SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio·2011·Molecular and Cellular Biology
Cited by (768)
Items 101–200 of 768
- Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammationS. Venkata Mohan, Damodar Gupta · 2018 · Biomedicine & Pharmacotherapy
- Targeting the KEAP1-NRF2 system to prevent kidney disease progressionNezu, Masahiro, Suzuki, Norio, Yamamoto, Masayuki · 2017 · American Journal of Nephrology
- iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 BindingWenjie Ge, Kunming Zhao, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Long Zhang, Yiwei Cheng et al. · 2017 · Cancer Cell
- Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and ChemoresistanceAzhwar Raghunath, Kiruthika Sundarraj, Frank Arfuso, Gautam Sethi, Ekambaram Perumal · 2018 · Cancers
- The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?Phillip M. Shelton, Anil K. Jaiswal · 2012 · The FASEB Journal
- Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3John D. Hayes, Sudhir Chowdhry, Albena T. Dinkova‐Kostova, Calum D. Sutherland · 2015 · Biochemical Society Transactions
- Potential Applications of NRF2 Inhibitors in Cancer TherapyEmiliano Panieri, Luciano Saso · 2019 · Oxidative Medicine and Cellular Longevity
- BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates*Étienne Coyaud, Monika Mis, Estelle M. N. Laurent, Wade H. Dunham, Amber L. Couzens, Mélanie Robitaille, Anne‐Claude Gingras, Stéphane Angers, Brian Raught · 2015 · Molecular & Cellular Proteomics
- Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathyAntonio Cuadrado, Sebastian Kügler, Isabel Lastres‐Becker · 2017 · Redox Biology
- Roles of Nrf2 in Protecting the Kidney from Oxidative DamageMasahiro Nezu, Norio Suzuki · 2020 · International Journal of Molecular Sciences
- TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signalingWei Liu, Yuechao Zhao, Guangfu Wang, Shuang Feng, Xuhui Ge, Wu Ye, Zhuanghui Wang, Yufeng Zhu, Weihua Cai, Jianling Bai et al. · 2022 · Redox Biology
- Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implicationsTian Liu, Yifei Lv, Jinglong Zhao, Qidong You, Zhengyu Jiang · 2021 · Free Radical Biology and Medicine
- Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease interventionBryan G. Harder, Tao Jiang, Tongde Wu, Shasha Tao, Montserrat Rojo de la Vega, Wang Tian, Eli Chapman, Donna D. Zhang · 2015 · Biochemical Society Transactions
- Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and TimeYuji Fuse, Makoto Kobayashi · 2017 · Molecules
- Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulationKouhei Tsuchida, Tadayuki Tsujita, Makiko Hayashi, Asaka Ojima, Nadine Keleku-Lukwete, Fumiki Katsuoka, Akihito Otsuki, Haruhisa Kikuchi, Yoshiteru Oshima, Mikiko Suzuki et al. · 2016 · Free Radical Biology and Medicine
- The Role of NRF2/KEAP1 Signaling Pathway in Cancer MetabolismMoon-Young Song, Da-Young Lee, Kyung‐Soo Chun, Eun‐Hee Kim · 2021 · International Journal of Molecular Sciences
- Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and functionNoemí Esteras, Albena T. Dinkova‐Kostova, Andrey Y. Abramov · 2016 · Biological Chemistry
- An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapyZhu, Jiayu, Wang, Huihui, Chen, Feng, Fu, Jingqi, Xu, Yuanyuan, Hou, Yongyong, Kou, Henry H., Zhai, Cheng, Nelson, M. Bud, Zhang, Qiang et al. · 2016 · Free Radical Biology and Medicine
- Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transportersXupeng Bai, Yibei Chen, Xiangyu Hou, Min Huang, Jing Jin · 2016 · Drug Metabolism Reviews
- Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disordersUddin, Md. Sahab, Mamun, Abdullah Al, Jakaria, Md., Thangapandiyan, Shanmugam, Ahmad, Jamil, Rahman, Md. Ataur, Mathew, Bijo, Abdel-Daim, Mohamed M., Aleya, Lotfi · 2020 · Science of The Total Environment
