MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
Open accessAbstract
MYC in human epidermal stem cells can stimulate differentiation rather than uncontrolled proliferation. This discovery was, understandably, greeted with scepticism by researchers. However, subsequent studies have confirmed that MYC can stimulate epidermal stem cells to differentiate and have shed light on the underlying mechanisms. Two concepts that are relevant to cancer have emerged: first, MYC regulates similar genes in different cell types, but the biological consequences are context-dependent; and second, MYC activation is not a simple 'on/off' switch - the cellular response depends on the strength and duration of MYC activity, which in turn is affected by the many cofactors and regulatory pathways with which MYC interacts.
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In an in vivo setting, c-Myc labels cells in the SGPZ and regulates both sebocyte proliferation and differentiation.
“In an in vivo setting, c-Myc labels cells in the SGPZ and regulates both sebocyte proliferation and differentiation31 (Supplementary Fig. 5a).”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [31]
The ‘Intersection of Myc with other regulatory molecules’ section reports that Myc stimulates proliferation in the sebaceous gland and promotes sebaceous-gland differentiation. The ‘Modulating Myc activity in the epidermis in vivo’ section also reports increased sebaceous differentiation after Myc activation in mice. Our copy does not identify c-Myc as a marker of cells in the SGPZ; the Introduction locates detected c-Myc protein in zones of the hair follicle instead. No page numbers were provided for these passages. (LLM, conf=0.87)
Experimental — accuracy not yet measuredc-Myc has been reported as a key regulator of differentiation in the SG in vivo.
“Accordingly, c-Myc has been reported as a key regulator of differentiation in the SG in vivo31, 33.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [31]
c-Myc is a fundamental factor that governs sebaceous gland expansion in vivo.
“A fundamental factor that governs SG expansion in vivo is c-Myc3, 29–31,.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [31]
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2007) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,781 · see citing works
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Wernig, M., Meissner, A., Foreman, R. K., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B., & Jaenisch, R. (2007) · Nature · doi:10.1038/nature05944 · Cited by 2,654 · see citing works
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030 · see citing works
Scratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930 · see citing works
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823 · see citing works
Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., & Evan, G. I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.10.1686 · Cited by 780 · see citing works
Role of integrins in regulating epidermal adhesion, growth and differentiation
Watt, F. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf399 · Cited by 647 · see citing works
Self-citationReversible Activation of c-Myc in Skin
Pelengaris, S., Littlewood, T. D., Khan, M., Elia, G., & Evan, G. I. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80350-0 · Cited by 469 · see citing works
Myc represses transcription through recruitment of DNA methyltransferase corepressor
Brenner, C., Deplus, R., Mirjolet, C., Loriot, A. E., Viré, E. A., Smet, C. D., Gutiérrez, A., Danovi, D., Bernard, D., Boon, T., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600509 · Cited by 443 · see citing works
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426 · see citing works
Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00703 · Cited by 425 · see citing works
Self-citationMYC recruits the TIP60 histone acetyltransferase complex to chromatin
Frank, S. R., Parisi, T., Taubert, S., Fernandez, P. C., Fuchs, M., Chan, H., Livingston, D. M., & Amati, B. B. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor861 · Cited by 402 · see citing works
Myc influences global chromatin structure
Knoepfler, P. S., Zhang, X.-Y., Cheng, P. F., Gafken, P. R., McMahon, S. B., & Eisenman, R. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601152 · Cited by 385 · see citing works
Contribution of stem cells and differentiated cells to epidermal tumours
Owens, D. M., & Watt, F. M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1096 · Cited by 346 · see citing works
Self-citationArnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341 · see citing works
Self-citationNon-melanoma skin cancer: what drives tumor development and progression?
