Cited by 600NF-κB Signaling PathwaysCancer-related Molecular PathwaysSignaling Pathways in Disease

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Transcriptional Cross Talk between NF-κB and p53

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Webster, Gill A., Perkins, Neil D.·1999·Molecular and Cellular Biology

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Abstract

Many cellular stimuli result in the induction of both the tumor suppressor p53 and NF-kappaB. In contrast to activation of p53, which is associated with the induction of apoptosis, stimulation of NF-kappaB has been shown to promote resistance to programmed cell death. These observations suggest that a regulatory mechanism must exist to integrate these opposing outcomes and coordinate this critical cellular decision-making event. Here we show that both p53 and NF-kappaB inhibit each other's ability to stimulate gene expression and that this process is controlled by the relative levels of each transcription factor. Expression of either wild-type p53 or the RelA(p65) NF-kappaB subunit suppresses stimulation of transcription by the other factor from a reporter plasmid in vivo. Moreover, endogenous, tumor necrosis factor alpha-activated NF-kappaB will inhibit endogenous wild-type p53 transactivation. Following exposure to UV light, however, the converse is observed, with p53 downregulating NF-kappaB-mediated transcriptional activation. Both p53 and RelA(p65) interact with the transcriptional coactivator proteins p300 and CREB-binding protein (CBP), and we demonstrate that these results are consistent with competition for a limiting pool of p300/CBP complexes in vivo. These observations have many implications for regulation of the transcriptional decision-making mechanisms that govern cellular processes such as apoptosis. Furthermore, they suggest a previously unrealized mechanism through which dysregulated NF-kappaB can contribute to tumorigenesis and disease.

