Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice
Open accessAbstract
The apparent worldwide resurgence of invasive Streptococcus pyogenes infection in the last two decades remains unexplained. At present, animal models in which toxic shock-like syndrome or necrotizing fasciitis is induced after S. pyogenes infection are not well developed. We demonstrate here that infection with a nonlethal dose of influenza A virus 2 days before intranasal infection with a nonlethal dose of S. pyogenes strains led to a death rate of more than 90% in mice, 10% of which showed necrotizing fasciitis. Infection of lung alveolar epithelial cells by the influenza A virus resulted in viral hemagglutinin expression on the cell surface and promoted internalization of S. pyogenes. However, treatment with monoclonal antibodies to hemagglutinin markedly decreased this internalization. Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice.
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Some bacteria, such as group B Streptococci, contain sialic acid, which allows direct binding to viral hemagglutinin expressed by influenza-infected host cells.
“Alternatively some bacteria, i.e., group B Streptococci, contain sialic acid which allows for direct binding to the viral HA expressed by influenza infected host cells (Okamoto et al., 2003; Peltola and McCullers, 2004).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Okamoto et al., 2003
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- Authors
- Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K., & Hamada, S.
- Affiliations
- The University of Osaka (JP)
- Japan Science and Technology Agency (JP)
- Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871
- Osaka Prefectural Institute of Public Health (JP)
- Osaka Medical and Pharmaceutical University (JP)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-04
- Volume
- 77
- Issue
- 7
- Pages
- 4104-4112
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC150641
- OpenAlex
- W2143002313
- Cited by
- 114
- References
- 39
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 6
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Corporation
- Precursory Research for Embryonic Science and Technology
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Streptococcus pyogenes, invasive streptococcal infection, influenza A virus, viral-bacterial coinfection, necrotizing fasciitis, toxic shock-like syndrome, hemagglutinin, bacterial internalization, alveolar epithelial cells, monoclonal antibodies, synergistic infection, mouse model
- MeSH terms
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Cell Line, Female, Hemagglutinins, Viral, Humans, Influenza, Human, Mice, Inbred BALB C, Microscopy, Electron, Influenza A virus, Streptococcal Infections, Streptococcus pyogenes, Tumor Necrosis Factor-alpha, Virulence, Superinfection, Interleukin-6, Fasciitis, Necrotizing, Mice
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