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Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density
Abstract
Bacteria can be highly social, controlling collective behaviors via cell-cell communication mechanisms known as quorum sensing (QS). QS is now a large research field, yet a basic question remains unanswered: what is the environmental resolution of QS? The notion of a threshold, or “quorum,” separating coordinated ON and OFF states is a central dogma in QS, but recent studies have shown heterogeneous responses at a single cell scale.
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“From a single-cell level perspective, P. aeruginosa appears to have a graded quorum sensing response to changes in population density, with substantial heterogeneity in quorum sensing activation even at high-cell densities69,70.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [69]
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Burnham, K. P., Anderson, D. R., & Huyvaert, K. P. (2011) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-010-1029-6 · Cited by 4,104 · cited 1×
“To confirm the lack of threshold behavior we assessed alternate statistical 118 models including threshold functions, and found that a linear fit model supports the data better 119 than a step-function fit (AIC linear: 89, AIC step-function: 190; relative likelihood that the linear 120 model is the best fit compared t…”
CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
WADDINGTON, C. H. (1942) · Nature · doi:10.1038/150563a0 · Cited by 3,255
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Cited by
Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility
Letizia, M., Diggle, S. P., & Whiteley, M. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01193-8 · Cited by 231
Metadata
- Authors
- Rattray, J. B., Thomas, S. A., Wang, Y., Molotkova, E., Gurney, J., Varga, J. J., & Brown, S. P.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2022-06-28
- Volume
- 13
- Issue
- 3
- ISSN
- 2150-7511
- Cited by
- 49
- References
- 2
- Language
- en
- Licence
- creativecommons.org/licenses/by/4.0/ (vor)
- journals.asm.org/non-commercial-tdm-license (tdm)
- Funders
- National Science Foundation (DGE-1650044)
- Simons Foundation (396001)
- HHS | National Institutes of Health (1R21AI143296, 1R21AI156817)
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- Rattray, J. B., Thomas, S. A., Wang, Y., Molotkova, E., Gurney, J., Varga, J. J., & Brown, S. P. (2022). Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density. mBio. https://doi.org/10.1128/mbio.00745-22
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