Boukamp, P. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi123 · Cited by 341 · see citing works
c-Myc promotes differentiation of human epidermal stem cells
Gandarillas, A., & Watt, F. M. (1997) · Genes & Development · doi:10.1101/gad.11.21.2869 · Cited by 326 · see citing works
Self-citationJensen, K. B., & Watt, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601886103 · Cited by 321 · see citing works
Self-citationCoffey, R. J., Bascom, C. C., Sipes, N. J., Graves‐Deal, R., Weissman, B. E., & Moses, H. L. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3088 · Cited by 320 · see citing works
Deregulated expression of c-Myc depletes epidermal stem cells
Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318 · see citing works
Wu, S., Cetinkaya, C., Muñoz-Alonso, M. J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., León, J., & Larsson, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206145 · Cited by 314 · see citing works
Niemann, C., Owens, D. M., Hülsken, J., Birchmeier, W., & Watt, F. M. (2002) · Development · doi:10.1242/dev.129.1.95 · Cited by 298 · see citing works
Self-citationFrye, M., & Watt, F. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.027 · Cited by 278 · see citing works
Self-citationSecombe, J., Li, L., Carlos, L. S., & Eisenman, R. N. (2007) · Genes & Development · doi:10.1101/gad.1523007 · Cited by 277 · see citing works
Stem Cell Depletion Through Epidermal Deletion of Rac1
Benitah, S. A., Frye, M., Glogauer, M., & Watt, F. M. (2005) · Science · doi:10.1126/science.1113579 · Cited by 249 · see citing works
Self-citationA FoxO–Smad synexpression group in human keratinocytes
Gomis, R. R., Alarcón, C. R., He, W., Wang, Q., Seoane, J., Lash, A., & Massagué, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605333103 · Cited by 245 · see citing works
Silva-Vargas, V., Celso, C. L., Giangreco, A., Ofstad, T. A., Prowse, D. M., Braun, K. M., & Watt, F. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.013 · Cited by 237 · see citing works
Self-citationTranscriptional repression by Myc
Wanzel, M., Herold, S., & Eilers, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00003-5 · Cited by 216 · see citing works
Zahir, N., Lakins, J. N., Russell, A. J., Ming, W., Chatterjee, C., Rozenberg, G. I., Marinkovich, M. P., & Weaver, V. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302023 · Cited by 195 · see citing works
Epidermal stem cells: an update
Watt, F. M., Celso, C. L., & Silva-Vargas, V. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.006 · Cited by 193 · see citing works
Self-citationFrye, M., Gardner, C., Li, E. R., Arnold, I., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00462 · Cited by 187 · see citing works
Self-citationMore than just proliferation: Myc function in stem cells
Murphy, M., Wilson, A., & Trumpp, A. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.01.008 · Cited by 183 · see citing works
Pemphigus vulgaris identifies plakoglobin as key suppressor of c‐Myc in the skin
Williamson, L., Raess, N. A., Caldelari, R., Zakher, A., de Bruin, A., Posthaus, H., Bolli, R., Hunziker, T., Suter, M. M., & Müller, E. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601224 · Cited by 180 · see citing works
Function of the c-Myc oncoprotein in chromatin remodeling and transcription
Amati, B. B., Frank, S. R., Donjerković, D., & Taubert, S. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00020-8 · Cited by 169 · see citing works
Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?
Jones, P. H., Simons, B. D., & Watt, F. M. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.09.014 · Cited by 167 · see citing works
Self-citationDai, X., Schonbaum, C. P., Degenstein, L., Bai, W., Mahowald, A. P., & Fuchs, E. V. (1998) · Genes & Development · doi:10.1101/gad.12.21.3452 · Cited by 154 · see citing works
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707323104 · Cited by 152 · cited 1× · see citing works
“and, like OVOL1, it binds to and negatively regulates the MYC promote”
Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis
Chrostek, A., Wu, X.-W., Quondamatteo, F., Hu, R., Sanecka, A., Niemann, C., Langbein, L., Haase, I., & Brakebusch, C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00075-06 · Cited by 143 · see citing works
Control of transcription by Pontin and Reptin
Gallant, P. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.02.005 · Cited by 142 · see citing works
Gandarillas, A., Goldsmith, L. A., Gschmeissner, S., Leigh, I. M., & Watt, F. M. (1999) · Experimental Dermatology · doi:10.1111/j.1600-0625.1999.tb00350.x · Cited by 136 · see citing works
Self-citationAlexandrow, M. G., Kawabata, M., Aakre, M. E., & Moses, H. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3239 · Cited by 130 · see citing works
Terminal differentiation of lymphocytes depends on Blimp-1
Kallies, A., & Nutt, S. L. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.01.003 · Cited by 126 · see citing works
Nair, M., Teng, A., Bilanchone, V., Agrawal, A., Li, B., & Dai, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508196 · Cited by 125 · see citing works
Zanet, J., Pibre, S., Jacquet, C., Ramirez, A., de Alborán, I. M., & Gandarillas, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02298 · Cited by 123 · see citing works
Knies, U. E., Fox, S. B., Poulsom, R., Evan, G. I., & Harris, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3176 · Cited by 121 · see citing works
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
Gebhardt, A., Frye, M., Herold, S., Benitah, S. A., Braun, K., Samans, B., Watt, F. M., Elsässer, H.-P., & Eilers, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506057 · Cited by 118 · see citing works
Self-citationShh Controls Epithelial Proliferation via Independent Pathways that Converge on N-Myc
Mill, P., Mo, R., Hu, M., Dagnino, L., Rosenblum, N. D., & Hui, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.009 · Cited by 107 · see citing works
The c-myc oncogene in tumor progression.
