The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages
Open accessAbstract
Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-α/β). However, recombinant HRSV lacking the NS1 and NS2 genes (ΔNS1/2) induced high levels of IFN-α and -β in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary human peripheral blood monocytes. Results with NS1 and NS2 single- and double-gene-deletion viruses indicated that the two proteins function independently as well as coordinately to achieve the full inhibitory effect, with NS1 having a greater independent role. The relative contributions of the individual NS proteins were the converse of that recently described for bovine RSV (J. F. Valarcher, J. Furze, S. Wyld, R. Cook, K. K. Conzelmann, and G. Taylor, J. Virol. 77:8426-8439, 2003). This pattern of inhibition by HRSV NS1 and NS2 also extended to the newly described antiviral cytokines IFN-λ1, -2 and -3.
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Cites
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F., Dickensheets, H., & Donnelly, R. P. (2003) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,868
IL-28, IL-29 and their class II cytokine receptor IL-28R
Sheppard, P., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T. E., Kuestner, R., Garrigues, U., Birks, C., Roraback, J., et al. (2003) · Nature Immunology · doi:10.1038/ni873 · Cited by 1,570
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Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
Goodbourn, S., Didcock, L., & Randall, R. E. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-10-2341 · Cited by 977
Biron, C. A. (1998) · Seminars in Immunology · doi:10.1006/smim.1998.0138 · Cited by 341
Wright, P. F., Karron, R. A., Belshe, R. B., Thompson, J., Crowe, Jr., Boyce, T. G., Halburnt, L. L., Reed, G. W., Whitehead, S. S., Anderson, E. L., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315859 · Cited by 307
The function of type I interferons in antimicrobial immunity
Bogdan, C. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00111-4 · Cited by 276
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Cited by
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
Weiss, S. R., & Navas-Martin, S. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.4.635-664.2005 · Cited by 1,256
Role of deficient type III interferon-λ production in asthma exacerbations
Contoli, M., Message, S. D., Laza-Stanca, V., Edwards, M. R., Wark, P. A. B., Bartlett, N. W., Kebadze, T., Mallia, P., Stanciu, L. A., Parker, H. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1462 · Cited by 1,006
Liu, P., Jamaluddin, M., Li, K., Garofalo, R. P., Casola, A., & Brasier, A. R. (2007) · Journal of Virology · doi:10.1128/jvi.01740-06 · Cited by 320
Lo, M. S., Brazas, R. M., & Holtzman, M. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9315-9319.2005 · Cited by 284
Bovine respiratory syncytial virus infection
Valarcher, J.-F., & Taylor, G. (2007) · Veterinary Research · doi:10.1051/vetres:2006053 · Cited by 267
Metadata
- Authors
- Spann, K. M., Tran, K.-C., Chi, B., Rabin, R. L., & Collins, P. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-04-15
- Volume
- 78
- Issue
- 8
- Pages
- 4363-4369
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2104898251
- Cited by
- 447
- References
- 27
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Spann, K. M., Tran, K.-C., Chi, B., Rabin, R. L., & Collins, P. L. (2004). Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages. Journal of Virology. https://doi.org/10.1128/jvi.78.8.4363-4369.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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