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Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae.
Open accessAbstract
SPT16 was previously identified as a high-copy-number suppressor of delta insertion mutations in the 5' regions of the HIS4 and LYS2 genes of Saccharomyces cerevisiae. We have constructed null mutations in the SPT16 gene and have demonstrated that it is essential for growth. Temperature-sensitive-lethality spt16 alleles have been isolated and shown to be pleiotropic; at a temperature permissive for growth, spt16 mutations suppress delta insertion mutations, a deletion of the SUC2 upstream activating sequence, and mutations in trans-acting genes required for both SUC2 and Ty expression. In addition, SPT16 is identical to CDC68, a gene previously shown to be required for passage through the cell cycle control point START. However, at least some transcriptional effects caused by spt16 mutations are independent of arrest at START. These results and those in the accompanying paper (A. Rowley, R. A. Singer, and G. C. Johnston, Mol. Cell. Biol. 11:5718-5726, 1991) indicate that SPT16/CDC68 is required for normal transcription of many loci in S. cerevisiae.
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Cites
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686
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Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., & Reinberg, D. (2006) · Cell · doi:10.1016/j.cell.2006.04.029 · Cited by 707
Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites
Kaplan, C. D., Laprade, L., & Winston, F. (2003) · Science · doi:10.1126/science.1087374 · Cited by 585
Self-citationThe chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
Orphanides, G., Wu, W.-H., Lane, W. S., Hampsey, M., & Reinberg, D. (1999) · Nature · doi:10.1038/22350 · Cited by 554
Gene Overexpression: Uses, Mechanisms, and Interpretation
Prelich, G. (2012) · Genetics · doi:10.1534/genetics.111.136911 · Cited by 490
Metadata
- Authors
- Malone, E. A., Clark, C. D., Chiang, A., & Winston, F.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1991-11
- Volume
- 11
- Issue
- 11
- Pages
- 5710-5717
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2124612478
- Cited by
- 169
- References
- 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae. https://app.cochat.ai/papers/10.1128/mcb.11.11.5710
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- Malone, E. A., Clark, C. D., Chiang, A., & Winston, F. (1991). Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.11.11.5710
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