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Structure, Regulation and Function of NF-kappaB
Siebenlist, U. K., Franzoso, G., & Brown, K. D. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002201 · Cited by 2,086
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
El‐Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculescu, V. E., Ce, C., Jackman, J., Pietenpol, J. A., Burrell, M., De, H., & Wang, Y. (1994) · PubMed · Cited by 2,021
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.
Osborn, L., Kunkel, S. L., & Nabel, G. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2336 · Cited by 1,583
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
Yang, X., Ogryzko, V. V., Nishikawa, J., Howard, B. H., & Nakatani, Y. (1996) · Nature · doi:10.1038/382319a0 · Cited by 1,497
Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300
Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80516-4 · Cited by 1,480
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
Torchia, J., Rose, D. W., Inostroza, J. A., Kamei, Y., Westin, S. K., Glass, C. K., & Rosenfeld, M. G. (1997) · Nature · doi:10.1038/42652 · Cited by 1,283
Steroid receptor coactivator-1 is a histone acetyltransferase
Spencer, T. E., Jenster, G. W., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Oñate, S. A., Tsai, S. Y., Tsai, M., et al. (1997) · Nature · doi:10.1038/38304 · Cited by 1,242
Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300
Yao, T., Oh, S. P., Fuchs, M., Zhou, N.-D., Ch'ng, L.-E., Newsome, D., Bronson, R. T., Li, E., Livingston, D. M., & Eckner, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81165-4 · Cited by 1,018
Role of CBP/P300 in nuclear receptor signalling
Chakravarti, D., LaMorte, V. J., Nelson, M. C., Nakajima, T., Schulman, I. G., Juguilon, H., Montminy, M., & Evans, R. M. (1996) · Nature · doi:10.1038/383099a0 · Cited by 932
p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
Caelles, C., Helmberg, A., & Karin, M. (1994) · Nature · doi:10.1038/370220a0 · Cited by 843
CREB-binding protein/p300 are transcriptional coactivators of p65
Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 820
Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth
Nakshatri, H., Bhat‐Nakshatri, P., Martin, D. A., Goulet, R. J., & Sledge, G. W. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3629 · Cited by 818
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H., Grinstein, E., Greiner, A., Scheidereit, C., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119849 · Cited by 757
Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730
Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator
Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D., & Nabel, G. J. (1997) · Science · doi:10.1126/science.275.5299.523 · Cited by 720
Self-citation
Binding and modulation of p53 by p300/CBP coactivators
Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J. A., & Livingston, D. M. (1997) · Nature · doi:10.1038/42981 · Cited by 693
Nuclear receptor coactivators
Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80066-x · Cited by 691
Recruitment of p300/CBP in p53-Dependent Signal Pathways
Avantaggiati, M. L., Ogryzko, V. V., Gardner, K., Giordano, A., Levine, A. S., & Kelly, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80304-9 · Cited by 668
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
Devary, Y., Rosette, C., DiDonato, J. A., & Karin, M. (1993) · Science · doi:10.1126/science.8367725 · Cited by 637
Cross‐coupling of the NF‐kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.
Stein, B., Baldwin, A. S., Ballard, D. W., Greene, W. C., Angel, P. E., & Herrlich, P. A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06066.x · Cited by 630
Synergistic activation of transcription by CBP and p53
Gu, W., Shi, X.-L., & Roeder, R. G. (1997) · Nature · doi:10.1038/42972 · Cited by 599
Inhibition of NF‐kappaB/Rel induces apoptosis of murine B cells.
Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., Fitzgerald, M. J., Rothstein, T. L., Sherr, D. H., & Sonenshein, G. E. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00845.x · Cited by 575
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
Leung, K., & Nabel, G. J. (1988) · Nature · doi:10.1038/333776a0 · Cited by 558
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K., Lowe, S. W., Der, C. J., & Baldwin, A. S. (1997) · Science · doi:10.1126/science.278.5344.1812 · Cited by 530
Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction
Stein, B., Cogswell, P. C., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3964 · Cited by 516
Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.
Jiang, H., Lin, J., Su, Z., Collart, F., Huberman, E., & Fisher, P. B. (1994) · PubMed · Cited by 495
The p300/CBP family: integrating signals with transcription factors and chromatin
Shiama, N. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01048-9 · Cited by 488
NF-κB Activation: The IκB Kinase Revealed?
Stancovski, I., & Baltimore, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80413-4 · Cited by 477
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
Yao, T., Ku, G., Zhou, N., Scully, R., & Livingston, D. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10626 · Cited by 456
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements.
Krikos, A., Laherty, C. D., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37138-8 · Cited by 444
Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription
Merika, M., Williams, A. J., Chen, G., Collins, T., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80028-3 · Cited by 435
Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435
CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.
Smith, C. L., Oñate, S. A., Tsai, M., & O’Malley, B. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.8884 · Cited by 415
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
Horvai, A., Xu, L., Korzus, E., Brard, G., Kalafus, D., Mullen, T.-M., Rose, D. W., Rosenfeld, M. G., & Glass, C. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1074 · Cited by 415
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., & Livingston, D. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80140-9 · Cited by 414
IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival
Wu, M. X., Ao, Z., Prasad, K. V. S., Wu, R., & Schlossman, S. F. (1998) · Science · doi:10.1126/science.281.5379.998 · Cited by 414
A requirement for NF-kappa B activation in Bcr-Abl-mediated transformationPreprint
