Hayes, John D.

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell

Redox biology and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 2,654

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressEndoplasmic Reticulum Stress and Disease

Cited by 1,472

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,141

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 837

SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 759

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 657

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

CHANAS, S. A., JIANG, Q., McMAHON, M., McWALTER, G. K., McLELLAN, L. I., ELCOMBE, C. R., HENDERSON, C. J., WOLF, C. R., MOFFAT, G. J., ITOH, K., et al. (2002) · Biochemical Journal

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 460

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., et al. (2013) · Cancer Research

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 382

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

Ohtsuji, M., Katsuoka, F., Kobayashi, A., Aburatani, H., Hayes, J. D., & Yamamoto, M. (2008) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 317

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 191

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., et al. (2011) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressCardiac Ischemia and Reperfusion

Cited by 133

Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants & Redox Signaling

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 66

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. D., & Hardingham, G. E. (2014) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressNuclear Receptors and Signaling

Cited by 30

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

Cuadrado, A., Cazalla, E., Bach, A., Bathish, B., Naidu, S. D., DeNicola, G. M., Dinkova-Kostova, A. T., Fernández-Ginés, R., Grochot-Przeczek, A., Hayes, J. D., et al. (2025) · Redox Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 28