Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis
Open accessAbstract
Phospholipase Cgamma2 (PLCgamma2) is a critical signaling effector of the B-cell receptor (BCR). Here we show that PLCgamma2 deficiency impedes early B-cell development, resulting in an increase of B220+ CD43+ BP-1+ CD24hi pre-BCR+ large pre-B cells. PLCgamma2 deficiency impairs pre-BCR-mediated functions, leading to enhanced interleukin-7 (IL-7) signaling and elevated levels of RAGs in the selected large pre-B cells. Consequently, PLCgamma2 deficiency renders large pre-B cells susceptible to transformation, resulting in dramatic acceleration of Myc-induced lymphomagenesis. PLCgamma2(-/-) Emu-Myc transgenic mice mainly develop lymphomas of B220+ CD43+ BP-1+ CD24hi pre-BCR+ large pre-B-cell origin, which are uncommon in wild-type Emu-Myc transgenics. Furthermore, lymphomas from PLCgamma2(-/-) Emu-Myc transgenic mice exhibited a loss of p27Kip1 and often displayed alterations in Arf or p53. Thus, PLCgamma2 plays an important role in pre-BCR-mediated early B-cell development, and its deficiency leads to markedly increased pools of the most at-risk large pre-B cells, which display hyperresponsiveness to IL-7 and express high levels of RAGs, making them prone to secondary mutations and Myc-induced malignancy.
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PLCγ2 is vital to early B cell development, as shown by accumulation of large pre-B cells in the Eμ-Myc lymphomagenesis mouse model in the absence of PLCγ2.
“Using this Eμ-Myc lymphomagenesis mouse model in the absence of PLCγ2 demonstrated that PLCγ2 was indeed vital to early B cell development, resulting in an accumulation of large pre-B cells (121).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [121]
PLCγ2 deficiency affects the functionality of pre-BCR, resulting in increased IL-7 signaling and upregulation of RAG recombinase in selected large pre-B cells, leaving them vulnerable to transformation and accelerating c-myc-mediated lymphomagenesis.
“PLCγ2 deficiency affects the functionality of pre-BCR, resulting in increased IL-7 signaling and upregulation of the RAG recombinase in selected large pre-B cells, thus leaving them vulnerable to transformation and accelerating c-myc-mediated lymphomagenesis (121).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [121]
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Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506 · see citing works
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · see citing works
RAG-1-deficient mice have no mature B and T lymphocytes
Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,651 · see citing works
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,778 · see citing works
Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764 · see citing works
Regulation of Phosphoinositide-Specific Phospholipase C
Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628 · see citing works
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604 · see citing works
Goodnow, C. C., Crosbie, J. C., Adelstein, S., Lavoie, T., Smith‐Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,568 · see citing works
Taub, R. A., Kirsch, I. R., Morton, C. C., Lenoir, G., Swan, D., Tronick, S. R., Aaronson, S. A., & Leder, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7837 · Cited by 1,421 · see citing works
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K. M., Hara, E., Vousden, K. H., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5001 · Cited by 1,165 · see citing works
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARFPreprint
Jacobs, J. J. L., Scheijen, B., Voncken, J. W., Kieboom, K., Berns, A. J. M., & van Lohuizen, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2678 · Cited by 1,060 · see citing works
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., & Sherr, C. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8292 · Cited by 899 · see citing works
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
Rhee, S. G., & Bae, Y. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15045 · Cited by 876 · see citing works
Loder, B. F., Mutschler, B., Ray, R. J., Paige, C. J., Sideras, P., Torres, R. M., Lamers, M. C., & Carsetti, R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.1.75 · Cited by 865 · see citing works
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., & Cleveland, J. L. (1999) · Genes & Development · doi:10.1101/gad.13.20.2658 · Cited by 819 · see citing works
Self-citationRegulation of inositol phospholipid-specific phospholipase C isozymes.
