The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Kinetics of Virus-Specific CD8+T Cells and the Control of Human Immunodeficiency Virus Infection
Open accessAbstract
Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.
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“Studies of the ability of memory T cells to control viral and bacterial growth suggest that both CD4+ T cells (in murine tuberculosis42) and CD8+ T cells (in simian immunodeficiency virus infection of macaques43,44) require an extended period of infection (7–10 days) before they are mobilized to control pathogen replication.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [43]
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Cites
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Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
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Self-citationDefective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
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Perils at mucosal front lines for HIV and SIV and their hosts
Haase, A. T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1706 · Cited by 436
Blanchet, F. P., Moris, A., Nikolic, D. S., Lehmann, M., Cardinaud, S., Stalder, R., Garcia, E., Dinkins, C., Leuba, F., Wu, L. J., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.011 · Cited by 307
Modeling the within-host dynamics of HIV infection
Perelson, A. S., & Ribeiro, R. M. (2013) · BMC Biology · doi:10.1186/1741-7007-11-96 · Cited by 293
Self-citationProspects for durable immune control of SARS-CoV-2 and prevention of reinfection
Cromer, D., Juno, J. A., Khoury, D., Reynaldi, A., Wheatley, A. K., Kent, S. J., & Davenport, M. P. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00550-x · Cited by 265
Self-citationRibeiro, R. M., Li, Q., Chavez, L. L., Li, D., Self, S. G., & Perelson, A. S. (2010) · Journal of Virology · doi:10.1128/jvi.00127-10 · Cited by 237
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Metadata
- Authors
- Davenport, M. P., Ribeiro, R. M., & Perelson, A. S.
- Affiliations
- UNSW Sydney (AU)
- Los Alamos National Laboratory (US)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-09-15
- Volume
- 78
- Issue
- 18
- Pages
- 10096-10103
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC515020
- OpenAlex
- W2093889144
- Cited by
- 101
- References
- 61
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy (W-7405, W-7405-ENG-36)
- James S. McDonnell Foundation
- National Institutes of Health (AI28433)
- National Institute of Allergy and Infectious Diseases (R37AI028433, AI28433, R01AI028433)
- National Center for Research Resources (RR 06555, R01RR006555)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- HIV infection, CD8+ T cells, cytotoxic T lymphocytes, vaccine-induced immunity, viral replication kinetics, viral load, persistent infection, HIV vaccine efficacy, disease progression
- MeSH terms
- Animals, Humans, Kinetics, Macaca mulatta, Time Factors, Virus Replication, Simian Immunodeficiency Virus, HIV-1, HIV Infections, Gene Products, gag, Immunodominant Epitopes, Simian Acquired Immunodeficiency Syndrome, AIDS Vaccines, CD8-Positive T-Lymphocytes, SAIDS Vaccines
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