection, Early and Persistent Suppression of Simian Immunodeficiency Virus SIVmac251Viremia, and Significant Reduction of Tissue Viral Burden after Mucosal Vaccination in Female Rhesus Macaques

Manrique, M. L., Kozlowski, P. A., Cobo-Molinos, A., Wang, S.-W., Wilson, R. L., Viedma, M. D. P. M., Montefiori, D. C., Carville, A., & Aldovini, A. (2013) · Journal of Virology · doi:10.1128/jvi.02523-13 · Cited by 20

Short Conserved Sequences of HIV-1 Are Highly Immunogenic and Shift Immunodominance

Yang, O. O., Ali, A., Kasahara, N., Faure-Kumar, E., Bae, J. Y., Picker, L. J., & Park, H. (2014) · Journal of Virology · doi:10.1128/jvi.02370-14 · Cited by 20

Old World Monkeys and New Age Science: The Evolution of Nonhuman Primate Systems Virology

Palermo, R. E., Tisoncik-Go, J., Korth, M. J., & Katze, M. G. (2013) · ILAR Journal · doi:10.1093/ilar/ilt039 · Cited by 20

Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys

Chan, M. L., Petravic, J., Ortiz, A. M., Engram, J. C., Paiardini, M., Cromer, D., Silvestri, G., & Davenport, M. P. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.0972 · Cited by 20

Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection

Mak, G., Zaunders, J. J., Bailey, M., Seddiki, N., Rogers, G. B., Leong, L. E. X., Phan, T. G., Kelleher, A. D., Koelsch, K. K., Boyd, M. A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688886 · Cited by 20

Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections

Estes, J. D. (2009) · Current HIV/AIDS Reports · doi:10.1007/s11904-009-0005-0 · Cited by 20

Impact of γ‐chain cytokines on T cell homeostasis in HIV‐1 infection: therapeutic implications

Gougeon, M., & Chiodi, F. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02221.x · Cited by 23

The use of BLT humanized mice to investigate the immune reconstitution of the gastrointestinal tract

Wahl, A. R., & García, J. V. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.06.009 · Cited by 20

Possible Correlates of Long-Term Protection againstHelicobacter pylorifollowing Systemic or Combinations of Mucosal and Systemic Immunizations

Taylor, J. M., Ziman, M. E., Fong, J. M., Solnick, J. V., & Vajdy, M. (2007) · Infection and Immunity · doi:10.1128/iai.01470-06 · Cited by 20

Decreased NK Cell FcRγ in HIV-1 Infected Individuals Receiving Combination Antiretroviral Therapy: a Cross Sectional Study

Leeansyah, E., Zhou, J., Paukovics, G., Lewin, S. R., Crowe, S. M., & Jaworowski, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009643 · Cited by 20

Immune reconstitution inflammatory syndrome in association with HIV/AIDS and tuberculosis: Views over hidden possibilities

Shankar, E. M., Vignesh, R., Murugavel, K. G., Balakrishnan, P., Sekar, R., Lloyd, C., Solomon, S., & Kumarasamy, N. (2007) · AIDS Research and Therapy · doi:10.1186/1742-6405-4-29 · Cited by 20

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues

Denton, P. W., Søgaard, O. S., & Tolstrup, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01956 · Cited by 19

Editing out HIV: application of gene editing technology to achieve functional cure

Xun, J., Zhang, X., Guo, S., Lu, H., & Chen, J. (2021) · Retrovirology · doi:10.1186/s12977-021-00581-1 · Cited by 22

Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections

Rocha, C. S., Alexander, K. L., Herrera, C., Weber, M. G., Grishina, I., Hirao, L. A., Kramer, D. J., Arredondo, J., Mende, A., Crakes, K. R., et al. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.01.011 · Cited by 18

Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond

Shacklett, B. L. (2018) · Current Immunology Reviews · doi:10.2174/1573395514666180528081204 · Cited by 21

The pathogenesis of HIV infection: stupid may not be so dumb after all

Smith, S. M. (2006) · Retrovirology · doi:10.1186/1742-4690-3-60 · Cited by 19

Preferential Cytolysis of Peripheral Memory CD4 + T Cells by In Vitro X4-Tropic Human Immunodeficiency Virus Type 1 Infection before the Completion of Reverse Transcription

Zhou, Y., Shen, L., Yang, H., & Siliciano, R. F. (2008) · Journal of Virology · doi:10.1128/jvi.00773-08 · Cited by 19

Immune Modulators of HIV Infection: The Role of Reactive Oxygen Species

Salmen, S., & Berrueta, L. (2012) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000121 · Cited by 19

Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T‐cell restoration during antiretroviral therapy

Verhoeven, D. E., Sankaran, S., & Dandekar, S. (2007) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2007.00239.x · Cited by 19

Adaptation of HIV-1 Depends on the Host-Cell Environment

van Opijnen, T., de Ronde, A., Boerlijst, M. C., & Berkhout, B. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000271 · Cited by 19

Prime-boost immunization strategies against HIV-1

Bråve, A. (2007) · Figshare · Cited by 19

Early Short-Term Antiretroviral Therapy Is Associated with a Reduced Prevalence of CD8 + FoxP3 + T Cells in Simian Immunodeficiency Virus-Infected Controller Rhesus Macaques

George, J., Cofano, E. B., Lybarger, E. A., Louder, M. K., Lafont, B. A. P., Mascola, J. R., Robert-Guroff, M., & Mattapallil, J. J. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0251 · Cited by 18

Differential Effects of Viremia and Microbial Translocation on Immune Activation in HIV-Infected Patients Throughout Ritonavir-Boosted Darunavir Monotherapy