Rhee, S. G., & Choi, K. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42284-3 · Cited by 741 · see citing works
Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00038-6 · Cited by 654 · see citing works
Regulation of B-cell fate by antigen-receptor signals
Niiro, H., & Clark, E. A. (2002) · Nature reviews. Immunology · doi:10.1038/nri955 · Cited by 626 · see citing works
Li, Y. S., Hayakawa, K., & Hardy, R. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.951 · Cited by 559 · see citing works
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
Bouchard, C., Thieke, K., Maier, A., Saffrich, R., Hanley‐Hyde, J., Ansorge, W., Reed, S., Siciński, P., Bartek, J., & Eilers, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5321 · Cited by 501 · see citing works
Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors
Wang, D., Feng, J., Wen, R., Marine, J.-C., Sangster, M. Y., Parganas, E., Hoffmeyer, A., Jackson, C. W., Cleveland, J. L., Murray, P. J., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00005-4 · Cited by 475 · see citing works
Self-citationINK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
Schmitt, C. A., McCurrach, M. E., de Stanchina, E., Wallace-Brodeur, R. R., & Lowe, S. W. (1999) · Genes & Development · doi:10.1101/gad.13.20.2670 · Cited by 458 · see citing works
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
Hemann, M. T., Bric, A., Teruya‐Feldstein, J., Herbst, A., Nilsson, J. A., Cordon‐Cardo, C., Cleveland, J. L., Tansey, W. P., & Lowe, S. W. (2005) · Nature · doi:10.1038/nature03845 · Cited by 452 · see citing works
Self-citationThe c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice
Langdon, W. Y., Harris, A. W., Cory, S., & Adams, J. M. (1986) · Cell · doi:10.1016/0092-8674(86)90361-2 · Cited by 433 · see citing works
GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Kurosaki, T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.555 · Cited by 433 · see citing works
Harris, A. W., Pinkert, C. A., Crawford, M., Langdon, W. Y., Brinster, R. L., & Adams, J. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.2.353 · Cited by 432 · see citing works
Zhu, C., Mills, K. D., Ferguson, D. O., Lee, C., Manis, J., Fleming, J., Gao, Y., Morton, C. C., & Alt, F. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00770-5 · Cited by 421 · cited 2× · see citing works
“RAG activity has been linked to an increased tendency for chromosomal translocations and for tumor development (72).”
BackgroundLymphoid Malignancies: the dark side of B-cell differentiation
Shaffer, A. L., Rosenwald, A., & Staudt, L. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri953 · Cited by 420 · see citing works
Molecular components of the B-cell antigen receptor complex of the IgM class
Hombach, J., Tsubata, T., Leclercq, L., Stappert, H., & Reth, M. G. (1990) · Nature · doi:10.1038/343760a0 · Cited by 400 · see citing works
B1 cells: similarities and differences with other B cell subsets
Martin, F., & Kearney, J. F. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00204-1 · Cited by 395 · see citing works
Grawunder, U., Leu, T. M. J., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F., & Winkler, T. (1995) · Immunity · doi:10.1016/1074-7613(95)90131-0 · Cited by 378 · see citing works
Yu, W., Nagaoka, H., Janković, M., Misulovin, Z., Suh, H., Rolink, A. G., Melchers, F., Meffre, E., & Nussenzweig, M. C. (1999) · Nature · doi:10.1038/23287 · Cited by 370 · see citing works
Cell cycle deregulation in B-cell lymphomas
Sánchez‐Beato, M., Sánchez‐Aguilera, A., & Piris, M. A. (2003) · Blood · doi:10.1182/blood-2002-07-2009 · Cited by 359 · see citing works
Robertson, K. D., & Jones, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6457 · Cited by 352 · see citing works
Karasuyama, H., Kudō, A., & Melchers, F. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.3.969 · Cited by 351 · see citing works
Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1
Pérez‐Roger, I., Kim, S., Griffiths, B. L., Sewing, A., & Land, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5310 · Cited by 327 · see citing works
Jumaa, H., Wollscheid, B., Mitterer, M., Wienands, J., Reth, M. G., & Nielsen, P. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80130-2 · Cited by 321 · see citing works
POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS
Healy, J. I., & Goodnow, C. C. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.645 · Cited by 317 · see citing works
Growth arrest by the cyclin‐dependent kinase inhibitor p27Kip1 is abrogated by c‐Myc.