- Role of Nrf2 in the pathogenesis of atherosclerosisJunsei Mimura, Ken Itoh · 2015 · Free Radical Biology and Medicine
- Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosisLastres-Becker, Isabel, Innamorato, Nadia G., Jaworski, Tomasz, Rábano, Alberto, Kügler, Sebastian, Van Leuven, Fred, Cuadrado, Antonio · 2014 · Brain
- Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s diseaseFiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez‐Nievas, Hélène Charlotte Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé et al. · 2017 · PLoS Genetics
- Regulation of Nrf2 SignalingY. Li, Zhenquan Jia, Hong Zhu · 2019
- AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genesManuel Matzinger, Katrin Fischhuber, Daniel Pölöske, Karl Mechtler, Elke H. Heiß · 2019 · Redox Biology
- Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondriaKen Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki · 2015 · Journal of Clinical Biochemistry and Nutrition
- Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s diseaseZhuo Qu, Jiachen Sun, Wannian Zhang, Jian‐Qiang Yu, Chunlin Zhuang · 2020 · Free Radical Biology and Medicine
- Therapeutic Targeting of the NRF2 Signaling Pathway in CancerPelin Telkoparan‐Akillilar, Emiliano Panieri, Dilek Cevik, Síbel Süzen, Luciano Saso · 2021 · Molecules
- The ketone body β-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insultsYudong Fang, Bohan Chen, Athena Y. Gong, Deepak K Malhotra, Rajesh Gupta, Lance D. Dworkin, Rujun Gong · 2021 · Kidney International
- The PTEN/NRF2 Axis Promotes Human CarcinogenesisAna Isabel Rojo, Patricia Rada, Marta Mendiola, Ana Ortega-Molina, Katarzyna Wojdyła, Adelina Rogowska-Wrzesińska, David Hardisson, Manuel Serrano, Antonio Cuadrado · 2014 · Antioxidants and Redox Signaling
- Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s DiseaseFrancisca Villavicencio-Tejo, Rodrigo A. Quintanilla · 2021 · Antioxidants
- Oxidative Stress in Methylmercury-Induced Cell ToxicityAlessandra Antunes dos Santos, Beatriz Ferrer, Filipe Marques Gonçalves, Aristidis Michael Tsatsakis, Elisavet A. Renieri, Anatoly V. Skalny, Marcelo Farina, João Batista Teixeira da Rocha, Michael Aschner · 2018 · Toxics
- Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathyTemitope Isaac Adelusi, Lei Du, Hao Meng, Xueyan Zhou, Xuan Qian, Apu Chowdhury, Ying Sun, Qian Lü, Xiaoxing Yin · 2020 · Biomedicine & Pharmacotherapy
- Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 ProteinNathan D. Camp, Richard G. James, David W. Dawson, Feng Yan, James M. Davison, Scott A. Houck, Xiaobo Tang, Ning Zheng, Michael B. Major, Randall T. Moon · 2012 · Journal of Biological Chemistry
- Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within CellsTatsuro Iso, Takafumi Suzuki, Liam Baird, Masayuki P. Yamamoto · 2016 · Molecular and Cellular Biology
- Nutritive values, flavor amino acids, healthcare fatty acids and flesh quality improved by manganese referring to up-regulating the antioxidant capacity and signaling molecules TOR and Nrf2 in the muscle of fishWei‐Dan Jiang, Pei Wu, Ren-Jun Tang, Yang Liu, Sheng‐Yao Kuang, Jun Jiang, Ling Yin Tang, Wu‐Neng Tang, Yong‐An Zhang, Xiao‐Qiu Zhou et al. · 2016 · Food Research International
- Neuroprotective Effects of Cholinesterase Inhibitors: Current Scenario in Therapies for Alzheimer’s Disease and Future PerspectivesNatália Chermont dos Santos Moreira, Jéssica Ellen Barbosa de Freitas Lima, Marcelo Fiori Marchiori, Ivone Carvalho, Elza Tiemi Sakamoto‐Hojo · 2022 · Journal of Alzheimer s Disease Reports
- Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancerAkhileshwar Namani, Yulong Li, Xiu Jun Wang, Xiuwen Tang · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Nrf2 in health and disease: current and future clinical implicationsOthman Al‐Sawaf, Tim Clarner, Athanassios Fragoulis, Yuet Wai Kan, Thomas Pufe, Konrad L. Streetz, Christoph Jan Wruck · 2015 · Clinical Science