Sj, G. (1993) · PubMed · Cited by 107 · see citing works
Senoo‐Matsuda, N., & Johnston, L. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709021104 · Cited by 101 · see citing works
Frye, M., Fisher, A. G., & Watt, F. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000763 · Cited by 100 · see citing works
Self-citationA Novel Transrepression Pathway of c-Myc
Satou, A., Taira, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104937200 · Cited by 96 · see citing works
Negative Control of the Myc Protein by the Stress-Responsive Kinase Pak2
Huang, Z., Traugh, J. A., & Bishop, J. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1582-1594.2004 · Cited by 85 · see citing works
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
Sumi, T., Tsuneyoshi, N., Nakatsuji, N., & Suemori, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210353 · Cited by 84 · see citing works
Etard, C., Gradl, D., Kunz, M., Eilers, M., & Wedlich, D. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.11.010 · Cited by 84 · see citing works
Óskarsson, T., Essers, M. A. G., Dubois, N. C., Offner, S. E., Dubey, C., Roger, C., METZGER, D., Chambon, P., Hümmler, E., Beard, P., et al. (2006) · Genes & Development · doi:10.1101/gad.381206 · Cited by 82 · see citing works
Omomyc expression in skin prevents Myc-induced papillomatosis
Soucek, L., Nasi, S., & Evan, G. I. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401443 · Cited by 77 · see citing works
Waikel, R. L., Wang, X., & Roop, D. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203040 · Cited by 76 · see citing works
A tumor-associated β1 integrin mutation that abrogates epithelial differentiation control
Evans, R. D., Perkins, V. C., Henry, A. J., Stephens, P. E., Robinson, M. K., & Watt, F. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209016 · Cited by 73 · see citing works
Self-citationGandarillas, A., & Watt, F. M. (1995) · PubMed · Cited by 71 · see citing works
Self-citationDefining the temporal requirements for Myc in the progression and maintenance of skin neoplasia
Flores, I., Murphy, D. J., Swigart, L. B., Knies, U. E., & Evan, G. I. (2004) · Oncogene · doi:10.1038/sj.onc.1207796 · Cited by 68 · see citing works
MYC levels govern hematopoietic tumor type and latency in transgenic mice
Smith, D. P., Bath, M. L., Metcalf, D., Harris, A. W., & Cory, S. (2006) · Blood · doi:10.1182/blood-2006-01-0172 · Cited by 67 · see citing works
Niemann, C., Owens, D. M., Schettina, P., & Watt, F. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3427 · Cited by 67 · see citing works
Self-citationCoffey, R. J., Bascom, C. C., Sipes, N. J., Graves‐Deal, R., Weissman, B. E., & Moses, H. L. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3088-3093.1988 · Cited by 66 · see citing works
Koster, M. I., Huntzinger, K. A., & Roop, D. R. (2002) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1523-1747.2002.19639.x · Cited by 65 · see citing works
E-cadherin repression contributes to c-Myc-induced epithelial cell transformation
Cowling, V. H., & Cole, M. D. (2006) · Oncogene · doi:10.1038/sj.onc.1210132 · Cited by 62 · see citing works
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells
CASTILHO, R. M., SQUARIZE, C. H., Patel, V., Millar, S. E., Zheng, Y., Molinolo, A., & Gutkind, J. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210322 · Cited by 56 · see citing works
Bull, J. J., Müller‐Röver, S., Patel, S. V., Chronnell, C. M. T., McKay, I. A., & Philpott, M. P. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.12771234.x · Cited by 48 · see citing works
Role of LIM Kinases in Normal and Psoriatic Human Epidermis
Honma, M., Benitah, S. A., & Watt, F. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-12-1173 · Cited by 48 · see citing works
Self-citationMyc lacks E2F1's ability to suppress skin carcinogenesis
Rounbehler, R. J., Schneider‐Broussard, R., Conti, C. J., & Johnson, D. G. (2001) · Oncogene · doi:10.1038/sj.onc.1204691 · Cited by 45 · see citing works
Genetic Analysis of Myc and Telomerase Interactions In Vivo
Flores, I., Evan, G. I., & Blasco, M. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00543-06 · Cited by 38 · see citing works
Miz1 is required for hair follicle structure and hair morphogenesis
Gebhardt, A., Kosan, C., Herkert, B., Möröy, T., Lutz, W., Eilers, M., & Elsässer, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.007104 · Cited by 34 · see citing works
