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Cited by 33

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Genetic Analysis of Myc and Telomerase Interactions In Vivo

Flores, Ignacio, Evan, Gerard, Blasco, María A.·2006·Molecular and Cellular Biology
DOI 10.1128/mcb.00543-06
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Abstract

Myc is a transcription factor with pleiotropic effects on tumorigenesis which are likely to be mediated by its target genes. A known Myc transcriptional target is the catalytic subunit of telomerase, Tert. However, the contribution of Tert activation to Myc-induced tumorigenesis in vivo remains unknown. In this study, we addressed the role of telomerase in Myc-induced skin papillomatosis by using compound mice with a switchable Myc gene, Inv-MycERTAM mice, in combination with either telomerase deficiency (Terc-/-) or telomerase overexpression (K5-mTert) in the skin. We first demonstrated that Myc activates telomerase in the skin. With Inv-MycERTAM x Terc-/- mice, we further showed that this telomerase activation is partially required to elicit a full hyperplastic Myc-induced response. The presence of critically short telomeres in late-generation Inv-MycERTAM x Terc-/- mice further reduced the skin lesion induced by Myc. On the other hand, telomerase overexpression in the skin of K5-mTert mice augments Myc-induced hyperplasia in the absence of changes in telomere length, suggesting a direct role of telomerase in the Myc protumorigenic response. Taken together, these results highlight telomerase as a mediator of Myc-induced papillomatosis and suggest telomerase as a putative therapeutic target for Myc-dependent lesions.

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Crossref · 10.1128/mcb.00543-06

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  • The level of mTERT protein over-expression achieved by using gene therapy vectors is in the same range of mTERT over-expression reached by classical mouse transgenesis, including the long-lived Sp53/Sp16/SARF/TgTERT mouse model.

    “This level of mTERT protein over-expression achieved by using gene therapy vectors is in the same range of mTERT over-expression reached by classical mouse transgenesis, including the long-lived Sp53/Sp16/SARF/TgTERT mouse model (Flores et al, 2006; Gonzalez-Suarez et al, 2001; Tomas-Loba et al, 2008).”

    From Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer (2012) · cites this paper as Flores et al, 2006

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Metadata

Authors
Flores, I., Evan, G., & Blasco, M. A.
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
2006-08-01
Volume
26
Issue
16
Pages
6130-6138
ISSN
1098-5549
DOI
10.1128/mcb.00543-06
Cited by
33
References
6
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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