- Recent progress on targeting ferroptosis for cancer therapyGuangxiang Xu, Han Wang, Xiaoling Li, Riming Huang, Lianxiang Luo · 2021 · Biochemical Pharmacology
- Mechanisms and functions of Nrf2 signaling in DrosophilaAndrew Pitoniak, Dirk Bohmann · 2015 · Free Radical Biology and Medicine
- Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modificationsYoung‐Sam Keum · 2011 · Annals of the New York Academy of Sciences
- Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In UteroXinghua Cheng, Sarah J. Chapple, Bijal Patel, William Matthew Puszyk, David Sugden, Xiaoke Yin, Manuel Mayr, Richard C. M. Siow, Giovanni E. Mann · 2013 · Diabetes
- USP15 Negatively Regulates Nrf2 through Deubiquitination of Keap1Nicole F. Villeneuve, Wang Tian, Tongde Wu, Zheng Sun, Alexandria Lau, Eli Chapman, Deyu Fang, Donna D. Zhang · 2013 · Molecular Cell
- Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic CardiomyopathyBin Zhang, Qiang Shen, Yaping Chen, Ruile Pan, Shihuan Kuang, Guiyan Liu, Guibo Sun, Xiaobo Sun · 2017 · Scientific Reports
- Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced ApoptosisJing Wang, Junqin Mao, Rong Wang, Shengnan Li, Bin Wu, Yongfang Yuan · 2020 · Frontiers in Pharmacology
- GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusionXi Chen, Yuanling Liu, Jin Zhu, Shipeng Lei, Yuan Dong, Lingyu Li, Beibei Jiang, Li Huan Tan, Jingxian Wu, Shanshan Yu et al. · 2016 · Scientific Reports
- The role of natural products in revealing NRF2 functionDonna D. Zhang, Eli Chapman · 2020 · Natural Product Reports
- Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2Gahee Bahn, Dong‐Gyu Jo · 2019 · NeuroMolecular Medicine
- Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2Sara Baldelli, Katia Aquilano, Maria Rosa Ciriolo · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
- A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancerE-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, Hyun‐Jeong Ko, Suhwan Chang, S-Y Kim, S-M Jeon · 2017 · Oncogene
- Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseasesZi Guo, Zhaohui Mo · 2020 · Journal of Tissue Engineering and Regenerative Medicine
- Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's diseaseVeerta Sharma, Amarjot Kaur, Thakur Gurjeet Singh · 2020 · Biomedicine & Pharmacotherapy
- p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 ComplexShasha Tao, Pengfei Liu, Gang Luo, Montserrat Rojo de la Vega, Richard Chen, Tongde Wu, Joseph Tillotson, Eli Chapman, Donna D. Zhang · 2017 · Molecular and Cellular Biology
- When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce NeurodegenerationPatrycja Michalska, Rafael M. Leon · 2020 · Antioxidants
- The KEAP1-NRF2 System and Neurodegenerative DiseasesAkira Uruno, Masayuki P. Yamamoto · 2023 · Antioxidants and Redox Signaling
- Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xLHui Tian, Baofu Zhang, Jiehui Di, Guan Jiang, FeiFei Chen, Huizhong Li, Liantao Li, Dong‐Sheng Pei, Junnian Zheng · 2012 · Cancer Letters
- Current mechanistic insights into the CCCP-induced cell survival responseMariame Selma Kane, Aurélien Paris, Philippe Codron, Julien Cassereau, Vincent Procaccio, Guy Lenaers, Pascal Reynier, Arnaud Chevrollier · 2017 · Biochemical Pharmacology
- Nrf2 as a Key Player of Redox Regulation in Cardiovascular DiseasesMiroslav Barančı́k, Linda Gresová, Monika Barteková, Ima Dovinová · 2016 · Physiological Research
- Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3βFernando Correa, Carina E. Mallard, Michael Nilsson, Mats Sandberg · 2011 · Neurobiology of Disease
- Epigenetic Regulation of NRF2/KEAP1 by PhytochemicalsShamee Bhattacharjee, Roderick H. Dashwood · 2020 · Antioxidants
