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Evolving views of telomerase and cancer
Abstract
The maintenance of telomeres, nucleoprotein structures that constitute the ends of eukaryotic chromosomes, regulates many crucial cellular functions and might, in multicellular organisms, participate in the control of complex phenotypes such as aging and cancer. Stabilization of telomere length is strongly associated with cellular immortalization, and constitutive telomerase activation occurs in most human cancers. Such observations form the basis for the prevailing model that postulates that alterations in telomere biology both suppress and facilitate malignant transformation by regulating genomic stability and cell life span. However, recent findings suggest that telomere maintenance might not be an obligate requirement for initial tumor formation in some settings and that telomerase activation contributes to tumorigenesis independently of its role in maintaining telomere length. These recent developments indicate that our understanding of telomere biology remains incomplete and implicate additional complexity in the relationships among telomeres, telomerase and cancer.
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TERT promotes tumor development even in settings of ample telomere reserve.
“Moreover, recent findings indicate that TERT promotes tumor development even in settings of ample telomere reserve, although the mechanisms underlying these telomere length-independent activities of TERT remain unclear9–13.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [13]
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Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910
Conditional telomerase induction causes proliferation of hair follicle stem cells
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Metadata
- Authors
- Blasco, M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Blasco, M
- ORCID
- Blasco, M
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 13
- Issue
- 6
- Pages
- 289-294
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2026654107
- Cited by
- 123
- References
- 60
- Citations by year
- 2024: 1 · 2022: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 8
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (K01CA94223, K01CA094223)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- telomerase, telomere maintenance, telomeres, cancer, malignant transformation, genome stability, cell immortalization, aging, carcinogenesis, cell lifespan
- MeSH terms
- Animals, Enzyme Activation, Humans, Neoplasms, Telomerase
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