SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

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    S. Venkata Mohan, Damodar Gupta · 2018 · Biomedicine & Pharmacotherapy
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    Nezu, Masahiro, Suzuki, Norio, Yamamoto, Masayuki · 2017 · American Journal of Nephrology
  3. iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding
    Wenjie Ge, Kunming Zhao, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Long Zhang, Yiwei Cheng et al. · 2017 · Cancer Cell
  4. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
    Azhwar Raghunath, Kiruthika Sundarraj, Frank Arfuso, Gautam Sethi, Ekambaram Perumal · 2018 · Cancers
  5. The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?
    Phillip M. Shelton, Anil K. Jaiswal · 2012 · The FASEB Journal
  6. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
    John D. Hayes, Sudhir Chowdhry, Albena T. Dinkova‐Kostova, Calum D. Sutherland · 2015 · Biochemical Society Transactions
  7. Potential Applications of NRF2 Inhibitors in Cancer Therapy
    Emiliano Panieri, Luciano Saso · 2019 · Oxidative Medicine and Cellular Longevity
  8. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates*
    Étienne Coyaud, Monika Mis, Estelle M. N. Laurent, Wade H. Dunham, Amber L. Couzens, Mélanie Robitaille, Anne‐Claude Gingras, Stéphane Angers, Brian Raught · 2015 · Molecular & Cellular Proteomics
  9. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
    Antonio Cuadrado, Sebastian Kügler, Isabel Lastres‐Becker · 2017 · Redox Biology
  10. Roles of Nrf2 in Protecting the Kidney from Oxidative Damage
    Masahiro Nezu, Norio Suzuki · 2020 · International Journal of Molecular Sciences
  11. TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling
    Wei Liu, Yuechao Zhao, Guangfu Wang, Shuang Feng, Xuhui Ge, Wu Ye, Zhuanghui Wang, Yufeng Zhu, Weihua Cai, Jianling Bai et al. · 2022 · Redox Biology
  12. Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications
    Tian Liu, Yifei Lv, Jinglong Zhao, Qidong You, Zhengyu Jiang · 2021 · Free Radical Biology and Medicine
  13. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
    Bryan G. Harder, Tao Jiang, Tongde Wu, Shasha Tao, Montserrat Rojo de la Vega, Wang Tian, Eli Chapman, Donna D. Zhang · 2015 · Biochemical Society Transactions
  14. Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
    Yuji Fuse, Makoto Kobayashi · 2017 · Molecules
  15. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
    Kouhei Tsuchida, Tadayuki Tsujita, Makiko Hayashi, Asaka Ojima, Nadine Keleku-Lukwete, Fumiki Katsuoka, Akihito Otsuki, Haruhisa Kikuchi, Yoshiteru Oshima, Mikiko Suzuki et al. · 2016 · Free Radical Biology and Medicine
  16. The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
    Moon-Young Song, Da-Young Lee, Kyung‐Soo Chun, Eun‐Hee Kim · 2021 · International Journal of Molecular Sciences
  17. Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
    Noemí Esteras, Albena T. Dinkova‐Kostova, Andrey Y. Abramov · 2016 · Biological Chemistry
  18. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
    Zhu, Jiayu, Wang, Huihui, Chen, Feng, Fu, Jingqi, Xu, Yuanyuan, Hou, Yongyong, Kou, Henry H., Zhai, Cheng, Nelson, M. Bud, Zhang, Qiang et al. · 2016 · Free Radical Biology and Medicine
  19. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
    Xupeng Bai, Yibei Chen, Xiangyu Hou, Min Huang, Jing Jin · 2016 · Drug Metabolism Reviews
  20. Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders
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  21. Role of Nrf2 in the pathogenesis of atherosclerosis
    Junsei Mimura, Ken Itoh · 2015 · Free Radical Biology and Medicine
  22. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis
    Lastres-Becker, Isabel, Innamorato, Nadia G., Jaworski, Tomasz, Rábano, Alberto, Kügler, Sebastian, Van Leuven, Fred, Cuadrado, Antonio · 2014 · Brain
  23. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
    Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K. Ivanov, Jemma Gatliff, Beatriz Gomez Perez‐Nievas, Hélène Charlotte Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M. Cochemé et al. · 2017 · PLoS Genetics
  24. Regulation of Nrf2 Signaling
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  25. AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes
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  26. Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
    Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki · 2015 · Journal of Clinical Biochemistry and Nutrition
