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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

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Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor

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Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

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Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway

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SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60

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BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways

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p53 Acetylation: Regulation and Consequences

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USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.

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Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

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USP7 Is a Master Regulator of Genome Stability

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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

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Modulation of the p53/MDM2 interplay by HAUSP inhibitors

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USP7 - a crucial regulator of cancer hallmarks

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Regulation of USP7: A High Incidence of E3 Complexes

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A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

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USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia

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Regulation of Mutant p53 Protein Expression

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Role of Deubiquitinating Enzymes in DNA Repair

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WP1130 increases doxorubicin sensitivity in hepatocellular carcinoma cells through usp9x-dependent p53 degradation

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The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers

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DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets

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USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells.

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Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

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14-3-3 Proteins Play a Role in the Cell Cycle by Shielding Cdt2 from Ubiquitin-Mediated Degradation

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Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

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Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1

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USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway

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CRL4Cdt2 E3 Ubiquitin Ligase and Proliferating Cell Nuclear Antigen (PCNA) Cooperate to Degrade Thymine DNA Glycosylase in S Phase

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USP7 enforces heterochromatinization of p53 target promoters by protecting SUV39H1 from MDM2-mediated degradation.

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Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

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Insights into regulators of p53 acetylation

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miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X-dependent degradation of p53 and regulation of autophagy

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The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

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The regulation of radiosensitivity by p53 and its acetylation

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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

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USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma

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Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma

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Cell Death and Deubiquitinases: Perspectives in Cancer

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Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

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Dying to Survive—The p53 Paradox

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Targeting ubiquitin specific protease 7 in cancer: A deubiquitinase with great prospects

Khusbu, F. Y., Chen, F., & Chen, H. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3336 · Cited by 36 · see citing works

USP7 Regulates Cytokinesis through FBXO38 and KIF20B

Georges, A. A., Coyaud, É., Marcon, E., Greenblatt, J. F., Raught, B., & Frappier, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-39368-y · Cited by 38 · see citing works

Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling

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USP7 manipulation by viral proteins

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Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode

Vainer, R., Cohen, S., Shahar, A., Zarivach, R., & Arbely, E. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.06.009 · Cited by 33 · see citing works

Nuclear Matrix Protein SMAR1 Represses c-Fos-mediated HPV18 E6 Transcription through Alteration of Chromatin Histone Deacetylation

Chakraborty, S., Das, K., Saha, S., Mazumdar, M., Manna, A., Chakraborty, S., Mukherjee, S., Khan, P., Adhikary, A., Mohanty, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.564872 · Cited by 32 · see citing works

Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218)

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Ubiquitin Regulation: The Histone Modifying Enzyme′s Story

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P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6

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FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7

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Termination of DNA replication forks: “Breaking up is hard to do”

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The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies

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Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers

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The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis

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Deubiquitylation and stabilization of ARMC5 by ubiquitin‐specific processing protease 7 (USP7) are critical for RCC proliferation

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Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach

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The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer

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Evaluating the Cellular Roles of the Lysine Acetyltransferase Tip60 in Cancer: A Multi-Action Molecular Target for Precision Oncology

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ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells

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TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer

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DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability

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Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancer

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A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection

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Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR Pathways

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USP7 protects TFEB from proteasome-mediated degradation

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TIPping the balance in adipogenesis

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Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway

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The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability

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Epstein–Barr Virus: Overcoming the DNA Damage Response

Frappier, L. (2019) · Future Virology · doi:10.2217/fvl-2019-0015 · Cited by 5 · see citing works

Targeting the Ubiquitin Proteasome System in Cancer

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Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to-mesenchymal transition

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HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins

Abdullah, O., & Alhosin, M. (2021) · Genes · doi:10.3390/genes13010042 · Cited by 3 · see citing works

Recent Progress of Ubiquitin-Specific-Processing Protease 7 Inhibitors

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Dynamic regulation of K33- and K48-linked ubiquitination of Tip60 by TRIM37 orchestrates host DNA damage response during Pseudomonas aeruginosa infection and recovery

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Functional Relevance of Deubiquitinases in Life and Disease

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p90 and UHRF1, Two Novel Regulators of the p53 Signaling Pathway

Dai, C. (2014) · doi:10.7916/d8sq8xcj

Structural Insight into the Mechanisms of Activation and Substrate Specificity of Human Deubiquitinating Enzyme USP7

Pozhidaeva, A. (2016) · OpenCommons at University of Connecticut (University of Connecticut)

DEUBIQUITINASES AND THEIR INHIBITORS: CHALLENGES AND RECENT ADVANCES

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Mdm2 restrains the activity of the CRL4 Cdt2 E3 ubiquitin ligase to promote cell cycle progression through the G2/M phasePreprint

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Interaction mechanisms of epigenetic integrator UHRF1 with TIP60 acetyltransferase

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Inhibition of UHRF1 protein by epigenetic partners and epi-drugs

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Ubiquitin’s code: UPS orchestrating DNA repair and genomic stability under genotoxic stress

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Role of the Histone Acetyl Transferase Tip60 in the p53 Pathway

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Ubiquitin-specific protease 7 (USP7): a key deubiquitinase governing tumor progression and therapeutic vulnerabilities

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Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage

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Negative Regulation of the Acetyltransferase TIP60-p53 Interplay by UHRF1 (Ubiquitin-like with PHD and RING Finger Domains 1)

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STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation

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