The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction
Open accessAbstract
Dioxins exert a variety of adverse effects on organisms, including teratogenesis, immunosuppression, tumor promotion, and estrogenic action. Studies using aryl hydrocarbon receptor (AhR)-deficient mice suggest that the majority of these toxic effects are mediated by the AhR. In spite of the adverse effects mediated by this receptor, the AhR gene is conserved among a number of animal species, ranging from invertebrates to vertebrates. This high degree of conservation strongly suggests that AhR possesses an important physiologic function, and a critical function is also supported by the reduced fertility observed with AhR-null female mice. We demonstrate that AhR plays a crucial role in female reproduction by regulating the expression of ovarian P450 aromatase (Cyp19), a key enzyme in estrogen synthesis. As revealed by in vitro reporter gene assay and in vivo chromatin immunoprecipitation assay, AhR cooperates with an orphan nuclear receptor, Ad4BP/SF-1, to activate Cyp19 gene transcription in ovarian granulosa cells. Administration to female mice of an AhR ligand, DMBA (9,10-dimethyl-1,2-benzanthracene), induced ovarian Cyp19 gene expression, irrespective of the intrinsic phase of the estrus cycle. In addition to elucidating a physiological function for AhR, our studies also suggest a possible mechanism for the toxic effects of exogenous AhR ligands as endocrine disruptors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This mouse has also been used to examine fertility endpoints such that females were reported to be sub-fertile due to impaired follicular development and ovulation (Baba et al., 2005).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Baba et al., 2005
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1×
“A number of genes encoding drug-metabolizing enzymes, including CYP1A1 and genes encoding UDP-glucuronosyl transferase and glutathione S-transferase, have been identified as targets of AhR (18, 21).”
BackgroundFero, M. L., Rivkin, M. J., Tasch, M., Porter, P. L., Carow, C. E., Firpo, E. J., Polyák, K., Tsai, L., Broudy, V. C., Perlmutter, R. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81239-8 · Cited by 1,459
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27
Kiyokawa, H., Kineman, R. D., Manova-Todorova, K. O., Soares, V., Hoffman, E. S., Ono, M., Khanam, D., Hayday, A., Frohman, L. A., & Koff, A. (1996) · Cell · doi:10.1016/s0092-8674(00)81238-6 · Cited by 1,243
Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development · doi:10.1242/dev.127.19.4277 · Cited by 1,064
Fisher, C. R., Graves, K. H., Parlow, A. F., & Simpson, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6965 · Cited by 867
Hormonal Control of Gene Expression in the Ovary
Richards, J. S. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-6-725 · Cited by 862
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
Ohtake, F., Takeyama, K., Μatsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., et al. (2003) · Nature · doi:10.1038/nature01606 · Cited by 798
Self-citation
Cited by
Sorted by citations
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., et al. (2007) · Nature · doi:10.1038/nature05683 · Cited by 585
Self-citationBonefeld‐Jørgensen, E. C., Long, M., Hofmeister, M. V., & Vinggaard, A. M. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9368 · Cited by 504
Omiecinski, C. J., Heuvel, J. P. V., Perdew, G. H., & Peters, J. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq338 · Cited by 385
Schroeder, J. C., DiNatale, B. C., Murray, I. A., Flaveny, C. A., Liu, Q., Laurenzana, E. M., Lin, J.-M., Strom, S. C., Omiecinski, C. J., Amin, S., et al. (2009) · Biochemistry · doi:10.1021/bi901786x · Cited by 340
An introduction to the molecular basics of aryl hydrocarbon receptor biology
Abel, J., & Haarmann‐Stemmann, T. (2010) · Biological Chemistry · doi:10.1515/bc.2010.128 · Cited by 309
Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes
Fujii-Kuriyama, Y., & Mimura, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.162 · Cited by 290
Self-citationCraig, Z. R., Wang, W., & Flaws, J. A. (2011) · Reproduction · doi:10.1530/rep-11-0136 · Cited by 285