Bull, J. J., Pelengaris, S., Hendrix, S., Chronnell, C. M. T., Khan, M., & Philpott, M. P. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06458.x · Cited by 32 · see citing works
Markova, N. G., Karaman‐Jurukovska, N., Pinkas-Sarafova, A., Marekov, L. N., & Simon, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700684 · Cited by 26 · see citing works
Hashiro, M., Matsumoto, K., Okumura, H., Hashimoto, K., & Yoshikawa, K. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90518-c · Cited by 25 · see citing works
Benitah, S. A., & Watt, F. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700738 · Cited by 19 · see citing works
Self-citationPattern of expression of c-Myc, Max and Bin1 in human anagen hair follicles
Barajon, I., Rumio, C., Donetti, E., Imberti, A., Brivio, M. F., & Castano, P. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04230.x · Cited by 13 · see citing works
Roberts, F. (1963) · BMJ · doi:10.1136/bmj.1.5330.603 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575 · see citing works
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270 · see citing works
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119 · see citing works
Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927 · see citing works
Cell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384 · see citing works
Self-citationThe circadian molecular clock creates epidermal stem cell heterogeneity
Janich, P., Pascual, G., Merlos-Suárez, A., Batlle, E., Ripperger, J., Albrecht, U., Cheng, H.-Y. M., Obrietan, K., Di Croce, L., & Benitah, S. A. (2011) · Nature · doi:10.1038/nature10649 · Cited by 326 · see citing works
Self-citationHuman keratinocytes are efficiently immortalized by a Rho kinase inhibitor
Chapman, S., Liu, X., Meyers, C., Schlegel, R., & McBride, A. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42297 · Cited by 314 · see citing works
THE CELL CYCLE AND MYC INTERSECT WITH MECHANISMS FOR PLURIPOTENCY AND REPROGRAMMING
Singh, A. M., & Dalton, S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.07.003 · Cited by 276 · see citing works
Wnt Signaling in Skin Development, Homeostasis, and Disease
Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268 · see citing works
RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis
Bid, H. K., Roberts, R. D., Manchanda, P. K., & Houghton, P. J. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0164 · Cited by 265 · see citing works
The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
Blanco, S., Kurowski, A., Nichols, J., Watt, F. M., Benitah, S. A., & Frye, M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002403 · Cited by 191 · see citing works
Self-citationEpidermal stem cell diversity and quiescence
Watt, F. M., & Jensen, K. B. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900033 · Cited by 187 · see citing works
Self-citationGrayson, A. R., Walsh, E. M., Cameron, M. J., Godec, J., Ashworth, T. D., Ambrose, J. M., Aserlind, A. B., Wang, H., Evan, G. I., Kluk, M., et al. (2013) · Oncogene · doi:10.1038/onc.2013.126 · Cited by 184 · see citing works
Fessing, M. Y., Mardaryev, A. N., Gdula, M. R., Sharov, A. A., Sharova, T. Y., Rapisarda, V., Gordon, K. B., Smorodchenko, A., Poterlowicz, K., Ferone, G., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201101148 · Cited by 166 · see citing works
Mazzone, M., Selfors, L. M., Albeck, J. G., Overholtzer, M., Šale, S., Carroll, D. L., Pandya, D., Lu, Y., Mills, G. B., Aster, J. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000896107 · Cited by 163 · see citing works
The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability
Hussain, S., Blanco, S., Nascimento, E. M., Dragoni, I., Kurowski, A., Gillich, A., Humphreys, P. D., & Frye, M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810180 · Cited by 145 · see citing works
Self-citationConcise Review: Control of Cell Fate Through Cell Cycle and Pluripotency Networks
Boward, B., Wu, T., & Dalton, S. (2016) · Stem Cells · doi:10.1002/stem.2345 · Cited by 132 · see citing works
Inoue, S., Hao, Z., Elia, A., Cescon, D. W., Zhou, L., Silvester, J., Snow, B. E., Harris, I. S., Sasaki, M., Li, W. Y., et al. (2013) · Genes & Development · doi:10.1101/gad.214577.113 · Cited by 132 · see citing works
Tang, S.-W., Chang, W.-H., Su, Y.-C., Chen, Y., Lai, Y.-H., Wu, P.-T., Hsu, C., Lin, W., Lai, M., & Lin, J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.07.038 · Cited by 131 · see citing works
p53/p63/p73 in the Epidermis in Health and DiseasePreprint