Vlach, J., Hennecke, S., Alevizopoulos, K., Conti, D., & Amati, B. B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01050.x · Cited by 313 · see citing works
Requirement for B Cell Linker Protein (BLNK) in B Cell Development
Pappu, R., Cheng, A. M., Li, B., Gong, Q., Chiu, C. W., Griffin, N., White, J. M., Sleckman, B. P., & Chan, A. C. (1999) · Science · doi:10.1126/science.286.5446.1949 · Cited by 305 · see citing works
IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development
Rolink, A. G., Grawunder, U., Winkler, T., Karasuyama, H., & Melchers, F. (1994) · International Immunology · doi:10.1093/intimm/6.8.1257 · Cited by 294 · see citing works
Packham, G., & Cleveland, J. L. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)00015-t · Cited by 250 · see citing works
Self-citationTsubata, T., & Reth, M. G. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.3.973 · Cited by 222 · see citing works
Scharenberg, A. M., & Kinet, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81214-3 · Cited by 219 · see citing works
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progressionPreprint
O’Hagan, R. C., Ohh, M., David, G., de Alborán, I. M., Alt, F. W., Kaelin, W. G., & DePinho, R. A. (2000) · Genes & Development · doi:10.1101/gad.827200 · Cited by 192 · see citing works
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
Flemming, A., Brummer, T., Reth, M. G., & Jumaa, H. (2002) · Nature Immunology · doi:10.1038/ni862 · Cited by 184 · see citing works
Involvement of Myc Activity in a G 1 /S-Promoting Mechanism Parallel to the pRb/E2F Pathway
Santoni‐Rugiu, E., Falck, J., Mailand, N., Bártek, J., & Lukas, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3497-3509.2000 · Cited by 172 · see citing works
Müller, D., Bouchard, C., Rudolph, B., Steiner, P., Stuckmann, I., Saffrich, R., Ansorge, W. J., Huttner, W. Β., & Eilers, M. (1997) · Oncogene · doi:10.1038/sj.onc.1201440 · Cited by 167 · see citing works
B-cell commitment, development and selection
Hardy, R. R., Li, Y., Allman, D., Asano, M., Gui, M., & Hayakawa, K. (2000) · Immunological Reviews · doi:10.1111/j.1600-065x.2000.imr017517.x · Cited by 163 · see citing works
A Conserved Transcriptional Enhancer Regulates RAG Gene Expression in Developing B Cells
Hsu, L., Lauring, J. D., Liang, H.-E., Greenbaum, S., Cado, D., Zhuang, Y., & Schlissel, M. S. (2003) · Immunity · doi:10.1016/s1074-7613(03)00181-x · Cited by 159 · see citing works
Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function
Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1738 · Cited by 155 · see citing works
Xu, S., Tan, J. E.-L., Wong, E. P.-Y., Manickam, A., Ponniah, S., & Lam, K. (2000) · International Immunology · doi:10.1093/intimm/12.3.397 · Cited by 152 · see citing works
Marshall, A. J., Fleming, H. E., Wu, G. E., & Paige, C. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6038 · Cited by 140 · see citing works
Coggeshall, K. M., McHugh, J. C., & Altman, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5660 · Cited by 126 · see citing works
Kersseboom, R., Middendorp, S., Dingjan, G. M., Dahlenborg, K., Reth, M. G., Jumaa, H., & Hendriks, R. W. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030615 · Cited by 113 · see citing works
Winkler, T., Rolink, A. G., Melchers, F., & Karasuyama, H. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250221 · Cited by 112 · see citing works
Hempel, W. M., Schatzman, R. C., & DeFranco, A. L. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.10.3021 · Cited by 104 · see citing works
p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53