Wincent, E., Amini, N., Luecke-Johansson, S., Glatt, H. R., Bergman, J., Crescenzi, C., Rannug, A., & Rannug, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808321200 · Cited by 288
Estrogen receptor and aryl hydrocarbon receptor signaling pathways
Matthews, J. B., & Gustafsson, J.-Α. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04016 · Cited by 277
Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug Target
Safe, S. H., Lee, S., & Jin, U.-H. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft128 · Cited by 281
Okey, A. B. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm096 · Cited by 264
The emerging roles of AhR in physiology and immunity
Hao, N., & Whitelaw, M. L. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.004 · Cited by 231
Wincent, E., Bengtsson, J., Mohammadi‐Bardbori, A., Alsberg, T. E., Luecke-Johansson, S., Rannug, U., & Rannug, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118467109 · Cited by 221
Bosse, M., Megens, H., Frantz, L., Madsen, O., Larson, G., Paudel, Y., Duijvesteijn, N., Harlizius, B., Hagemeijer, Y. P., Crooijmans, R. P. M. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms5392 · Cited by 209
Kawajiri, K., & Fujii-Kuriyama, Y. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.038 · Cited by 197
Self-citationThe roles of aryl hydrocarbon receptor in immune responses
Nguyen, N. T., Hanieh, H., Nakahama, T., & Kishimoto, T. (2013) · International Immunology · doi:10.1093/intimm/dxt011 · Cited by 195
Sekine, H., Mimura, J., Oshima, M., Okawa, H., Kanno, J., Igarashi, K., Gonzalez, F. J., Ikuta, T., Kawajiri, K., & Fujii‐Kuriyama, Y. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00337-09 · Cited by 184
Self-citationExternal influences on the immune system via activation of the aryl hydrocarbon receptor
Stockinger, B., Hirota, K., Duarte, J. H., & Veldhoen, M. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.008 · Cited by 190
The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
McMillan, B. J., & Bradfield, C. A. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037259 · Cited by 183
Hahn, M. E., Allan, L. L., & Sherr, D. H. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.016 · Cited by 190
The role of the aryl hydrocarbon receptor in the female reproductive system
Hernández‐Ochoa, I., Karman, B. N., & Flaws, J. A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.037 · Cited by 171
AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions
Ohtake, F., Fujii‐Kuriyama, Y., & Kato, S. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.08.034 · Cited by 173
Self-citationRegulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor
Harper, P. A., Riddick, D. S., & Okey, A. B. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.01.007 · Cited by 160
Hahn, M. E., Karchner, S. I., Evans, B. R., Franks, D. G., Merson, R. R., & Lapseritis, J. M. (2006) · Journal of Experimental Zoology Part A: Comparative Experimental Biology · doi:10.1002/jez.a.323 · Cited by 153
Endocrine Disruptors and Leydig Cell Function
Svechnikov, K., Izzo, G., Landreh, L., Weisser, J., & Söder, O. (2010) · BioMed Research International · doi:10.1155/2010/684504 · Cited by 154
The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model
Avilla, M. N., Malecki, K. M. C., Hahn, M. E., Wilson, R. H., & Bradfield, C. A. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00476 · Cited by 148
Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)
Safe, S. H., Jin, U.-H., Park, H., Chapkin, R. S., & Jayaraman, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186654 · Cited by 143
Mescher, M., & Haarmann‐Stemmann, T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.012 · Cited by 138
Fujii‐Kuriyama, Y., & Kawajiri, K. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.40 · Cited by 135
Self-citationEndocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis
Plunk, E. C., & Richards, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239191 · Cited by 127
Rannug, A., & Rannug, U. (2018) · Critical Reviews in Toxicology · doi:10.1080/10408444.2018.1493086 · Cited by 126
Izzotti, A., Kanitz, S., D’Agostini, F., Camoirano, A., & Flora, S. D. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.07.011 · Cited by 117
Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings.
