SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

β‐catenin is a target for the ubiquitin–proteasome pathway

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP

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Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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Lithium in the Kidney: Friend and Foe?

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Pharmacology and Clinical Drug Candidates in Redox Medicine

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“NRF2 addiction” in lung cancer cells and its impact on cancer therapy

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c‐Jun NH2‐Terminal Protein Kinase Phosphorylates the Nrf2‐ECH Homology 6 Domain of Nuclear Factor Erythroid 2–Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen‐Induced Liver Injury in Mice

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Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C

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Nrf2: a potential therapeutic target for diabetic neuropathy

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p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Shah, S. Z. A., Zhao, D., Hussain, T. A., Sabir, N., Mangi, M. H., & Yang, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00310 · Cited by 88

Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases

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TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

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Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

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Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases

Manda, G., Rojo, A. I., Martínez‐Klimova, E., Pedraza‐Chaverrí, J., & Cuadrado, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00151 · Cited by 89

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

Miller, W. P., Sunilkumar, S., Giordano, J. F., Toro, A. L., Barber, A. J., & Dennis, M. D. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013093 · Cited by 84

Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells

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Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

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PI3K signaling-regulated metabolic reprogramming: From mechanism to application

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Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation

Liu, Y., Liu, X., Kong, L., Zhang, M., Chen, Y., Xia Shuang, Z. H. U., & Hao, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.066 · Cited by 83

Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells

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A Novel Non-Catalytic Scaffolding Activity of Hexokinase 2 Contributes to EMT and Metastasis

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Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target

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Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs

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Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses

Luo, M., & Wicha, M. S. (2018) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2018.10.003 · Cited by 81

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

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Cerebrovascular and Neurological Disorders: Protective Role of NRF2

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Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

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The Role of Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches

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A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites

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Oxidative Stress and Its Regulation in Diabetic Retinopathy

Haydinger, C. D., Oliver, G. F., Ashander, L. M., & Smith, J. R. (2023) · Antioxidants · doi:10.3390/antiox12081649 · Cited by 91

Regulation of oxidative stress by Nrf2 in the pathophysiology of infectious diseases

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Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

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The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism

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The role of Nrf2 in acute kidney injury: Novel molecular mechanisms and therapeutic approaches

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Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

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Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma

Audousset, C., McGovern, T. K., & Martin, J. G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.727806 · Cited by 80

Nrf2 as a regulator of energy metabolism and mitochondrial function

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Overview of Nrf2 as Therapeutic Target in Epilepsy

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Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

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The characteristics and roles of β‐TrCP1/2 in carcinogenesis

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Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks

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Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

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Omega-3 polyunsaturated fatty acids improve the antioxidative defense in rat astrocytes via an Nrf2-dependent mechanism

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Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome

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Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases

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Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration

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Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

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The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation

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The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease

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Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: A novel mechanism of Nrf2/ARE signaling activation

Meng, X., Sun, G., Ye, J., Xu, H., Wang, H.-Y., & Sun, X. (2014) · Free Radical Research · doi:10.3109/10715762.2014.885117 · Cited by 71

Caffeic acid inhibits HCV replication via induction of IFNα antiviral response through p62-mediated Keap1/Nrf2 signaling pathway

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GSK-3β, a double-edged sword in Nrf2 regulation: Implications for neurological dysfunction and disease

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Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

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NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis

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NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells

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Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects

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Targeting the NF-E2-Related Factor 2 Pathway: a Novel Strategy for Traumatic Brain Injury

Zhang, L., & Wang, H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0456-z · Cited by 67

Regulation of Nrf2 signaling pathway in heart failure: Role of extracellular vesicles and non-coding RNAs

Tian, C., Gao, L., & Zucker, I. H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.013 · Cited by 67

The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

Mata, A., & Cadenas, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111939 · Cited by 70

The Role of NRF2 in Bone Metabolism – Friend or Foe?

Han, J., Yang, K., An, J., Jiang, N., Fu, S., & Tang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.813057 · Cited by 67

Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD

Zhang, Y., Wang, M., & Chang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.983623 · Cited by 67

Nrf2: bane or blessing in cancer?

Xiang, M., Namani, A., Wu, S., & Wang, X. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1627-1 · Cited by 70

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

Swamy, S., Rajasekaran, N. S., & Thannickal, V. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.02.022 · Cited by 67

The Pleiotropic Role of the KEAP1/NRF2 Pathway in Cancer

Wu, W., & Papagiannakopoulos, T. Y. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055627 · Cited by 70

Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5455 · Cited by 66

Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases

Lin, D.-W., Hsu, Y., Chang, C., Hsieh, C., & Lin, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076053 · Cited by 70

Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs

Telkoparan‐Akillilar, P., Süzen, S., & Saso, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082025 · Cited by 69

Nrf2 in early vascular ageing: Calcification, senescence and therapy

Arefin, S., Buchanan, S. J., Hobson, S., Steinmetz, J. L., Alsalhi, S., Shiels, P. G., Kublickiene, K. R., & Stenvinkel, P. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.02.026 · Cited by 67

Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin

Kanwugu, O. N., & Glukhareva, T. V. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109601 · Cited by 65

An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases

Jiang, S., Yang, Y., Li, T. X., Ma, Z., Hu, W., Deng, C., Fan, C., Lv, J., Sun, Y., & Yi, W. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1250887 · Cited by 66

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia

Anzovino, A., Chiang, S., Brown, B. E., Hawkins, C. L., Richardson, D. R., & Huang, M. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.021 · Cited by 64

The Role of Nrf2 in the Response to Normal Tissue Radiation Injury

Cameron, B. D., Sekhar, K. R., Ofori, M., & Freeman, M. L. (2018) · Radiation Research · doi:10.1667/rr15059.1 · Cited by 63

Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress

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F-Box Proteins and Cancer

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WNT-3A Regulates an Axin1/NRF2 Complex That Regulates Antioxidant Metabolism in Hepatocytes

Rada, P., Rojo, A. I., Offergeld, A., Feng, G. J., Velasco-Martin, J. P., González‐Sancho, J. M., Valverde, Á. M., Dale, T. C., Regadera, J., & Cuadrado, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6040 · Cited by 65

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

Unoki, T., Akiyama, M., Kumagai, Y., Gonçalves, F. M., Farina, M., da Rocha, J. B. T., & Aschner, M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00373 · Cited by 62

Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

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Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

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NRF2 in Viral Infection

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The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization

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UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

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HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction

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6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts

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