  27. Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease
    Zhuo Qu, Jiachen Sun, Wannian Zhang, Jian‐Qiang Yu, Chunlin Zhuang · 2020 · Free Radical Biology and Medicine
  28. Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
    Pelin Telkoparan‐Akillilar, Emiliano Panieri, Dilek Cevik, Síbel Süzen, Luciano Saso · 2021 · Molecules
  29. The ketone body β-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults
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  30. The PTEN/NRF2 Axis Promotes Human Carcinogenesis
    Ana Isabel Rojo, Patricia Rada, Marta Mendiola, Ana Ortega-Molina, Katarzyna Wojdyła, Adelina Rogowska-Wrzesińska, David Hardisson, Manuel Serrano, Antonio Cuadrado · 2014 · Antioxidants and Redox Signaling
  31. Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease
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  32. Oxidative Stress in Methylmercury-Induced Cell Toxicity
    Alessandra Antunes dos Santos, Beatriz Ferrer, Filipe Marques Gonçalves, Aristidis Michael Tsatsakis, Elisavet A. Renieri, Anatoly V. Skalny, Marcelo Farina, João Batista Teixeira da Rocha, Michael Aschner · 2018 · Toxics
  33. Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy
    Temitope Isaac Adelusi, Lei Du, Hao Meng, Xueyan Zhou, Xuan Qian, Apu Chowdhury, Ying Sun, Qian Lü, Xiaoxing Yin · 2020 · Biomedicine & Pharmacotherapy
  34. Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
    Nathan D. Camp, Richard G. James, David W. Dawson, Feng Yan, James M. Davison, Scott A. Houck, Xiaobo Tang, Ning Zheng, Michael B. Major, Randall T. Moon · 2012 · Journal of Biological Chemistry
  35. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
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  36. Nutritive values, flavor amino acids, healthcare fatty acids and flesh quality improved by manganese referring to up-regulating the antioxidant capacity and signaling molecules TOR and Nrf2 in the muscle of fish
    Wei‐Dan Jiang, Pei Wu, Ren-Jun Tang, Yang Liu, Sheng‐Yao Kuang, Jun Jiang, Ling Yin Tang, Wu‐Neng Tang, Yong‐An Zhang, Xiao‐Qiu Zhou et al. · 2016 · Food Research International
  37. Neuroprotective Effects of Cholinesterase Inhibitors: Current Scenario in Therapies for Alzheimer’s Disease and Future Perspectives
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  38. Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
    Akhileshwar Namani, Yulong Li, Xiu Jun Wang, Xiuwen Tang · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  39. Nrf2 in health and disease: current and future clinical implications
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  40. Recent progress on targeting ferroptosis for cancer therapy
    Guangxiang Xu, Han Wang, Xiaoling Li, Riming Huang, Lianxiang Luo · 2021 · Biochemical Pharmacology
  41. Mechanisms and functions of Nrf2 signaling in Drosophila
    Andrew Pitoniak, Dirk Bohmann · 2015 · Free Radical Biology and Medicine
  42. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young‐Sam Keum · 2011 · Annals of the New York Academy of Sciences
  43. Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In Utero
    Xinghua Cheng, Sarah J. Chapple, Bijal Patel, William Matthew Puszyk, David Sugden, Xiaoke Yin, Manuel Mayr, Richard C. M. Siow, Giovanni E. Mann · 2013 · Diabetes
  44. USP15 Negatively Regulates Nrf2 through Deubiquitination of Keap1
    Nicole F. Villeneuve, Wang Tian, Tongde Wu, Zheng Sun, Alexandria Lau, Eli Chapman, Deyu Fang, Donna D. Zhang · 2013 · Molecular Cell
  45. Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy
    Bin Zhang, Qiang Shen, Yaping Chen, Ruile Pan, Shihuan Kuang, Guiyan Liu, Guibo Sun, Xiaobo Sun · 2017 · Scientific Reports
  46. Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced Apoptosis
    Jing Wang, Junqin Mao, Rong Wang, Shengnan Li, Bin Wu, Yongfang Yuan · 2020 · Frontiers in Pharmacology
  47. GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion
    Xi Chen, Yuanling Liu, Jin Zhu, Shipeng Lei, Yuan Dong, Lingyu Li, Beibei Jiang, Li Huan Tan, Jingxian Wu, Shanshan Yu et al. · 2016 · Scientific Reports
  48. The role of natural products in revealing NRF2 function
    Donna D. Zhang, Eli Chapman · 2020 · Natural Product Reports
  49. Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2
    Gahee Bahn, Dong‐Gyu Jo · 2019 · NeuroMolecular Medicine
  50. Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
    Sara Baldelli, Katia Aquilano, Maria Rosa Ciriolo · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
