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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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Combined Donepezil with Astaxanthin via Nanostructured Lipid Carriers Effective Delivery to Brain for Alzheimer’s Disease in Rat Model

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NRF2-targeted therapeutics: New targets and modes of NRF2 regulation

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Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

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Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats

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Nrf2 as a potential target for Parkinson’s disease therapy

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TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62

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Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis

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The naked mole-rat as an animal model in biomedical research: current perspectives

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Nrf2‐dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

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IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model

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Binding partners of NRF2: Functions and regulatory mechanisms

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Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2

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Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis‐Induced Acute Lung Injury through GSK3 β /Keap1‐Nrf2‐GPX4 Pathway

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Degrons: defining the rules of protein degradation

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Sulforaphane Protects against Brain Diseases: Roles of Cytoprotective Enzymes

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NRF-2 and nonalcoholic fatty liver disease

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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase

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Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

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Keap1–Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics

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Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis

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Neddylation regulation of mitochondrial structure and functions

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Heme oxygenase-1-derived bilirubin protects endothelial cells against high glucose-induced damage

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Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

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Polyherbal and Multimodal Treatments: Kaempferol- and Quercetin-Rich Herbs Alleviate Symptoms of Alzheimer’s Disease

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Keap1-independent Nrf2 regulation: A novel therapeutic target for treating kidney disease

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Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease

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Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

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Activators of Nrf2 to Counteract Neurodegenerative Diseases

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Mechanisms of Nrf2/Keap1-Dependent Phase II Cytoprotective and Detoxifying Gene Expression and Potential Cellular Targets of Chemopreventive Isothiocyanates

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Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells

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The NRF2 antagonist ML385 inhibits PI3K‐mTOR signaling and growth of lung squamous cell carcinoma cells

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The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease

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Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption

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Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression

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β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling

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The KEAP1-NRF2 System and Esophageal Cancer

Hirose, W., Oshikiri, H., Taguchi, K., & Yamamoto, M. P. (2022) · Cancers · doi:10.3390/cancers14194702 · Cited by 48

Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2

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Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties

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Significance of NRF2 in physiological and pathological conditions an comprehensive review

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The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease

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The Nrf2-Keap1/ARE signaling pathway in aquatic animals

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Nrf2 as a master regulator of tissue damage control and disease tolerance to infection

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Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

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Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3β in MPP+-Induced Cell Damage

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The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich’s Ataxia

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NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS

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SUMO-Modification of Human Nrf2 at K110 and K533 Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity

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Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress

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Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance

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A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells

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Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation

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ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

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Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease Milieu

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Nrf2: A promising therapeutic target in bone-related diseases

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The scaffold protein AXIN1: gene ontology, signal network, and physiological function

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Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes

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Identification and Functional Studies of a New Nrf2 Partner IQGAP1: A Critical Role in the Stability and Transactivation of Nrf2

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Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention

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Proteome Stability as a Key Factor of Genome Integrity

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Cardioprotective effects of a Fructus Aurantii polysaccharide in isoproterenol-induced myocardial ischemic rats

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Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease

Michalska, P., Mayo, P., Fernández‐Mendívil, C., Tenti, G., Duarte, P., Buendía, I., Ramos, M. T., López, M. G., Menéndez, J. C., & Leon, R. M. (2020) · Antioxidants · doi:10.3390/antiox9080650 · Cited by 42

KEAP1/NRF2 (NFE2L2) mutations in NSCLC – Fuel for a superresistant phenotype?

Dempke, W. C. M., & Reck, M. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.07.006 · Cited by 43

Exercise-induced Nrf2 activation increases antioxidant defenses in skeletal muscles

Powers, S. K., Lategan-Potgieter, R., & Goldstein, E. R. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.041 · Cited by 45

MicroRNA mediated regulation of the major redox homeostasis switch, Nrf2, and its impact on oxidative stress-induced ischemic/reperfusion injury

Padmavathi, G., & Ramkumar, K. M. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108725 · Cited by 40

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

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Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

Hushpulian, D. M., Kaidery, N. A., Ahuja, M., Poloznikov, A. A., Sharma, S. M., Gazaryan, I. G., & Thomas, B. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.673205 · Cited by 41

Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses

Wang, Y., Zhang, X., Meng, F.-G., & Zeng, T. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1894624 · Cited by 40

Nuclear Factor Erythroid-2-Related Factor 2 Signaling in the Neuropathophysiology of Inherited Metabolic Disorders

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Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment

Feng, J., Read, O. J., & Dinkova‐Kostova, A. T. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.2183 · Cited by 42

Role of NRF2 in Pathogenesis of Alzheimer’s Disease

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The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance

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Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

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Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma

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KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo

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Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

Haque, E., Karim, M. R., Teeli, A. S., Śmiech, M., Leszczyński, P., Winiarczyk, D., Parvanov, E. D., Atanasov, A. G., & Taniguchi, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155378 · Cited by 40

Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo

Ghosh, S., Dutta, N., Banerjee, P., Gajbhiye, R. L., SARENG, H. R., Kapse, P., Pal, S., Burdelya, L. G., Mandal, N. C., Ravichandiran, V., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.037 · Cited by 36

Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans

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Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

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The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance

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Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: Mechanisms of action and therapeutic implications

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