The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1
Open accessAbstract
The androgen receptor is unusual among nuclear receptors in that most, if not all, of its activity is mediated via the constitutive activation function in the N terminus. Here we demonstrate that p160 coactivators such as SRC1 (steroid receptor coactivator 1) interact directly with the N terminus in a ligand-independent manner via a conserved glutamine-rich region between residues 1053 and 1123. Although SRC1 is capable of interacting with the ligand-binding domain by means of LXXLL motifs, this interaction is not essential since an SRC1 mutant with no functional LXXLL motifs retains its ability to potentiate androgen receptor activity. In contrast, mutants lacking the glutamine-rich region are inactive, indicating that this region is both necessary and sufficient for recruitment of SRC1 to the androgen receptor. This recruitment is in direct contrast to the recruitment of SRC1 to the estrogen receptor, which requires interaction with the ligand-binding domain.
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A signature motif in transcriptional co-activators mediates binding to nuclear receptors
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Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819
Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0594 · Cited by 834
Heemers, H. V., & Tindall, D. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0019 · Cited by 753
Metadata
- Authors
- Bevan, C. L., Hoare, S., Claessens, F., Heery, D. M., & Parker, M. G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-12-01
- Volume
- 19
- Issue
- 12
- Pages
- 8383-8392
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2164472870
- Cited by
- 425
- References
- 5
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Bevan, C. L., Hoare, S., Claessens, F., Heery, D. M., & Parker, M. G. (1999). The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.19.12.8383
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