Lindström, M. S., Klangby, U., & Wiman, K. G. (2001) · Oncogene · doi:10.1038/sj.onc.1204303 · Cited by 98 · see citing works
Loss of p27Kip1 but not p21Cip1 decreases survival and synergizes with MYC in murine lymphomagenesis
Martins, C. P., & Berns, A. J. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf364 · Cited by 90 · see citing works
Impaired Precursor B Cell Differentiation in Bruton’s Tyrosine Kinase-Deficient Mice
Middendorp, S., Dingjan, G. M., & Hendriks, R. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2695 · Cited by 88 · see citing works
Reth, M. G., Wienands, J., & Schamel, W. W. A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.00610.x · Cited by 76 · see citing works
Wei, C., Zeff, R. A., & Goldschneider, I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1961 · Cited by 68 · see citing works
The pre‐B‐cell receptor induces silencing of VpreB and λ5 transcription
Parker, M. J., Licence, S., Erlandsson, L., Galler, G. R., Chakalova, L., Osborne, C. S., Morgan, G., Fraser, P., Jumaa, H., Winkler, T., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600850 · Cited by 63 · see citing works
Inactivation of the ARF–MDM-2–p53 pathway in sporadic Burkitt's lymphoma in children
Wilda, M., Bruch, J., Harder, L., Rawer, D., Reiter, A., Borkhardt, A., & Woessmann, W. (2003) · Leukemia · doi:10.1038/sj.leu.2403254 · Cited by 59 · see citing works
Differential surrogate light chain expression governs B-cell differentiation
Wang, Y., Stephan, R. P., Scheffold, A., Kunkel, D., Karasuyama, H., Radbruch, A., & Cooper, M. D. (2002) · Blood · doi:10.1182/blood.v99.7.2459 · Cited by 50 · see citing works
Self-citationJacobsen, K. A., Prasad, V., Sidman, C., & Osmond, D. G. (1994) · Blood · doi:10.1182/blood.v84.8.2784.2784 · Cited by 49 · see citing works
An important role of phospholipase Cγ1 in pre‐B‐cell development and allelic exclusion
Wen, R., Chen, Y., Schuman, J., Fu, G., Yang, S., Zhang, W., Newman, D. K., & Wang, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600405 · Cited by 39 · see citing works
Self-citationGenetic Studies on Eµ-myc Transgenic Mice
Sidman, C. L., Marshall, J. D., & Harris, A. W. (1988) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74006-0_13 · Cited by 13 · see citing works
Analysis of VpreB Expression During B Lineage Differentiation in λ5-Deficient Mice
Stephan, R. P., Elgavish, E., Karasuyama, H., Kubagawa, H., & Cooper, M. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.3734 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Phospholipase signalling networks in cancer
Park, J. B., Lee, C. S., Jang, J.-H., Ghim, J., Kim, Y.-J., You, S., Hwang, D., Suh, P.-G., & Ryu, S. H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3379 · Cited by 276 · see citing works
Joshi, I., Yoshida, T., Jena, N., Qi, X., Zhang, J., Etten, R. A. V., & Georgopoulos, K. (2014) · Nature Immunology · doi:10.1038/ni.2821 · Cited by 158 · see citing works
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
Zhang, S., Readinger, J. A., Dubois, W., Janka-Junttila, M., Robinson, R., Pruitt, M., Bliskovsky, V., Wu, J. Z., Sakakibara, K., Patel, J. D., et al. (2010) · Blood · doi:10.1182/blood-2010-05-287821 · Cited by 126 · see citing works
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100905 · Cited by 113 · see citing works
Verkoczy, L. K., Duong, B. H., Skog, P. D., Aït‐Azzouzene, D., Puri, K. D., Vela, J. L., & Nemazee, D. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6332 · Cited by 102 · see citing works
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity
Cooke, M., & Kazanietz, M. G. (2022) · Science Signaling · doi:10.1126/scisignal.abo0264 · Cited by 92 · see citing works