Botchkarev, V. A., & Flores, E. R. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015248 · Cited by 111 · see citing works
Inhibition of Notch Signaling Blocks Growth of Glioblastoma Cell Lines and Tumor Neurospheres
Chen, J., Kesari, S., Rooney, C., Strack, P. R., Chen, J., Shen, H., Wu, L., & Griffin, J. D. (2010) · Genes & Cancer · doi:10.1177/1947601910383564 · Cited by 104 · see citing works
Raf-1 Addiction in Ras-Induced Skin Carcinogenesis
Ehrenreiter, K., Kern, F., Velamoor, V., Meissl, K., Galabova‐Kovacs, G., Sibilia, M. C., & Baccarini, M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.008 · Cited by 103 · see citing works
A systems biology view of cancer
Laubenbacher, R., Hower, V., Jarrah, A. S., Torti, S. V., Shulaev, V., Mendes, P., Torti, F. M., & Akman, S. A. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.06.001 · Cited by 101 · see citing works
Myc's other life: stem cells and beyond
Laurenti, E., Wilson, A., & Trumpp, A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.09.006 · Cited by 101 · see citing works
Melnik, S., Werth, N., Boeuf, S., Hahn, E.-M., Gotterbarm, T., Anton, M., & Richter, W. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1187-z · Cited by 96 · see citing works
A Circadian Clock in HaCaT Keratinocytes
Spörl, F., Schellenberg, K., Blatt, T., Wenck, H., Wittern, K., Schrader, A., & Kramer, A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.315 · Cited by 94 · see citing works
Mishra, V. K., Wegwitz, F., Kosinsky, R. L., Sen, M., Baumgartner, R., Wulff, T., Siveke, J. T., Schildhaus, H., Najafova, Z., Kari, V., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx212 · Cited by 96 · see citing works
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer
Descargues, P., Sil, A. K., & Karin, M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.196 · Cited by 95 · see citing works
Yamada, Y., Hidaka, H., Seki, N., Yoshino, H., Yamasaki, T., Itesako, T., Nakagawa, M., & Enokida, H. (2012) · Cancer Science · doi:10.1111/cas.12072 · Cited by 93 · see citing works
Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex
Kuwahara, A., Hirabayashi, Y., Knoepfler, P. S., Taketo, M. M., Sakai, J., Kodama, T., & Gotoh, Y. (2010) · Development · doi:10.1242/dev.046417 · Cited by 93 · see citing works
The histone methyltransferase Setd8 acts in concert with c‐Myc and is required to maintain skin
Driskell, I. M., Oda, H., Blanco, S., Nascimento, E. M., Humphreys, P. D., & Frye, M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.421 · Cited by 91 · see citing works
Self-citationThe human papillomavirus E7 oncoprotein as a regulator of transcription
Songock, W. K., Kim, S., & Bodily, J. M. (2016) · Virus Research · doi:10.1016/j.virusres.2016.10.017 · Cited by 91 · see citing works
Santoro, A., Vlachou, T., Luzi, L., Melloni, G. E. M., Mazzarella, L., D’Elia, E., Xieraili, A., Pasi, C. E., Reavie, L. B., Bonetti, P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.071 · Cited by 88 · see citing works
miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration
Amelio, I., Lena, A. M., Viticchiè, G., Shalom‐Feuerstein, R., Terrinoni, A., Dinsdale, D. D., Russo, G., Fortunato, C., Bonanno, E., Spagnoli, L. G., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203134 · Cited by 88 · see citing works
c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis
Cottle, D. L., Kretzschmar, K., Schweiger, P. J., Quist, S. R., Gollnick, H. P., Natsuga, K., Aoyagi, S., & Watt, F. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.013 · Cited by 80 · see citing works
Self-citationThe cell cycle and pluripotency
Hindley, C. J., & Philpott, A. (2013) · Biochemical Journal · doi:10.1042/bj20121627 · Cited by 78 · see citing works
Wu, N., Rollin, J., Masse, I., Lamartine, J., & Gidrol, X. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328120 · Cited by 76 · see citing works
N6‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness
Lee, J., Wu, Y., Harada, B. T., Li, Y., Zhao, J. C., He, C., Ma, Y., & Wu, X. (2021) · The EMBO Journal · doi:10.15252/embj.2020106276 · Cited by 70 · see citing works
m6A RNA methylation impacts fate choices during skin morphogenesis
Xi, L., Carroll, T., Matos, I., Luo, J., Polak, L., Pasolli, H. A., Jaffrey, S. R., & Fuchs, E. V. (2020) · eLife · doi:10.7554/elife.56980 · Cited by 70 · see citing works
Nascimento, E. M., Cox, C. L., MacArthur, S., Hussain, S., Trotter, M. W. B., Blanco, S., Menon, S., Nichols, J., Kübler, B., Benitah, S. A., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2385 · Cited by 67 · see citing works
