The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis
Open accessAbstract
Beta-Catenin-dependent canonical Wnt signaling plays an important role in bone metabolism by controlling differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. To investigate its function in osteocytes, the cell type constituting the majority of bone cells, we generated osteocyte-specific beta-catenin-deficient mice (Ctnnb1(loxP/loxP); Dmp1-Cre). Homozygous mutants were born at normal Mendelian frequency with no obvious morphological abnormalities or detectable differences in size or body weight, but bone mass accrual was strongly impaired due to early-onset, progressive bone loss in the appendicular and axial skeleton with mild growth retardation and premature lethality. Cancellous bone mass was almost completely absent, and cortical bone thickness was dramatically reduced. The low-bone-mass phenotype was associated with increased osteoclast number and activity, whereas osteoblast function and osteocyte density were normal. Cortical bone Wnt/beta-catenin target gene expression was reduced, and of the known regulators of osteoclast differentiation, osteoprotegerin (OPG) expression was significantly downregulated in osteocyte bone fractions of mutant mice. Moreover, the OPG levels expressed by osteocytes were higher than or comparable to the levels expressed by osteoblasts during skeletal growth and at maturity, suggesting that the reduction in osteocytic OPG and the concomitant increase in osteocytic RANKL/OPG ratio contribute to the increased number of osteoclasts and resorption in osteocyte-specific beta-catenin mutants. Together, these results reveal a crucial novel function for osteocyte beta-catenin signaling in controlling bone homeostasis.
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Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
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Functions of RANKL/RANK/OPG in bone modeling and remodeling
Boyce, B. F., & Xing, L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.018 · Cited by 1,844 · cited 1×
“Moreover, osteoblasts also secrete osteoprotegerin (OPG), a soluble RANKL decoy receptor that antagonizes the proosteoclastogenic activity of RANKL by preventing it from binding to its cognate RANK receptor present on osteoclasts and their precursor cells (12).”
BackgroundJho, E.-H., Zhang, T., Domon, C., Joo, C.-K., Freund, J.-N., & Costantini, F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,678
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Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
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Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
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A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
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Cited by
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
Self-citationWNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
Self-citationEvidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
Self-citationThe Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
Self-citationThe contribution of bone to whole-organism physiology
Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537
Metadata
- Authors
- Kramer, I., Halleux, C., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2010-06-01
- Volume
- 30
- Issue
- 12
- Pages
- 3071-3085
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2013293643
- Cited by
- 567
- References
- 74
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Kramer, I., Halleux, C., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M. (2010). Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.01428-09
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