Mori, S., Rempel, R. E., Chang, J. T., Yao, G., Lagoo, A. S., Potti, A., Bild, A. H., & Nevins, J. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1329 · Cited by 71 · see citing works
Feng, X., Wu, Z., Yong-sheng, W., Hankey, W., Prior, T. W., Li, L., Ganju, R. K., Shen, R. Z., & Zou, X. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05523-11 · Cited by 71 · see citing works
Signaling Circuits in Early B-Cell Development
Reth, M. G., & Nielsen, P. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800267-4.00004-3 · Cited by 68 · see citing works
IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia
Pathak, S., Ma, S., Trinh, L., Eudy, J. D., Wagner, K., Joshi, S. S., & Lu, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022628 · Cited by 54 · see citing works
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
Yu, M., Chen, Y.-H., Zeng, H., Zheng, Y., Fu, G., Zhu, W., Broeckel, U., Aggarwal, P., Turner, A., Neale, G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01388-5 · Cited by 45 · see citing works
Self-citationZeng, H., Yu, M., Tan, H., Li, Y., Su, W., Shi, H., Dhungana, Y., Guy, C. S., Neale, G. A. M., Cloer, C., et al. (2018) · Science Advances · doi:10.1126/sciadv.aar5701 · Cited by 44 · see citing works
Self-citationRoles of Phospholipase C Isozymes in Organogenesis and Embryonic Development
Nakamura, Y., & Fukami, K. (2009) · Physiology · doi:10.1152/physiol.00031.2009 · Cited by 36 · see citing works
Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas
Gallardo, M., Malaney, P., Aitken, M. J. L., Zhang, X., Link, T. M., Shah, V. V., Alybayev, S., Wu, M., Pageon, L. R., Ma, H., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz078 · Cited by 36 · see citing works
Duong, B. H., Ota, T., Aoki-Ota, M., Cooper, A. B., Aït‐Azzouzene, D., Vela, J. L., Gavin, A. L., & Nemazee, D. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102479 · Cited by 33 · see citing works
Liu, L., Sánchez-Bonilla, M., Crouthamel, M. H., Giachelli, C. M., & Keel, S. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.01.004 · Cited by 32 · see citing works
A Role for E2F Activities in Determining the Fate of Myc-Induced Lymphomagenesis
Rempel, R. E., Mori, S., Gasparetto, M., Glozak, M. A., Andrechek, E. R., Adler, S., Laakso, N., Lagoo, A. S., Storms, R. W., Smith, C., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000640 · Cited by 28 · see citing works
Phospholipase Signaling in Breast Cancer
Lee, Y. J., Shin, K. J., Jang, H., Noh, D., Ryu, S. H., & Suh, P. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9620-6_2 · Cited by 21 · see citing works
Rac-mediated stimulation of phospholipase Cγ2 amplifies B cell receptor-induced calcium signaling
Walliser, C., Tron, K., Clauss, K., Gutman, O., Kobitski, A. Y., Retlich, M., Schade, A., Röcker, C., Henis, Y. I., Nienhaus, G. U., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645739 · Cited by 21 · see citing works
Ta, V. B. T., de Bruijn, M. J. W., ter Brugge, P. J., van Hamburg, J. P., Diepstraten, H. J. A., van Loo, P. F., Kersseboom, R., & Hendriks, R. W. (2009) · Blood · doi:10.1182/blood-2009-05-222166 · Cited by 18 · see citing works
CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis
Lu, Y., Yong-sheng, W., Feng, X., Shen, R. Z., Wang, J. H., Fallahi, M., Li, W., Yang, C., Hankey, W., Zhao, W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci63139 · Cited by 18 · see citing works
Self-citationOsborne, L. C., Duthie, K. A., Seo, J. H., Gascoyne, R. D., & Abraham, N. B. (2010) · Oncogene · doi:10.1038/onc.2010.133 · Cited by 16 · see citing works
Nepal, R. M., Tong, L., Kolaj, B., Edelmann, W., & Martín, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905965106 · Cited by 14 · see citing works