Self-citationManipulation of Epithelial Differentiation by HPV Oncoproteins
White, E. A. (2019) · Viruses · doi:10.3390/v11040369 · Cited by 65 · see citing works
Epidermal stem cells: location, potential and contribution to cancer
Ambler, C. A., & Määttå, A. (2008) · The Journal of Pathology · doi:10.1002/path.2468 · Cited by 63 · see citing works
Kwa, M. Q., Huynh, J., Aw, J., Zhang, L., Nguyen, T. U., Reynolds, E. C., Sweet, M. J., Hamilton, J. A., & Scholz, G. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589382 · Cited by 61 · see citing works
Role of -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and CancerPreprint
Watt, F. M., & Collins, C. A. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.011 · Cited by 61 · see citing works
Self-citationRing, N., Valdivieso, K., Grillari, J., Redl, H. R., & Ogrodnik, M. B. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.04.005 · Cited by 57 · see citing works
MYCgene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma
Toll, A., Salgado, R., Yébenes, M., Martín‐Ezquerra, G., Gilaberte, M., Baró, T., Solé, F. G., Alameda, F., Espinet, B., & Pujol, R. M. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09351.x · Cited by 60 · see citing works
An Adult Passive Transfer Mouse Model to Study Desmoglein 3 Signaling in Pemphigus Vulgaris
Schulze, K., Galichet, A., Sayar, B. S., Scothern, A., Howald, D., Zymann, H., Siffert, M., Zenhäusern, D., Bolli, R., Koch, P. J., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.299 · Cited by 57 · see citing works
Aberdam, D., Candi, E., Knight, R. A., & Melino, G. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.09.002 · Cited by 56 · see citing works
Biology of urothelial tumorigenesis: insights from genetically engineered mice
Wu, X. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-009-9189-4 · Cited by 56 · see citing works
Wells, J., Lee, B., Cai, A. Q., Karapetyan, A., Lee, W.-J., Rugg, E. L., Sinha, S., Nie, Q. H., & Dai, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008847 · Cited by 56 · see citing works
Transcription factors, chromatin and cancer.
Thorne, J., Campbell, M., & Turner, B. (2009) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2008.08.029 · Cited by 50 · see citing works
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
Feldman, A., Mukha, D., Maor, I. I., Sedov, E., Koren, E., Yosefzon, Y., Shlomi, T., & Fuchs, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-10261-6 · Cited by 52 · see citing works
Assessing the Impact of Polyethylene Nano/Microplastic Exposure on Human Vaginal Keratinocytes
Pontecorvi, P., Ceccarelli, S., Cece, F., Camero, S., Lotti, L. V., Niccolai, E., Nannini, G., Gerini, G., Anastasiadou, E., Scialis, E. S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411379 · Cited by 51 · see citing works
Disruption of Prostate Epithelial Differentiation Pathways and Prostate Cancer Development
Frank, S. B., & Miranti, C. K. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00273 · Cited by 50 · see citing works
C‐myc as a modulator of renal stem/progenitor cell population
Couillard, M., & Trudel, M. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21841 · Cited by 49 · see citing works
Thyroid hormone signaling controls hair follicle stem cell function
Contreras‐Jurado, C., Lorz, C., García-Serrano, L., Paramio, J. M., & Aranda, A. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1251 · Cited by 48 · see citing works
Cyclin E drives human keratinocyte growth into differentiation
Freije, A., Ceballos, L., Coisy‐Quivy, M., Barnes, L., Rosa‐Garrido, M., de Diego, E., Blanchard, J., & Gandarillas, A. (2012) · Oncogene · doi:10.1038/onc.2012.22 · Cited by 47 · see citing works
TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells
Sato, T. Z., Okumura, F., Ariga, T., & Hatakeyama, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.095273 · Cited by 46 · see citing works
PRMT7 promotes the growth of renal cell carcinoma through modulating the β-catenin/C-MYC axis
Liu, F., Wan, L., Zou, H., Pan, Z., Zhou, W., & Lu, X. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105686 · Cited by 45 · see citing works
From oncogene to tumor suppressor
Uribesalgo, I., Benitah, S. A., & Croce, L. D. (2012) · Cell Cycle · doi:10.4161/cc.19883 · Cited by 44 · see citing works
Self-citationAltered Histone Modifications in Cancer
Campbell, M. J., & Turner, B. M. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9967-2_4 · Cited by 43 · see citing works