BenMarzouk‐Hidalgo, O. J., Torres-Cornejo, A., Gutiérrez‐Valencia, A., Ruiz-Valderas, R., Viciana, P., & López-Cortés, L. F. (2015) · Medicine · doi:10.1097/md.0000000000000781 · Cited by 18

Integrin α4β7 in HIV-1 infection: A critical review

Liu, Q., & Lusso, P. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0120-208r · Cited by 18

Detection of HIV-1 RNA/DNA and CD4 mRNA in feces and urine from chronic HIV-1 infected subjects with and without anti-retroviral therapy

Chakrabarti, A. K., Caruso, L., Ding, M., Shen, C., Buchanan, W., Gupta, P., Rinaldo, C. R., & Chen, Y. (2009) · AIDS Research and Therapy · doi:10.1186/1742-6405-6-20 · Cited by 18

Estimating the Infectivity of CCR5-Tropic Simian Immunodeficiency Virus SIV mac251 in the Gut

Wilson, D. P., Mattapallil, J. J., Lay, M. D. H., Zhang, L., Roederer, M., & Davenport, M. P. (2007) · Journal of Virology · doi:10.1128/jvi.01771-06 · Cited by 18

HIV-1 Infection and the Aging of the Immune System: Facts, Similarities and Perspectives

Biasi, S. D., Pinti, M., Nasi, M., Gibellini, L., Bertoncelli, L., Manzini, S., Mussini, C., & Cossarizza, A. (2011) · Journal of Experimental & Clinical Medicine · doi:10.1016/j.jecm.2011.06.001 · Cited by 17

Immune‐Based Therapy for HIV Infection: Are Acute and Chronic HIV Infection Different Diseases?

Hunt, P. W., & Deeks, S. G. (2006) · The Journal of Infectious Diseases · doi:10.1086/509627 · Cited by 17

Gut germinal center regeneration and enhanced antiviral immunity by mesenchymal stem/stromal cells in SIV infection

Weber, M. G., Walters-Laird, C. J., Kol, A., Rocha, C. S., Hirao, L. A., Mende, A., Balan, B., Arredondo, J., Elizaldi, S. R., Iyer, S. S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.149033 · Cited by 17

Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

Lim, H., Kim, K.-C., Son, J., Shin, Y., Yoon, C., Kang, C., & Choi, B. (2016) · Virus Research · doi:10.1016/j.virusres.2016.09.015 · Cited by 17

CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals

Zaunders, J. J., Danta, M., Bailey, M., Mak, G., Marks, K., Seddiki, N., Xu, Y., Templeton, D. J., Cooper, D. A., Boyd, M. A., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00438 · Cited by 17

Association Between CD4 Count and Chemoradiation Therapy Outcomes Among Cervical Cancer Patients With HIV

Grover, S., Mehta, P., Wang, Q., Bhatia, R. K., Bvochora-Nsingo, M. F., Davey, S. R., Iyengar, M., Shah, S., Shin, S. S., & Zetola, N. M. (2020) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002420 · Cited by 17

IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes

Papasavvas, E., Sun, J., Luo, Q., Moore, E. C., Thiel, B. D., MacGregor, R. R., Minty, A. J., Mounzer, K., Kostman, J. R., & Montaner, L. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5532 · Cited by 17

Chapter 9 HIV Induced AIDS and Related Cancers

Cadogan, M., & Dalgleish, A. G. (2008) · Advances in cancer research · doi:10.1016/s0065-230x(08)00409-0 · Cited by 17

HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies

Lau, J. S. Y., Lewin, S. R., & Telwatte, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1650852 · Cited by 19

Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research

Denton, P. W., Søgaard, O. S., & Tolstrup, M. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0807-y · Cited by 17

Walk on the wild side: SIV infection in African non-human primate hosts—from the field to the laboratory

Jasinska, A. J., Apetrei, C., & Pandrea, I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1060985 · Cited by 20

Severe intestinal barrier damage in HIV-infected immunological non-responders

Guo, X., Guo, Y., Wang, Z.-R., Jiao, Y., Hu, Y., Fan, L.-N., Cheng, R.-Q., Qu, M., Zhang, C., Song, J., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20790 · Cited by 16

Effects of Co-Trimoxazole on Microbial Translocation in HIV-1-Infected Patients Initiating Antiretroviral Therapy

Vesterbacka, J., Barqasho, B., Häggblom, A., & Nowak, P. (2015) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0366 · Cited by 17

Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection

Guadalupe, M., Sankaran, S., George, M. D., Reay, E., Verhoeven, D. E., Shacklett, B. L., Flamm, J., Wegelin, J. A., Prindiville, T. P., & Dandekar, S. (2006) · Journal of Virology · doi:10.1128/jvi.00120-06 · Cited by 248

Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses

Macal, M., Sankaran, S., Chun, T.-W., Reay, E., Flamm, J., Prindiville, T., & Dandekar, S. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.35 · Cited by 195

Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4 + T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells

Verhoeven, D. E., Sankaran, S., Silvey, M., & Dandekar, S. (2008) · Journal of Virology · doi:10.1128/jvi.02164-07 · Cited by 67

Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Mehandru, S., Poles, M. A., Tenner‐Racz, K., Jean-Pierre, P., Manuelli, V., Lopez, P., Shet, A., Low, A., Mohri, H., Boden, D., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030484 · Cited by 287

Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4 � T Lymphocytes from Effector Sites in the Gastrointestinal Tract

Meh, S., Poles, M. A., Tenner‐Racz, K., Horowitz, A., Hurley, A., Hogan, C., Boden, D., Rácz, P., & Markowitz, M. H. (2004)