Cited by 101HIV Research and TreatmentT-cell and B-cell ImmunologyT-cell and Retrovirus Studies

Kinetics of Virus-Specific CD8+T Cells and the Control of Human Immunodeficiency Virus Infection

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Davenport, Miles P., Ribeiro, Ruy M., Perelson, Alan S.·2004·Journal of Virology

Abstract

Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.

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Crossref · 10.1128/jvi.78.18.10096-10103.2004

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  • Memory T cells require an extended period of infection, 7-10 days, before controlling pathogen replication in murine tuberculosis and SIV macaque studies.

    “Studies of the ability of memory T cells to control viral and bacterial growth suggest that both CD4+ T cells (in murine tuberculosis42) and CD8+ T cells (in simian immunodeficiency virus infection of macaques43,44) require an extended period of infection (7–10 days) before they are mobilized to control pathogen replication.”

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Research works printed but not linked: 1

  1. [57]Zimmermann, C., A. Prevost-Blondel, C. Blaser, and H. Pircher. 1999. Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences. Eur. J. Immunol. 29:284-290. [DOI] [PubMed] [Google Scholar]

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Authors
Davenport, M. P., Ribeiro, R. M., & Perelson, A. S.
Affiliations
  • UNSW Sydney (AU)
  • Los Alamos National Laboratory (US)
Venue
Journal of Virology
Published
2004-09-15
Volume
78
Issue
18
Pages
10096-10103
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2093889144
Cited by
101
References
61
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
2.95
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Energy (W-7405, W-7405-ENG-36)
  • James S. McDonnell Foundation
  • National Institutes of Health (AI28433)
  • National Institute of Allergy and Infectious Diseases (R37AI028433, AI28433, R01AI028433)
  • National Center for Research Resources (RR 06555, R01RR006555)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
HIV infection, CD8+ T cells, cytotoxic T lymphocytes, vaccine-induced immunity, viral replication kinetics, viral load, persistent infection, HIV vaccine efficacy, disease progression
MeSH terms
Animals, Humans, Kinetics, Macaca mulatta, Time Factors, Virus Replication, Simian Immunodeficiency Virus, HIV-1, HIV Infections, Gene Products, gag, Immunodominant Epitopes, Simian Acquired Immunodeficiency Syndrome, AIDS Vaccines, CD8-Positive T-Lymphocytes, SAIDS Vaccines

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