Stress-Induced Loss of Heterozygosity in Candida : a Possible Missing Link in the Ability to Evolve
Open accessAbstract
Diploid organisms are buffered against the effects of mutations by carrying two sets of each gene, which allows compensation if one is mutated. But recombination between "mom" and "dad" chromosomes causes loss of heterozygosity (LOH), stretches of "mom-only" or "dad-only" DNA sequence, suddenly revealing effects of mutations accumulated in entire chromosome arms. LOH creates new phenotypes from old mutations, drives cancer development and evolution, and, in a new study by Forche et al., is shown to be induced by stress in Candida albicans [Forche A, et al, mBio 2(4):e00129-11, 2011]. Stress-induced LOH could speed evolution of Candida specifically when it is poorly adapted to its environment. Moreover, the findings may provide a missing link between recombination-dependent mutagenesis in bacteria and yeast, suggesting that both might be stress induced, both maximizing genetic variation when populations could benefit most from diversity.
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C. albicans lab isolates likely undergo a stress-induced elevation of mutation and mitotic recombination rates.
“Third, C. albicans lab isolates likely undergo a stress-induced elevation of mutation and mitotic recombination rates (Ponder et al., 2005; Forche et al., 2011; Rosenberg, 2011)”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Rosenberg, 2011
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Cites
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612 · see citing works
The growth of biological thought. Diversity, evolution, and inheritance
Farner, D. S. (1983) · The Auk · doi:10.1093/auk/100.2.507 · Cited by 2,511 · see citing works
The Growth of Biological Thought: Diversity, Evolution, and Inheritance
Mayr, E. (1982) · CERN Document Server (European Organization for Nuclear Research) · Cited by 2,295 · see citing works
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
Cavenee, W. K., Dryja, T. P., Phillips, R. A., Benedict, W. F., Godbout, R., Gallie, B. L., Murphree, A. L., Strong, L. C., & White, R. L. (1983) · Nature · doi:10.1038/305779a0 · Cited by 1,919 · see citing works
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by Mutagenesis
Radman, M. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2895-7_48 · Cited by 666 · see citing works
Mutation as a Stress Response and the Regulation of Evolvability
Galhardo, R. S., Hastings, P. J., & Rosenberg, S. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648502 · Cited by 643 · see citing works
Break-induced replication: What is it and what is it for?
Llorente, B., Smith, C. E., & Symington, L. S. (2008) · Cell Cycle · doi:10.4161/cc.7.7.5613 · Cited by 313 · see citing works
Break-Induced Replication Is Highly Inaccurate
Deem, A. K., Keszthelyi, A., Blackgrove, T., Vayl, A., Coffey, B. M., Mathur, R., Chabes, A., & Malkova, A. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000594 · Cited by 297 · see citing works
DNA synthesis errors associated with double-strand-break repair.
Strathern, J. N., Shafer, B. K., & McGill, C. B. (1995) · Genetics · doi:10.1093/genetics/140.3.965 · Cited by 282 · see citing works
Recombination in adaptive mutation.
Harris, R. S., Longerich, S., & Rosenberg, S. (1994) · Science · doi:10.1126/science.8146657 · Cited by 261 · see citing works
Ponder, R. G., Fonville, N. C., & Rosenberg, S. M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.025 · Cited by 257 · see citing works
Self-citationStress Alters Rates and Types of Loss of Heterozygosity in Candida albicans
Forche, A., Abbey, D., Pisithkul, T., Weinzierl, M. A., Ringstrom, T., Bruck, D., Petersen, K., & Berman, J. (2011) · mBio · doi:10.1128/mbio.00129-11 · Cited by 234 · see citing works
Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion
Hicks, W. M., Kim, M., & Haber, J. E. (2010) · Science · doi:10.1126/science.1191125 · Cited by 233 · see citing works
Adaptive mutation by deletions in small mononucleotide repeats.