  51. A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer
    E-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, Hyun‐Jeong Ko, Suhwan Chang, S-Y Kim, S-M Jeon · 2017 · Oncogene
  52. Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseases
    Zi Guo, Zhaohui Mo · 2020 · Journal of Tissue Engineering and Regenerative Medicine
  53. Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease
    Veerta Sharma, Amarjot Kaur, Thakur Gurjeet Singh · 2020 · Biomedicine & Pharmacotherapy
  54. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
    Shasha Tao, Pengfei Liu, Gang Luo, Montserrat Rojo de la Vega, Richard Chen, Tongde Wu, Joseph Tillotson, Eli Chapman, Donna D. Zhang · 2017 · Molecular and Cellular Biology
  55. When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration
    Patrycja Michalska, Rafael M. Leon · 2020 · Antioxidants
  56. The KEAP1-NRF2 System and Neurodegenerative Diseases
    Akira Uruno, Masayuki P. Yamamoto · 2023 · Antioxidants and Redox Signaling
  57. Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL
    Hui Tian, Baofu Zhang, Jiehui Di, Guan Jiang, FeiFei Chen, Huizhong Li, Liantao Li, Dong‐Sheng Pei, Junnian Zheng · 2012 · Cancer Letters
  58. Current mechanistic insights into the CCCP-induced cell survival response
    Mariame Selma Kane, Aurélien Paris, Philippe Codron, Julien Cassereau, Vincent Procaccio, Guy Lenaers, Pascal Reynier, Arnaud Chevrollier · 2017 · Biochemical Pharmacology
  59. Nrf2 as a Key Player of Redox Regulation in Cardiovascular Diseases
    Miroslav Barančı́k, Linda Gresová, Monika Barteková, Ima Dovinová · 2016 · Physiological Research
  60. Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β
    Fernando Correa, Carina E. Mallard, Michael Nilsson, Mats Sandberg · 2011 · Neurobiology of Disease
  61. Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
    Shamee Bhattacharjee, Roderick H. Dashwood · 2020 · Antioxidants
  62. New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
    Dionysios V. Chartoumpekis, Thomas W. Kensler · 2013 · Current Diabetes Reviews
  63. Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)
    Alicia R. Timme‐Laragy, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Rachel C. Harbeitner, Jared V. Goldstone, Andrew G. McArthur, Mark E. Hahn · 2011 · Journal of Biological Chemistry
  64. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
    Haibin Zhou, Jianfeng Lü, Liu Liu, Denzil Bernard, Chao‐Yie Yang, Ester Fernández‐Salas, Krishnapriya Chinnaswamy, Stephanie Danielle Layton, Jeanne A. Stuckey, Qing Yu et al. · 2017 · Nature Communications
  65. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects
    Dinesh Singh Tekcham, Di Chen, Yu Liu, Ting Ling, Yi Zhang, Huan Chen, Wen Wang, Wuxiyar Otkur, Huan Qi, Tian Xia et al. · 2020 · Theranostics
  66. Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin
    Youngnam N. Jin, Yanxun V. Yu, Soner Gundemir, Chulman Jo, Mei Cui, Kim Tieu, Gail V.W. Johnson · 2013 · PLoS ONE
  67. GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition
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  68. Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
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  69. Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP- and Hrd1-Dependent Degradation Mechanisms
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  70. Role of Nrf2 and Autophagy in Acute Lung Injury
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  71. Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling
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  72. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)
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  73. The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease
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  74. Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway
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  75. A partnership with the proteasome; the destructive nature of GSK3
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  77. Attenuation of Aβ25–35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways
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  78. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
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  82. Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder
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  100. Targeting NRF2 to treat cancer
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