van der Sligte, N. E., Scherpen, F. J. G., Boer, T. M.-D., Lourens, H. J., ter Elst, A., Diks, S. H., Guryev, V., Peppelenbosch, M. P., van Leeuwen, F. N., & de Bont, E. S. J. M. (2014) · PROTEOMICS · doi:10.1002/pmic.201400286 · Cited by 13 · see citing works
Iotti, G., Mejetta, S., Modica, L., Penkov, D., Ponzoni, M., & Blasi, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048353 · Cited by 10 · see citing works
STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't
Wang, Z., & Bunting, K. D. (2016) · Cancer Cell & Microenvironment · doi:10.14800/ccm.1186 · Cited by 7 · see citing works
Lessons from Using Genetically Engineered Mouse Models of MYC-Induced Lymphoma
Winkler, R., Piskor, E.-M., & Kosan, C. (2022) · Cells · doi:10.3390/cells12010037 · Cited by 6 · see citing works
Ta, V. B. T., de Haan, A. B., de Bruijn, M. J. W., Dingjan, G. M., & Hendriks, R. W. (2010) · Leukemia · doi:10.1038/leu.2010.246 · Cited by 5 · see citing works
Sensitive detection of pathway perturbations in cancers
Rivera, C. G., Tyler, B. M., & Murali, T. M. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s3-s9 · Cited by 4 · see citing works
Chander, A., Zaim, S. R., Dillon, M. A., Genge, P. C., Moss, N., McGrath, P. I., Kopp, M. S., Lee, K. J., Kuan, E. L., Reading, J., et al. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100087 · Cited by 3 · see citing works
Signal transduction mechanisms of phospholipases and their roles in cancer signaling and progression
Finnerty, M. C., & Cummings, B. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95697-0.00003-0 · Cited by 1 · see citing works
Chander, A., Zaim, S. R., Dillon, M. A., Genge, P. C., Moss, N., McGrath, P. I., Kopp, M. S., Lee, K. J., Kuan, E. L., Reading, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.08.717307 · Cited by 1 · see citing works
Gutierrez-Kuri, E., Marie Garcia-Rogers, J. L., Perez, J., Smith, S., Kenwood, M. R., Archuleta, K. S., Xiao, Y., Campos, G., Barannikov, S., Wang, H., et al. (2026) · doi:10.64898/2026.07.13.738356
Role of Pre-B Cell Receptor Signaling Molecules in B Cell Differentiation and Tumor Suppression
Tạ, T. B. (2005) · RePub (Erasmus University Rotterdam)
Automatic Reconstruction of the Building Blocks of Molecular Interaction Networks
Rivera, C. G. (2008) · VTechWorks (Virginia Tech)
- Authors
- Wen, R., Chen, Y., Bai, L., Fu, G., Schuman, J., Dai, X., Zeng, H., Yang, C., Stephan, R. P., Cleveland, J. L., & Wang, D.
- Affiliations
- Versiti Blood Center of Wisconsin (US)
- St. Jude Children's Research Hospital (US)
- University of Alabama (US)
- Medical College of Wisconsin (US)
- Corresponding author
- Wen, Renren
- Wang, Demin
- ORCID
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-12-01
- Volume
- 26
- Issue
- 24
- Pages
- 9364-9376
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1698523
- OpenAlex
- W2161911875
- Cited by
- 34
- References
- 73
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL073284)
- National Cancer Institute (R01 CA76379, R01CA076379, CA21765, P30CA021765)
- National Institute of Allergy and Infectious Diseases (R01AI052327, R01 AI52327)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- PLCγ2, early B cell development, pre-B cells, RAG genes, Eμ-myc transgenic mice, p27, ARF, p53, B cell receptor signaling, lymphoma transformation
- MeSH terms
- Animals, B-Lymphocytes, Cell Differentiation, Isoenzymes, Lymphoma, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Antigen, B-Cell, Proto-Oncogene Proteins c-myc, Mice, Knockout, Mice, Phospholipase C gamma, Pre-B Cell Receptors
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