Cited by 88Endometriosis Research and TreatmentEffects and risks of endocrine disrupting chemicalsToxic Organic Pollutants Impact

Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease

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Sofo, Vincenza, Götte, Martin, Laganà, Antonio Simone, Salmeri, Francesca Maria, Triolo, Onofrio, Sturlese, Emanuele, Retto, Giovanni, Alfa, Maria +2 more·2015·Archives of Gynecology and Obstetrics

Abstract

Introduction Environmental toxicants can act as endocrine disrupters on the female reproductive system. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is resistant to degradation and due to its lipophilic nature, accumulates in the fat tissue and in the food chain. Human and animal exposure to TCDD affects levels of the steroid receptors and steroid-responsive gene expression and has an impact on metabolism and serum transport of steroids. Gene expression is commonly altered in endometriosis and in the eutopic endometrium of women with the disease. Aberrantly expressed genes include those associated with the regulation of transcription, proliferation, sex steroid metabolism, apoptosis, cell cycle, the immune response and cell adhesion.Methods In this paper, we review the evidence about TCDD's effect on eutopic and ectopic endometrium, in order to unravel the machinery behind the dysregulation of immune and hormonal homeostasis caused by this environmental toxicant.Conclusion The evidence collected in this review suggests that TCDD could modulate transcription at multiple levels, including the epigenetic level, and via microRNAs, thus disturbing the physiologic processes mediated through the aryl hydrocarbon receptor pathways. Exposure to TCDD also modulates the immune response by influencing the production and action of endometrial cytokines and chemokines, destroying mucosal immunity of the reproductive tract and re-directing the tissue distribution and behavior of leukocytes. Despite this large body of evidence, current human-based epidemiological studies on the association between TCDD and endometriosis remain controversial.

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Crossref · 10.1007/s00404-015-3739-5

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195 of 195 references verified0 citation errors · 0 not checkable

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  • Dioxin and total body radiation can have genomic or epigenetic effects.

    “Both can have genomic or epigenetic effects (193).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [193]

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Authors
Sofo, V., Götte, M., Laganà, A. S., Salmeri, F. M., Triolo, O., Sturlese, E., Retto, G., Alfa, M., Granese, R., & Abrão, M. S.
Affiliations
  • University of Messina (IT)
  • University Hospital Münster (DE)
Corresponding author
Laganà, Antonio Simone
Venue
Archives of Gynecology and Obstetrics
Published
2015-04-29
Volume
292
Issue
5
Pages
973-986
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W2015065613
Cited by
88
References
195
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 12 · 2019: 13 · 2018: 7 · 2017: 14 · 2016: 12
FWCI
1.67
Type
journal article
Language
en
Open access
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
endometriosis, TCDD, dioxins, endocrine disruptors, epigenetics, aryl hydrocarbon receptor, microRNA, endometrial immune response, cytokines and chemokines, sex steroid metabolism, eutopic endometrium, ectopic endometrium, environmental toxins
MeSH terms
Polychlorinated Dibenzodioxins, Animals, Dioxins, Endometriosis, Endometrium, Female, Humans, Gene Expression

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