Lorenzo‐Martín, L. F., Fernández-Parejo, N., Menacho-Márquez, M., Rodríguez‐Fdez, S., Robles‐Valero, J., Zumalave, S., Fabbiano, S., Pascual, G., Garcia-Pedrero, J. M., Abad, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18524-3 · Cited by 43 · see citing works
Self-citationNotch Signaling and the Developing Skin Epidermis
Massi, D., & Panelos, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0899-4_10 · Cited by 42 · see citing works
An Activating β1 Integrin Mutation Increases the Conversion of Benign to Malignant Skin Tumors
Ferreira, M. M., Fujiwara, H., Morita, K., & Watt, F. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3051 · Cited by 42 · see citing works
Self-citationIs Myc an Important Biomarker? Myc Expression in Immune Disorders and Cancer
Trop-Steinberg, S., & Azar, Y. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.06.007 · Cited by 39 · see citing works
Arasu, U. T., Deen, A. J., Pasonen‐Seppänen, S., Heikkinen, S., Lalowski, M. M., Kärnä, R., Härkönen, K., Mäkinen, P. I., Lázaro‐Ibáñez, E., Siljander, P. R. M., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03399-5 · Cited by 38 · see citing works
Epigenetic regulation of adult stem cell function
Rinaldi, L., & Benitah, S. A. (2014) · FEBS Journal · doi:10.1111/febs.12946 · Cited by 37 · see citing works
Self-citationChromatin regulators in mammalian epidermis
Frye, M., & Benitah, S. A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.009 · Cited by 35 · see citing works
Self-citationGenetically modified laboratory mice with sebaceous glands abnormalities
Ehrmann, C., & Schneider, M. R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2312-0 · Cited by 33 · see citing works
Normal and Neoplastic Growth Suppression by the Extended Myc Network
Wang, H., & Prochownik, E. (2022) · Cells · doi:10.3390/cells11040747 · Cited by 31 · see citing works
Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation
Berta, M., Baker, C. M., Cottle, D. L., & Watt, F. M. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900047 · Cited by 33 · see citing works
Self-citationUsing myc genes to search for stem cells in the ciliary margin of the Xenopus retina
Xue, X. Y., & Harris, W. A. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20887 · Cited by 33 · see citing works
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Mortimer, T., Zinna, V. M., Atalay, M., Laudanna, C., Deryagin, O., Posas, G., Smith, J. G., García-Lara, E., Vaca-Dempere, M., de Assis, L. V. M., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.04.013 · Cited by 32 · see citing works
Self-citationTranslation Regulation in Skin Cancer from a tRNA Point of View
Grafanaki, K., Anastasakis, D. G., Kyriakopoulos, G. C., Skeparnias, I., Georgiou, S., & Stathopoulos, C. (2018) · Epigenomics · doi:10.2217/epi-2018-0176 · Cited by 30 · see citing works
Post-translational control of Myc function during differentiation
Conacci‐Sorrell, M., & Eisenman, R. N. (2011) · Cell Cycle · doi:10.4161/cc.10.4.14794 · Cited by 29 · see citing works
MYC expression and distribution in normal mature lymphoid cells
Cattoretti, G. (2012) · The Journal of Pathology · doi:10.1002/path.4141 · Cited by 29 · see citing works
The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice
Li, G., Ye, Z., Shi, C., Sun, L. V., Han, M., Zhuang, Y., Xu, T., Zhao, S., & Wu, X. (2017) · Scientific Reports · doi:10.1038/srep45401 · Cited by 29 · see citing works
Singhal, S. S., Garg, R., Mohanty, A. R., Garg, P., Ramisetty, S. K., Mirzapoiazova, T., Soldi, R., Sharma, S., Kulkarni, P., & Salgia, R. (2023) · Cancers · doi:10.3390/cancers15112961 · Cited by 29 · see citing works
The role of intracellular protein O-glycosylation in cell adhesion and disease
Bektas, M., & Rubenstein, D. S. (2011) · Journal of Biomedical Research · doi:10.1016/s1674-8301(11)60031-6 · Cited by 28 · see citing works
Richards, H. W., & Medrano, E. E. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00534.x · Cited by 26 · see citing works
Guan, Y., Yang, Y. J., Nagarajan, P., & Ge, Y. (2020) · Experimental Dermatology · doi:10.1111/exd.14247 · Cited by 25 · see citing works
Molinuevo, R., Freije, A., de Pedro, I., Stoll, S. W., Elder, J., & Gandarillas, A. (2016) · Oncogene · doi:10.1038/onc.2016.262 · Cited by 25 · see citing works
Bernabé‐Rubio, M., Ali, S., Bhosale, P. G., Goss, G., Mobasseri, S. A., Tapia‐Rojo, R., Zhu, T., Hiratsuka, T., Battilocchi, M., Tomás, I. M., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01234-5 · Cited by 24 · see citing works