Ohtake, F., Baba, A., Fujii-Kuriyama, Y., & Kato, S. (2008) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.03.054 · Cited by 121
Self-citationChang, J. T., Chang, H., Chen, P., Lin, S., & Lin, P. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1166 · Cited by 115
Diversity across major and candidate genes in European local pig breeds
Muñoz, M., Bozzi, R., García, F., Núñez, Y., Geraci, C., Crovetti, A., García-Casco, J. M., Alves, E., Škrlep, M., Charneca, R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207475 · Cited by 114
Hall, J. M., Barhoover, M. A., Kazmin, D. A., McDonnell, D. P., Greenlee, W. F., & Thomas, R. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0346 · Cited by 112
Bock, K. W. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.015 · Cited by 114
Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance
Lindén, J., Lensu, S., Tuomisto, J., & Pohjanvirta, R. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.002 · Cited by 108
Medjakovic, S., & Jungbauer, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.10.001 · Cited by 103
Groh, K. J., Brion, F., Page, Y. L., Hinfray, N., Pakdel, F., Kah, O., Segner, H. E., & Eggen, R. I. L. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfm003 · Cited by 103
Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues
Jiang, Y., Wang, K., FANG, R. ‐., & Zheng, J. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955955 · Cited by 100
Naves, L. A., Daly, A., Vanbellinghen, J.-F., Casulari, L. A., Spilioti, C., de Magalhães, A. V., Azevedo, M. F., Giacomini, L., Nascimento, P. P., Nunes, R. O., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0533 · Cited by 94
Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist
Muku, G. E., Murray, I. A., Espı́n, J. C., & Perdew, G. H. (2018) · Metabolites · doi:10.3390/metabo8040086 · Cited by 94
Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity
Zollner, G., Wagner, M., & Trauner, M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.03.005 · Cited by 91
Sofo, V., Götte, M., Laganà, A. S., Salmeri, F. M., Triolo, O., Sturlese, E., Retto, G., Alfa, M., Granese, R., & Abrão, M. S. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3739-5 · Cited by 88
Activation of xenobiotic receptors: driving into the nucleus
Li, H., & Wang, H. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425251003598886 · Cited by 92
Ghisari, M., Long, M., Tabbo, A., & Bonefeld‐Jørgensen, E. C. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.02.004 · Cited by 94
Endocrine Disrupter Bisphenol A Increases In Situ Estrogen Production in the Mouse Urogenital Sinus
Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J., & Sugimura, Y. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087502 · Cited by 86
Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system
Ohtake, F., Fujii‐Kuriyama, Y., Kawajiri, K., & Kato, S. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.007 · Cited by 86
Self-citationMurray, I. A., Gowda, K., DiNatale, B. C., Flaveny, C. A., Chiaro, C. R., Lin, J.-M., Sharma, A. K., Amin, S., & Perdew, G. H. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100045h · Cited by 84
Bock, K. W. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114093 · Cited by 84
Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M. A., Kuzu, G., Tian, Y., Smith, P., Kennett, M. J., Patterson, A. D., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.038 · Cited by 87
Tarnow, P., Tralau, T., & Luch, A. (2019) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1569627 · Cited by 79
Aryl Hydrocarbon Receptor as a Target for Lycopene Preventing DEHP-Induced Spermatogenic Disorders
Zhao, Y., Lin, J., Talukder, M., Zhu, S., Li, M., Wang, H., & Li, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07795 · Cited by 76
Bergander, L. V., Cai, W., Klocke, B., Seifert, M., & Pongratz, I. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1351 · Cited by 74
Species extrapolation for the 21st century
Celander, M., Goldstone, J. V., Denslow, N. D., Iguchi, T., Kille, P., Meyerhoff, R. D., Smith, B. A., Hutchinson, T. H., & Wheeler, J. R. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.382 · Cited by 70
Bock, K. W. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114220 · Cited by 73
Greytak, S. R., & Callard, G. V. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.07.017 · Cited by 68
Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies
Safe, S. H., Han, H., Goldsby, J. S., Mohankumar, K., & Chapkin, R. S. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.11.005 · Cited by 70
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
Wallace, B. D., & Redinbo, M. R. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.740049 · Cited by 69
AhR protein trafficking and function in the skin
Ikuta, T., Namiki, T., Fujii-Kuriyama, Y., & Kawajiri, K. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.003 · Cited by 68
Self-citationFurness, S. G. B., & Whelan, F. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.09.004 · Cited by 63
Dimethyl-Benz(a)anthracene: A mammary carcinogen and a neuroendocrine disruptor
