Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi
Open accessAbstract
Antifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in the fungal community lack consensus, particularly for filamentous fungi, as they present further complexities when compared to single-celled microorganisms. Hence, with the aim to ensure consistency in the literature, in this Perspective article, we propose tailored definitions for tolerance and persistence in filamentous fungi and suggest methods to detect and investigate these phenomena in the laboratory.
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A drug that can kill at least 90% of spores in 24 h (MDK90 ≤ 24 h) of all isolates of a given species should be considered fungicidal.
“A paper proposes that a drug that can kill ≥90% of spores in 24 h (MDK90 ≤ 24 h) of all isolates of a given species should be considered fungicidal [42].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [42]
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- Authors
- Amich, J., Bromley, M., Goldman, G. H., & Valero, C.
- Affiliations
- Instituto de Salud Carlos III (ES)
- University of Manchester (GB)
- Universidade de São Paulo (BR)
- Corresponding author
- Amich, Jorge
- Bromley, Michael
- Goldman, Gustavo H.
- Valero, Clara
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2025-04-09
- Volume
- 16
- Issue
- 4
- Pages
- e0347524-e0347524
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC11980573
- OpenAlex
- W4407913755
- Cited by
- 14
- References
- 31
- Citations by year
- 2026: 9 · 2025: 5
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- antifungal tolerance, filamentous fungi, fungal pathogens, terminology, definitions, detection methods, antifungal resistance
- MeSH terms
- Antifungal Agents, Drug Tolerance, Fungi, Microbial Sensitivity Tests, Terminology as Topic, Drug Resistance, Fungal, Consensus
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