Self-citationc-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis
Lobo, V. J. S.-A., Fernández, L. C., Pau, E. C. D. S., Richart, L., Cobo, I., Cendrowski, J., Moreno‐Celis, U., del Pozo, N., Megı́as, D., Bréant, B., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312306 · Cited by 24 · see citing works
Kiuchi, M., Onodera, A., Kokubo, K., Ichikawa, T., Morimoto, Y., Kawakami, E., Takayama, N., Eto, K., Koseki, H., Hirahara, K., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201690 · Cited by 23 · see citing works
Peterson, C., Moore, R. F., Hicks, J. L., Morsberger, L. A., Marzo, A. M. D., Zou, Y. S., Eberhart, C. G., & Campbell, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168454 · Cited by 22 · see citing works
Lysyl Oxidase silencing impairs keratinocyte differentiation in a reconstructed‐epidermis model
Provost, G. S. L., Debret, R., Cenizo, V., Aimond, G., Pez, F., Kaniewski, B., André, V., & Sommer, P. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01135.x · Cited by 21 · see citing works
Ultimate Precision: Targeting Cancer but Not Normal Self-replication
Velcheti, V., Schrump, D. S., & Saunthararajah, Y. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_199753 · Cited by 20 · see citing works
Kusano, S., & Ikeda, M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008193 · Cited by 19 · see citing works
Human Embryonic and Mesenchymal Stem Cells Express Different Nuclear Proteomes
Jaishankar, A., Barthéléry, M., Freeman, W. M., Salli, U., Ritty, T. M., & Vrana, K. E. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0156 · Cited by 19 · see citing works
Lee, S. I., Roney, M. S. I., Park, J. H., Baek, J., Park, J., Kim, S. K., & Park, S. (2019) · The Prostate · doi:10.1002/pros.23779 · Cited by 19 · see citing works
Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer
Alameda, J. P., Gaspar, M., Ramı́rez, Á., Navarro, M., Page, A., Suárez-Cabrera, C., Fernández, M. G., Mérida‐Velasco, J. R., Paramio, J. M., García-Fernández, R. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8792 · Cited by 18 · see citing works
Wang, X., Langer, E. M., Daniel, C. J., Janghorban, M., Wu, V. F., Wang, X., & Sears, R. C. (2020) · Oncogenesis · doi:10.1038/s41389-020-00261-3 · Cited by 18 · see citing works
Seifi, A., Weaver, E. M., Whipple, M., Ikoma, M., Farrenberg, J., Huang, M.-L. W., & Vieira, J. (2010) · Virology · doi:10.1016/j.virol.2010.10.023 · Cited by 18 · see citing works
Ishitsuka, Y., Kawachi, Y., Taguchi, S., Maruyama, H., Fujisawa, Y., Furuta, J., Nakamura, Y., & Otsuka, F. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.74 · Cited by 18 · see citing works
Pammer, J., Rossiter, H., Bilban, M., Eckhart, L., Buchberger, M., Monschein, L., & Mildner, M. (2020) · Archives of Dermatological Research · doi:10.1007/s00403-020-02052-7 · Cited by 15 · see citing works
Schuler, N., Timm, S., & Rübe, C. E. (2017) · Stem Cells · doi:10.1002/stem.2768 · Cited by 15 · see citing works
Manipulating Myc for reparative regeneration
Ascanelli, C., Dahir, R., & Wilson, C. H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1357589 · Cited by 14 · see citing works
Portal, C., Wang, Z., Scott, D. K., Wolosin, J. M., & Iomini, C. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.2.3 · Cited by 13 · see citing works
- Authors
- Watt, F. M., Frye, M., & Benitah, S. A.
- Affiliations
- Cancer Research UK (GB)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Barcelona Biomedical Research Park (ES)
- Corresponding author
- Watt, Fiona M.
- Venue
- Nature Reviews Cancer
- Published
- 2008-03
- Volume
- 8
- Issue
- 3
- Pages
- 234-242
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC2494614
- OpenAlex
- W2011019484
- Cited by
- 157
- References
- 79
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-04-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (78769, 079894)
- Cancer Research UK (A7989, A3602, A10212, A7006)
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- c-Myc, epidermal stem cells, differentiation, oncogene function, carcinogenesis, context-dependent gene regulation, skin cancer
- MeSH terms
- Animals, Cell Adhesion, Cell Differentiation, Chromatin, Epidermis, Gene Expression Regulation, Humans, Models, Biological, Oncogenes, Skin Neoplasms, Keratinocytes, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Cell Proliferation, Mice
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