Kerdelhué, B., Forest, C. D., & Coumoul, X. (2016) · Biochimie Open · doi:10.1016/j.biopen.2016.09.003 · Cited by 63
Sauzeau, V., Carvajal-González, J. M., Riolobos, A. S., Sevilla, M. A., Menacho-Márquez, M., Román, Á., Abad, A., Montero, M. J., Fernández‐Salguero, P. M., & Bustelo, X. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187534 · Cited by 67
Role of the Aryl Hydrocarbon Receptor in Sugen 5416–induced Experimental Pulmonary Hypertension
Dean, A., Gregorc, T., Docherty, C. K., Harvey, K. Y., Nilsen, M., Morrell, N. W., & MacLean, M. R. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0260oc · Cited by 59
Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure
Molina-López, A. M., Abril, N., Morales‐Prieto, N., Monterde, J. G., Lora-Benítez, A. J., Ayala-Soldado, N., & Moyano, R. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.026 · Cited by 60
Heiden, T. C. K., Struble, C. A., Rise, M. L., Hessner, M. J., Hutz, R. J., & Carvan, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.013 · Cited by 60
Sekine, H., Mimura, J., Yamamoto, M. P., & Fujii‐Kuriyama, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606910200 · Cited by 60
Self-citationKarman, B. N., Basavarajappa, M. S., Craig, Z. R., & Flaws, J. A. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.03.015 · Cited by 57
Signatures of Selection and Interspecies Introgression in the Genome of Chinese Domestic Pigs
Zhu, Y., Li, W., Yang, B. J., Zhang, Z., Ai, H., Ren, J., & Huang, L. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx186 · Cited by 58
Tiong, C. T., Chen, C., Zhang, S. J., Li, J., Soshilov, A. A., Denison, M. S., Lee, L., Tam, V. H., Wong, S. P., Xu, H. E., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs110 · Cited by 54
Zheng, X., Zhao, P., Yang, K., Ning, C., Wang, H., Zhou, L., & Liu, J. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00442-5 · Cited by 55
Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish
Lanham, K. A., Plavicki, J. S., Peterson, R. E., & Heideman, W. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu111 · Cited by 51
Hernández‐Ochoa, I., Barnett-Ringgold, K., Dehlinger, S. L., Gupta, R. K., Leslie, T. C., Roby, K. F., & Flaws, J. A. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087015 · Cited by 51
Baba, T., Shima, Y., Owaki, A., Mimura, J., Oshima, M., Fujii-Kuriyama, Y., & Morohashi, K. (2008) · Sexual Development · doi:10.1159/000117714 · Cited by 50
Self-citationRieke, S., Koehn, S., Hirsch‐Ernst, K. I., Pfeil, R., Kneuer, C., & Marx‐Stoelting, P. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110909660 · Cited by 50
Sexual differentiation of the rodent hypothalamus: Hormonal and environmental influences
Negri-Cesi, P., Colciago, A., Pravettoni, A., Casati, L., Conti, L., & Celotti, F. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.003 · Cited by 50
Karman, B. N., Basavarajappa, M. S., Hannon, P. R., & Flaws, J. A. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.031 · Cited by 48
Matthews, J. B., Wihlén, B., Heldring, N., MacPherson, L., Helguero, L. A., Treuter, E., Haldosén, L., & Gustafsson, J.-Α. (2007) · Biochemical Journal · doi:10.1042/bj20070585 · Cited by 49
Chen, H., Chiang, P., Wang, Y., Kao, M.-C., Shieh, T.-H., Tsai, C., & Tsai, E. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.11.004 · Cited by 51
Wihlén, B., Ahmed, S., Inzunza, J., & Matthews, J. B. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0396 · Cited by 49
Dysregulation of Notch and ERα signaling in AhR −/− male mice
Huang, B., Butler, R., Miao, Y., Dai, Y., Wu, W., Su, W., Fujii‐Kuriyama, Y., Warner, M. N., & Gustafsson, J.-Α. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613269113 · Cited by 47
Self-citationPolychlorinated biphenyls and its potential role in endometriosis
Yao, M., Hu, T., Wang, Y., Du, Y., Hu, C., & Wu, R. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.06.088 · Cited by 47
Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta
Wakx, A., Nedder, M., Tomkiewicz, C., Dalmasso, J., Chissey, A., Boland, S., Vibert, F., Degrelle, S. A., Fournier, T., Coumoul, X., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123762 · Cited by 48
Pulmonary arterial hypertension: Sex matters
Dignam, J. P., Sharma, S., Stasinopoulos, I. A., & MacLean, M. R. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16277 · Cited by 46
Oshima, M., Mimura, J., Yamamoto, M. P., & Fujii‐Kuriyama, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.131 · Cited by 44
Self-citationCavallini, A., Lippolis, C., Vacca, M. P., Nardelli, C., Castegna, A., Arnesano, F., Carella, N., & Depalo, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152181 · Cited by 43
Eichenlaub-Ritter, U., Winterscheidt, U., Vogt, E.-J., Shen, Y., Tinneberg, H., & Sorensen, R. A. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.055111 · Cited by 43
Kummer, V., Mašková, J., Zralý, Z., & Faldyna, M. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1714 · Cited by 42
Environmental toxicants and effects on female reproductive function.