Reuther, J. Y., Reuther, G. W., Cortez, D., Pendergast, A. M., & Baldwin, A. S., Jr. (1998) · Genes & Development · doi:10.1101/gad.12.7.968 · Cited by 401
Interaction and functional collaboration of p300 and C/EBPβ
Mink, S., Haenig, B., & Klempnauer, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6609 · Cited by 346
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathwayPreprint
Caelles, C., González‐Sancho, J. M., & Múñoz, A. (1997) · Genes & Development · doi:10.1101/gad.11.24.3351 · Cited by 327
Untitled work
(1995) · PubMed · Cited by 312
Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein–Taybi syndrome
Tanaka, Y., Naruse, I., Maekawa, T., Masuya, H., Shiroishi, T., & Ishii, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10215 · Cited by 299
The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK
Nakajima, T., Fukamizu, A., Takahashi, J. B., Gage, F. H., Fisher, T., Blenis, J., & Montminy, M. (1996) · Cell · doi:10.1016/s0092-8674(00)80119-1 · Cited by 254
Catalysis by a Multiprotein IκB Kinase Complex
Maniatis, T. (1997) · Science · doi:10.1126/science.278.5339.818 · Cited by 246
Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations
Na, S.-Y., Lee, S., Han, S., Choi, H., Im, S., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10831 · Cited by 235
An Interaction between the DNA-Binding Domains of RelA(p65) and Sp1 Mediates Human Immunodeficiency Virus Gene Activation
Perkins, N. D., Agranoff, A. B., Pascal, E., & Nabel, G. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6570 · Cited by 229
Self-citation
Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.
Perkins, N. D., Schmid, R. M., Duckett, C. S., Leung, K., Rice, N. R., & Nabel, G. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1529 · Cited by 228
Self-citation
IκB kinase: Beginning, not the end
Verma, I. M., & Stevenson, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11758 · Cited by 199
Activation of the cryptic DNA binding function of mutant forms of p53
Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3167 · Cited by 190
Achieving transcriptional specificity with nf-κb
Perkins, N. D. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00088-5 · Cited by 183
Self-citation
Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α
Jung, M., Zhang, Y., Lee, S., & Dritschilo, A. (1995) · Science · doi:10.1126/science.7777860 · Cited by 171
Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting regionSelfcloseTable
Somasundaram, K., & El‐Deiry, W. S. (1997) · Oncogene · doi:10.1038/sj.onc.1201002 · Cited by 169
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.
Ravi, R. K., Mookerjee, B., van Hensbergen, Y., Bedi, G. C., Giordano, A., El‐Deiry, W. S., Fuchs, E. J., & Bedi, A. (1998) · PubMed · Cited by 156
Modulation of cytokine‐induced HIV gene expression by competitive binding of transcription factors to the coactivator p300
Hottiger, M. O., Felzien, L. K., & Nabel, G. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3124 · Cited by 137
Defective IκBα in Hodgkin cell lines with constitutively active NF-κB
Wood, K. M., Roff, M. A., & Hay, R. T. (1998) · Oncogene · doi:10.1038/sj.onc.1201735 · Cited by 127
MDM2-arbiter of p53's destruction
Lane, D. P., & Hall, P. A. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01119-5 · Cited by 126
Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction
Stein, B., Cogswell, P. C., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3964-3974.1993 · Cited by 120
Inhibition of Protein Phosphatase Activity Induces p53-dependent Apoptosis in the Absence of p53 Transactivation
Yan, Y., Shay, J. W., Wright, W. E., & Mumby, M. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15220 · Cited by 117
Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activation
Klefström, J. T., Arighi, E., Littlewood, T., Jäättelä, M., Saksela, E., Evan, G. I., & Alitalo, K. K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7382 · Cited by 117
Functional interplay between p53 and E2F through co-activator p300
Lee, C., Sørensen, T. S., Shikama, N., & Thangue, N. B. L. (1998) · Oncogene · doi:10.1038/sj.onc.1201818 · Cited by 115
EDITORIAL. p53—INTEGRATING THE COMPLEXITY
Hall, P. A., Meek, D. W., & Lane, D. P. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199609)180:1 · Cited by 112
DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.
Allday, M. J., Inman, G. J., Crawford, D., & Farrell, P. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00182.x · Cited by 109
A Role for Nuclear Factor κB in the Antiapoptotic Function of Insulin
Bertrand, F., Atfi, A., Cadoret, A., L’Allemain, G., Robin, H., Lascols, O., Capeau, J., & Cherqui, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2931 · Cited by 107
Tumor Necrosis Factor-induced Apoptosis Stimulates p53 Accumulation and p21WAF1 Proteolysis in ME-180 Cells
Donato, N. J., & Perez, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5067 · Cited by 88
Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.
Vojtěšek, B., Dolezalova, H., Lauerová, L., Svitáková, M., Havlis, P., Kovařík, J., Midgley, C. A., & Lane, D. P. (1995) · PubMed · Cited by 72
Inhibition of Phorbol Ester-Induced Cellular Adhesion by Competitive Binding of NF-κB In Vivo
Eck, S. L., Perkins, N. D., Carr, D. P., & Nabel, G. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6530-6536.1993 · Cited by 64
Self-citation
Transcriptional squelching re-examined
Natesan, S., Rivera, V. M., Molinari, E., & Gilman, M. Z. (1997) · Nature · doi:10.1038/37019 · Cited by 56
An Interaction between the DNA-Binding Domains of RelA(p65) and Sp1 Mediates Human Immunodeficiency Virus Gene Activation
Perkins, N. D., Agranoff, A. B., Pascal, E., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6570-6583.1994 · Cited by 55
Self-citation
A Proliferative p53-Responsive Element Mediates Tumor Necrosis Factor Alpha Induction of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat
Gualberto, A., Hixon, M. L., Finco, T. S., Perkins, N. D., Nabel, G. J., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3450 · Cited by 37
Self-citation
IκB kinase all zipped up
Israë, A. (1997) · Nature · doi:10.1038/41433 · Cited by 35
Distinct domains of IkappaB-alpha inhibit human immunodeficiency virus type 1 replication through NF-kappaB and Rev
Wu, B., Woffendin, C., MacLachlan, I., & Nabel, G. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.3161-3167.1997 · Cited by 26
Induction of p53 DNA-binding activity by tumor necrosis factor-alpha
Mukhopadhyay, T., Roth, J. A., & Maxwell, S. A. (1996) · International Journal of Oncology · doi:10.3892/ijo.9.4.715 · Cited by 4

