The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.
Cyr61, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion
Open accessAbstract
cyr61 was first identified as a growth factor-inducible immediate-early gene in mouse fibroblasts. The encoded Cyr61 protein is a secreted, cystein-rich heparin-binding protein that associates with the cell surface and the extracellular matrix, and in these aspects it resembles the Wnt-1 protein and a number of known growth factors. During embryogenesis, cyr61 is expressed most notably in mesenchymal cells that are differentiating into chondrocytes and in the vessel walls of the developing circulatory system. cyr61 is a member of an emerging gene family that encodes growth regulators, including the connective tissue growth factor and an avian proto-oncoprotein, Nov cyr61 also shares sequence similarities with two Drosophila genes, twisted gastrulation and short gastrulation, which interact with decapentaplegic to regulate dorsal-ventral patterning. In this report we describe the purification of the Cyr61 protein in a biologically active form, and we show that purified Cyr61 has the following activities: (i) it promotes the attachment and spreading of endothelial cells in a manner similar to that of fibronectin; (ii) it enhances the effects of basic fibroblast growth factor and platelet-derived growth factor on the rate of DNA synthesis of fibroblasts and vascular endothelial cells, although it has no detectable mitogenic activity by itself; and (iii) it acts as a chemotactic factor for fibroblasts. Taken together, these activities indicate that Cyr61 is likely to function as an extracellular matrix signaling molecule rather than as a classical growth factor and may regulate processes of cell proliferation, migration, adhesion, and differentiation during development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“early studies on CCN1 showed that it is tightly associated with the ECM upon secretion [13] and supports cell adhesion through direct binding to integrin receptors [14,15]”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [14]
In the citing paper
“CCN1 does not induce cell proliferation on its own but only enhances DNA synthesis induced by other mitogens [14]”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [14]
In the citing paper
“Although CCN1 does not induce DNA synthesis on its own, it can synergize with other mitogenic growth factors to augment growth factor-induced DNA synthesis in both fibroblasts and endothelial cells through integrin αvβ3 [14,71].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Novel Regulators of Bone Formation: Molecular Clones and Activities
Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R., Hewick, R. M., & Wang, E. A. (1988) · Science · doi:10.1126/science.3201241 · Cited by 3,874
Integrins and Signal Transduction Pathways: the Road Taken
Clark, E. A., & Brugge, J. S. (1995) · Science · doi:10.1126/science.7716514 · Cited by 2,911
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.
Summers, & Smith, G. (1987) · OakTrust (Texas A&M University Libraries) · Cited by 1,670
Peptide Growth Factors and Their Receptors
Arai, K., Battey, J. F., Sporn, M. B., & Roberts, A. B. (1991) · Medical Entomology and Zoology · Cited by 1,225
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122
Primary response genes induced by growth factors and tumor promoters.
Herschman, H. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001433 · Cited by 1,077
Bradham, D. M., Igarashi, A., Potter, R. L., & Grotendorst, G. R. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.6.1285 · Cited by 878
Igarashi, A., Okochi, H., Bradham, D. M., & Grotendorst, G. R. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.6.637 · Cited by 699
Peer Bork, B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80155-n · Cited by 623
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- 10.1128/mcb.12.1.10-21.1992 · DOI
- 10.1128/mcb.10.7.3569-3577.1990 · DOI · Paper page
- Yang, G. P. 1993. Ph.D. thesis. The University of Illinois at Chicago, Chicago.
Cited by
Sorted by citations
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily
Hwa, V., Oh, Y., & Rosenfeld, R. G. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0382 · Cited by 1,076
Connective tissue growth factor: a mediator of TGF-β action on fibroblasts
Grotendorst, G. R. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00010-5 · Cited by 754
All in the CCN family: essential matricellular signaling modulators emerge from the bunker
Leask, A., & Abraham, D. (2006) · Journal of Cell Science · doi:10.1242/jcs.03270 · Cited by 666
The CCN Family of Angiogenic Regulators: The Integrin Connection
Lau, L. F., & Lam, S. C.-T. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4456 · Cited by 645
Self-citation
Metadata
- Authors
- Kireeva, M. L., Mo, F.-E., Yang, G. P., & Lau, L. F.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-04
- Volume
- 16
- Issue
- 4
- Pages
- 1326-1334
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC231116
- OpenAlex
- W1925481732
- Cited by
- 341
- References
- 50
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 10
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Cancer Institute (R01 CA46565-08, R01CA046565)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- CYR61, connective tissue growth factor, immediate early genes, heparin-binding protein, extracellular matrix signaling, cell adhesion, cell migration, cell proliferation, endothelial cell adhesion, basic fibroblast growth factor, platelet-derived growth factor, chemotaxis, fibroblast differentiation, chondrogenic differentiation, twisted gastrulation, short gastrulation, decapentaplegic, dorsoventral patterning, embryonic development
- MeSH terms
- Animals, Cell Adhesion, Cell Division, Cell Movement, Chemotaxis, DNA, Growth Substances, Heparin, Recombinant Proteins, 3T3 Cells, Genes, Immediate-Early, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Mice, Cysteine-Rich Protein 61
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