Hutz, R. J., Carvan, M. J., Baldridge, M. G., Conley, L. K., & Heiden, T. K. (2006) · PubMed · doi:10.1901/jaba.2006.2-1 · Cited by 42
Girer, N. G., Tomlinson, C. R., & Elferink, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010049 · Cited by 40
Merisalu, A., Punab, M., Altmäe, S., Haller, K., Tiido, T., Peters, M., & Salumets, A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.041 · Cited by 40
Pansoy, A., Ahmed, S., Valen, E., Sandelin, A., & Matthews, J. B. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq096 · Cited by 37
G‐protein signalling negatively regulates the stability of aryl hydrocarbon receptor
Nakata, A., Urano, D., Fujii‐Kuriyama, Y., Mizuno, N., Tago, K., & Itoh, H. (2009) · EMBO Reports · doi:10.1038/embor.2009.35 · Cited by 38
Self-citationThe aryl hydrocarbon receptor is required for normal gonadotropin responsiveness in the mouse ovary
Barnett-Ringgold, K., Tomic, D., Gupta, R. K., Babus, J. K., Roby, K. F., Terranova, P. F., & Flaws, J. A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.05.014 · Cited by 38
Piccinni, M., Lombardelli, L., Logiodice, F., Kullolli, O., Maggi, E., & Barkley, M. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00642 · Cited by 36
Aryl hydrocarbon receptor catabolic activity in bone metabolism is osteoclast dependent in vivo
Yu, T., Kondo, T., Μatsumoto, T., Fujii‐Kuriyama, Y., & Imai, Y. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.114 · Cited by 37
Self-citationElson, D. J., & Kolluri, S. K. (2023) · Biology · doi:10.3390/biology12040526 · Cited by 38
Neal, M. S., Tuttle, A. M., Casper, R. F., Lagunov, A., & Foster, W. G. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.03.025 · Cited by 36
Metadata
- Authors
- Baba, T., Mimura, J., Nakamura, N., Harada, N., Yamamoto, M., Morohashi, K.-I., & Fujii-Kuriyama, Y.
- Affiliations
- National Institute for Basic Biology (JP)
- University of Tsukuba (JP)
- Fujita Health University (JP)
- TARA Center, University of Tsukuba, 1-1-1 Tennoudai
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-11
- Volume
- 25
- Issue
- 22
- Pages
- 10040-10051
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1280268
- OpenAlex
- W2142798058
- Cited by
- 256
- References
- 62
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 16 · 2019: 11 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 20 · 2012: 15
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- aryl hydrocarbon receptor, dioxins, female reproduction, aromatase, estrogen synthesis, granulosa cells, Ad4BP/SF-1, nuclear receptor transcriptional regulation, endocrine disruptors, 7,12-dimethylbenz(a)anthracene, fertility
- MeSH terms
- Animals, Aromatase, Estradiol, Estrogens, Female, Gene Expression Regulation, Genotype, Granulosa Cells, Humans, Immunohistochemistry, Ligands, Luciferases, Male, Models, Genetic, Ovary, Ovulation, Phenotype, Promoter Regions, Genetic, Reproduction, Steroids, Transcription Factors, Transcription, Genetic, Transfection, 9,10-Dimethyl-1,2-benzanthracene, Up-Regulation, Polymerase Chain Reaction, Genes, Reporter, DNA Primers, Receptors, Cytoplasmic and Nuclear, Receptors, Aryl Hydrocarbon, Homeodomain Proteins, Chromatin Immunoprecipitation, Immunoprecipitation, Mice, Steroidogenic Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