Rosenberg, S. M., Longerich, S., Gee, P., & Harris, R. S. (1994) · Science · doi:10.1126/science.8023163 · Cited by 229 · see citing works
An Age-Induced Switch to a Hyper-Recombinational State
McMurray, M. A., & Gottschling, D. E. (2003) · Science · doi:10.1126/science.1087706 · Cited by 208 · see citing works
A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiae
Holbeck, S. L., & Strathern, J. N. (1997) · Genetics · doi:10.1093/genetics/147.3.1017 · Cited by 198 · see citing works
Mechanisms that rapidly reorganize the genome
McClintock, B. (1978) · Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) · Cited by 196 · see citing works
Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms
Jarosz, D. F., Taipale, M., & Lindquist, S. (2010) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090412 · Cited by 179 · see citing works
Yang, Y., Sterling, J. F., Storici, F., Resnick, M. A., & Gordenin, D. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000264 · Cited by 145 · see citing works
Control of recA gene RNA in E. coli: Regulatory and signal genes
McPartland, A., Green, L., & Echols, H. (1980) · Cell · doi:10.1016/0092-8674(80)90319-0 · Cited by 136 · see citing works
Shee, C., Gibson, J. L., Darrow, M. C., González, C., & Rosenberg, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104681108 · Cited by 120 · see citing works
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer
Pavelka, N., Rancati, G. I., & Li, R. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.06.003 · Cited by 110 · see citing works
Petrosino, J. F., Galhardo, R. S., Morales, L. D., & Rosenberg, S. M. (2009) · Journal of Bacteriology · doi:10.1128/jb.00732-09 · Cited by 96 · see citing works
Frisch, R. L., Su, Y., Thornton, P. C., Gibson, J. L., Rosenberg, S. M., & Hastings, P. J. (2010) · Journal of Bacteriology · doi:10.1128/jb.00570-10 · Cited by 51 · see citing works
Damage-induced localized hypermutability
Burch, L. H., Yang, Y., Sterling, J. F., Roberts, S. A., Chao, F., Xu, H., Zhang, L., Walsh, J. L., Resnick, M. A., Mieczkowski, P. A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.7.15319 · Cited by 50 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antifungal drug resistance among <i>Candida</i> species: mechanisms and clinical impact
Sanguinetti, M., Posteraro, B., & Lass‐Flörl, C. (2015) · Mycoses · doi:10.1111/myc.12330 · Cited by 394 · see citing works
The evolution of drug resistance in clinical isolates of Candida albicans.
Ford, C. B., Funt, J. M., Abbey, D., Issi, L., Guiducci, C., Martinez, D. A., Delorey, T., Li, B. Y., White, T. C., Cuomo, C., et al. (2015) · eLife · doi:10.7554/elife.00662 · Cited by 348 · see citing works
Lamour, K., Mudge, J., Gobena, D., Hurtado‐Gonzales, O. P., Schmutz, J., Kuo, A., Miller, N., Rice, B., Raffaele, S., Cano, L. M., et al. (2012) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-02-12-0028-r · Cited by 271 · see citing works
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
Ene, I. V., Farrer, R. A., Hirakawa, M. P., Agwamba, K., Cuomo, C. A., & Bennett, R. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806002115 · Cited by 155 · see citing works
Rosenberg, S. M., Shee, C., Frisch, R. L., & Hastings, P. J. (2012) · BioEssays · doi:10.1002/bies.201200050 · Cited by 116 · see citing works
Mechanisms of genome evolution in Candida albicans
Ene, I. V., Bennett, R. J., & Anderson, M. Z. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.05.001 · Cited by 46 · see citing works
Gunka, K., Stannek, L., Care, R. A., & Commichau, F. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066120 · Cited by 24 · see citing works
Correia, I., Wilson, D., Hube, B., & Plá, J. (2020) · Journal of Fungi · doi:10.3390/jof6040230 · Cited by 23 · see citing works
Hu, J. H., Shrestha, S. K., Zhou, Y., Mudge, J., Liu, X., & Lamour, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227250 · Cited by 19 · see citing works
Shee, C., Ponder, R. G., Gibson, J. L., & Rosenberg, S. M. (2011) · Microbial Physiology · doi:10.1159/000335354 · Cited by 19 · see citing works
Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · BMC Biology · doi:10.1186/s12915-023-01608-z · Cited by 18 · see citing works
Moorhouse, A. J., López, R. M., Gow, N. A. R., & Hijazi, K. (2021) · Journal of Oral Microbiology · doi:10.1080/20002297.2021.1894047 · Cited by 16 · see citing works
Increased diversity in the genus Debaryomyces from Arctic glacier samples
Jacques, N., Zenouche, A., Gunde‐Cimerman, N., & Casarégola, S. (2014) · Antonie van Leeuwenhoek · doi:10.1007/s10482-014-0345-7 · Cited by 16 · see citing works
Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression
Rosa, A. M., Dabas, N., Byrnes, D. M., Eller, M. S., & Grichnik, J. M. (2012) · Journal of Skin Cancer · doi:10.1155/2012/621968 · Cited by 13 · see citing works
Peters, M. J., Suwannapong, G., Pelin, A., & Corradi, N. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1268-z · Cited by 12 · see citing works
Sahoo, B., Goyal, R., Dutta, S., Joshi, P., & Sanyal, K. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5c00079 · Cited by 12 · see citing works
Li, M., Wang, W., Pang, Y., Domingo, J., Ali, J., Xu, J., Fu, B., Venus, E. B., & Li, Z. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00977 · Cited by 10 · see citing works
Satpati, S., Kodavati, M. M., Acharya, N., & Dixit, A. (2017) · Scientific Reports · doi:10.1038/srep41087 · Cited by 7 · see citing works
Bettauer, V., Massahi, S., Khurdia, S. S., Costa, A., Omran, R., Khosravi, N., Simpson, S., Harb, M., Dumeaux, V., Whiteway, M. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.21.914549 · Cited by 4 · see citing works
Duality Of Stochasticity And Natural Selection: A Cybernetic Evolution Theory
Heininger, K. (2015) · Cited by 2 · see citing works
Cauldron, N. C., Daniels, H. A., LeBoldus, J. M., & Grünwald, N. J. (2025) · Phytopathology · doi:10.1094/phyto-10-24-0329-fi · Cited by 1 · see citing works
Genetic and Genome Analyses of Native Populations of the Honeybee Pathogen Nosema ceranae
Peters, M. J. (2018) · uO Research (University of Ottawa) · doi:10.20381/ruor-22304
Samanta, I., & Bandyopadhyay, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815770-1.00026-2
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · UvA-DARE (University of Amsterdam) · doi:10.6084/m9.figshare.22807386
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Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · UvA-DARE (University of Amsterdam) · doi:10.6084/m9.figshare.22807353
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · UvA-DARE (University of Amsterdam) · doi:10.6084/m9.figshare.22807377
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807401
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807356
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807407
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807404
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807344
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807383
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807341
Mixão, V., Nunez‐Rodriguez, J. C., del Olmo, V., Księżopolska, E., Saus, E., Boekhout, T., Gácser, A., & Gabaldón, T. (2023) · Figshare · doi:10.6084/m9.figshare.22807365
- Authors
- Rosenberg, S. M.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Rosenberg, Susan M.
- ORCID
- Rosenberg, Susan M.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2011-11
- Volume
- 2
- Issue
- 5
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC3175628
- OpenAlex
- W2138925583
- Cited by
- 32
- References
- 25
- Citations by year
- 2025: 2 · 2023: 9 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Cancer Institute (DP1CA174424)
- National Institute of General Medical Sciences (R01GM53158, R01GM053158)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- loss of heterozygosity, Candida albicans, stress response, diploidy, recombination, genetic variation, evolution, mutagenesis
- MeSH terms
- Candida albicans, Stress, Physiological, Loss of Heterozygosity
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