Flagged first, then by citations

Research works printed but not linked: 11

Bannister A. J., 1995, Oncogene, 11, 2509
Eck S. L., 1993, Mol. Cell. Biol., 13, 6530
el-Deiry W. S., 1994, Cancer Res., 54, 1169
10.1073/pnas.94.4.1074 · DOI
Israel A., 1997, Nature, 388, 519
Jiang H., 1994, Oncogene, 9, 3397
Mukhopadhyay T., 1996, Int. J. Oncol., 9, 715
Perkins N. D., 1994, Mol. Cell. Biol., 14, 6570
Ravi R., 1998, Cancer Res., 58, 4531
Stein B., 1993, Mol. Cell. Biol., 13, 3964
Vojtesek B., 1995, Oncogene, 10, 389

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Authors: Webster, G. A., & Perkins, N. D.
Affiliations: University of Dundee (GB)
ORCID: Perkins, Neil D.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1999-05-01
Volume: 19
Issue: 5
Pages: 3485-3495
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.19.5.3485
PMC: PMC84141
OpenAlex: W2134542375
Cited by: 598
References: 87
Citations by year: 2026: 10 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 19 · 2021: 30 · 2020: 17 · 2019: 16 · 2018: 16 · 2017: 12 · 2016: 20 · 2015: 23 · 2014: 14 · 2013: 20 · 2012: 15
FWCI: 13.41
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Royal Society
Tenovus
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, p53, transcriptional crosstalk, RelA/p65, P300, CREB-binding protein, transcriptional coactivator, apoptosis, TNF-α, transcriptional repression, carcinogenesis
MeSH terms: Binding, Competitive, Cell Line, Gene Expression Regulation, Humans, Mutation, Repressor Proteins, Transcription, Genetic, Tumor Necrosis Factor-alpha, Ultraviolet Rays, Trans-Activators, Tumor Suppressor Protein p53, NF-kappa B, Apoptosis, Genes, Reporter, Transcription Factor RelA

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Transcriptional Cross Talk between NF-κB and p53

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