- New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic SyndromeDionysios V. Chartoumpekis, Thomas W. Kensler · 2013 · Current Diabetes Reviews
- Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)Alicia R. Timme‐Laragy, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Rachel C. Harbeitner, Jared V. Goldstone, Andrew G. McArthur, Mark E. Hahn · 2011 · Journal of Biological Chemistry
- A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylationHaibin Zhou, Jianfeng Lü, Liu Liu, Denzil Bernard, Chao‐Yie Yang, Ester Fernández‐Salas, Krishnapriya Chinnaswamy, Stephanie Danielle Layton, Jeanne A. Stuckey, Qing Yu et al. · 2017 · Nature Communications
- F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospectsDinesh Singh Tekcham, Di Chen, Yu Liu, Ting Ling, Yi Zhang, Huan Chen, Wen Wang, Wuxiyar Otkur, Huan Qi, Tian Xia et al. · 2020 · Theranostics
- Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant HuntingtinYoungnam N. Jin, Yanxun V. Yu, Soner Gundemir, Chulman Jo, Mei Cui, Kim Tieu, Gail V.W. Johnson · 2013 · PLoS ONE
- GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transitionMinglei Lu, Pei Wang, Yingjin Qiao, Chunming Jiang, Yan Ge, Bryce Flickinger, Deepak K Malhotra, Lance D. Dworkin, Zhangsuo Liu, Rujun Gong · 2019 · Redox Biology
- Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseasesYao Xiang, Xiaohua Song, Dingxin Long · 2024 · Archives of Toxicology
- Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP- and Hrd1-Dependent Degradation MechanismsYoshiki Tsuchiya, Tomoko Morita, Mehee Kim, Shun-ichiro Iemura, Tohru Natsume, Masayuki P. Yamamoto, Akira Kobayashi · 2011 · Molecular and Cellular Biology
- Role of Nrf2 and Autophagy in Acute Lung InjuryMontserrat Rojo de la Vega, Matthew B. Dodson, Christine Groß, Heidi M. Mansour, Robert Clark Lantz, Eli Chapman, Ting Wang, Stephen M. Black, Joe G. N. Garcia, Donna D. Zhang · 2016 · Current Pharmacology Reports
- Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signalingYan Hong, Zhongping An · 2015 · Archives of Pharmacal Research
- Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)Wang Tian, Montserrat Rojo de la Vega, Cody J. Schmidlin, Aikseng Ooi, Donna D. Zhang · 2017 · Journal of Biological Chemistry
- The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel diseaseSem Geertsema, Arno R. Bourgonje, Raphael R. Fagundes, Ranko Gaćeša, Rinse Karel Weersma, Harry van Goor, Giovanni E. Mann, Gerard D. H. Dijkstra, Klaas Nico Faber · 2023 · Trends in Molecular Medicine
- Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathwayGuoguo Shang, Xinjun Tang, Pan Gao, Fanli Guo, Hongpeng Liu, Zhonghua Zhao, Qi Chen, Tao Jiang, Nong Zhang, Hui Li · 2015 · The Journal of Nutritional Biochemistry
- A partnership with the proteasome; the destructive nature of GSK3Holly Robertson, John D. Hayes, Calum D. Sutherland · 2017 · Biochemical Pharmacology
- The intricacies of NRF2 regulation in cancerCody J. Schmidlin, Aryatara Shakya, Matthew B. Dodson, Eli Chapman, Donna D. Zhang · 2021 · Seminars in Cancer Biology
- Attenuation of Aβ25–35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathwaysXiangbao Meng, Min Wang, Guibo Sun, Jingxue Ye, Yanhui Zhou, Xi Dong, Tingting Wang, Shan Lu, Xiaobo Sun · 2014 · Toxicology and Applied Pharmacology
- C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shapeSharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki P. Yamamoto, Takafumi Suzuki, Albena T. Dinkova‐Kostova · 2018 · Scientific Reports
- Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke managementAnil Kumar Rana, Damanpreet Singh · 2018 · Neuropharmacology
- F-box protein interactions with the hallmark pathways in cancerSuzanne J. Randle, Heike Laman · 2015 · Seminars in Cancer Biology
- Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanismsDushani L. Palliyaguru, Dionysios V. Chartoumpekis, Nobunao Wakabayashi, John Skoko, Yoko Yagishita, Shivendra Vikram Singh, Thomas W. Kensler · 2016 · Free Radical Biology and Medicine
- Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorderPeter Huppke, Susann Weißbach, Joseph A. Church, Rhonda E. Schnur, Martina Krusen, Steffi F. Dreha‐Kulaczewski, W. Nikolaus Kühn‐Velten, Annika Wolf, Brenda Huppke, Francisca Millan et al. · 2017 · Nature Communications
- Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient LiversKeiko Taguchi, Ikuo Hirano, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Akira Suzuki, Hozumi Motohashi, Masayuki P. Yamamoto · 2013 · Molecular and Cellular Biology
- Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic OpportunitiesByung-Jin Jung, Hwan-Sic Yoo, Sooyoung Shin, Young‐Joon Park, Sang‐Min Jeon · 2017 · Biomolecules & Therapeutics
- The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic PerspectivesEmiliano Panieri, Pelin Telkoparan‐Akillilar, Síbel Süzen, Luciano Saso · 2020 · Biomolecules
- Aging-InducedNrf2-AREPathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice viaPI3K-Wnt/β-CateninDysregulationFrancesca L’Episcopo, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C. Morale, Francesco Impagnatiello, Stefano Pluchino, Bianca Marchetti · 2013 · Journal of Neuroscience
- Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer MetabolismKatarína Smolková, Edit Mikó, Tündé Kovàcs, Alberto Leguina‐Ruzzi, Adrienn Sipos, Péter Bai · 2020 · Antioxidants and Redox Signaling
- Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6Bhavana Chhunchha, Eri Kubo, Dhirendra P. Singh · 2020 · Cells
- Living on the Edge: ROS Homeostasis in Cancer Cells and Its Potential as a Therapeutic TargetNoah Brandl, Rebecca Seitz, Noah Sendtner, Martina Müller, Karsten Gülow · 2025 · Antioxidants
- Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cellsJuanjuan Wu, Devin M. Williams, Grant A. Walter, Winston E. Thompson, Neil Sidell · 2014 · Experimental Cell Research
- Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targetsAna Catarina Pereira, Joana M. Oliveira, Sónia Silva, Nuno Gonçalo Gomes Fernandes Madeira, Cláudia Pereira, Maria Teresa Cruz · 2020 · Pharmacological Research
- Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatmentGanesh Venkatraman, Matthew G.K. Benesch, Xiaoyun Tang, Jay W. Dewald, Todd P W McMullen, David N. Brindley · 2014 · The FASEB Journal
- Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic reviewJiang‐Jiang Qin, Xiangdong Cheng, Jia Zhang, Weidong Zhang · 2019 · Cell Communication and Signaling
- Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasisJohn D. Hayes, Sharadha Dayalan Naidu, Albena T. Dinkova‐Kostova · 2025 · Trends in Biochemical Sciences
- Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and CarcinogenesisT.M. Penning · 2016 · Chemical Research in Toxicology
- Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker PerspectivePietro Ghezzi, Luciano Floridi, Diana Boraschi, Antonio Cuadrado, Gina Manda, Snezana Levic, Fulvio D’Acquisto, Alice Hamilton, Toby James Athersuch, Liza Selley · 2017 · Antioxidants and Redox Signaling
- lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic CancerQingzhu Yang, Kai Li, Xuemei Huang, Chen Ning Zhao, Yu Mei, Xinyuan Li, Lin Jiao, Huanjie Yang · 2020 · Molecular Therapy — Nucleic Acids
- NRF2 and Diabetes: The Good, the Bad, and the ComplexMatthew B. Dodson, Aryatara Shakya, Annadurai Anandhan, Jinjing Chen, Joe G. N. Garcia, Donna D. Zhang · 2022 · Diabetes
- Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZMaribel Escoll, Ricardo Gargini, Antonio Cuadrado, Inés M. Antón, Francisco G. Wandosell · 2017 · Oncogene
- Targeting NRF2 to treat cancerJared Sivinski, Donna D. Zhang, Eli Chapman · 2021 · Seminars in Cancer Biology